Target Gene/Pathway Pathway / Gene

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No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

FoxO signaling pathway 💬

[1] S1PR1 💬

[1] 49 💬

2

FoxO signaling pathway 💬

[1] S1PR1 💬

Fingolimod 💬

[3] 13, 14, 156 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
14	Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy;
156	Rett syndrome;

3

FoxO signaling pathway 💬

[1] S1PR1 💬

[1] 13 💬

4

FoxO signaling pathway 💬

[1] S1PR1 💬

[2] 13, 50 💬

5

FoxO signaling pathway 💬

[2] S1PR1, S1PR4 💬

Amiselimod 💬

[1] 97 💬

6

FoxO signaling pathway 💬

[2] S1PR1, S1PR4 💬

[3] 96, 97, 98 💬

Disease ID	Name
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;

7

FoxO signaling pathway 💬

[2] S1PR1, S1PR4 💬

[3] 13, 96, 97 💬

8

Neuroactive ligand-receptor interaction 💬

[1] S1PR1 💬

[1] 49 💬

9

Neuroactive ligand-receptor interaction 💬

[1] S1PR1 💬

Fingolimod 💬

[3] 13, 14, 156 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
14	Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy;
156	Rett syndrome;

10

Neuroactive ligand-receptor interaction 💬

[1] S1PR1 💬

[1] 13 💬

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