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KEGG GENES
KEGG PATHWAY
KEGG DRUG
DrugBank
Disease ID
1
CDK4
💬
1. CDK4
×
Name
Full Name
CDK4
cyclin dependent kinase 4
[28]
Endocrine resistance
Endocrine resistance
,
Cell cycle
,
p53 signaling pathway
,
PI3K-Akt signaling pathway
,
Cellular senescence
,
Tight junction
,
T cell receptor signaling pathway
,
AGE-RAGE signaling pathway in diabetic complications
,
Cushing syndrome
,
Hepatitis C
,
Measles
,
Human cytomegalovirus infection
,
Influenza A
,
Human papillomavirus infection
,
Human T-cell leukemia virus 1 infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Epstein-Barr virus infection
,
Pathways in cancer
,
Viral carcinogenesis
,
Pancreatic cancer
,
Glioma
,
Melanoma
,
Bladder cancer
,
Chronic myeloid leukemia
,
Small cell lung cancer
,
Non-small cell lung cancer
,
Breast cancer
,
Hepatocellular carcinoma
[28]
Endocrine resistance
,
Cell cycle
,
p53 signaling pathway
,
PI3K-Akt signaling pathway
,
Cellular s
...
Abemaciclib
Abemaciclib
💬
1. CDK4
×
Name
Other Names
Abemaciclib
Abemaciclib (JAN/USAN)
Verzenio (TN)
Abemaciclib
[1]
34
34
💬
1. CDK4
×
Disease ID
Name
34
Neurofibromatosis
2
MAPK14
💬
2. MAPK14
×
Name
Full Name
MAPK14
mitogen-activated protein kinase 14
[62]
Endocrine resistance
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
Sphingolipid signaling pathway
,
Oocyte meiosis
,
Cellular senescence
,
Adrenergic signaling in cardiomyocytes
,
VEGF signaling pathway
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
Platelet activation
,
Neutrophil extracellular trap formation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Leukocyte transendothelial migration
,
Thermogenesis
,
Neurotrophin signaling pathway
,
Retrograde endocannabinoid signaling
,
Dopaminergic synapse
,
Inflammatory mediator regulation of TRP channels
,
GnRH signaling pathway
,
Progesterone-mediated oocyte maturation
,
Prolactin signaling pathway
,
Relaxin signaling pathway
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Growth hormone synthesis, secretion and action
,
Alcoholic liver disease
,
Amyotrophic lateral sclerosis
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Epithelial cell signaling in Helicobacter pylori infection
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis B
,
Human cytomegalovirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Proteoglycans in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
[62]
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
S
...
Losmapimod
Losmapimod
💬
2. MAPK14
×
Name
Other Names
Losmapimod
Losmapimod (USAN/INN)
Losmapimod
[2]
113
113
,
222
💬
2. MAPK14
×
Disease ID
Name
113
Muscular dystrophy
222
Primary nephrotic syndrome
3
MAPK14
💬
3. MAPK14
×
Name
Full Name
MAPK14
mitogen-activated protein kinase 14
[62]
Endocrine resistance
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
Sphingolipid signaling pathway
,
Oocyte meiosis
,
Cellular senescence
,
Adrenergic signaling in cardiomyocytes
,
VEGF signaling pathway
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
Platelet activation
,
Neutrophil extracellular trap formation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Leukocyte transendothelial migration
,
Thermogenesis
,
Neurotrophin signaling pathway
,
Retrograde endocannabinoid signaling
,
Dopaminergic synapse
,
Inflammatory mediator regulation of TRP channels
,
GnRH signaling pathway
,
Progesterone-mediated oocyte maturation
,
Prolactin signaling pathway
,
Relaxin signaling pathway
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Growth hormone synthesis, secretion and action
,
Alcoholic liver disease
,
Amyotrophic lateral sclerosis
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Epithelial cell signaling in Helicobacter pylori infection
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis B
,
Human cytomegalovirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Proteoglycans in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
[62]
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
S
...
Neflamapimod
Neflamapimod
💬
3. MAPK14
×
Name
Other Names
Neflamapimod
Neflamapimod (USAN)
Neflamapimod
[1]
8
8
💬
3. MAPK14
×
Disease ID
Name
8
Huntington disease
4
AGTR1
💬
4. AGTR1
×
Name
Full Name
AGTR1
angiotensin II receptor type 1
[16]
Calcium signaling pathway
Calcium signaling pathway
,
cGMP-PKG signaling pathway
,
Phospholipase D signaling pathway
,
Neuroactive ligand-receptor interaction
,
Adrenergic signaling in cardiomyocytes
,
Vascular smooth muscle contraction
,
Apelin signaling pathway
,
Renin-angiotensin system
,
Renin secretion
,
Aldosterone synthesis and secretion
,
Cortisol synthesis and secretion
,
AGE-RAGE signaling pathway in diabetic complications
,
Cushing syndrome
,
Coronavirus disease - COVID-19
,
Pathways in cancer
,
Diabetic cardiomyopathy
[16]
Calcium signaling pathway
,
cGMP-PKG signaling pathway
,
Phospholipase D signaling pathway
,
Neuro
...
Angiotensin II
Angiotensin II
💬
4. AGTR1
×
Name
Other Names
Angiotensin II
Angiotensin II (INN)
Angiotensin II
[7]
17
17
,
19
,
46
,
66
,
86
,
222
,
224
💬
4. AGTR1
×
Disease ID
Name
17
Multiple system atrophy
19
Lysosomal storage disease
46
Malignant rheumatoid arthritis
66
IgA nephropathy
86
Pulmonary arterial hypertension
222
Primary nephrotic syndrome
224
Purpura nephritis
5
AGTR1
💬
5. AGTR1
×
Name
Full Name
AGTR1
angiotensin II receptor type 1
[16]
Calcium signaling pathway
Calcium signaling pathway
,
cGMP-PKG signaling pathway
,
Phospholipase D signaling pathway
,
Neuroactive ligand-receptor interaction
,
Adrenergic signaling in cardiomyocytes
,
Vascular smooth muscle contraction
,
Apelin signaling pathway
,
Renin-angiotensin system
,
Renin secretion
,
Aldosterone synthesis and secretion
,
Cortisol synthesis and secretion
,
AGE-RAGE signaling pathway in diabetic complications
,
Cushing syndrome
,
Coronavirus disease - COVID-19
,
Pathways in cancer
,
Diabetic cardiomyopathy
[16]
Calcium signaling pathway
,
cGMP-PKG signaling pathway
,
Phospholipase D signaling pathway
,
Neuro
...
Valsartan
Valsartan
💬
5. AGTR1
×
Name
Other Names
Valsartan
Valsartan (JP18/USP/INN)
Diovan (TN)
Valsartan
[7]
57
57
,
58
,
66
,
75
,
218
,
222
,
224
💬
5. AGTR1
×
Disease ID
Name
57
Idiopathic dilated cardiomyopathy
58
Hypertrophic cardiomyopathy
66
IgA nephropathy
75
Cushing disease
218
Alport syndrome
222
Primary nephrotic syndrome
224
Purpura nephritis
6
AGTR1
💬
6. AGTR1
×
Name
Full Name
AGTR1
angiotensin II receptor type 1
[16]
Calcium signaling pathway
Calcium signaling pathway
,
cGMP-PKG signaling pathway
,
Phospholipase D signaling pathway
,
Neuroactive ligand-receptor interaction
,
Adrenergic signaling in cardiomyocytes
,
Vascular smooth muscle contraction
,
Apelin signaling pathway
,
Renin-angiotensin system
,
Renin secretion
,
Aldosterone synthesis and secretion
,
Cortisol synthesis and secretion
,
AGE-RAGE signaling pathway in diabetic complications
,
Cushing syndrome
,
Coronavirus disease - COVID-19
,
Pathways in cancer
,
Diabetic cardiomyopathy
[16]
Calcium signaling pathway
,
cGMP-PKG signaling pathway
,
Phospholipase D signaling pathway
,
Neuro
...
Candesartan
Candesartan
💬
6. AGTR1
×
Name
Other Names
Candesartan
Candesartan (USAN/INN)
Candesartan
[2]
58
58
,
67
💬
6. AGTR1
×
Disease ID
Name
58
Hypertrophic cardiomyopathy
67
Polycystic kidney disease
7
AGTR1
💬
7. AGTR1
×
Name
Full Name
AGTR1
angiotensin II receptor type 1
[16]
Calcium signaling pathway
Calcium signaling pathway
,
cGMP-PKG signaling pathway
,
Phospholipase D signaling pathway
,
Neuroactive ligand-receptor interaction
,
Adrenergic signaling in cardiomyocytes
,
Vascular smooth muscle contraction
,
Apelin signaling pathway
,
Renin-angiotensin system
,
Renin secretion
,
Aldosterone synthesis and secretion
,
Cortisol synthesis and secretion
,
AGE-RAGE signaling pathway in diabetic complications
,
Cushing syndrome
,
Coronavirus disease - COVID-19
,
Pathways in cancer
,
Diabetic cardiomyopathy
[16]
Calcium signaling pathway
,
cGMP-PKG signaling pathway
,
Phospholipase D signaling pathway
,
Neuro
...
Irbesartan
Irbesartan
💬
7. AGTR1
×
Name
Other Names
Irbesartan
Irbesartan (JP18/USP/INN)
Avapro (TN)
Irbesartan
[4]
66
66
,
167
,
168
,
222
💬
7. AGTR1
×
Disease ID
Name
66
IgA nephropathy
167
Marfan syndrome
168
Ehlers-Danlos syndrome
222
Primary nephrotic syndrome
8
AGTR1
💬
8. AGTR1
×
Name
Full Name
AGTR1
angiotensin II receptor type 1
[16]
Calcium signaling pathway
Calcium signaling pathway
,
cGMP-PKG signaling pathway
,
Phospholipase D signaling pathway
,
Neuroactive ligand-receptor interaction
,
Adrenergic signaling in cardiomyocytes
,
Vascular smooth muscle contraction
,
Apelin signaling pathway
,
Renin-angiotensin system
,
Renin secretion
,
Aldosterone synthesis and secretion
,
Cortisol synthesis and secretion
,
AGE-RAGE signaling pathway in diabetic complications
,
Cushing syndrome
,
Coronavirus disease - COVID-19
,
Pathways in cancer
,
Diabetic cardiomyopathy
[16]
Calcium signaling pathway
,
cGMP-PKG signaling pathway
,
Phospholipase D signaling pathway
,
Neuro
...
Candesartan cilexetil
Candesartan cilexetil
💬
8. AGTR1
×
Name
Other Names
Candesartan cilexetil
Candesartan cilexetil (JP18/USP)
Atacand (TN)
CANDESARTAN
Candesartan cilexetil
[1]
67
67
💬
8. AGTR1
×
Disease ID
Name
67
Polycystic kidney disease
9
AGTR1
💬
9. AGTR1
×
Name
Full Name
AGTR1
angiotensin II receptor type 1
[16]
Calcium signaling pathway
Calcium signaling pathway
,
cGMP-PKG signaling pathway
,
Phospholipase D signaling pathway
,
Neuroactive ligand-receptor interaction
,
Adrenergic signaling in cardiomyocytes
,
Vascular smooth muscle contraction
,
Apelin signaling pathway
,
Renin-angiotensin system
,
Renin secretion
,
Aldosterone synthesis and secretion
,
Cortisol synthesis and secretion
,
AGE-RAGE signaling pathway in diabetic complications
,
Cushing syndrome
,
Coronavirus disease - COVID-19
,
Pathways in cancer
,
Diabetic cardiomyopathy
[16]
Calcium signaling pathway
,
cGMP-PKG signaling pathway
,
Phospholipase D signaling pathway
,
Neuro
...
Telmisartan
Telmisartan
💬
9. AGTR1
×
Name
Other Names
Telmisartan
Telmisartan (JP18/USP/INN)
Micardis (TN)
Telmisartan
[2]
66
66
,
67
💬
9. AGTR1
×
Disease ID
Name
66
IgA nephropathy
67
Polycystic kidney disease
10
AGTR1
💬
10. AGTR1
×
Name
Full Name
AGTR1
angiotensin II receptor type 1
[16]
Calcium signaling pathway
Calcium signaling pathway
,
cGMP-PKG signaling pathway
,
Phospholipase D signaling pathway
,
Neuroactive ligand-receptor interaction
,
Adrenergic signaling in cardiomyocytes
,
Vascular smooth muscle contraction
,
Apelin signaling pathway
,
Renin-angiotensin system
,
Renin secretion
,
Aldosterone synthesis and secretion
,
Cortisol synthesis and secretion
,
AGE-RAGE signaling pathway in diabetic complications
,
Cushing syndrome
,
Coronavirus disease - COVID-19
,
Pathways in cancer
,
Diabetic cardiomyopathy
[16]
Calcium signaling pathway
,
cGMP-PKG signaling pathway
,
Phospholipase D signaling pathway
,
Neuro
...
Angiotensin II
Angiotensin II
💬
10. AGTR1
×
Name
Other Names
Angiotensin II
Angiotensin II (USAN)
Angiotensin II (human type) (JAN)
Delivert (TN)
Angiotensin II
[7]
17
17
,
19
,
46
,
66
,
86
,
222
,
224
💬
10. AGTR1
×
Disease ID
Name
17
Multiple system atrophy
19
Lysosomal storage disease
46
Malignant rheumatoid arthritis
66
IgA nephropathy
86
Pulmonary arterial hypertension
222
Primary nephrotic syndrome
224
Purpura nephritis