302. Leber hereditary optic neuropathy Disease details / Clinical trials / Drug dev / DR info

Clinical trials : 23 /  Drugs : 15 - (DrugBank : 5) / Drug target genes : 5 - Drug target pathways : 33

Drugs and their primary sponsors and trial info
Béfizal   
   Hôpital Necker-Enfants Malades
      2019   Phase 2/Phase 3   NCT04561466   France;
Cyclosporine   
   University Hospital, Angers
      2011   Phase 2   NCT02176733   France;
GS010   
   GENSIGHT BIOLOGICS
      2019   Phase 3   EUCTR2017-002187-40-NL   Belgium;France;Italy;Netherlands;Spain;United Kingdom;
      2018   Phase 3   EUCTR2017-002187-40-IT   Belgium;France;Italy;Netherlands;Spain;United Kingdom;
      2018   Phase 3   EUCTR2017-002187-40-GB   Belgium;France;Italy;Netherlands;Spain;United Kingdom;
      2018   Phase 3   EUCTR2017-002187-40-FR   Belgium;France;Italy;Netherlands;Spain;United Kingdom;
      2018   Phase 3   EUCTR2017-002187-40-ES   Belgium;France;Italy;Netherlands;Spain;United Kingdom;
      2018   Phase 3   EUCTR2017-002187-40-BE   Belgium;France;Italy;Netherlands;Spain;United Kingdom;
      2018   Phase 3   EUCTR2017-002153-11-GB   France;Germany;Italy;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-001266-26-IT   France;Germany;Italy;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-001265-11-IT   France;Germany;Italy;United Kingdom;United States;
      -   Phase 4   EUCTR2017-002153-11-IT   France;Germany;Italy;United Kingdom;United States;
   GENSIGHT-BIOLOGICS
      2016   Phase 3   EUCTR2015-001266-26-DE   France;Germany;Italy;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-001265-11-DE   France;Germany;Italy;United Kingdom;United States;
      2015   Phase 3   EUCTR2015-001266-26-GB   France;Germany;Italy;United Kingdom;United States;
      2015   Phase 3   EUCTR2015-001265-11-GB   France;Germany;Italy;United Kingdom;United States;
      2013   Phase 1;Phase 2   EUCTR2013-001405-90-FR   France;
   GenSight Biologics
      2018   Phase 3   NCT03293524   Belgium;France;Italy;Spain;Taiwan;United Kingdom;United States;
Idebenone   
   Hyogo College of Medicine
      2013   Phase 1,2   JPRN-UMIN000017939   Japan;
Lenadogene nolparvovec   
   GENSIGHT BIOLOGICS
      2019   Phase 3   EUCTR2017-002187-40-NL   Belgium;France;Italy;Netherlands;Spain;United Kingdom;
      2018   Phase 3   EUCTR2017-002187-40-IT   Belgium;France;Italy;Netherlands;Spain;United Kingdom;
      2018   Phase 3   EUCTR2017-002187-40-GB   Belgium;France;Italy;Netherlands;Spain;United Kingdom;
      2018   Phase 3   EUCTR2017-002187-40-FR   Belgium;France;Italy;Netherlands;Spain;United Kingdom;
      2018   Phase 3   EUCTR2017-002187-40-ES   Belgium;France;Italy;Netherlands;Spain;United Kingdom;
      2018   Phase 3   EUCTR2017-002187-40-BE   Belgium;France;Italy;Netherlands;Spain;United Kingdom;
NR082 injection   
   Wuhan Neurophth Biotechnology Limited Company
      2021   Phase 1/Phase 2   NCT04912843   China;
PENDING   
   GENSIGHT BIOLOGICS
      2016   Phase 3   EUCTR2015-001265-11-IT   France;Germany;Italy;United Kingdom;United States;
Pending   
   GENSIGHT-BIOLOGICS
      2016   Phase 3   EUCTR2015-001266-26-DE   France;Germany;Italy;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-001265-11-DE   France;Germany;Italy;United Kingdom;United States;
      2015   Phase 3   EUCTR2015-001266-26-GB   France;Germany;Italy;United Kingdom;United States;
      2015   Phase 3   EUCTR2015-001265-11-GB   France;Germany;Italy;United Kingdom;United States;
RAAV2-ND4   
   Bin Li
      2011   -   NCT01267422   China;
   Huazhong University of Science and Technology
      2017   Phase 2/Phase 3   NCT03153293   China;
RAAV2/2-ND4 VECTOR   
   GENSIGHT BIOLOGICS
      2016   Phase 3   EUCTR2015-001266-26-IT   France;Germany;Italy;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-001265-11-IT   France;Germany;Italy;United Kingdom;United States;
   GENSIGHT-BIOLOGICS
      2016   Phase 3   EUCTR2015-001266-26-DE   France;Germany;Italy;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-001265-11-DE   France;Germany;Italy;United Kingdom;United States;
      2015   Phase 3   EUCTR2015-001266-26-GB   France;Germany;Italy;United Kingdom;United States;
      2015   Phase 3   EUCTR2015-001265-11-GB   France;Germany;Italy;United Kingdom;United States;
      2013   Phase 1;Phase 2   EUCTR2013-001405-90-FR   France;
Recombinant AAV vector serotype 2 containing the human wild type mitochondrial ND4 gene   
   GENSIGHT BIOLOGICS
      2019   Phase 3   EUCTR2017-002187-40-NL   Belgium;France;Italy;Netherlands;Spain;United Kingdom;
      2018   Phase 3   EUCTR2017-002187-40-GB   Belgium;France;Italy;Netherlands;Spain;United Kingdom;
      2018   Phase 3   EUCTR2017-002187-40-FR   Belgium;France;Italy;Netherlands;Spain;United Kingdom;
      2018   Phase 3   EUCTR2017-002187-40-ES   Belgium;France;Italy;Netherlands;Spain;United Kingdom;
      2018   Phase 3   EUCTR2017-002187-40-BE   Belgium;France;Italy;Netherlands;Spain;United Kingdom;
      2018   Phase 3   EUCTR2017-002153-11-GB   France;Germany;Italy;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-001266-26-IT   France;Germany;Italy;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-001265-11-IT   France;Germany;Italy;United Kingdom;United States;
      -   Phase 4   EUCTR2017-002153-11-IT   France;Germany;Italy;United Kingdom;United States;
   GENSIGHT-BIOLOGICS
      2016   Phase 3   EUCTR2015-001266-26-DE   France;Germany;Italy;United Kingdom;United States;
      2016   Phase 3   EUCTR2015-001265-11-DE   France;Germany;Italy;United Kingdom;United States;
      2015   Phase 3   EUCTR2015-001266-26-GB   France;Germany;Italy;United Kingdom;United States;
      2015   Phase 3   EUCTR2015-001265-11-GB   France;Germany;Italy;United Kingdom;United States;
      2013   Phase 1;Phase 2   EUCTR2013-001405-90-FR   France;
Recombinant AAV vector serotype 2 containing the human wild typemitochondrial ND4 gene   
   GENSIGHT BIOLOGICS
      2018   Phase 3   EUCTR2017-002187-40-IT   Belgium;France;Italy;Netherlands;Spain;United Kingdom;
Recombinant Adeno-Associated Viral vector, serotype 2 (rAAV2/2) containing the human wild-type mitochondrial NADH Dehydrogenase 4 gene (ND4)   
   GENSIGHT BIOLOGICS
      2019   Phase 3   EUCTR2017-002187-40-NL   Belgium;France;Italy;Netherlands;Spain;United Kingdom;
      2018   Phase 3   EUCTR2017-002187-40-GB   Belgium;France;Italy;Netherlands;Spain;United Kingdom;
      2018   Phase 3   EUCTR2017-002187-40-FR   Belgium;France;Italy;Netherlands;Spain;United Kingdom;
      2018   Phase 3   EUCTR2017-002187-40-ES   Belgium;France;Italy;Netherlands;Spain;United Kingdom;
      2018   Phase 3   EUCTR2017-002187-40-BE   Belgium;France;Italy;Netherlands;Spain;United Kingdom;
VA   
   Hyogo College of Medicine
      2013   Phase 1,2   JPRN-UMIN000017939   Japan;