Target Gene/Pathway Pathway / Gene

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No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

Th17 cell differentiation 💬

[3] CD3D, CD3E, CD3G 💬

Otelixizumab 💬

[1] 46 💬

2

Th17 cell differentiation 💬

[3] CD3D, CD3E, CD3G 💬

Visilizumab 💬

[2] 96, 97 💬

3

Th17 cell differentiation 💬

[1] CD3E 💬

Mosunetuzumab 💬

[1] 49 💬

4

Th17 cell differentiation 💬

[1] CD4 💬

Zanolimumab 💬

[1] 46 💬

5

Th17 cell differentiation 💬

[1] IFNG 💬

Emapalumab 💬

[3] 49, 65, 107 💬

6

Th17 cell differentiation 💬

[1] IFNG 💬

Fontolizumab 💬

[1] 46 💬

7

Th17 cell differentiation 💬

[2] IFNGR1, IFNGR2 💬

Interferon gamma-1b 💬

Interferon gamma-1b

[7] 18, 65, 85, 228, 299, 301, 326 💬

Disease ID	Name
18	Spinocerebellar degeneration;SCD;
65	Primary immunodeficiency;
85	Idiopathic interstitial pneumonia;IIPs;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;
299	Cystic fibrosis;
301	Macular dystrophy;
326	Osteopetrosis;

8

Th17 cell differentiation 💬

[1] IL17A 💬

Ixekizumab 💬

[8] 36, 37, 46, 107, 160, 162, 269, 271 💬

Disease ID	Name
36	Epidermolysis bullosa;
37	Generalised pustular psoriasis;Pustular psoriasis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
107	Juvenile idiopathic arthritis;JIA;
160	Congenital ichthyosis;
162	Pemphigoid;
269	Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

9

Th17 cell differentiation 💬

[1] IL17A 💬

Secukinumab 💬

[8] 13, 37, 41, 46, 107, 160, 269, 271 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
37	Generalised pustular psoriasis;Pustular psoriasis;
41	Giant cell arteritis;Temporal arteritis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
107	Juvenile idiopathic arthritis;JIA;
160	Congenital ichthyosis;
269	Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

10

Th17 cell differentiation 💬

[1] IL17A 💬

Tibulizumab 💬

[1] 53 💬

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