KEGG DRUG

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Drug (Description in trials)

DrugBank

KEGG DRUG

KEGG GENES

KEGG PATHWAY

Disease ID

ALEMTUZUMAB
(Campath (TN))

[1] Alemtuzumab (Campath)

[1] Alemtuzumab (Campath (TN)) 💬

[1] CD52 💬

[17] 13, 15, 19, 20, 36, 43, 44, 46, 51, 60, 63, 65, 85, 96, 164, 283, 284 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica
15	Inclusion body myositis
19	Lysosomal storage disease
20	Adrenoleukodystrophy
36	Epidermolysis bullosa
43	Microscopic polyangiitis
44	Wegener granulomatosis
46	Malignant rheumatoid arthritis
51	Scleroderma
60	Aplastic anemia
63	Idiopathic thrombocytopenic purpura
65	Primary immunodeficiency
85	Idiopathic interstitial pneumonia
96	Crohn disease
164	Oculocutaneous albinism
283	Acquired pure red cell aplasia
284	Diamond-Blackfan anemia

Alemtuzumab (already received by alemtuzumab cohort between 1991 and 1994
(Campath (TN))

[1] Alemtuzumab (Campath)

[1] Alemtuzumab (Campath (TN)) 💬

[1] CD52 💬

[1] 46 💬

Alemtuzumab (already received by alemtuzumab cohort between 1991 and 1994)
(Campath (TN))

[1] Alemtuzumab (Campath)

[1] Alemtuzumab (Campath (TN)) 💬

[1] CD52 💬

[1] 46 💬

Alemtuzumab (Campath )

[1] Alemtuzumab (Campath)

[1] Alemtuzumab (Campath (TN)) 💬

[1] CD52 💬

[1] 60 💬

Alemtuzumab (Campath)

[1] Alemtuzumab (Campath)

[1] Alemtuzumab (Campath (TN)) 💬

[1] CD52 💬

[1] 15 💬

Alemtuzumab (GZ402673)
(Campath (TN))

[1] Alemtuzumab (Campath)

[1] Alemtuzumab (Campath (TN)) 💬

[1] CD52 💬

[1] 13 💬

Alemtuzumab 0.2 mg
(Campath (TN))

[1] Alemtuzumab (Campath)

[1] Alemtuzumab (Campath (TN)) 💬

[1] CD52 💬

[2] 65, 164 💬

Alemtuzumab 0.3 mg
(Campath (TN))

[1] Alemtuzumab (Campath)

[1] Alemtuzumab (Campath (TN)) 💬

[1] CD52 💬

[2] 65, 164 💬

Alemtuzumab 12 mg
(Campath (TN))

[1] Alemtuzumab (Campath)

[1] Alemtuzumab (Campath (TN)) 💬

[1] CD52 💬

[1] 13 💬

Alemtuzumab 24 mg
(Campath (TN))

[1] Alemtuzumab (Campath)

[1] Alemtuzumab (Campath (TN)) 💬

[1] CD52 💬

[1] 13 💬

Alemtuzumab and Rituximab
(Campath (TN))

[2] Alemtuzumab (Campath),
Rituximab

[2] Alemtuzumab (Campath (TN)),
Rituximab 💬

Name	Other Names
Alemtuzumab	Alemtuzumab (USAN/INN) Alemtuzumab (genetical recombination) (JAN) Campath (TN) Lemtrada (TN)
Rituximab	Rituximab (USAN/INN) Rituximab (genetical recombination) (JAN) Rituximab (genetical recombination) [Rituximab biosimilar 1] (JAN) Rituximab (genetical recombination) [Rituximab biosimilar 2] (JAN) Rituximab-abbs Rituximab-pvvr Rituximab-arrx Rituxan (TN) Riabni (TN) Truximab (TN) RUXIENCE TRUXIMA

[2] CD52,
MS4A1 💬

[1] Hematopoietic cell lineage 💬

[1] 60 💬

Alemtuzumab GZ402673
(Campath (TN))

[1] Alemtuzumab (Campath)

[1] Alemtuzumab (Campath (TN)) 💬

[1] CD52 💬

[1] 13 💬

Alemtuzumab immunotherapy
(Campath (TN))

[1] Alemtuzumab (Campath)

[1] Alemtuzumab (Campath (TN)) 💬

[1] CD52 💬

[1] 13 💬

Alemtuzumab Injection
(Campath (TN))

[1] Alemtuzumab (Campath)

[1] Alemtuzumab (Campath (TN)) 💬

[1] CD52 💬

[1] 13 💬

Alemtuzumab Injection [Lemtrada]
(Campath (TN))

[1] Alemtuzumab (Campath)

[1] Alemtuzumab (Campath (TN)) 💬

[1] CD52 💬

[1] 13 💬

Alemtuzumab, Rituximab
(Campath (TN))

[2] Alemtuzumab (Campath),
Rituximab

[2] Alemtuzumab (Campath (TN)),
Rituximab 💬

Name	Other Names
Alemtuzumab	Alemtuzumab (USAN/INN) Alemtuzumab (genetical recombination) (JAN) Campath (TN) Lemtrada (TN)
Rituximab	Rituximab (USAN/INN) Rituximab (genetical recombination) (JAN) Rituximab (genetical recombination) [Rituximab biosimilar 1] (JAN) Rituximab (genetical recombination) [Rituximab biosimilar 2] (JAN) Rituximab-abbs Rituximab-pvvr Rituximab-arrx Rituxan (TN) Riabni (TN) Truximab (TN) RUXIENCE TRUXIMA

[2] CD52,
MS4A1 💬

[1] Hematopoietic cell lineage 💬

[1] 63 💬

Campath

[1] Alemtuzumab (Campath)

[1] Alemtuzumab (Campath (TN)) 💬

[1] CD52 💬

[12] 19, 20, 49, 51, 60, 62, 65, 164, 234, 283, 285, 326 💬

Disease ID	Name
19	Lysosomal storage disease
20	Adrenoleukodystrophy
49	Systemic lupus erythematosus
51	Scleroderma
60	Aplastic anemia
62	Paroxysmal nocturnal hemoglobinuria
65	Primary immunodeficiency
164	Oculocutaneous albinism
234	Peroxisomal disease (except Adrenoleukodystrophy)
283	Acquired pure red cell aplasia
285	Fanconi anemia
326	Osteopetrosis

Campath -1H

[1] Alemtuzumab (Campath)

[1] Alemtuzumab (Campath (TN)) 💬

[1] CD52 💬

[1] 65 💬

Campath 1H

[1] Alemtuzumab (Campath)

[1] Alemtuzumab (Campath (TN)) 💬

[1] CD52 💬

[4] 60, 65, 164, 285 💬

Campath, Busulfan, Clofarabine

[2] Busulfan,
Clofarabine

[2] Busulfan ,
Clofarabine 💬

[3] POLA1,
POLA2,
RRM1 💬

[7] DNA replication, Drug metabolism - other enzymes, Glutathione metabolism, Metabolic pathways, Nucleotide metabolism, Purine metabolism, Pyrimidine metabolism 💬

[1] 326 💬

Campath, Chemo and/or TBI Allo SCT

[1] Alemtuzumab (Campath)

[1] Alemtuzumab (Campath (TN)) 💬

[1] CD52 💬

[3] 60, 62, 283 💬

Campath, Fludarabine, Cyclophosphamide

[2] Cyclophosphamide,
Fludarabine

[3] Cyclophosphamide ,
Cyclophosphamide ,
Fludarabine 💬

Name	Other Names
Cyclophosphamide	Cyclophosphamide (USP) Cyclophosphamide hydrate (JP18) Cytoxan (TN) Neosar (TN)
Cyclophosphamide	Cyclophosphamide (INN) Cyclophosphamide (TN) Cytoxan (TN)
Fludarabine	Fludarabine (INN) Fluradosa (TN)

[1] RRM1 💬

[6] Drug metabolism - other enzymes, Glutathione metabolism, Metabolic pathways, Nucleotide metabolism, Purine metabolism, Pyrimidine metabolism 💬

[2] 65, 284 💬

Campath-1H

[1] Alemtuzumab (Campath)

[1] Alemtuzumab (Campath (TN)) 💬

[1] CD52 💬

[6] 19, 20, 60, 234, 285, 326 💬

CAMPATH-1H (Alemtuzumab)

[1] Alemtuzumab (Campath)

[1] Alemtuzumab (Campath (TN)) 💬

[1] CD52 💬

[1] 60 💬

Cyclophosphamide,Campath IH and TBI

[1] Cyclophosphamide

[2] Cyclophosphamide ,
Cyclophosphamide 💬

[1] 60 💬

Filgrastim, Alemtuzumab
(Campath (TN))

[2] Alemtuzumab (Campath),
Filgrastim

[2] Alemtuzumab (Campath (TN)),
Filgrastim 💬

Name	Other Names
Alemtuzumab	Alemtuzumab (USAN/INN) Alemtuzumab (genetical recombination) (JAN) Campath (TN) Lemtrada (TN)
Filgrastim	Filgrastim (USP/INN) Filgrastim (genetical recombination) (JP18) Filgrastim (genetical recombination) [Filgrastim biosimilar 1] (JAN) Tbo-filgrastim Filgrastim (genetical recombination) [Filgrastim biosimilar 2] (JAN) Filgrastim (genetical recombination) [Filgrastim biosimilar 3] (JAN) Filgrastim-sndz Filgrastim-aafi Neupogen (TN) Nivestym (TN) Grastofil (TN) Zarxio (TN) GRANIX RELEUKO

[2] CD52,
CSF3R 💬

[5] Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, JAK-STAT signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer 💬

[1] 65 💬

Interferons, glatiramer acetate, teriflunomide, dimethyl fumarate, alemtuzumab, cladribine, fingolimod, ponesimod, rituximab, ocrelizumab, ofatumumab, natalizumab
(Campath (TN))

[12] Acetate,
Alemtuzumab (Campath),
Cladribine,
Dimethyl fumarate,
Fingolimod,
Glatiramer,
Natalizumab,
Ocrelizumab,
Ofatumumab,
Ponesimod,
Rituximab,
Teriflunomide

[10] Cladribine ,
Alemtuzumab (Campath (TN)),
Rituximab ,
Dimethyl fumarate ,
Ocrelizumab ,
Natalizumab ,
Ofatumumab ,
Fingolimod ,
Teriflunomide ,
Ponesimod 💬

Name	Other Names
Cladribine	Cladribine (JAN/USP/INN) Leustatin (TN) Mavenclad (TN)
Alemtuzumab	Alemtuzumab (USAN/INN) Alemtuzumab (genetical recombination) (JAN) Campath (TN) Lemtrada (TN)
Rituximab	Rituximab (USAN/INN) Rituximab (genetical recombination) (JAN) Rituximab (genetical recombination) [Rituximab biosimilar 1] (JAN) Rituximab (genetical recombination) [Rituximab biosimilar 2] (JAN) Rituximab-abbs Rituximab-pvvr Rituximab-arrx Rituxan (TN) Riabni (TN) Truximab (TN) RUXIENCE TRUXIMA
Dimethyl fumarate	Dimethyl fumarate (JAN/USAN) Tecfidera (TN)
Ocrelizumab	Ocrelizumab (USAN) Ocrelizumab (genetical recombination) (JAN) Ocrevus (TN)
Natalizumab	Natalizumab (USAN/INN) Natalizumab (genetical recombination) (JAN) Tysabri (TN)
Ofatumumab	Ofatumumab (USAN/INN) Ofatumumab (genetical recombination) (JAN) Arzerra (TN) Kesimpta (TN)
Fingolimod	Fingolimod (INN) Gilenya (TN)
Teriflunomide	Teriflunomide (USAN) Aubagio (TN)
Ponesimod	Ponesimod (USAN/INN) Ponvory (TN)

[7] CD52,
DHODH,
ITGA4,
KEAP1,
MS4A1,
RRM1,
S1PR1 💬

Name	Full Name
CD52	CD52 molecule
DHODH	dihydroorotate dehydrogenase (quinone)
ITGA4	integrin subunit alpha 4
KEAP1	kelch like ECH associated protein 1
MS4A1	membrane spanning 4-domains A1
RRM1	ribonucleotide reductase catalytic subunit M1
S1PR1	sphingosine-1-phosphate receptor 1

[30] Arrhythmogenic right ventricular cardiomyopathy, Biosynthesis of cofactors, Cell adhesion molecules, Chemical carcinogenesis - reactive oxygen species, Dilated cardiomyopathy, Drug metabolism - other enzymes, ECM-receptor interaction, Fluid shear stress and atherosclerosis, Focal adhesion, FoxO signaling pathway, Glutathione metabolism, Hematopoietic cell lineage, Hepatocellular carcinoma, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, Metabolic pathways, Neuroactive ligand-receptor interaction, Nucleotide metabolism, PI3K-Akt signaling pathway, Parkinson disease, Pathways in cancer, Purine metabolism, Pyrimidine metabolism, Regulation of actin cytoskeleton, Sphingolipid signaling pathway, Ubiquitin mediated proteolysis, Yersinia infection 💬

[1] 13 💬

Transplant Conditioning with Mobilization and Alemtuzumab
(Campath (TN))

[1] Alemtuzumab (Campath)

[1] Alemtuzumab (Campath (TN)) 💬

[1] CD52 💬

[1] 65 💬

Transplant preparative regimen of alemtuzumab, fludarabine, thiotepa, and melphalan
(Campath (TN))

[4] Alemtuzumab (Campath),
Fludarabine,
Melphalan,
Thiotepa

[4] Melphalan ,
Thiotepa ,
Alemtuzumab (Campath (TN)),
Fludarabine 💬

Name	Other Names
Melphalan	Melphalan (JP18/USP/INN) Alkeran (TN)
Thiotepa	Thiotepa (JAN/USP/INN) Thioplex (TN) Tepadina (TN) Rethio (TN)
Alemtuzumab	Alemtuzumab (USAN/INN) Alemtuzumab (genetical recombination) (JAN) Campath (TN) Lemtrada (TN)
Fludarabine	Fludarabine (INN) Fluradosa (TN)

[2] CD52,
RRM1 💬

[6] Drug metabolism - other enzymes, Glutathione metabolism, Metabolic pathways, Nucleotide metabolism, Purine metabolism, Pyrimidine metabolism 💬

[2] 65, 164 💬