72. Pituitary ADH secretion disorder Disease details / Clinical trials / Drug dev / DR info
Clinical trials : 41 / Drugs : 27 - (DrugBank : 8) / Drug target genes : 7 - Drug target pathways : 10
Drugs and their primary sponsors and trial info
C03XA01
Department of Medical Research
2014 Phase 2 EUCTR2013-003800-38-DK Denmark;
University Clinic in Nephrology and Hypertension, Department of Medical Research
2014 - EUCTR2014-001973-15-DK Denmark;
Desmopressin Oral Melt
Ferring Pharmaceuticals
2011 Phase 3 NCT01280188 Japan;
Desmopressin intranasal
Ferring Pharmaceuticals
2011 Phase 3 NCT01280188 Japan;
Empagliflozin
University Hospital, Basel, Switzerland
2021 Phase 4 NCT04447911 Switzerland;
2017 Phase 2/Phase 3 NCT03202667 Switzerland;
2016 Phase 2/Phase 3 NCT02874807 Switzerland;
Empagliflozin 25mg Tbl
University Hospital, Basel, Switzerland
2016 Phase 2/Phase 3 NCT02729766 Switzerland;
Experimental: CRH administration
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
2021 Phase 4 NCT04902235 Spain;
Experimental: GLP1-RA (exenatide) administration
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
2021 Phase 4 NCT04897802 Spain;
IUPAC
Sanofi-Synthelabo Research
2004 - EUCTR2004-002349-11-ES Spain;
Oxytocin nasal spray
Elizabeth Austen Lawson
2022 Phase 1 NCT04789148 United States;
SAMSCA*10CPR
FONDAZIONE IRCCS CA' GRANDA OSPEDALE MAGGIORE POLICLINICO DI MILANO
2012 - EUCTR2012-004071-39-IT Italy;
SR121463B
Sanofi
2005 Phase 3 NCT00264914 Australia;Belgium;Brazil;Canada;France;Germany;Hong Kong;Hungary;Russian Federation;Switzerland;United States;
2004 Phase 3 NCT00264927 Belgium;Brazil;Canada;Croatia;Germany;Hong Kong;Hungary;Netherlands;Portugal;Spain;United States;
Sanofi-Synthelabo Research
2005 Phase 3 EUCTR2004-005239-25-ES Germany;Hungary;Spain;
2005 Phase 3 EUCTR2004-003985-14-BE Belgium;Denmark;Hungary;Sweden;
2005 - EUCTR2004-005239-25-HU Germany;Hungary;Spain;
2005 - EUCTR2004-005239-25-DE Germany;Hungary;Spain;
2005 - EUCTR2004-003985-14-HU Denmark;Hungary;Sweden;
2004 - EUCTR2004-002349-11-ES Spain;
sanofi-aventis recherche & développement
2005 - EUCTR2004-003985-14-SE Denmark;Hungary;Sweden;
2005 - EUCTR2004-003985-14-DK Denmark;Hungary;Sweden;
sanofi-aventis recherche et développement
2008 Phase 3 EUCTR2007-007941-10-FR Belgium;France;Germany;Hungary;
2008 - EUCTR2007-007941-10-HU Belgium;France;Germany;Hungary;
2008 - EUCTR2007-007941-10-DE Belgium;France;Germany;Hungary;
2008 - EUCTR2007-007941-10-BE Belgium;France;Germany;Hungary;
Samsca
Department of Medical Research
2014 Phase 2 EUCTR2013-003800-38-DK Denmark;
2012 Phase 2 EUCTR2012-001169-33-DK Denmark;
University Clinic in Nephrology and Hypertension, Department of Medical Research
2014 - EUCTR2014-001973-15-DK Denmark;
Satavaptan
sanofi-aventis recherche et développement
2008 Phase 3 EUCTR2007-007941-10-FR Belgium;France;Germany;Hungary;
2008 - EUCTR2007-007941-10-HU Belgium;France;Germany;Hungary;
2008 - EUCTR2007-007941-10-DE Belgium;France;Germany;Hungary;
2008 - EUCTR2007-007941-10-BE Belgium;France;Germany;Hungary;
Satavaptan (SR121463)
Sanofi
2008 Phase 3 NCT00728091 United States;
Satavaptan (SR121463B)
Sanofi
2001 Phase 2 NCT00032734 Belgium;Canada;France;Germany;Hungary;United States;
Tolvaptan
Otsuka Frankfurt Research Institute GmbH
2010 - NCT01228682 Denmark;Germany;Italy;Norway;Spain;Sweden;United Kingdom;
Otsuka Pharmaceutical Co., LTD.
2017 Phase 3 JPRN-JapicCTI-173512 Japan;
Otsuka Pharmaceutical Development & Commercialization, Inc.
2013 Phase 1/Phase 2 NCT02009878 Czech Republic;Denmark;Germany;Hungary;Spain;Sweden;United Kingdom;
2010 Phase 3 NCT01227512 United States;
2003 Phase 3 NCT00201994 Germany;
2003 Phase 3 NCT00072683 United States;
Polderman, Kees, H., MD, PhD
2015 - NCT02545114 United States;
Tolvaptan (SAMSCA)
Otsuka Pharmaceutical Co., Ltd.
2021 - NCT04790175 Japan;
Tolvaptan Oral Tablet
Otsuka Pharmaceutical Co., Ltd.
2017 Phase 3 NCT03048747 Japan;
Tolvaptan in euvolemic hyponatremia
NYU Langone Health
2011 - NCT01425125 United States;
Urea
Helbert Rondon Berrios, MD, MS
2022 Phase 2 NCT04588207 United States;
University Hospital, Grenoble
2020 - NCT04552873 France;
Department of Medical Research
2014 Phase 2 EUCTR2013-003800-38-DK Denmark;
University Clinic in Nephrology and Hypertension, Department of Medical Research
2014 - EUCTR2014-001973-15-DK Denmark;
Desmopressin Oral Melt
Ferring Pharmaceuticals
2011 Phase 3 NCT01280188 Japan;
Desmopressin intranasal
Ferring Pharmaceuticals
2011 Phase 3 NCT01280188 Japan;
Empagliflozin
University Hospital, Basel, Switzerland
2021 Phase 4 NCT04447911 Switzerland;
2017 Phase 2/Phase 3 NCT03202667 Switzerland;
2016 Phase 2/Phase 3 NCT02874807 Switzerland;
Empagliflozin 25mg Tbl
University Hospital, Basel, Switzerland
2016 Phase 2/Phase 3 NCT02729766 Switzerland;
Experimental: CRH administration
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
2021 Phase 4 NCT04902235 Spain;
Experimental: GLP1-RA (exenatide) administration
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
2021 Phase 4 NCT04897802 Spain;
IUPAC
Sanofi-Synthelabo Research
2004 - EUCTR2004-002349-11-ES Spain;
Oxytocin nasal spray
Elizabeth Austen Lawson
2022 Phase 1 NCT04789148 United States;
SAMSCA*10CPR
FONDAZIONE IRCCS CA' GRANDA OSPEDALE MAGGIORE POLICLINICO DI MILANO
2012 - EUCTR2012-004071-39-IT Italy;
SR121463B
Sanofi
2005 Phase 3 NCT00264914 Australia;Belgium;Brazil;Canada;France;Germany;Hong Kong;Hungary;Russian Federation;Switzerland;United States;
2004 Phase 3 NCT00264927 Belgium;Brazil;Canada;Croatia;Germany;Hong Kong;Hungary;Netherlands;Portugal;Spain;United States;
Sanofi-Synthelabo Research
2005 Phase 3 EUCTR2004-005239-25-ES Germany;Hungary;Spain;
2005 Phase 3 EUCTR2004-003985-14-BE Belgium;Denmark;Hungary;Sweden;
2005 - EUCTR2004-005239-25-HU Germany;Hungary;Spain;
2005 - EUCTR2004-005239-25-DE Germany;Hungary;Spain;
2005 - EUCTR2004-003985-14-HU Denmark;Hungary;Sweden;
2004 - EUCTR2004-002349-11-ES Spain;
sanofi-aventis recherche & développement
2005 - EUCTR2004-003985-14-SE Denmark;Hungary;Sweden;
2005 - EUCTR2004-003985-14-DK Denmark;Hungary;Sweden;
sanofi-aventis recherche et développement
2008 Phase 3 EUCTR2007-007941-10-FR Belgium;France;Germany;Hungary;
2008 - EUCTR2007-007941-10-HU Belgium;France;Germany;Hungary;
2008 - EUCTR2007-007941-10-DE Belgium;France;Germany;Hungary;
2008 - EUCTR2007-007941-10-BE Belgium;France;Germany;Hungary;
Samsca
Department of Medical Research
2014 Phase 2 EUCTR2013-003800-38-DK Denmark;
2012 Phase 2 EUCTR2012-001169-33-DK Denmark;
University Clinic in Nephrology and Hypertension, Department of Medical Research
2014 - EUCTR2014-001973-15-DK Denmark;
Satavaptan
sanofi-aventis recherche et développement
2008 Phase 3 EUCTR2007-007941-10-FR Belgium;France;Germany;Hungary;
2008 - EUCTR2007-007941-10-HU Belgium;France;Germany;Hungary;
2008 - EUCTR2007-007941-10-DE Belgium;France;Germany;Hungary;
2008 - EUCTR2007-007941-10-BE Belgium;France;Germany;Hungary;
Satavaptan (SR121463)
Sanofi
2008 Phase 3 NCT00728091 United States;
Satavaptan (SR121463B)
Sanofi
2001 Phase 2 NCT00032734 Belgium;Canada;France;Germany;Hungary;United States;
Tolvaptan
Otsuka Frankfurt Research Institute GmbH
2010 - NCT01228682 Denmark;Germany;Italy;Norway;Spain;Sweden;United Kingdom;
Otsuka Pharmaceutical Co., LTD.
2017 Phase 3 JPRN-JapicCTI-173512 Japan;
Otsuka Pharmaceutical Development & Commercialization, Inc.
2013 Phase 1/Phase 2 NCT02009878 Czech Republic;Denmark;Germany;Hungary;Spain;Sweden;United Kingdom;
2010 Phase 3 NCT01227512 United States;
2003 Phase 3 NCT00201994 Germany;
2003 Phase 3 NCT00072683 United States;
Polderman, Kees, H., MD, PhD
2015 - NCT02545114 United States;
Tolvaptan (SAMSCA)
Otsuka Pharmaceutical Co., Ltd.
2021 - NCT04790175 Japan;
Tolvaptan Oral Tablet
Otsuka Pharmaceutical Co., Ltd.
2017 Phase 3 NCT03048747 Japan;
Tolvaptan in euvolemic hyponatremia
NYU Langone Health
2011 - NCT01425125 United States;
Urea
Helbert Rondon Berrios, MD, MS
2022 Phase 2 NCT04588207 United States;
University Hospital, Grenoble
2020 - NCT04552873 France;