Target Gene/Pathway Pathway / Gene

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No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

Breast cancer 💬

[1] ESR1 💬

Ethinyl estradiol 💬

Ethinylestradiol

[4] 13, 46, 49, 299 💬

2

Breast cancer 💬

[2] ESR1, ESR2 💬

[1] 74 💬

3

Breast cancer 💬

[2] ESR1, ESR2 💬

[1] 53 💬

4

Breast cancer 💬

[2] ESR1, ESR2 💬

[1] 53 💬

5

Breast cancer 💬

[2] ESR1, ESR2 💬

Name	Other Names
Estradiol	Estradiol (JAN/USP/INN) Climara (TN) Divigel (TN) Estrace (TN) Estraderm (TN) Estrasorb (TN) Estring (TN) Estrogel (TN) Innofem (TN) Vagifem (TN) Vivelle (TN) IMVEXXY MENOSTAR MINIVELLE VIVELLE-DOT DOTTI ESTRADIOL TRANSDERMAL SYSTEM ESTRADIOL VAGINAL ESTRADIOL VAGINAL CREAM LYLLANA YUVAFEM

[7] 13, 46, 49, 65, 76, 226, 299 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
65	Primary immunodeficiency;
76	Pituitary gonadotropin secretion hyperthyroidism;Gonadotropin secreting pituitary adenoma;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
299	Cystic fibrosis;

6

Breast cancer 💬

[2] ESR1, ESR2 💬

Estradiol valerate 💬

Estradiol valerate

[1] 65 💬

7

Breast cancer 💬

[2] ESR1, ESR2 💬

[2] 13, 227 💬

8

Breast cancer 💬

[2] ESR1, ESR2 💬

Estriol tripropionate 💬

[2] 13, 227 💬

9

Breast cancer 💬

[2] ESR1, ESR2 💬

Fulvestrant 💬

[2] 49, 86 💬

10

Breast cancer 💬

[2] ESR1, ESR2 💬

[2] 46, 49 💬

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