Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY KEGG GENES KEGG DRUG DrugBank Disease ID
1 Th17 cell differentiation 💬
 [3] CD3D, CD3E, CD3G 💬 Otelixizumab 💬 Otelixizumab [1] 46 💬 💬
2 Th17 cell differentiation 💬
 [3] CD3D, CD3E, CD3G 💬 Visilizumab 💬 Visilizumab [2] 96, 97 💬 💬
3 Th17 cell differentiation 💬
 [1] CD3E 💬 Mosunetuzumab 💬 Mosunetuzumab [1] 49 💬 💬
4 Th17 cell differentiation 💬
 [1] CD4 💬 Zanolimumab 💬 Zanolimumab [1] 46 💬 💬
5 Th17 cell differentiation 💬
 [1] IFNG 💬 Emapalumab 💬 Emapalumab [3] 49, 65, 107 💬 💬
6 Th17 cell differentiation 💬
 [1] IFNG 💬 Fontolizumab 💬 Fontolizumab [1] 46 💬 💬
7 Th17 cell differentiation 💬
 [2] IFNGR1, IFNGR2 💬 Interferon gamma-1b 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬 💬
8 Th17 cell differentiation 💬
 [1] IL17A 💬 Ixekizumab 💬 Ixekizumab [8] 36, 37, 46, 107, 160, 162, 269, 271 💬 💬
9 Th17 cell differentiation 💬
 [1] IL17A 💬 Secukinumab 💬 Secukinumab [8] 13, 37, 41, 46, 107, 160, 269, 271 💬 💬
10 Th17 cell differentiation 💬
 [1] IL17A 💬 Tibulizumab 💬 Tibulizumab [1] 53 💬 💬
11 Th17 cell differentiation 💬
 [2] IL17A, IL17F 💬 Bimekizumab 💬 Bimekizumab [3] 46, 97, 271 💬 💬
12 Th17 cell differentiation 💬
 [1] IL1B 💬 Canakinumab 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬
13 Th17 cell differentiation 💬
 [1] IL1B 💬 Gevokizumab 💬 Gevokizumab [4] 41, 50, 56, 269 💬 💬
14 Th17 cell differentiation 💬
 [1] IL1B 💬 Rilonacept 💬 Rilonacept [4] 51, 106, 107, 266 💬 💬
15 Th17 cell differentiation 💬
 [2] IL1B, IL6 💬 Pirfenidone 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬
16 Th17 cell differentiation 💬
 [1] IL1R1 💬 Anakinra 💬 Anakinra [18]  2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 💬
17 Th17 cell differentiation 💬
 [1] IL22 💬 Efmarodocokin alfa 💬 Efmarodocokin alfa [2] 96, 97 💬 💬
18 Th17 cell differentiation 💬
 [1] IL23A 💬 Brazikumab 💬 Brazikumab [2] 96, 97 💬 💬
19 Th17 cell differentiation 💬
 [1] IL23A 💬 Guselkumab 💬 Guselkumab [5] 37, 41, 51, 96, 97 💬 💬
20 Th17 cell differentiation 💬
 [1] IL23A 💬 Mirikizumab 💬 Mirikizumab [3] 37, 96, 97 💬 💬
21 Th17 cell differentiation 💬
 [1] IL23A 💬 Risankizumab 💬 Risankizumab [4] 37, 96, 97, 271 💬 💬
22 Th17 cell differentiation 💬
 [1] IL23A 💬 Tildrakizumab 💬 Tildrakizumab [2] 162, 271 💬 💬
23 Th17 cell differentiation 💬
 [1] IL23A 💬 Ustekinumab 💬 Ustekinumab [16] 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬 💬
24 Th17 cell differentiation 💬
 [1] IL2RA 💬 Basiliximab 💬 Basiliximab [6]  2 , 50, 66, 97, 222, 228 💬 💬
25 Th17 cell differentiation 💬
 [1] IL2RA 💬 Daclizumab 💬 Daclizumab [8] 13, 56, 60, 65, 97, 107, 283, 284 💬 💬
26 Th17 cell differentiation 💬
 [3] IL2RA, IL2RB, IL2RG 💬 Aldesleukin 💬 Aldesleukin [6]  2 , 35, 49, 65, 96, 97 💬 💬
27 Th17 cell differentiation 💬
 [1] IL4 💬 Binetrakin 💬 Binetrakin [1] 46 💬 💬
28 Th17 cell differentiation 💬
 [1] IL4R 💬 Dupilumab 💬 Dupilumab [5] 51, 97, 98, 160, 162 💬 💬
29 Th17 cell differentiation 💬
 [1] IL6 💬 Olokizumab 💬 Olokizumab [2] 46, 96 💬 💬
30 Th17 cell differentiation 💬
 [1] IL6 💬 Pomalidomide 💬 Pomalidomide [5] 28, 51, 85, 227, 331 💬 💬
31 Th17 cell differentiation 💬
 [1] IL6 💬 Siltuximab 💬 Siltuximab [2] 28, 331 💬 💬
32 Th17 cell differentiation 💬
 [1] IL6 💬 Sirukumab 💬 Sirukumab [2] 41, 46 💬 💬
33 Th17 cell differentiation 💬
 [1] IL6R 💬 Sarilumab 💬 Sarilumab [5] 41, 46, 84, 107, 271 💬 💬
34 Th17 cell differentiation 💬
 [1] IL6R 💬 Satralizumab 💬 Satralizumab [3] 11, 13, 86 💬 💬
35 Th17 cell differentiation 💬
 [1] IL6R 💬 Tocilizumab 💬 Tocilizumab [21]  2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬 💬
36 Th17 cell differentiation 💬
 [1] JAK1 💬 Abrocitinib 💬 Abrocitinib [1] 84 💬 💬
37 Th17 cell differentiation 💬
 [1] JAK1 💬 Filgotinib 💬 Filgotinib [6] 46, 53, 96, 97, 222, 271 💬 💬
38 Th17 cell differentiation 💬
 [1] JAK1 💬 Itacitinib 💬 Itacitinib [4] 46, 51, 97, 228 💬 💬
39 Th17 cell differentiation 💬
 [1] JAK1 💬 Upadacitinib 💬 Upadacitinib [8] 40, 41, 46, 49, 96, 97, 107, 271 💬 💬
40 Th17 cell differentiation 💬
 [2] JAK1, JAK2 💬 Baricitinib 💬 Baricitinib [13]  2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬
41 Th17 cell differentiation 💬
 [2] JAK1, JAK2 💬 Ruxolitinib 💬 Ruxolitinib [3] 60, 65, 228 💬 💬
42 Th17 cell differentiation 💬
 [3] JAK1, JAK2, JAK3 💬 Peficitinib 💬 Peficitinib [1] 46 💬 💬
43 Th17 cell differentiation 💬
 [4] JAK1, JAK2, JAK3, TYK2 💬 Tofacitinib 💬 Tofacitinib [15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬 💬
44 Th17 cell differentiation 💬
 [1] LCK 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬 💬
45 Th17 cell differentiation 💬
 [1] LCK 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬 💬
46 Th17 cell differentiation 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Losmapimod 💬 Losmapimod [2] 113, 222 💬 💬
47 Th17 cell differentiation 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Neflamapimod 💬 Neflamapimod [1]  8  💬 💬
48 Th17 cell differentiation 💬
 [1] MTOR 💬 Everolimus 💬 Everolimus [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 💬
49 Th17 cell differentiation 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
50 Th17 cell differentiation 💬
 [1] MTOR 💬 Temsirolimus 💬 Temsirolimus [1] 13 💬 💬
51 Th17 cell differentiation 💬
 [1] NFKB1 💬 Iguratimod 💬 Iguratimod [5] 46, 51, 53, 271, 300 💬 💬
52 Th17 cell differentiation 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Cyclosporine 💬 Cyclosporine [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬
53 Th17 cell differentiation 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Pimecrolimus 💬 Pimecrolimus [1] 160 💬 💬
54 Th17 cell differentiation 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Tacrolimus 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬
55 Th17 cell differentiation 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Tacrolimus 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬
56 Th17 cell differentiation 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Voclosporin 💬 Voclosporin [2] 49, 222 💬 💬
57 Th17 cell differentiation 💬
 [1] PRKCQ 💬 Sotrastaurin 💬 Sotrastaurin [1] 97 💬 💬
58 Th17 cell differentiation 💬
 [1] RARA 💬 Fenretinide 💬 Fenretinide [1] 299 💬 💬
59 Th17 cell differentiation 💬
 [1] RARA 💬 Isotretinoin 💬 Isotretinoin [4] 36, 39, 159, 160 💬 💬
60 Th17 cell differentiation 💬
 [1] RARA 💬 Tamibarotene 💬 Tamibarotene [2] 26, 96 💬 💬
61 Th17 cell differentiation 💬
 [1] RARA 💬 Tretinoin 💬 Tretinoin [6]  2 , 62, 63, 75, 94, 231 💬 💬
62 Th17 cell differentiation 💬
 [1] RARA 💬 Vitamin A 💬 Vitamin A [3] 13, 53, 90 💬 💬
63 Th17 cell differentiation 💬
 [4] RARA, RXRA, RXRB, RXRG 💬 Acitretin 💬 Acitretin [1] 37 💬 💬
64 Th17 cell differentiation 💬
 [4] RARA, RXRA, RXRB, RXRG 💬 Alitretinoin 💬 Alitretinoin [1] 49 💬 💬
65 Th17 cell differentiation 💬
 [1] RELA 💬 Edasalonexent 💬 Edasalonexent [1] 113 💬 💬
66 Th17 cell differentiation 💬
 [3] RXRA, RXRB, RXRG 💬 Bexarotene 💬 Bexarotene [2] 13, 75 💬 💬
67 Th17 cell differentiation 💬
 [1] TGFB1 💬 Fresolimumab 💬 Fresolimumab [3] 51, 85, 222 💬 💬
68 Th17 cell differentiation 💬
 [1] TYK2 💬 Deucravacitinib 💬 Deucravacitinib [3] 49, 96, 97 💬 💬