Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Neutrophil extracellular trap formation 💬
 [1] C3 💬 Pegcetacoplan 💬 Pegcetacoplan [4]  2 , 61, 62, 222 💬
2 Neutrophil extracellular trap formation 💬
 [1] C5 💬 Crovalimab 💬 Crovalimab [2] 62, 109 💬
3 Neutrophil extracellular trap formation 💬
 [1] C5 💬 Eculizumab 💬 Eculizumab [7] 11, 13, 14, 61, 62, 109, 222 💬
4 Neutrophil extracellular trap formation 💬
 [1] C5 💬 Nomacopan 💬 Nomacopan [3] 62, 109, 162 💬
5 Neutrophil extracellular trap formation 💬
 [1] C5 💬 Pozelimab 💬 Pozelimab [2] 11, 62 💬
6 Neutrophil extracellular trap formation 💬
 [1] C5 💬 Ravulizumab 💬 Ravulizumab [7]  2 , 11, 13, 50, 62, 66, 109 💬
7 Neutrophil extracellular trap formation 💬
 [1] C5 💬 Vilobelimab 💬 Vilobelimab [3] 43, 44, 269 💬
8 Neutrophil extracellular trap formation 💬
 [1] C5 💬 Zilucoplan 💬 Zilucoplan [3]  2 , 11, 62 💬
9 Neutrophil extracellular trap formation 💬
 [1] C5AR1 💬 Avacopan 💬 Avacopan [3] 43, 44, 222 💬
10 Neutrophil extracellular trap formation 💬
 [1] ELANE 💬 Sivelestat 💬 Sivelestat [3] 13, 85, 96 💬
11 Neutrophil extracellular trap formation 💬
 [11] HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9 💬 Vorinostat 💬 Vorinostat [2] 75, 96 💬
12 Neutrophil extracellular trap formation 💬
 [1] ITGAL 💬 Efalizumab 💬 Efalizumab [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 💬
13 Neutrophil extracellular trap formation 💬
 [2] MAP2K1, MAP2K2 💬 Binimetinib 💬 Binimetinib [1] 34 💬
14 Neutrophil extracellular trap formation 💬
 [2] MAP2K1, MAP2K2 💬 Cobimetinib 💬 Cobimetinib [1] 280 💬
15 Neutrophil extracellular trap formation 💬
 [2] MAP2K1, MAP2K2 💬 Mirdametinib 💬 Mirdametinib [1] 34 💬
16 Neutrophil extracellular trap formation 💬
 [2] MAP2K1, MAP2K2 💬 Selumetinib 💬 Selumetinib [1] 34 💬
17 Neutrophil extracellular trap formation 💬
 [2] MAP2K1, MAP2K2 💬 Trametinib 💬 Trametinib [4]  2 , 34, 279, 280 💬
18 Neutrophil extracellular trap formation 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Losmapimod 💬 Losmapimod [2] 113, 222 💬
19 Neutrophil extracellular trap formation 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Neflamapimod 💬 Neflamapimod [1]  8  💬
20 Neutrophil extracellular trap formation 💬
 [1] MPO 💬 Verdiperstat 💬 Verdiperstat [3]  2 , 17, 127 💬
21 Neutrophil extracellular trap formation 💬
 [1] MTOR 💬 Everolimus 💬 Everolimus [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
22 Neutrophil extracellular trap formation 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬
23 Neutrophil extracellular trap formation 💬
 [1] MTOR 💬 Temsirolimus 💬 Temsirolimus [1] 13 💬
24 Neutrophil extracellular trap formation 💬
 [1] NFKB1 💬 Iguratimod 💬 Iguratimod [5] 46, 51, 53, 271, 300 💬
25 Neutrophil extracellular trap formation 💬
 [1] PIK3CA 💬 Alpelisib 💬 Alpelisib [1] 138 💬
26 Neutrophil extracellular trap formation 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 Leniolisib 💬 Leniolisib [2] 53, 65 💬
27 Neutrophil extracellular trap formation 💬
 [1] PIK3CD 💬 Parsaclisib 💬 Parsaclisib [3] 35, 53, 61 💬
28 Neutrophil extracellular trap formation 💬
 [1] PRKCB 💬 Enzastaurin 💬 Enzastaurin [1] 168 💬
29 Neutrophil extracellular trap formation 💬
 [1] RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
30 Neutrophil extracellular trap formation 💬
 [1] RELA 💬 Edasalonexent 💬 Edasalonexent [1] 113 💬
31 Neutrophil extracellular trap formation 💬
 [1] SRC 💬 Bosutinib 💬 Bosutinib [2]  2 , 67 💬
32 Neutrophil extracellular trap formation 💬
 [1] SRC 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
33 Neutrophil extracellular trap formation 💬
 [1] SRC 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
34 Neutrophil extracellular trap formation 💬
 [1] SRC 💬 Saracatinib 💬 Saracatinib [3]  6 , 89, 272 💬
35 Neutrophil extracellular trap formation 💬
 [1] SYK 💬 Fostamatinib 💬 Fostamatinib [4] 46, 49, 61, 66 💬
36 Neutrophil extracellular trap formation 💬
 [1] TLR7 💬 Imiquimod 💬 Imiquimod [2] 34, 51 💬
37 Neutrophil extracellular trap formation 💬
 [1] VWF 💬 Caplacizumab 💬 Caplacizumab [1] 64 💬