Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Breast cancer 💬
 [1] ESR1 💬 Ethinyl estradiol 💬 Ethinylestradiol [4] 13, 46, 49, 299 💬
2 Breast cancer 💬
 [2] ESR1, ESR2 💬 Clomifene 💬 Clomifene [1] 74 💬
3 Breast cancer 💬
 [2] ESR1, ESR2 💬 Estetrol 💬 Estetrol [1] 53 💬
4 Breast cancer 💬
 [2] ESR1, ESR2 💬 Estetrol 💬 Estetrol [1] 53 💬
5 Breast cancer 💬
 [2] ESR1, ESR2 💬 Estradiol 💬 Estradiol [7] 13, 46, 49, 65, 76, 226, 299 💬
6 Breast cancer 💬
 [2] ESR1, ESR2 💬 Estradiol valerate 💬 Estradiol valerate [1] 65 💬
7 Breast cancer 💬
 [2] ESR1, ESR2 💬 Estriol 💬 Estriol [2] 13, 227 💬
8 Breast cancer 💬
 [2] ESR1, ESR2 💬 Estriol tripropionate 💬 Estriol [2] 13, 227 💬
9 Breast cancer 💬
 [2] ESR1, ESR2 💬 Fulvestrant 💬 Fulvestrant [2] 49, 86 💬
10 Breast cancer 💬
 [2] ESR1, ESR2 💬 Mestranol 💬 Mestranol [2] 46, 49 💬
11 Breast cancer 💬
 [2] ESR1, ESR2 💬 Prasterone 💬 Prasterone [6] 49, 53, 83, 86, 96, 113 💬
12 Breast cancer 💬
 [2] ESR1, ESR2 💬 Raloxifene 💬 Raloxifene [1] 46 💬
13 Breast cancer 💬
 [2] ESR1, ESR2 💬 Tamoxifen 💬 Tamoxifen [3]  2 , 113, 227 💬
14 Breast cancer 💬
 [2] ESR1, PGR 💬 Danazol 💬 Danazol [5] 60, 63, 64, 65, 285 💬
15 Breast cancer 💬
 [2] ESR1, PGR 💬 Desogestrel 💬 Desogestrel [1] 230 💬
16 Chemical carcinogenesis - receptor activation 💬
 [3] AR, ESR1, ESR2 💬 Prasterone 💬 Prasterone [6] 49, 53, 83, 86, 96, 113 💬
17 Chemical carcinogenesis - receptor activation 💬
 [3] AR, ESR1, PGR 💬 Danazol 💬 Danazol [5] 60, 63, 64, 65, 285 💬
18 Chemical carcinogenesis - receptor activation 💬
 [1] ESR1 💬 Ethinyl estradiol 💬 Ethinylestradiol [4] 13, 46, 49, 299 💬
19 Chemical carcinogenesis - receptor activation 💬
 [2] ESR1, ESR2 💬 Clomifene 💬 Clomifene [1] 74 💬
20 Chemical carcinogenesis - receptor activation 💬
 [2] ESR1, ESR2 💬 Estetrol 💬 Estetrol [1] 53 💬
21 Chemical carcinogenesis - receptor activation 💬
 [2] ESR1, ESR2 💬 Estetrol 💬 Estetrol [1] 53 💬
22 Chemical carcinogenesis - receptor activation 💬
 [2] ESR1, ESR2 💬 Estradiol 💬 Estradiol [7] 13, 46, 49, 65, 76, 226, 299 💬
23 Chemical carcinogenesis - receptor activation 💬
 [2] ESR1, ESR2 💬 Estradiol valerate 💬 Estradiol valerate [1] 65 💬
24 Chemical carcinogenesis - receptor activation 💬
 [2] ESR1, ESR2 💬 Estriol 💬 Estriol [2] 13, 227 💬
25 Chemical carcinogenesis - receptor activation 💬
 [2] ESR1, ESR2 💬 Estriol tripropionate 💬 Estriol [2] 13, 227 💬
26 Chemical carcinogenesis - receptor activation 💬
 [2] ESR1, ESR2 💬 Fulvestrant 💬 Fulvestrant [2] 49, 86 💬
27 Chemical carcinogenesis - receptor activation 💬
 [2] ESR1, ESR2 💬 Mestranol 💬 Mestranol [2] 46, 49 💬
28 Chemical carcinogenesis - receptor activation 💬
 [2] ESR1, ESR2 💬 Raloxifene 💬 Raloxifene [1] 46 💬
29 Chemical carcinogenesis - receptor activation 💬
 [2] ESR1, ESR2 💬 Tamoxifen 💬 Tamoxifen [3]  2 , 113, 227 💬
30 Chemical carcinogenesis - receptor activation 💬
 [2] ESR1, PGR 💬 Desogestrel 💬 Desogestrel [1] 230 💬
31 Endocrine and other factor-regulated calcium reabsorption 💬
 [1] ESR1 💬 Clomifene 💬 Clomifene [1] 74 💬
32 Endocrine and other factor-regulated calcium reabsorption 💬
 [1] ESR1 💬 Danazol 💬 Danazol [5] 60, 63, 64, 65, 285 💬
33 Endocrine and other factor-regulated calcium reabsorption 💬
 [1] ESR1 💬 Desogestrel 💬 Desogestrel [1] 230 💬
34 Endocrine and other factor-regulated calcium reabsorption 💬
 [1] ESR1 💬 Estetrol 💬 Estetrol [1] 53 💬
35 Endocrine and other factor-regulated calcium reabsorption 💬
 [1] ESR1 💬 Estetrol 💬 Estetrol [1] 53 💬
36 Endocrine and other factor-regulated calcium reabsorption 💬
 [1] ESR1 💬 Estradiol 💬 Estradiol [7] 13, 46, 49, 65, 76, 226, 299 💬
37 Endocrine and other factor-regulated calcium reabsorption 💬
 [1] ESR1 💬 Estradiol valerate 💬 Estradiol valerate [1] 65 💬
38 Endocrine and other factor-regulated calcium reabsorption 💬
 [1] ESR1 💬 Estriol 💬 Estriol [2] 13, 227 💬
39 Endocrine and other factor-regulated calcium reabsorption 💬
 [1] ESR1 💬 Estriol tripropionate 💬 Estriol [2] 13, 227 💬
40 Endocrine and other factor-regulated calcium reabsorption 💬
 [1] ESR1 💬 Ethinyl estradiol 💬 Ethinylestradiol [4] 13, 46, 49, 299 💬
41 Endocrine and other factor-regulated calcium reabsorption 💬
 [1] ESR1 💬 Fulvestrant 💬 Fulvestrant [2] 49, 86 💬
42 Endocrine and other factor-regulated calcium reabsorption 💬
 [1] ESR1 💬 Mestranol 💬 Mestranol [2] 46, 49 💬
43 Endocrine and other factor-regulated calcium reabsorption 💬
 [1] ESR1 💬 Prasterone 💬 Prasterone [6] 49, 53, 83, 86, 96, 113 💬
44 Endocrine and other factor-regulated calcium reabsorption 💬
 [1] ESR1 💬 Raloxifene 💬 Raloxifene [1] 46 💬
45 Endocrine and other factor-regulated calcium reabsorption 💬
 [1] ESR1 💬 Tamoxifen 💬 Tamoxifen [3]  2 , 113, 227 💬
46 Endocrine resistance 💬
 [1] ESR1 💬 Danazol 💬 Danazol [5] 60, 63, 64, 65, 285 💬
47 Endocrine resistance 💬
 [1] ESR1 💬 Desogestrel 💬 Desogestrel [1] 230 💬
48 Endocrine resistance 💬
 [1] ESR1 💬 Ethinyl estradiol 💬 Ethinylestradiol [4] 13, 46, 49, 299 💬
49 Endocrine resistance 💬
 [2] ESR1, ESR2 💬 Clomifene 💬 Clomifene [1] 74 💬
50 Endocrine resistance 💬
 [2] ESR1, ESR2 💬 Estetrol 💬 Estetrol [1] 53 💬
51 Endocrine resistance 💬
 [2] ESR1, ESR2 💬 Estetrol 💬 Estetrol [1] 53 💬
52 Endocrine resistance 💬
 [2] ESR1, ESR2 💬 Estradiol 💬 Estradiol [7] 13, 46, 49, 65, 76, 226, 299 💬
53 Endocrine resistance 💬
 [2] ESR1, ESR2 💬 Estradiol valerate 💬 Estradiol valerate [1] 65 💬
54 Endocrine resistance 💬
 [2] ESR1, ESR2 💬 Estriol 💬 Estriol [2] 13, 227 💬
55 Endocrine resistance 💬
 [2] ESR1, ESR2 💬 Estriol tripropionate 💬 Estriol [2] 13, 227 💬
56 Endocrine resistance 💬
 [2] ESR1, ESR2 💬 Fulvestrant 💬 Fulvestrant [2] 49, 86 💬
57 Endocrine resistance 💬
 [2] ESR1, ESR2 💬 Mestranol 💬 Mestranol [2] 46, 49 💬
58 Endocrine resistance 💬
 [2] ESR1, ESR2 💬 Prasterone 💬 Prasterone [6] 49, 53, 83, 86, 96, 113 💬
59 Endocrine resistance 💬
 [2] ESR1, ESR2 💬 Raloxifene 💬 Raloxifene [1] 46 💬
60 Endocrine resistance 💬
 [2] ESR1, ESR2 💬 Tamoxifen 💬 Tamoxifen [3]  2 , 113, 227 💬
61 Estrogen signaling pathway 💬
 [1] ESR1 💬 Ethinyl estradiol 💬 Ethinylestradiol [4] 13, 46, 49, 299 💬
62 Estrogen signaling pathway 💬
 [2] ESR1, ESR2 💬 Clomifene 💬 Clomifene [1] 74 💬
63 Estrogen signaling pathway 💬
 [2] ESR1, ESR2 💬 Estetrol 💬 Estetrol [1] 53 💬
64 Estrogen signaling pathway 💬
 [2] ESR1, ESR2 💬 Estetrol 💬 Estetrol [1] 53 💬
65 Estrogen signaling pathway 💬
 [2] ESR1, ESR2 💬 Estradiol 💬 Estradiol [7] 13, 46, 49, 65, 76, 226, 299 💬
66 Estrogen signaling pathway 💬
 [2] ESR1, ESR2 💬 Estradiol valerate 💬 Estradiol valerate [1] 65 💬
67 Estrogen signaling pathway 💬
 [2] ESR1, ESR2 💬 Estriol 💬 Estriol [2] 13, 227 💬
68 Estrogen signaling pathway 💬
 [2] ESR1, ESR2 💬 Estriol tripropionate 💬 Estriol [2] 13, 227 💬
69 Estrogen signaling pathway 💬
 [2] ESR1, ESR2 💬 Fulvestrant 💬 Fulvestrant [2] 49, 86 💬
70 Estrogen signaling pathway 💬
 [2] ESR1, ESR2 💬 Mestranol 💬 Mestranol [2] 46, 49 💬
71 Estrogen signaling pathway 💬
 [2] ESR1, ESR2 💬 Prasterone 💬 Prasterone [6] 49, 53, 83, 86, 96, 113 💬
72 Estrogen signaling pathway 💬
 [2] ESR1, ESR2 💬 Raloxifene 💬 Raloxifene [1] 46 💬
73 Estrogen signaling pathway 💬
 [2] ESR1, ESR2 💬 Tamoxifen 💬 Tamoxifen [3]  2 , 113, 227 💬
74 Estrogen signaling pathway 💬
 [2] ESR1, PGR 💬 Danazol 💬 Danazol [5] 60, 63, 64, 65, 285 💬
75 Estrogen signaling pathway 💬
 [2] ESR1, PGR 💬 Desogestrel 💬 Desogestrel [1] 230 💬
76 Pathways in cancer 💬
 [2] AR, ESR1 💬 Danazol 💬 Danazol [5] 60, 63, 64, 65, 285 💬
77 Pathways in cancer 💬
 [3] AR, ESR1, ESR2 💬 Prasterone 💬 Prasterone [6] 49, 53, 83, 86, 96, 113 💬
78 Pathways in cancer 💬
 [1] ESR1 💬 Desogestrel 💬 Desogestrel [1] 230 💬
79 Pathways in cancer 💬
 [1] ESR1 💬 Ethinyl estradiol 💬 Ethinylestradiol [4] 13, 46, 49, 299 💬
80 Pathways in cancer 💬
 [2] ESR1, ESR2 💬 Clomifene 💬 Clomifene [1] 74 💬
81 Pathways in cancer 💬
 [2] ESR1, ESR2 💬 Estetrol 💬 Estetrol [1] 53 💬
82 Pathways in cancer 💬
 [2] ESR1, ESR2 💬 Estetrol 💬 Estetrol [1] 53 💬
83 Pathways in cancer 💬
 [2] ESR1, ESR2 💬 Estradiol 💬 Estradiol [7] 13, 46, 49, 65, 76, 226, 299 💬
84 Pathways in cancer 💬
 [2] ESR1, ESR2 💬 Estradiol valerate 💬 Estradiol valerate [1] 65 💬
85 Pathways in cancer 💬
 [2] ESR1, ESR2 💬 Estriol 💬 Estriol [2] 13, 227 💬
86 Pathways in cancer 💬
 [2] ESR1, ESR2 💬 Estriol tripropionate 💬 Estriol [2] 13, 227 💬
87 Pathways in cancer 💬
 [2] ESR1, ESR2 💬 Fulvestrant 💬 Fulvestrant [2] 49, 86 💬
88 Pathways in cancer 💬
 [2] ESR1, ESR2 💬 Mestranol 💬 Mestranol [2] 46, 49 💬
89 Pathways in cancer 💬
 [2] ESR1, ESR2 💬 Raloxifene 💬 Raloxifene [1] 46 💬
90 Pathways in cancer 💬
 [2] ESR1, ESR2 💬 Tamoxifen 💬 Tamoxifen [3]  2 , 113, 227 💬
91 Prolactin signaling pathway 💬
 [1] ESR1 💬 Danazol 💬 Danazol [5] 60, 63, 64, 65, 285 💬
92 Prolactin signaling pathway 💬
 [1] ESR1 💬 Desogestrel 💬 Desogestrel [1] 230 💬
93 Prolactin signaling pathway 💬
 [1] ESR1 💬 Ethinyl estradiol 💬 Ethinylestradiol [4] 13, 46, 49, 299 💬
94 Prolactin signaling pathway 💬
 [2] ESR1, ESR2 💬 Clomifene 💬 Clomifene [1] 74 💬
95 Prolactin signaling pathway 💬
 [2] ESR1, ESR2 💬 Estetrol 💬 Estetrol [1] 53 💬
96 Prolactin signaling pathway 💬
 [2] ESR1, ESR2 💬 Estetrol 💬 Estetrol [1] 53 💬
97 Prolactin signaling pathway 💬
 [2] ESR1, ESR2 💬 Estradiol 💬 Estradiol [7] 13, 46, 49, 65, 76, 226, 299 💬
98 Prolactin signaling pathway 💬
 [2] ESR1, ESR2 💬 Estradiol valerate 💬 Estradiol valerate [1] 65 💬
99 Prolactin signaling pathway 💬
 [2] ESR1, ESR2 💬 Estriol 💬 Estriol [2] 13, 227 💬
100 Prolactin signaling pathway 💬
 [2] ESR1, ESR2 💬 Estriol tripropionate 💬 Estriol [2] 13, 227 💬
101 Prolactin signaling pathway 💬
 [2] ESR1, ESR2 💬 Fulvestrant 💬 Fulvestrant [2] 49, 86 💬
102 Prolactin signaling pathway 💬
 [2] ESR1, ESR2 💬 Mestranol 💬 Mestranol [2] 46, 49 💬
103 Prolactin signaling pathway 💬
 [2] ESR1, ESR2 💬 Prasterone 💬 Prasterone [6] 49, 53, 83, 86, 96, 113 💬
104 Prolactin signaling pathway 💬
 [2] ESR1, ESR2 💬 Raloxifene 💬 Raloxifene [1] 46 💬
105 Prolactin signaling pathway 💬
 [2] ESR1, ESR2 💬 Tamoxifen 💬 Tamoxifen [3]  2 , 113, 227 💬
106 Proteoglycans in cancer 💬
 [1] ESR1 💬 Clomifene 💬 Clomifene [1] 74 💬
107 Proteoglycans in cancer 💬
 [1] ESR1 💬 Danazol 💬 Danazol [5] 60, 63, 64, 65, 285 💬
108 Proteoglycans in cancer 💬
 [1] ESR1 💬 Desogestrel 💬 Desogestrel [1] 230 💬
109 Proteoglycans in cancer 💬
 [1] ESR1 💬 Estetrol 💬 Estetrol [1] 53 💬
110 Proteoglycans in cancer 💬
 [1] ESR1 💬 Estetrol 💬 Estetrol [1] 53 💬
111 Proteoglycans in cancer 💬
 [1] ESR1 💬 Estradiol 💬 Estradiol [7] 13, 46, 49, 65, 76, 226, 299 💬
112 Proteoglycans in cancer 💬
 [1] ESR1 💬 Estradiol valerate 💬 Estradiol valerate [1] 65 💬
113 Proteoglycans in cancer 💬
 [1] ESR1 💬 Estriol 💬 Estriol [2] 13, 227 💬
114 Proteoglycans in cancer 💬
 [1] ESR1 💬 Estriol tripropionate 💬 Estriol [2] 13, 227 💬
115 Proteoglycans in cancer 💬
 [1] ESR1 💬 Ethinyl estradiol 💬 Ethinylestradiol [4] 13, 46, 49, 299 💬
116 Proteoglycans in cancer 💬
 [1] ESR1 💬 Fulvestrant 💬 Fulvestrant [2] 49, 86 💬
117 Proteoglycans in cancer 💬
 [1] ESR1 💬 Mestranol 💬 Mestranol [2] 46, 49 💬
118 Proteoglycans in cancer 💬
 [1] ESR1 💬 Prasterone 💬 Prasterone [6] 49, 53, 83, 86, 96, 113 💬
119 Proteoglycans in cancer 💬
 [1] ESR1 💬 Raloxifene 💬 Raloxifene [1] 46 💬
120 Proteoglycans in cancer 💬
 [1] ESR1 💬 Tamoxifen 💬 Tamoxifen [3]  2 , 113, 227 💬
121 Thyroid hormone signaling pathway 💬
 [1] ESR1 💬 Clomifene 💬 Clomifene [1] 74 💬
122 Thyroid hormone signaling pathway 💬
 [1] ESR1 💬 Danazol 💬 Danazol [5] 60, 63, 64, 65, 285 💬
123 Thyroid hormone signaling pathway 💬
 [1] ESR1 💬 Desogestrel 💬 Desogestrel [1] 230 💬
124 Thyroid hormone signaling pathway 💬
 [1] ESR1 💬 Estetrol 💬 Estetrol [1] 53 💬
125 Thyroid hormone signaling pathway 💬
 [1] ESR1 💬 Estetrol 💬 Estetrol [1] 53 💬
126 Thyroid hormone signaling pathway 💬
 [1] ESR1 💬 Estradiol 💬 Estradiol [7] 13, 46, 49, 65, 76, 226, 299 💬
127 Thyroid hormone signaling pathway 💬
 [1] ESR1 💬 Estradiol valerate 💬 Estradiol valerate [1] 65 💬
128 Thyroid hormone signaling pathway 💬
 [1] ESR1 💬 Estriol 💬 Estriol [2] 13, 227 💬
129 Thyroid hormone signaling pathway 💬
 [1] ESR1 💬 Estriol tripropionate 💬 Estriol [2] 13, 227 💬
130 Thyroid hormone signaling pathway 💬
 [1] ESR1 💬 Ethinyl estradiol 💬 Ethinylestradiol [4] 13, 46, 49, 299 💬
131 Thyroid hormone signaling pathway 💬
 [1] ESR1 💬 Fulvestrant 💬 Fulvestrant [2] 49, 86 💬
132 Thyroid hormone signaling pathway 💬
 [1] ESR1 💬 Mestranol 💬 Mestranol [2] 46, 49 💬
133 Thyroid hormone signaling pathway 💬
 [1] ESR1 💬 Prasterone 💬 Prasterone [6] 49, 53, 83, 86, 96, 113 💬
134 Thyroid hormone signaling pathway 💬
 [1] ESR1 💬 Raloxifene 💬 Raloxifene [1] 46 💬
135 Thyroid hormone signaling pathway 💬
 [1] ESR1 💬 Tamoxifen 💬 Tamoxifen [3]  2 , 113, 227 💬

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