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No. 薬物名（臨床試験情報から抽出） DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
100244301----1件: 274
2Aclasta----3件: 13, 271, 274
3Actonel 5mg Film Coated Tablets1件: Risedronic acid3件: D00942 ,
D03234 ,
D08484 		1件: FDPS 💬4件: Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis 💬1件: 274
4Actonel Once a Week 35 mg film-coated tablets1件: Risedronic acid3件: D00942 ,
D03234 ,
D08484 		1件: FDPS 💬4件: Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis 💬1件: 274
5Actonel/Optinate 5mg film-coated tablets1件: Risedronic acid3件: D00942 ,
D03234 ,
D08484 		1件: FDPS 💬4件: Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis 💬1件: 274
6Alendronate1件: Alendronic acid2件: D00939 ,
D07119 		1件: FDPS 💬4件: Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis 💬7件: 19, 41, 46, 50, 271, 274, 299
7ALENDRONIC ACID1件: Alendronic acid2件: D00939 ,
D07119 		1件: FDPS 💬4件: Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis 💬2件: 46, 274
8Alternative osteoporosis medications----1件: 274
9AMG 162----2件: 46, 274
10AMG 785----1件: 274
11ANTI-SCLEROSTIN MONOCLONAL ANTIBODY----1件: 274
12Bisphosphonates----2件: 6, 274
13Blood sample----18件: 8, 13, 46, 49, 51, 53, 61, 65, 66, 84, 96, 97, 107, 127, 235, 274, 288, 299
14Bone Marrow Transplant----2件: 60, 274
15Bonefos1件: Clodronic acid2件: D03544 ,
D03545 		--1件: 274
16BOOST cells----1件: 274
17BPS804----2件: 172, 274
18Busulfan1件: Busulfan1件: D00248 --13件: 19, 20, 28, 36, 49, 51, 60, 65, 164, 274, 284, 285, 326
19Calcichew D3----1件: 274
20Calcichew tablets----1件: 274
21Calcio1件: Calcium---4件: 13, 96, 97, 274
22Calcio carbonato2件: Calcium,
Calcium carbonate		2件: D00932 ,
D10802 		--1件: 274
23CALCIO CARBONATO/COLECALCIFEROLO2件: Calcium,
Calcium carbonate		2件: D00932 ,
D10802 		--1件: 274
24Calcium1件: Calcium---30件: 3, 6, 13, 15, 19, 46, 49, 51, 53, 56, 68, 75, 79, 84, 93, 94, 95, 96, 97, 186, 214, 215, 222, 224, 235, 256, 265, 274, 298, 299
25Calcium D31件: Calcium---1件: 274
26CALCIUM D3 SANDOZ - 1000 MG + 880 U.I. COMPRESSE EFFERVESCENTI 30 COMPRESSE DIVISIBILI1件: Calcium---1件: 274
27Celulas madre mesenquimales troncales adultas alogenicas de médula ósea no expandida----1件: 274
28Clasteon1件: Clodronic acid2件: D03544 ,
D03545 		--1件: 274
29Cyclophosphamide1件: Cyclophosphamide2件: D00287 ,
D07760 		--45件: 11, 13, 14, 16, 19, 20, 26, 28, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 56, 60, 62, 65, 66, 84, 85, 93, 96, 162, 164, 172, 205, 222, 224, 256, 265, 274, 283, 284, 285, 288, 326, 331
30Cyclosporin1件: Cyclosporine1件: D00184 5件: PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬		33件: Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬17件: 38, 46, 49, 50, 53, 56, 60, 62, 63, 93, 95, 97, 113, 164, 222, 274, 326
31Células mesenquimales troncales adultas alogénicas de médula ósea no expandidas----1件: 274
32Células mesenquimales troncales adultas alogénicas de médula ósea no expandidas(ref cruzada PEI nº 12-088)----1件: 274
33Denosumab1件: Denosumab1件: D03684 1件: TNFSF11 💬8件: Breast cancer, Chemical carcinogenesis - receptor activation, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Osteoclast differentiation, Parathyroid hormone synthesis, secretion and action, Prolactin signaling pathway, Rheumatoid arthritis 💬7件: 46, 50, 93, 95, 96, 274, 299
34Denosumab - - Immunoglobulin G2 Human Monoclonal Antibody to RANK Ligand1件: Denosumab1件: D03684 1件: TNFSF11 💬8件: Breast cancer, Chemical carcinogenesis - receptor activation, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Osteoclast differentiation, Parathyroid hormone synthesis, secretion and action, Prolactin signaling pathway, Rheumatoid arthritis 💬1件: 274
35Denosumab - Immunoglobulin G2 Human Monoclonal Antibody to RANK Ligand1件: Denosumab1件: D03684 1件: TNFSF11 💬8件: Breast cancer, Chemical carcinogenesis - receptor activation, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Osteoclast differentiation, Parathyroid hormone synthesis, secretion and action, Prolactin signaling pathway, Rheumatoid arthritis 💬1件: 274
36Denusomab----1件: 274
37Disodium Pamidronate 15mg (15mg strength)1件: Pamidronic acid2件: D00941 ,
D07281 		1件: FDPS 💬4件: Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis 💬1件: 274
38Evenity1件: Romosozumab1件: D10156 1件: SOST 💬2件: Parathyroid hormone synthesis, secretion and action, Wnt signaling pathway 💬1件: 274
39Evenity 105mg1件: Romosozumab1件: D10156 1件: SOST 💬2件: Parathyroid hormone synthesis, secretion and action, Wnt signaling pathway 💬1件: 274
40Expanded human first trimester fetal liver-derived mesenchymal stem cells----1件: 274
41Forsteo1件: Teriparatide1件: D06078 1件: PTH1R 💬3件: Endocrine and other factor-regulated calcium reabsorption, Neuroactive ligand-receptor interaction, Parathyroid hormone synthesis, secretion and action 💬3件: 70, 235, 274
42Fresolimumab1件: Fresolimumab1件: D09620 3件: TGFB1,
TGFB2,
TGFB3 💬		35件: AGE-RAGE signaling pathway in diabetic complications, Amoebiasis, Cell cycle, Cellular senescence, Chagas disease, Chronic myeloid leukemia, Colorectal cancer, Cytokine-cytokine receptor interaction, Diabetic cardiomyopathy, Dilated cardiomyopathy, FoxO signaling pathway, Gastric cancer, Hepatitis B, Hepatocellular carcinoma, Hippo signaling pathway, Human T-cell leukemia virus 1 infection, Hypertrophic cardiomyopathy, Inflammatory bowel disease, Intestinal immune network for IgA production, Leishmaniasis, MAPK signaling pathway, Malaria, MicroRNAs in cancer, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pancreatic cancer, Pathways in cancer, Proteoglycans in cancer, Relaxin signaling pathway, Renal cell carcinoma, Rheumatoid arthritis, TGF-beta signaling pathway, Th17 cell differentiation, Toxoplasmosis, Tuberculosis 💬3件: 51, 222, 274
43Fultium-D3 800IU capsules----1件: 274
44GENOTROPIN*1TBF 5,3MG (16UI)1件: Somatotropin1件: D02691 1件: GHR 💬5件: Cytokine-cytokine receptor interaction, Growth hormone synthesis, secretion and action, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway 💬1件: 274
45H05AA02----1件: 274
46High-dose vitamin D (2000 IU per day)1件: Vitamin D---1件: 274
47Humatrope----2件: 78, 274
48Ibandronic acid1件: Ibandronate1件: D08056 1件: FDPS 💬4件: Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis 💬1件: 274
49Mesenchymal stem cell transplantation----2件: 36, 274
50Mesenchymal stem cells----11件: 2, 6, 13, 20, 49, 51, 60, 96, 222, 274, 299
51Mesenchymal Stromal Cells1件: Human Umbilical Cord Mesenchymal Stem Cells---10件: 2, 36, 49, 51, 60, 96, 97, 107, 274, 284
52NERIXIA*INFUS IV CONC 2F 100MG----1件: 274
53Optinate 5 mg filmcoated tablets----1件: 274
54Other: Bone Marrow Cell Transplantation----1件: 274
55Other: No active treatment----1件: 274
56Other: No treatment----2件: 53, 274
57Other: Saline----8件: 2, 6, 46, 97, 98, 256, 274, 301
58Pamidronate1件: Pamidronic acid2件: D00941 ,
D07281 		1件: FDPS 💬4件: Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis 💬3件: 270, 271, 274
59Pamidronate (Aredia)1件: Pamidronic acid2件: D00941 ,
D07281 		1件: FDPS 💬4件: Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis 💬1件: 274
60PLASMASAFE----1件: 274
61PLASMASAFE - SOLUZIONE PER INFUSIONE 1 SACCA DA 200 ML----1件: 274
62Prolia1件: Denosumab1件: D03684 1件: TNFSF11 💬8件: Breast cancer, Chemical carcinogenesis - receptor activation, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Osteoclast differentiation, Parathyroid hormone synthesis, secretion and action, Prolactin signaling pathway, Rheumatoid arthritis 💬1件: 274
63Radiation: Irradiation, Total Body----1件: 274
64REF CRUZADA PEI Nº 12-088----1件: 274
65Risedronate1件: Risedronic acid3件: D00942 ,
D03234 ,
D08484 		1件: FDPS 💬4件: Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis 💬7件: 46, 50, 66, 96, 107, 113, 274
66Risedronate Oral Tablet1件: Risedronic acid3件: D00942 ,
D03234 ,
D08484 		1件: FDPS 💬4件: Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis 💬1件: 274
67RISEDRONATE SODIUM1件: Risedronic acid3件: D00942 ,
D03234 ,
D08484 		1件: FDPS 💬4件: Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis 💬4件: 50, 107, 113, 274
68Risedronate sodium (Actonel)1件: Risedronic acid3件: D00942 ,
D03234 ,
D08484 		1件: FDPS 💬4件: Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis 💬1件: 274
69Risedronate sodium 2.5mg1件: Risedronic acid3件: D00942 ,
D03234 ,
D08484 		1件: FDPS 💬4件: Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis 💬1件: 274
70Risedronate sodium 5mg1件: Risedronic acid3件: D00942 ,
D03234 ,
D08484 		1件: FDPS 💬4件: Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis 💬1件: 274
71Risedronato sódico 2.5mg----1件: 274
72Risedronato sódico 5mg----1件: 274
73Risedronic acid1件: Risedronic acid3件: D00942 ,
D03234 ,
D08484 		1件: FDPS 💬4件: Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis 💬3件: 93, 95, 274
74Rituximab1件: Rituximab1件: D02994 1件: MS4A1 💬1件: Hematopoietic cell lineage 💬49件: 6, 11, 13, 14, 17, 19, 35, 36, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 127, 162, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331
75ROMOSOZUMAB1件: Romosozumab1件: D10156 1件: SOST 💬2件: Parathyroid hormone synthesis, secretion and action, Wnt signaling pathway 💬1件: 274
76SAR439459----1件: 274
77Setrusumab1件: Setrusumab---1件: 274
78Somatropin1件: Somatotropin1件: D02691 1件: GHR 💬5件: Cytokine-cytokine receptor interaction, Growth hormone synthesis, secretion and action, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway 💬19件: 2, 3, 19, 46, 65, 74, 75, 78, 96, 107, 113, 187, 193, 195, 238, 265, 274, 276, 299
79Standard-dose vitamin D (400IU per day)1件: Vitamin D---1件: 274
80Teriparatide1件: Teriparatide1件: D06078 1件: PTH1R 💬3件: Endocrine and other factor-regulated calcium reabsorption, Neuroactive ligand-receptor interaction, Parathyroid hormone synthesis, secretion and action 💬6件: 46, 68, 70, 71, 235, 274
81Teriparatide (FORTEO)1件: Teriparatide1件: D06078 1件: PTH1R 💬3件: Endocrine and other factor-regulated calcium reabsorption, Neuroactive ligand-receptor interaction, Parathyroid hormone synthesis, secretion and action 💬1件: 274
82Teriparatide Pen Injector1件: Teriparatide1件: D06078 1件: PTH1R 💬3件: Endocrine and other factor-regulated calcium reabsorption, Neuroactive ligand-receptor interaction, Parathyroid hormone synthesis, secretion and action 💬1件: 274
83VARI----2件: 62, 274
84Vitamin D1件: Vitamin D---24件: 3, 13, 15, 19, 41, 43, 44, 46, 49, 50, 68, 93, 95, 96, 97, 98, 179, 222, 228, 235, 256, 274, 298, 299
85Vitamina D e calcio1件: Calcium---1件: 274
86XGEVA1件: Denosumab1件: D03684 1件: TNFSF11 💬8件: Breast cancer, Chemical carcinogenesis - receptor activation, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Osteoclast differentiation, Parathyroid hormone synthesis, secretion and action, Prolactin signaling pathway, Rheumatoid arthritis 💬1件: 274
87XGEVA - 120 MG - SOLUZIONE INIETTABILE - USO SOTTOCUTANEO - FLACONCINO (VETRO) - 1.7 ML 4 FLACONCINI1件: Denosumab1件: D03684 1件: TNFSF11 💬8件: Breast cancer, Chemical carcinogenesis - receptor activation, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Osteoclast differentiation, Parathyroid hormone synthesis, secretion and action, Prolactin signaling pathway, Rheumatoid arthritis 💬1件: 274
88ZOL446----1件: 274
89Zoledronic acid1件: Zoledronic acid4件: D01968 ,
D06378 ,
D06379 ,
D08689 		1件: FDPS 💬4件: Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis 💬12件: 5, 6, 13, 17, 46, 93, 95, 96, 270, 274, 299, 333
90Zoledronic Acid Kern Pharma 4 mg/100 mL solution for infusion, generic medicinal product1件: Zoledronic acid4件: D01968 ,
D06378 ,
D06379 ,
D08689 		1件: FDPS 💬4件: Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis 💬1件: 274
91Zoledronic Acid Kern Pharma 4 mg/100 mL solution for infusion, generic medicinal product.1件: Zoledronic acid4件: D01968 ,
D06378 ,
D06379 ,
D08689 		1件: FDPS 💬4件: Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis 💬1件: 274
92Zoledronic Acid Kern Pharma 4 mg/100 mL solution for infusion,generic medicinal product1件: Zoledronic acid4件: D01968 ,
D06378 ,
D06379 ,
D08689 		1件: FDPS 💬4件: Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis 💬1件: 274
93Zometa----1件: 274
94Ácido risedrónico----1件: 274