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Target Gene/Pathway Pathway / Gene

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KEGG GENES

KEGG PATHWAY

KEGG DRUG

DrugBank

Disease ID

1

[16] Calcium signaling pathway, cGMP-PKG signaling pathway, Phospholipase D signaling pathway, Neuro ...

[17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬

Disease ID	Name
17	Multiple system atrophy
19	Lysosomal storage disease
36	Epidermolysis bullosa
58	Hypertrophic cardiomyopathy
66	IgA nephropathy
67	Polycystic kidney disease
85	Idiopathic interstitial pneumonia
96	Crohn disease
97	Ulcerative colitis
98	Eosinophilic gastrointestinal disease
113	Muscular dystrophy
164	Oculocutaneous albinism
167	Marfan syndrome
179	Williams syndrome
215	Tetralogy of Fallot
222	Primary nephrotic syndrome
299	Cystic fibrosis

2

[7] MAPK signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Oxyt ...

Pregabalin 💬

[5] 13, 36, 46, 70, 298 💬

3

[7] MAPK signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Oxyt ...

Pregabalin 💬

[5] 13, 36, 46, 70, 298 💬

4

[7] MAPK signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Oxyt ...

Pregabalin 💬

[5] 13, 36, 46, 70, 298 💬

5

[7] MAPK signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Oxyt ...

Pregabalin 💬

[5] 13, 36, 46, 70, 298 💬

6

-

Alemtuzumab 💬

[22] 13, 15, 19, 20, 36, 43, 44, 46, 49, 51, 60, 62, 63, 65, 85, 96, 164, 234, 283, 284, 285, 326 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica
15	Inclusion body myositis
19	Lysosomal storage disease
20	Adrenoleukodystrophy
36	Epidermolysis bullosa
43	Microscopic polyangiitis
44	Wegener granulomatosis
46	Malignant rheumatoid arthritis
49	Systemic lupus erythematosus
51	Scleroderma
60	Aplastic anemia
62	Paroxysmal nocturnal hemoglobinuria
63	Idiopathic thrombocytopenic purpura
65	Primary immunodeficiency
85	Idiopathic interstitial pneumonia
96	Crohn disease
164	Oculocutaneous albinism
234	Peroxisomal disease (except Adrenoleukodystrophy)
283	Acquired pure red cell aplasia
284	Diamond-Blackfan anemia
285	Fanconi anemia
326	Osteopetrosis

7

[4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Thermogenesis, Retrograde endoc ...

Cannabidiol 💬

[20] 2, 6, 8, 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis
6	Parkinson disease
8	Huntington disease
13	Multiple sclerosis/Neuromyelitis optica
36	Epidermolysis bullosa
46	Malignant rheumatoid arthritis
51	Scleroderma
95	Autoimmune hepatitis
96	Crohn disease
97	Ulcerative colitis
140	Dorabe syndrome
144	Lennox-Gastaut syndrome
145	West syndrome
156	Rett syndrome
157	Sturge-Weber syndrome
158	Tuberous sclerosis
193	Prader-Willi syndrome
206	Fragile X syndrome
226	Interstitial cystitis with Hunners ulcer
271	Ankylosing spondylitis

8

[4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Thermogenesis, Retrograde endoc ...

Dronabinol 💬

[8] 2, 8, 13, 36, 46, 96, 271, 298 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis
8	Huntington disease
13	Multiple sclerosis/Neuromyelitis optica
36	Epidermolysis bullosa
46	Malignant rheumatoid arthritis
96	Crohn disease
271	Ankylosing spondylitis
298	Hereditary pancreatitis

9

[1] Neuroactive ligand-receptor interaction

Cannabidiol 💬

[20] 2, 6, 8, 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis
6	Parkinson disease
8	Huntington disease
13	Multiple sclerosis/Neuromyelitis optica
36	Epidermolysis bullosa
46	Malignant rheumatoid arthritis
51	Scleroderma
95	Autoimmune hepatitis
96	Crohn disease
97	Ulcerative colitis
140	Dorabe syndrome
144	Lennox-Gastaut syndrome
145	West syndrome
156	Rett syndrome
157	Sturge-Weber syndrome
158	Tuberous sclerosis
193	Prader-Willi syndrome
206	Fragile X syndrome
226	Interstitial cystitis with Hunners ulcer
271	Ankylosing spondylitis

10

[1] Neuroactive ligand-receptor interaction

Dronabinol 💬

[8] 2, 8, 13, 36, 46, 96, 271, 298 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis
8	Huntington disease
13	Multiple sclerosis/Neuromyelitis optica
36	Epidermolysis bullosa
46	Malignant rheumatoid arthritis
96	Crohn disease
271	Ankylosing spondylitis
298	Hereditary pancreatitis

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