DR info

Clinical trials : 525 / Drugs : 565 - (DrugBank : 148) / Drug target genes : 114 - Drug target pathways : 217

Scleroderma and other diseases between which drug repositioning might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Drug repositionability

ID	Diseases (Sorted by drug repositionability)
51	Scleroderma
46	Malignant rheumatoid arthritis
85	Idiopathic interstitial pneumonia
13	Multiple sclerosis/Neuromyelitis optica
49	Systemic lupus erythematosus
96	Crohn disease
28	Systemic amyloidosis
65	Primary immunodeficiency
50	Dermatomyositis
42	Polyarteritis nodosa
2	Amyotrophic lateral sclerosis
97	Ulcerative colitis
84	Sarcoidosis
228	Bronchiolitis obliterans
34	Neurofibromatosis
86	Pulmonary arterial hypertension
93	Primary biliary cholangitis
107	Juvenile idiopathic arthritis
6	Parkinson disease
41	Giant cell arteritis
56	Behcet disease
53	Sjogren syndrome
222	Primary nephrotic syndrome
11	Myasthenia gravis
271	Ankylosing spondylitis
226	Interstitial cystitis with Hunners ulcer
58	Hypertrophic cardiomyopathy
162	Pemphigoid
164	Oculocutaneous albinism
40	Takayasu arteritis
285	Fanconi anemia
283	Acquired pure red cell aplasia
331	Idiopathic multicentric castleman disease
284	Diamond-Blackfan anemia
38	Stevens-Johnson syndrome
45	Eosinophilic granulomatosis with Polyangiitis
44	Wegener granulomatosis
60	Aplastic anemia
35	Pemphigus
55	Relapsing polychondritis
256	Muscle glycogenosis
36	Epidermolysis bullosa
26	HTLV-1-associated myelopathy
70	Spinal stenosis
299	Cystic fibrosis
227	Osler disease
266	Familial mediterranean fever
89	Lymphangioleiomyomatosis
113	Muscular dystrophy
300	IgG4-related disease
298	Hereditary pancreatitis
66	IgA nephropathy
43	Microscopic polyangiitis
62	Paroxysmal nocturnal hemoglobinuria
269	Pyogenic arthritis
224	Purpura nephritis
210	Single Ventricle
95	Autoimmune hepatitis
286	Hereditary sideroblastic anemia
88	Chronic thromboembolic pulmonary hypertension
19	Lysosomal storage disease
61	Autoimmune hemolytic anemia
63	Idiopathic thrombocytopenic purpura
160	Congenital ichthyosis
20	Adrenoleukodystrophy
274	Osteogenesis Imperfecta
151	Rasmussen encephalitis
10	Charcot-Marie-Tooth disease
39	Toxic epidermal necrolysis
234	Peroxisomal disease (except Adrenoleukodystrophy)
64	Thrombotic thrombocytopenic purpura
326	Osteopetrosis
302	Leber hereditary optic neuropathy
294	Congenital diaphragmatic hernia
8	Huntington disease
47	Buerger disease
158	Tuberous sclerosis
168	Ehlers-Danlos syndrome
67	Polycystic kidney disease
90	Retinitis pigmentosa
1	Spinal and bulbar muscular atrophy
94	Primary sclerosing cholangitis
140	Dorabe syndrome
16	Crow-Fukase syndrome
211	Hypoplastic left heart syndrome
193	Prader-Willi syndrome
225	Congenital nephrogenic diabetes insipidus
156	Rett syndrome
265	Lipodystrophy
231	Alpha-1-antitrypsin deficiency
21	Mitochondrial disease
144	Lennox-Gastaut syndrome
124	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
127	Frontotemporal lobar degeneration
78	Hypopituitarism
87	Pulmonary veno-occlusive disease
251	Urea cycle disorder
81	Congenital adrenal hyperplasia
288	Autoimmune acquired coagulation factor deficiency
98	Eosinophilic gastrointestinal disease
268	Nakajo-Nishimura syndrome
325	Hereditary autoinflammatory syndrome
337	Homocystinuria
282	Congenital dyserythropoietic anemia
280	Huge arteriovenous malformation with cervicofacial or limb lesion
7	Corticobasal degeneration
276	Achondroplasia
167	Marfan syndrome
272	Fibrodysplasia ossificans progressiva
114	Non-dystrophic myotonia syndrome
15	Inclusion body myositis
270	Chronic recurrent multifocal osteomyelitis
218	Alport syndrome
310	Congenital anomalies syndrome
172	Hypophosphatasia
25	Progressive multifocal leukoencephalopathy
75	Cushing disease
212	Tricuspid atresia
5	Progressive supranuclear palsy
74	Prolactin secreting pituitary adenoma
296	Biliary atresia
79	Homozygous familial hypercholesterolemia
106	Cryopyrin-associated periodic syndrome
235	Hypoparathyroidism
71	Idiopathic osteonecrosis of the femoral head
137	Focal cortical dysplasia
192	Cockayne syndrome
277	Lymphangiomatosis
281	Klippel-Trenaunay-Weber syndrome
232	Carney complex
108	TNF receptor-associated periodic syndrome
267	Hyper-IgD syndrome
99	Chronic intestinal pseudo-obstruction
317	Trifunctional protein deficiency
54	Adult still disease
52	Mixed connective tissue disease
220	Rapidly progressive glomerulonephritis
30	Distal myopathy