Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Adrenergic signaling in cardiomyocytes 💬
 [1] ADRB1 💬 Atenolol 💬 Atenolol [1] 167 💬
2 Adrenergic signaling in cardiomyocytes 💬
 [1] ADRB1 💬 Nebivolol 💬 Nebivolol [4] 17, 85, 113, 167 💬
3 Adrenergic signaling in cardiomyocytes 💬
 [2] ADRB1, ADRB2 💬 Propranolol 💬 Propranolol [6]  6 , 158, 167, 227, 278, 296 💬
4 Adrenergic signaling in cardiomyocytes 💬
 [1] AGTR1 💬 Irbesartan 💬 Irbesartan [4] 66, 167, 168, 222 💬
5 Adrenergic signaling in cardiomyocytes 💬
 [1] AGTR1 💬 Losartan 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
6 Adrenergic signaling in cardiomyocytes 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
7 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] AGTR1 💬 Irbesartan 💬 Irbesartan [4] 66, 167, 168, 222 💬
8 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] AGTR1 💬 Losartan 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
9 Aldosterone synthesis and secretion 💬
 [1] AGTR1 💬 Irbesartan 💬 Irbesartan [4] 66, 167, 168, 222 💬
10 Aldosterone synthesis and secretion 💬
 [1] AGTR1 💬 Losartan 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
11 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
12 Alzheimer disease 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
13 Amphetamine addiction 💬
 [2] CACNA1C, CACNA1D 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
14 Apelin signaling pathway 💬
 [1] AGTR1 💬 Irbesartan 💬 Irbesartan [4] 66, 167, 168, 222 💬
15 Apelin signaling pathway 💬
 [1] AGTR1 💬 Losartan 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
16 Arrhythmogenic right ventricular cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
17 Calcium signaling pathway 💬
 [1] ADRB1 💬 Atenolol 💬 Atenolol [1] 167 💬
18 Calcium signaling pathway 💬
 [1] ADRB1 💬 Nebivolol 💬 Nebivolol [4] 17, 85, 113, 167 💬
19 Calcium signaling pathway 💬
 [3] ADRB1, ADRB2, ADRB3 💬 Propranolol 💬 Propranolol [6]  6 , 158, 167, 227, 278, 296 💬
20 Calcium signaling pathway 💬
 [1] AGTR1 💬 Irbesartan 💬 Irbesartan [4] 66, 167, 168, 222 💬
21 Calcium signaling pathway 💬
 [1] AGTR1 💬 Losartan 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
22 Calcium signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
23 cAMP signaling pathway 💬
 [1] ADRB1 💬 Atenolol 💬 Atenolol [1] 167 💬
24 cAMP signaling pathway 💬
 [1] ADRB1 💬 Nebivolol 💬 Nebivolol [4] 17, 85, 113, 167 💬
25 cAMP signaling pathway 💬
 [2] ADRB1, ADRB2 💬 Propranolol 💬 Propranolol [6]  6 , 158, 167, 227, 278, 296 💬
26 cAMP signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
27 Carbohydrate digestion and absorption 💬
 [1] CACNA1D 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
28 Cardiac muscle contraction 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
29 Cellular senescence 💬
 [1] CACNA1D 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
30 cGMP-PKG signaling pathway 💬
 [1] ADRB1 💬 Atenolol 💬 Atenolol [1] 167 💬
31 cGMP-PKG signaling pathway 💬
 [1] ADRB1 💬 Nebivolol 💬 Nebivolol [4] 17, 85, 113, 167 💬
32 cGMP-PKG signaling pathway 💬
 [3] ADRB1, ADRB2, ADRB3 💬 Propranolol 💬 Propranolol [6]  6 , 158, 167, 227, 278, 296 💬
33 cGMP-PKG signaling pathway 💬
 [1] AGTR1 💬 Irbesartan 💬 Irbesartan [4] 66, 167, 168, 222 💬
34 cGMP-PKG signaling pathway 💬
 [1] AGTR1 💬 Losartan 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
35 cGMP-PKG signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
36 Chagas disease 💬
 [1] ACE 💬 Perindopril 💬 Perindopril [4] 58, 113, 167, 222 💬
37 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB1 💬 Atenolol 💬 Atenolol [1] 167 💬
38 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB1 💬 Nebivolol 💬 Nebivolol [4] 17, 85, 113, 167 💬
39 Chemical carcinogenesis - receptor activation 💬
 [3] ADRB1, ADRB2, ADRB3 💬 Propranolol 💬 Propranolol [6]  6 , 158, 167, 227, 278, 296 💬
40 Chemical carcinogenesis - receptor activation 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
41 Cholinergic synapse 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
42 Circadian entrainment 💬
 [2] CACNA1C, CACNA1D 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
43 Coronavirus disease - COVID-19 💬
 [1] ACE 💬 Perindopril 💬 Perindopril [4] 58, 113, 167, 222 💬
44 Coronavirus disease - COVID-19 💬
 [1] AGTR1 💬 Irbesartan 💬 Irbesartan [4] 66, 167, 168, 222 💬
45 Coronavirus disease - COVID-19 💬
 [1] AGTR1 💬 Losartan 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
46 Cortisol synthesis and secretion 💬
 [1] AGTR1 💬 Irbesartan 💬 Irbesartan [4] 66, 167, 168, 222 💬
47 Cortisol synthesis and secretion 💬
 [1] AGTR1 💬 Losartan 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
48 Cortisol synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
49 Cushing syndrome 💬
 [1] AGTR1 💬 Irbesartan 💬 Irbesartan [4] 66, 167, 168, 222 💬
50 Cushing syndrome 💬
 [1] AGTR1 💬 Losartan 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
51 Cushing syndrome 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
52 Diabetic cardiomyopathy 💬
 [1] ACE 💬 Perindopril 💬 Perindopril [4] 58, 113, 167, 222 💬
53 Diabetic cardiomyopathy 💬
 [1] AGTR1 💬 Irbesartan 💬 Irbesartan [4] 66, 167, 168, 222 💬
54 Diabetic cardiomyopathy 💬
 [1] AGTR1 💬 Losartan 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
55 Diabetic cardiomyopathy 💬
 [1] REN 💬 Aliskiren 💬 Aliskiren [3] 66, 167, 222 💬
56 Dilated cardiomyopathy 💬
 [1] ADRB1 💬 Atenolol 💬 Atenolol [1] 167 💬
57 Dilated cardiomyopathy 💬
 [1] ADRB1 💬 Nebivolol 💬 Nebivolol [4] 17, 85, 113, 167 💬
58 Dilated cardiomyopathy 💬
 [1] ADRB1 💬 Propranolol 💬 Propranolol [6]  6 , 158, 167, 227, 278, 296 💬
59 Dilated cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
60 Dopaminergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
61 GABAergic synapse 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
62 Gap junction 💬
 [1] ADRB1 💬 Atenolol 💬 Atenolol [1] 167 💬
63 Gap junction 💬
 [1] ADRB1 💬 Nebivolol 💬 Nebivolol [4] 17, 85, 113, 167 💬
64 Gap junction 💬
 [1] ADRB1 💬 Propranolol 💬 Propranolol [6]  6 , 158, 167, 227, 278, 296 💬
65 Glutamatergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
66 GnRH secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
67 GnRH signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
68 Growth hormone synthesis, secretion and action 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
69 Hypertrophic cardiomyopathy 💬
 [1] ACE 💬 Perindopril 💬 Perindopril [4] 58, 113, 167, 222 💬
70 Hypertrophic cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
71 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
72 Long-term potentiation 💬
 [1] CACNA1C 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
73 MAPK signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
74 Neuroactive ligand-receptor interaction 💬
 [1] ADRB1 💬 Atenolol 💬 Atenolol [1] 167 💬
75 Neuroactive ligand-receptor interaction 💬
 [1] ADRB1 💬 Nebivolol 💬 Nebivolol [4] 17, 85, 113, 167 💬
76 Neuroactive ligand-receptor interaction 💬
 [3] ADRB1, ADRB2, ADRB3 💬 Propranolol 💬 Propranolol [6]  6 , 158, 167, 227, 278, 296 💬
77 Neuroactive ligand-receptor interaction 💬
 [1] AGTR1 💬 Irbesartan 💬 Irbesartan [4] 66, 167, 168, 222 💬
78 Neuroactive ligand-receptor interaction 💬
 [1] AGTR1 💬 Losartan 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
79 Oxytocin signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
80 Pathways in cancer 💬
 [1] AGTR1 💬 Irbesartan 💬 Irbesartan [4] 66, 167, 168, 222 💬
81 Pathways in cancer 💬
 [1] AGTR1 💬 Losartan 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
82 Pathways of neurodegeneration - multiple diseases 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
83 Phospholipase D signaling pathway 💬
 [1] AGTR1 💬 Irbesartan 💬 Irbesartan [4] 66, 167, 168, 222 💬
84 Phospholipase D signaling pathway 💬
 [1] AGTR1 💬 Losartan 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
85 Prion disease 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
86 Regulation of lipolysis in adipocytes 💬
 [1] ADRB1 💬 Atenolol 💬 Atenolol [1] 167 💬
87 Regulation of lipolysis in adipocytes 💬
 [1] ADRB1 💬 Nebivolol 💬 Nebivolol [4] 17, 85, 113, 167 💬
88 Regulation of lipolysis in adipocytes 💬
 [3] ADRB1, ADRB2, ADRB3 💬 Propranolol 💬 Propranolol [6]  6 , 158, 167, 227, 278, 296 💬
89 Renin secretion 💬
 [1] ACE 💬 Perindopril 💬 Perindopril [4] 58, 113, 167, 222 💬
90 Renin secretion 💬
 [1] ADRB1 💬 Atenolol 💬 Atenolol [1] 167 💬
91 Renin secretion 💬
 [1] ADRB1 💬 Nebivolol 💬 Nebivolol [4] 17, 85, 113, 167 💬
92 Renin secretion 💬
 [3] ADRB1, ADRB2, ADRB3 💬 Propranolol 💬 Propranolol [6]  6 , 158, 167, 227, 278, 296 💬
93 Renin secretion 💬
 [1] AGTR1 💬 Irbesartan 💬 Irbesartan [4] 66, 167, 168, 222 💬
94 Renin secretion 💬
 [1] AGTR1 💬 Losartan 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
95 Renin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
96 Renin secretion 💬
 [1] REN 💬 Aliskiren 💬 Aliskiren [3] 66, 167, 222 💬
97 Renin-angiotensin system 💬
 [1] ACE 💬 Perindopril 💬 Perindopril [4] 58, 113, 167, 222 💬
98 Renin-angiotensin system 💬
 [1] AGTR1 💬 Irbesartan 💬 Irbesartan [4] 66, 167, 168, 222 💬
99 Renin-angiotensin system 💬
 [1] AGTR1 💬 Losartan 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
100 Renin-angiotensin system 💬
 [1] REN 💬 Aliskiren 💬 Aliskiren [3] 66, 167, 222 💬
101 Retrograde endocannabinoid signaling 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
102 Salivary secretion 💬
 [1] ADRB1 💬 Atenolol 💬 Atenolol [1] 167 💬
103 Salivary secretion 💬
 [1] ADRB1 💬 Nebivolol 💬 Nebivolol [4] 17, 85, 113, 167 💬
104 Salivary secretion 💬
 [3] ADRB1, ADRB2, ADRB3 💬 Propranolol 💬 Propranolol [6]  6 , 158, 167, 227, 278, 296 💬
105 Serotonergic synapse 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
106 Taste transduction 💬
 [1] CACNA1C 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
107 Thermogenesis 💬
 [1] ADRB3 💬 Propranolol 💬 Propranolol [6]  6 , 158, 167, 227, 278, 296 💬
108 Tight junction 💬
 [1] CACNA1D 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
109 Type II diabetes mellitus 💬
 [2] CACNA1C, CACNA1D 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
110 Vascular smooth muscle contraction 💬
 [1] AGTR1 💬 Irbesartan 💬 Irbesartan [4] 66, 167, 168, 222 💬
111 Vascular smooth muscle contraction 💬
 [1] AGTR1 💬 Losartan 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
112 Vascular smooth muscle contraction 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬

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