KEGG DRUG

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No.

DrugBank

Drug (Description in trials)

KEGG DRUG

KEGG GENES

KEGG PATHWAY

Disease ID

Acetaminophen
(Extra Strength Tylenol Sinus Nighttime)

[4] Acetaminophen; PARACETAMOL; Tylenol; Ultracet

[1] Acetaminophen (Tylenol (TN)) 💬

[2] PTGS1,
PTGS2 💬

[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬

[15] 3, 6, 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬

Disease ID	Name
3	Spinal muscular atrophy
6	Parkinson disease
11	Myasthenia gravis
13	Multiple sclerosis/Neuromyelitis optica
34	Neurofibromatosis
35	Pemphigus
46	Malignant rheumatoid arthritis
49	Systemic lupus erythematosus
51	Scleroderma
70	Spinal stenosis
86	Pulmonary arterial hypertension
222	Primary nephrotic syndrome
256	Muscle glycogenosis
271	Ankylosing spondylitis
337	Homocystinuria

Caffeine
(Tylenol No1 Forte Tablets With Codeine)

[1] Caffeine

[2] Caffeine ,
Caffeine hydrate 💬

[11] ADORA1,
ADORA2A,
PDE1B,
PDE2A,
PDE3A,
PDE3B,
PDE4A,
PDE4B,
PDE4C,
PDE4D,
PDE5A 💬

Name	Full Name
ADORA1	adenosine A1 receptor
ADORA2A	adenosine A2a receptor
PDE1B	phosphodiesterase 1B
PDE2A	phosphodiesterase 2A
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D
PDE5A	phosphodiesterase 5A

[22] Alcoholism, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Glucagon signaling pathway, Insulin signaling pathway, Metabolic pathways, Morphine addiction, Neuroactive ligand-receptor interaction, Olfactory transduction, Parathyroid hormone synthesis, secretion and action, Parkinson disease, Progesterone-mediated oocyte maturation, Purine metabolism, Rap1 signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion, Sphingolipid signaling pathway, Taste transduction, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬

[8] 2, 6, 21, 46, 78, 96, 97, 265 💬

Chlorpheniramine
(Extra Strength Tylenol Sinus Nighttime)

[1] Clorfenamina

[1] Chlorphenamine 💬

[1] HRH1 💬

[3] Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬

[1] 14 💬

Dextromethorphan
(Extra Strength Tylenol Cold Daytime)

[4] Dextromethorphan; Dextromethorphan hydrobromide; Dextrometorfano; Nuedexta

[1] Dextromethorphan 💬

[6] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D,
SIGMAR1 💬

Name	Full Name
GRIN1	glutamate ionotropic receptor NMDA type subunit 1
GRIN2A	glutamate ionotropic receptor NMDA type subunit 2A
GRIN2B	glutamate ionotropic receptor NMDA type subunit 2B
GRIN2C	glutamate ionotropic receptor NMDA type subunit 2C
GRIN2D	glutamate ionotropic receptor NMDA type subunit 2D
SIGMAR1	sigma non-opioid intracellular receptor 1

[20] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬

[11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis
6	Parkinson disease
8	Huntington disease
13	Multiple sclerosis/Neuromyelitis optica
21	Mitochondrial disease
46	Malignant rheumatoid arthritis
78	Hypopituitarism
85	Idiopathic interstitial pneumonia
96	Crohn disease
97	Ulcerative colitis
156	Rett syndrome

Diphenhydramine
(Childrens Tylenol Plus Cold and Allergy)

[2] Diphenhydramine; Diphenhydramine hydrochloride

[1] Diphenhydramine 💬

[1] HRH1 💬

[3] Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬

[8] 11, 13, 49, 51, 70, 86, 222, 256 💬

Disease ID	Name
11	Myasthenia gravis
13	Multiple sclerosis/Neuromyelitis optica
49	Systemic lupus erythematosus
51	Scleroderma
70	Spinal stenosis
86	Pulmonary arterial hypertension
222	Primary nephrotic syndrome
256	Muscle glycogenosis

Phenylephrine
(Extra Strength Tylenol Sinus Nighttime)

[1] Phenylephrine

[1] Phenylephrine 💬

[3] ADRA1A,
ADRA1B,
ADRA1D 💬

[7] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬

[1] 22 💬

Pseudoephedrine
(Extra Strength Tylenol Cold Nighttime Caplet)

[1] Pseudoephedrine

[1] Pseudoephedrine 💬

[9] ADRA1A,
ADRA1B,
ADRA1D,
ADRA2A,
ADRA2B,
ADRA2C,
ADRB1,
ADRB2,
ADRB3 💬

Name	Full Name
ADRA1A	adrenoceptor alpha 1A
ADRA1B	adrenoceptor alpha 1B
ADRA1D	adrenoceptor alpha 1D
ADRA2A	adrenoceptor alpha 2A
ADRA2B	adrenoceptor alpha 2B
ADRA2C	adrenoceptor alpha 2C
ADRB1	adrenoceptor beta 1
ADRB2	adrenoceptor beta 2
ADRB3	adrenoceptor beta 3

[14] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Thermogenesis, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬

[1] 17 💬