338. Progressive familial intrahepatic cholestasis Disease details / Clinical trials / Drug dev / DR info

Clinical trials : 60 /  Drugs : 26 - (DrugBank : 6) / Drug target genes : 2 - Drug target pathways : 2

Drugs and their primary sponsors and trial info
A4250   
   Albireo
      2013   Phase 1   NCT02963077   -
A4250 (1200 µg)   
   ALBIREO AB
      2018   Phase 3   EUCTR2017-002338-21-IT   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
   Albireo AB
      2019   Phase 3   EUCTR2017-002325-38-BE   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002338-21-NL   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002338-21-GB   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002338-21-FR   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002338-21-ES   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002338-21-BE   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002325-38-SE   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002325-38-NL   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002325-38-IT   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002325-38-GB   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002325-38-FR   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002325-38-ES   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2017-002338-21-SE   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2017-002338-21-PL   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2017-002338-21-DE   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2017-002325-38-PL   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2017-002325-38-DE   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
A4250 (200 µg)   
   ALBIREO AB
      2018   Phase 3   EUCTR2017-002338-21-IT   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
   Albireo AB
      2019   Phase 3   EUCTR2017-002325-38-BE   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002338-21-NL   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002338-21-GB   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002338-21-FR   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002338-21-ES   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002338-21-BE   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002325-38-SE   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002325-38-NL   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002325-38-IT   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002325-38-GB   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002325-38-FR   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002325-38-ES   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2017-002338-21-SE   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2017-002338-21-PL   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2017-002338-21-DE   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2017-002325-38-PL   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2017-002325-38-DE   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
A4250 (400 µg)   
   ALBIREO AB
      2018   Phase 3   EUCTR2017-002338-21-IT   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
   Albireo AB
      2019   Phase 3   EUCTR2017-002325-38-BE   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002338-21-NL   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002338-21-GB   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002338-21-FR   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002338-21-ES   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002338-21-BE   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002325-38-SE   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002325-38-NL   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002325-38-IT   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002325-38-GB   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002325-38-FR   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002325-38-ES   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2017-002338-21-SE   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2017-002338-21-PL   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2017-002338-21-DE   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2017-002325-38-PL   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2017-002325-38-DE   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
A4250 (600 µg)   
   ALBIREO AB
      2018   Phase 3   EUCTR2017-002338-21-IT   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
   Albireo AB
      2019   Phase 3   EUCTR2017-002325-38-BE   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002338-21-NL   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002338-21-GB   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002338-21-FR   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002338-21-ES   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002338-21-BE   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002325-38-SE   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002325-38-NL   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002325-38-IT   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002325-38-GB   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002325-38-FR   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-002325-38-ES   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2017-002338-21-SE   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2017-002338-21-PL   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2017-002338-21-DE   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2017-002325-38-PL   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2017-002325-38-DE   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
A4250 (odevixibat)   
   Albireo
      2018   Phase 3   NCT03659916   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
      2018   Phase 3   NCT03566238   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
CRC (A3384)   
   Albireo
      2013   Phase 1   NCT02963077   -
Eicosapentaenoic acid   
   Sumida Wataru
      2016   -   JPRN-jRCTs041180088   Japan;
LUM001   
   Lumena Pharmaceuticals, Inc.
      -   Phase 2   EUCTR2013-003833-14-FR   France;Poland;United Kingdom;United States;
   Mirum Pharmaceuticals, Inc.
      2014   Phase 2   NCT02057718   France;Poland;United Kingdom;United States;
      2014   Phase 2   EUCTR2013-003833-14-GB   France;Poland;United Kingdom;
   Mirum Pharmaceuticals, LLC.
      -   Phase 2   EUCTR2013-003833-14-PL   France;Poland;United Kingdom;
   Shire Human Genetic Therapies Inc
      2015   Phase 2   EUCTR2015-000906-20-GB   Australia;Canada;United Kingdom;United States;
MARALIXIBAT CHLORIDE   
   Mirum Pharmaceuticals Inc
      2021   Phase 2   EUCTR2020-004628-40-FR   Belgium;France;Poland;United Kingdom;
      2021   Phase 2   EUCTR2020-004628-40-BE   Belgium;France;Poland;United Kingdom;
      -   Phase 2   EUCTR2020-004628-40-PL   Belgium;France;Poland;United Kingdom;
   Mirum Pharmaceuticals Inc.
      2020   Phase 3   EUCTR2019-003395-39-HU   Argentina;Austria;Belgium;Brazil;Canada;Colombia;France;Germany;Hungary;Italy;Lebanon;Mexico;Poland;Singapore;Turkey;United Kingdom;United States;
      2020   Phase 3   EUCTR2019-003395-39-GB   Argentina;Austria;Belgium;Brazil;Canada;Colombia;France;Germany;Hungary;Italy;Lebanon;Mexico;Poland;Singapore;Turkey;United Kingdom;United States;
      2020   Phase 3   EUCTR2019-003395-39-FR   Argentina;Austria;Belgium;Brazil;Canada;Colombia;France;Germany;Hungary;Italy;Lebanon;Mexico;Poland;Singapore;Turkey;United Kingdom;United States;
      2020   Phase 3   EUCTR2019-003395-39-AT   Argentina;Austria;Belgium;Brazil;Canada;Colombia;France;Germany;Hungary;Italy;Lebanon;Mexico;Poland;Singapore;Turkey;United Kingdom;United States;
      2020   Phase 2   EUCTR2019-002755-42-GB   Australia;Belgium;Canada;France;Poland;Spain;United Kingdom;United States;
      2020   Phase 2   EUCTR2019-002755-42-FR   Australia;Belgium;Canada;France;Poland;Spain;United Kingdom;United States;
      2020   Phase 2   EUCTR2019-002755-42-ES   Australia;Belgium;Canada;France;Poland;Spain;United Kingdom;United States;
      2019   Phase 3   EUCTR2019-001211-22-HU   Argentina;Austria;Belgium;Brazil;Canada;Colombia;France;Germany;Hungary;Italy;Lebanon;Mexico;Poland;Singapore;Turkey;United Kingdom;United States;
      2019   Phase 3   EUCTR2019-001211-22-GB   Argentina;Austria;Belgium;Brazil;Canada;Chile;Colombia;France;Germany;Hungary;Italy;Lebanon;Mexico;Poland;Saudi Arabia;Singapore;Turkey;United Kingdom;United States;
      2019   Phase 3   EUCTR2019-001211-22-FR   Argentina;Austria;Belgium;Brazil;Canada;Chile;France;Germany;Hungary;Italy;Lebanon;Mexico;Poland;Saudi Arabia;Singapore;Turkey;United Kingdom;United States;
      2019   Phase 3   EUCTR2019-001211-22-DE   Argentina;Austria;Belgium;Brazil;Canada;Colombia;France;Germany;Hungary;Italy;Lebanon;Mexico;Poland;Singapore;Turkey;United Kingdom;United States;
      2019   Phase 3   EUCTR2019-001211-22-AT   Argentina;Austria;Belgium;Brazil;Canada;Colombia;France;Germany;Hungary;Italy;Lebanon;Mexico;Poland;Singapore;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2019-003395-39-PL   Argentina;Austria;Belgium;Brazil;Canada;Colombia;France;Germany;Hungary;Italy;Lebanon;Mexico;Poland;Singapore;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2019-003395-39-DE   Argentina;Austria;Belgium;Brazil;Canada;Colombia;France;Germany;Hungary;Italy;Lebanon;Mexico;Poland;Singapore;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2019-003395-39-BE   Argentina;Austria;Belgium;Brazil;Canada;Colombia;France;Germany;Hungary;Italy;Lebanon;Mexico;Poland;Singapore;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2019-001211-22-PL   Argentina;Austria;Belgium;Brazil;Canada;Colombia;France;Germany;Hungary;Italy;Lebanon;Mexico;Poland;Singapore;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2019-001211-22-BE   Argentina;Austria;Belgium;Brazil;Canada;Colombia;France;Germany;Hungary;Italy;Lebanon;Mexico;Poland;Singapore;Turkey;United Kingdom;United States;
      -   Phase 2   EUCTR2019-002755-42-PL   Australia;Belgium;Canada;France;Poland;Spain;United Kingdom;United States;
      -   Phase 2   EUCTR2019-002755-42-BE   Australia;Belgium;Canada;France;Poland;Spain;United Kingdom;United States;
MRX Drug Substance (formerly Maralixibat , SHP625 or LUM001)   
   Mirum Pharmaceuticals Inc.
      -   Phase 3   EUCTR2019-001211-22-BE   Argentina;Austria;Belgium;Brazil;Canada;Colombia;France;Germany;Hungary;Italy;Lebanon;Mexico;Poland;Singapore;Turkey;United Kingdom;United States;
MRX Drug Substance (formerly Maralixibat, SHP625 or LUM001)   
   Mirum Pharmaceuticals Inc.
      2019   Phase 3   EUCTR2019-001211-22-GB   Argentina;Austria;Belgium;Brazil;Canada;Chile;Colombia;France;Germany;Hungary;Italy;Lebanon;Mexico;Poland;Saudi Arabia;Singapore;Turkey;United Kingdom;United States;
      2019   Phase 3   EUCTR2019-001211-22-DE   Argentina;Austria;Belgium;Brazil;Canada;Colombia;France;Germany;Hungary;Italy;Lebanon;Mexico;Poland;Singapore;Turkey;United Kingdom;United States;
      2019   Phase 3   EUCTR2019-001211-22-AT   Argentina;Austria;Belgium;Brazil;Canada;Colombia;France;Germany;Hungary;Italy;Lebanon;Mexico;Poland;Singapore;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2019-001211-22-PL   Argentina;Austria;Belgium;Brazil;Canada;Colombia;France;Germany;Hungary;Italy;Lebanon;Mexico;Poland;Singapore;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2019-001211-22-BE   Argentina;Austria;Belgium;Brazil;Canada;Colombia;France;Germany;Hungary;Italy;Lebanon;Mexico;Poland;Singapore;Turkey;United Kingdom;United States;
Maralixibat   
   Mirum Pharmaceuticals, Inc.
      2021   Phase 2   NCT04729751   Belgium;France;Poland;United Kingdom;United States;
      2020   Phase 3   NCT04185363   Argentina;Austria;Belgium;Brazil;Canada;Colombia;France;Germany;Italy;Lebanon;Mexico;Poland;Singapore;United Kingdom;United States;
      2019   Phase 3   NCT03905330   Argentina;Austria;Belgium;Brazil;Canada;Colombia;France;Germany;Hungary;Italy;Lebanon;Mexico;Poland;Singapore;Turkey;United Kingdom;United States;
      2018   Phase 3   NCT03353454   -
Maralixibat (formely SHP625 or LUM001)   
   Mirum Pharmaceuticals Inc
      2021   Phase 2   EUCTR2020-004628-40-FR   Belgium;France;Poland;United Kingdom;
      2021   Phase 2   EUCTR2020-004628-40-BE   Belgium;France;Poland;United Kingdom;
      -   Phase 2   EUCTR2020-004628-40-PL   Belgium;France;Poland;United Kingdom;
   Mirum Pharmaceuticals Inc.
      2020   Phase 2   EUCTR2019-002755-42-GB   Australia;Belgium;Canada;France;Poland;Spain;United Kingdom;United States;
      2020   Phase 2   EUCTR2019-002755-42-FR   Australia;Belgium;Canada;France;Poland;Spain;United Kingdom;United States;
      2020   Phase 2   EUCTR2019-002755-42-ES   Australia;Belgium;Canada;France;Poland;Spain;United Kingdom;United States;
      -   Phase 2   EUCTR2019-002755-42-PL   Australia;Belgium;Canada;France;Poland;Spain;United Kingdom;United States;
      -   Phase 2   EUCTR2019-002755-42-BE   Australia;Belgium;Canada;France;Poland;Spain;United Kingdom;United States;
Maralixibat (formerly SHP625 or LUM001)   
   Mirum Pharmaceuticals Inc.
      2019   Phase 3   EUCTR2019-001211-22-HU   Argentina;Austria;Belgium;Brazil;Canada;Colombia;France;Germany;Hungary;Italy;Lebanon;Mexico;Poland;Singapore;Turkey;United Kingdom;United States;
      2019   Phase 3   EUCTR2019-001211-22-FR   Argentina;Austria;Belgium;Brazil;Canada;Chile;France;Germany;Hungary;Italy;Lebanon;Mexico;Poland;Saudi Arabia;Singapore;Turkey;United Kingdom;United States;
Maralixibat (in precedenza SHP625 o LUM001)   
   Mirum Pharmaceuticals Inc.
      2019   Phase 3   EUCTR2019-001211-22-IT   Argentina;Austria;Belgium;Brazil;Canada;Colombia;France;Germany;Hungary;Italy;Lebanon;Mexico;Poland;Singapore;Turkey;United Kingdom;United States;
Maralixibat chloride   
   Mirum Pharmaceuticals, Inc.
      2014   Phase 2   EUCTR2013-003833-14-GB   France;Poland;United Kingdom;
   Mirum Pharmaceuticals, LLC.
      -   Phase 2   EUCTR2013-003833-14-PL   France;Poland;United Kingdom;
Maralixibat cloruro   
   Mirum Pharmaceuticals Inc.
      2020   Phase 3   EUCTR2019-003395-39-IT   Argentina;Austria;Belgium;Brazil;Canada;Colombia;France;Germany;Hungary;Italy;Lebanon;Mexico;Poland;Singapore;Turkey;United Kingdom;United States;
      2019   Phase 3   EUCTR2019-001211-22-IT   Argentina;Austria;Belgium;Brazil;Canada;Colombia;France;Germany;Hungary;Italy;Lebanon;Mexico;Poland;Singapore;Turkey;United Kingdom;United States;
Odevixibat   
   Albireo
      2021   -   NCT04483531   United States;
   Albireo AB
      2018   Phase 3   EUCTR2017-002325-38-SE   Australia;Belgium;Canada;France;Germany;Israel;Italy;Netherlands;Poland;Saudi Arabia;Spain;Sweden;Turkey;United Kingdom;United States;
Phenylbutyrate   
   Juntendo University
      2014   -   JPRN-UMIN000012782   Japan;
   Saiseikai Yokohama City Tobu Hospital
      2010   -   JPRN-UMIN000003802   Japan;
Questran   
   Albireo
      2013   Phase 1   NCT02963077   -
RFP   
   Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University
      2013   -   JPRN-UMIN000017823   Japan;
Rifampicin   
   Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University
      2013   -   JPRN-UMIN000017823   Japan;
[14C]-A4250 capsule   
   Albireo
      2017   Phase 1   NCT03082937   United Kingdom;