Gene

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No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

Bile secretion 💬

[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬

Name	Full Name
ATP1A1	ATPase Na+/K+ transporting subunit alpha 1
ATP1A2	ATPase Na+/K+ transporting subunit alpha 2
ATP1A3	ATPase Na+/K+ transporting subunit alpha 3
ATP1A4	ATPase Na+/K+ transporting subunit alpha 4

Digitoxin 💬

Digitoxin

[1] 299 💬

Bile secretion 💬

[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬

Name	Full Name
ATP1A1	ATPase Na+/K+ transporting subunit alpha 1
ATP1A2	ATPase Na+/K+ transporting subunit alpha 2
ATP1A3	ATPase Na+/K+ transporting subunit alpha 3
ATP1A4	ATPase Na+/K+ transporting subunit alpha 4

Digoxin 💬

Digoxin

[3] 8 , 46, 210 💬

Disease ID	Name
8	Huntington disease;Huntington chorea;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;

Bile secretion 💬

[1] CA2 💬

Acetazolamide 💬

Acetazolamide

[8] 13, 86, 90, 115, 154, 155, 225, 230 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
86	Pulmonary arterial hypertension;PAH;
90	Retinitis pigmentosa;
115	Hereditary periodic paralysis;
154	Epilepsy with continuous spikes and waves during slow sleep;Epileptic encephalopathy with continuous spike-and-wave during sleep;
155	Acquired aphasia with convulsive disorder;Landau-Kleffner syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
230	Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;

Bile secretion 💬

[1] CA2 💬

Dichlorphenamide 💬

Diclofenamide

[1] 114 💬

Bile secretion 💬

[1] CA2 💬

Dorzolamide 💬

Dorzolamide

[1] 90 💬

Bile secretion 💬

[1] CA2 💬

Topiramate 💬

Topiramate

[6] 6 , 97, 140, 144, 156, 193 💬

Bile secretion 💬

[1] CFTR 💬

Deutivacaftor 💬

Deutivacaftor

[1] 299 💬

Bile secretion 💬

[1] CFTR 💬

Elexacaftor 💬

Elexacaftor

[1] 299 💬

Bile secretion 💬

[1] CFTR 💬

Galicaftor 💬

Galicaftor

[1] 299 💬

Bile secretion 💬

[1] CFTR 💬

Ivacaftor 💬

Ivacaftor

[1] 299 💬

Bile secretion 💬

[1] CFTR 💬

Lumacaftor 💬

Lumacaftor

[1] 299 💬

Bile secretion 💬

[1] CFTR 💬

Tezacaftor 💬

Tezacaftor

[1] 299 💬

Bile secretion 💬

[1] HMGCR 💬

Atorvastatin 💬

Atorvastatin

[19] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
58	Hypertrophic cardiomyopathy;HCM;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
79	Homozygous familial hypercholesterolemia;
84	Sarcoidosis;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
160	Congenital ichthyosis;
222	Primary nephrotic syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
265	Lipodystrophy;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
297	Alagille syndrome;
299	Cystic fibrosis;

Bile secretion 💬

[1] HMGCR 💬

Fluvastatin 💬

Fluvastatin

[3] 79, 218, 222 💬

Bile secretion 💬

[1] HMGCR 💬

Lovastatin 💬

Lovastatin

[11] 6 , 34, 46, 79, 156, 160, 195, 206, 263, 280, 310 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
79	Homozygous familial hypercholesterolemia;
156	Rett syndrome;
160	Congenital ichthyosis;
195	Noonan syndrome;
206	Fragile X syndrome;
263	Cerebrotendinous xanthomatosis;27-hydroxylase deficiency;CYP27 deficiency;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;
310	Congenital anomalies syndrome;

Bile secretion 💬

[1] HMGCR 💬

Pravastatin 💬

Pravastatin

[9] 13, 46, 49, 67, 79, 96, 164, 265, 333 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
79	Homozygous familial hypercholesterolemia;
96	Crohn disease;Terminal ileitis;
164	Oculocutaneous albinism;
265	Lipodystrophy;
333	Hutchinson-Gilford syndrome;Hutchinson-Gilford progeria syndrome;HGPS;

Bile secretion 💬

[1] HMGCR 💬

Rosuvastatin 💬

Rosuvastatin

[11] 6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
18	Spinocerebellar degeneration;SCD;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
56	Behcet disease;Behçet disease;BD;
79	Homozygous familial hypercholesterolemia;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
299	Cystic fibrosis;

Bile secretion 💬

[1] HMGCR 💬

Simvastatin 💬

Simvastatin

[21] 6 , 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
15	Inclusion body myositis;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
79	Homozygous familial hypercholesterolemia;
86	Pulmonary arterial hypertension;PAH;
89	Lymphangioleiomyomatosis;LAM;
94	Primary sclerosing cholangitis;PSC;
158	Tuberous sclerosis;Tuberous sclerosis complex;
160	Congenital ichthyosis;
162	Pemphigoid;
195	Noonan syndrome;
265	Lipodystrophy;
288	Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;
310	Congenital anomalies syndrome;

Bile secretion 💬

[1] NR1H4 💬

Chenodiol 💬

Chenodeoxycholic acid

[4] 20, 96, 234, 263 💬

Disease ID	Name
20	Adrenoleukodystrophy;ALD;
96	Crohn disease;Terminal ileitis;
234	Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder;
263	Cerebrotendinous xanthomatosis;27-hydroxylase deficiency;CYP27 deficiency;

Bile secretion 💬

[1] NR1H4 💬

Cholic acid 💬

Cholic Acid

[4] 20, 234, 265, 310 💬

Disease ID	Name
20	Adrenoleukodystrophy;ALD;
234	Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder;
265	Lipodystrophy;
310	Congenital anomalies syndrome;

Bile secretion 💬

[1] NR1H4 💬

Obeticholic acid 💬

Obeticholic acid

[3] 93, 265, 296 💬

Bile secretion 💬

[1] NR1H4 💬

Tropifexor 💬

Tropifexor

[1] 93 💬

Bile secretion 💬

[1] NR1H4 💬

Ursodiol 💬

Ursodeoxycholic acid

[14] 6 , 8 , 20, 46, 67, 84, 93, 94, 95, 96, 97, 234, 296, 299 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
20	Adrenoleukodystrophy;ALD;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
84	Sarcoidosis;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
94	Primary sclerosing cholangitis;PSC;
95	Autoimmune hepatitis;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
234	Peroxisomal disease (except Adrenoleukodystrophy);Peroxisomal disease;Peroxisomal disorder;Peroxisome biogenesis disorder;
296	Biliary atresia;
299	Cystic fibrosis;