Drug Description in Trials / DrugBank / KEGG DRUG

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No.

DrugBank

Drug (Description in trials)

KEGG DRUG

KEGG GENES

KEGG PATHWAY

Disease ID

1

Donepezil
(Memantine and Donepezil Hydrochlorides Extended-release)

[3] ARICEPT; Donepezil; Donepezil Hydrochloride

[1] Donepezil 💬

[1] ACHE 💬

[2] Cholinergic synapse, Glycerophospholipid metabolism 💬

[9] 5, 6, 13, 46, 78, 124, 127, 156, 206 💬

Disease ID	Name
5	Progressive supranuclear palsy
6	Parkinson disease
13	Multiple sclerosis/Neuromyelitis optica
46	Malignant rheumatoid arthritis
78	Hypopituitarism
124	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
127	Frontotemporal lobar degeneration
156	Rett syndrome
206	Fragile X syndrome

2

[3] EBIXA; Memantine; Memantine hydrochloride

[1] Memantine 💬

[5] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬

Name	Full Name
GRIN1	glutamate ionotropic receptor NMDA type subunit 1
GRIN2A	glutamate ionotropic receptor NMDA type subunit 2A
GRIN2B	glutamate ionotropic receptor NMDA type subunit 2B
GRIN2C	glutamate ionotropic receptor NMDA type subunit 2C
GRIN2D	glutamate ionotropic receptor NMDA type subunit 2D

[20] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬

[8] 2, 6, 8, 13, 49, 127, 205, 206 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis
6	Parkinson disease
8	Huntington disease
13	Multiple sclerosis/Neuromyelitis optica
49	Systemic lupus erythematosus
127	Frontotemporal lobar degeneration
205	Fragile X syndrome related disease
206	Fragile X syndrome