Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. Drug (Description in trials) DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
1150-mg IVACAFTOR[1] Ivacaftor[1] Ivacaftor 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
2150mg IVACAFTOR[1] Ivacaftor[1] Ivacaftor 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
375-mg IVACAFTOR[1] Ivacaftor[1] Ivacaftor 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
4CF patients with a G551D mutation and treated with Ivacaftor[1] Ivacaftor[1] Ivacaftor 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
5Deuterated Ivacaftor[1] Ivacaftor[1] Ivacaftor 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
6Elexacaftor / Ivacaftor / Tezacaftor[3] Elexacaftor,
Ivacaftor,
Tezacaftor		[3] Ivacaftor ,
Tezacaftor ,
Elexacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
7Elexacaftor 100 MG / Ivacaftor 75 MG / Tezacaftor 50 MG, 2 tablets each morning + Ivacaftor 150 mg one tablet each evening[3] Elexacaftor,
Ivacaftor,
Tezacaftor		[3] Ivacaftor ,
Tezacaftor ,
Elexacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
8Elexacaftor-tezacaftor-ivacaftor exposure[3] Elexacaftor,
Ivacaftor,
Tezacaftor		[3] Ivacaftor ,
Tezacaftor ,
Elexacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
9Elexacaftor/tezacaftor/ivacaftor[3] Elexacaftor,
Ivacaftor,
Tezacaftor		[3] Ivacaftor ,
Tezacaftor ,
Elexacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
10IVACAFTOR[1] Ivacaftor[1] Ivacaftor 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
11Ivacaftor (proposed INN)[1] Ivacaftor[1] Ivacaftor 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
12Ivacaftor 125mg tablet[1] Ivacaftor[1] Ivacaftor 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
13Ivacaftor 150 mg[1] Ivacaftor[1] Ivacaftor 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
14Ivacaftor 150 mg or 250 mg[1] Ivacaftor[1] Ivacaftor 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
15Ivacaftor 25 mg/75 mg[1] Ivacaftor[1] Ivacaftor 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
16IVACAFTOR 59,5mg[1] Ivacaftor[1] Ivacaftor 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
17IVACAFTOR 59.5mg[1] Ivacaftor[1] Ivacaftor 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
18Ivacaftor 75 mg[1] Ivacaftor[1] Ivacaftor 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
19Ivacaftor 75 mg/150 mg[1] Ivacaftor[1] Ivacaftor 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
20IVACAFTOR 75mg[1] Ivacaftor[1] Ivacaftor 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
21Ivacaftor Exposed[1] Ivacaftor[1] Ivacaftor 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
22Ivacaftor or elexacaftor/tezacaftor/ivacaftor[3] Elexacaftor,
Ivacaftor,
Tezacaftor		[3] Ivacaftor ,
Tezacaftor ,
Elexacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
23Ivacaftor+lumacaftor[2] Ivacaftor,
Lumacaftor		[2] Ivacaftor ,
Lumacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
24Ivacaftor/Ataluren[2] Ataluren,
Ivacaftor		[2] Ataluren ,
Ivacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
25Ivacaftor/Kalydeco[1] Ivacaftor[1] Ivacaftor 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
26Ivacaftor/Trikafta[3] Elexacaftor,
Ivacaftor,
Tezacaftor		[3] Ivacaftor ,
Tezacaftor ,
Elexacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
27Lumacaftor / ivacaftor[2] Ivacaftor,
Lumacaftor		[2] Ivacaftor ,
Lumacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
28Lumacaftor plus Ivacaftor[2] Ivacaftor,
Lumacaftor		[2] Ivacaftor ,
Lumacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
29Lumacaftor Plus Ivacaftor Combination[2] Ivacaftor,
Lumacaftor		[2] Ivacaftor ,
Lumacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
30Lumacaftor, Ivacaftor Drug Combination[2] Ivacaftor,
Lumacaftor		[2] Ivacaftor ,
Lumacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
31Lumacaftor-ivacaftor[2] Ivacaftor,
Lumacaftor		[2] Ivacaftor ,
Lumacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
32Lumacaftor-Ivacaftor treatment[2] Ivacaftor,
Lumacaftor		[2] Ivacaftor ,
Lumacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
33Lumacaftor/Ivacaftor[2] Ivacaftor,
Lumacaftor		[2] Ivacaftor ,
Lumacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
34Lumacaftor/ivacaftor 100mg/125mg tablets[2] Ivacaftor,
Lumacaftor		[2] Ivacaftor ,
Lumacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
35Lumacaftor/ivacaftor 200mg/125mg[2] Ivacaftor,
Lumacaftor		[2] Ivacaftor ,
Lumacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
36Lumacaftor/ivacaftor 200mg/125mg tablets[2] Ivacaftor,
Lumacaftor		[2] Ivacaftor ,
Lumacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
37Lumacaftor/ivacaftor 200mg/83mg tablet[2] Ivacaftor,
Lumacaftor		[2] Ivacaftor ,
Lumacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
38Orkambi: contains lumacaftor and ivacaftor[2] Ivacaftor,
Lumacaftor		[2] Ivacaftor ,
Lumacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
39Tezacaftor/Ivacaftor[2] Ivacaftor,
Tezacaftor		[2] Ivacaftor ,
Tezacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
40Tezacaftor/Ivacaftor + Ivacaftor[2] Ivacaftor,
Tezacaftor		[2] Ivacaftor ,
Tezacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
41Tezacaftor/Ivacaftor 100mg/150mg[2] Ivacaftor,
Tezacaftor		[2] Ivacaftor ,
Tezacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
42Tezacaftor/Ivacaftor/100mg/150mg[2] Ivacaftor,
Tezacaftor		[2] Ivacaftor ,
Tezacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
43Treatment with cystic fibrosis transmembrane regulator (CFTR) modualtors Ivacaftor, Lumacaftor-Ivacaftor, Tezacaftor-Ivacaftor, Elexacaftor-Tezacaftor-Ivacaftor[4] Elexacaftor,
Ivacaftor,
Lumacaftor,
Tezacaftor		[4] Ivacaftor ,
Lumacaftor ,
Tezacaftor ,
Elexacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
44VX-659/Tezacaftor/Ivacaftor[3] Ivacaftor,
Tezacaftor,
VX-659		[2] Ivacaftor ,
Tezacaftor 💬 		[1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
45VX-661 Plus Ivacaftor Combination[1] Ivacaftor[1] Ivacaftor 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
46VX-661/Ivacaftor[1] Ivacaftor[1] Ivacaftor 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
47VX-661/ivacaftor (VX-770) 100mg/150 mg[1] Ivacaftor[1] Ivacaftor 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
48VX-661/ivacaftor 100 mg/ 150 mg[1] Ivacaftor[1] Ivacaftor 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
49VX-661/ivacaftor 100mg/150 mg[1] Ivacaftor[1] Ivacaftor 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
50VX-661/ivacaftor 100mg/150mg[1] Ivacaftor[1] Ivacaftor 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬
51VX-661/ivacaftor 50 mg/ 75 mg[1] Ivacaftor[1] Ivacaftor 💬 [1] CFTR 💬 [8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299 💬