Target Gene/Pathway Pathway / Gene

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No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

Th1 and Th2 cell differentiation 💬

[3] CD3D, CD3E, CD3G 💬

Otelixizumab 💬

[1] 46 💬

2

Th1 and Th2 cell differentiation 💬

[3] CD3D, CD3E, CD3G 💬

Visilizumab 💬

[2] 96, 97 💬

3

Th1 and Th2 cell differentiation 💬

[1] CD3E 💬

Mosunetuzumab 💬

[1] 49 💬

4

Th1 and Th2 cell differentiation 💬

[1] CD4 💬

Zanolimumab 💬

[1] 46 💬

5

Th1 and Th2 cell differentiation 💬

[1] IFNG 💬

Emapalumab 💬

[3] 49, 65, 107 💬

6

Th1 and Th2 cell differentiation 💬

[1] IFNG 💬

Fontolizumab 💬

[1] 46 💬

7

Th1 and Th2 cell differentiation 💬

[2] IFNGR1, IFNGR2 💬

Interferon gamma-1b 💬

Interferon gamma-1b

[7] 18, 65, 85, 228, 299, 301, 326 💬

Disease ID	Name
18	Spinocerebellar degeneration;SCD;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;
299	Cystic fibrosis;
301	Macular dystrophy;
326	Osteopetrosis;

8

Th1 and Th2 cell differentiation 💬

[2] IL12A, IL12B 💬

Ustekinumab 💬

[16] 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬

Disease ID	Name
37	Generalised pustular psoriasis;Pustular psoriasis;
40	Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome;
41	Giant cell arteritis;Temporal arteritis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;
56	Behcet disease;Behçet disease;BD;
65	Primary immunodeficiency;
84	Sarcoidosis;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
160	Congenital ichthyosis;
162	Pemphigoid;
269	Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

9

Th1 and Th2 cell differentiation 💬

[1] IL13 💬

Anrukinzumab 💬

[1] 97 💬

10

Th1 and Th2 cell differentiation 💬

[1] IL13 💬

Lebrikizumab 💬

[1] 85 💬

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