DDrare: Database of Drug Development for Rare Diseases

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39 / 2,001 drugs

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No.	DrugBank	薬物名（臨床試験情報から抽出）	KEGG DRUG	KEGG GENES	KEGG PATHWAY On map, Yellow: Drug target genes	指定難病告示番号
1	Alemtuzumab	20件: Alemtuzumab; Alemtuzumab (already received by alemtuzumab cohort between 1991 and 1994; Alemtuzumab (already received by alemtuzumab cohort between 1991 and 1994); Alemtuzumab (campath ); Alemtuzumab (campath); Alemtuzumab (gz402673); Alemtuzumab 0.2 mg; Alemtuzumab 0.3 mg; Alemtuzumab 12 mg; Alemtuzumab 24 mg; Alemtuzumab and rituximab; Alemtuzumab gz402673; Alemtuzumab immunotherapy; Alemtuzumab injection; Alemtuzumab injection [lemtrada]; Alemtuzumab, rituximab; Campath-1h (alemtuzumab); Filgrastim, alemtuzumab; Transplant conditioning with mobilization and alemtuzumab; Transplant preparative regimen of alemtuzumab, fludarabine, thiotepa, and melphalan;	1件: D02802 💬	-	-	21件: 13, 15, 19, 20, 43, 44, 46, 49, 51, 60, 62, 63, 65, 85, 96, 164, 234, 283, 284, 285, 326 💬
2	Aminophylline	1件: Aminophylline;	2件: D00227 D05429 💬	18件: ADORA1, ADORA2B, PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬	23件: Alcoholism, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Cortisol synthesis and secretion, Cushing syndrome, Glucagon signaling pathway, Insulin signaling pathway, Metabolic pathways, Morphine addiction, Neuroactive ligand-receptor interaction, Olfactory transduction, Parathyroid hormone synthesis, secretion and action, Progesterone-mediated oocyte maturation, Purine metabolism, Rap1 signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion, Sphingolipid signaling pathway, Taste transduction, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	1件: 63 💬
3	Amoxicillin	8件: Amoxicillin; Amoxicillin and clavulanic acid; Amoxicillin and tetracycline; Amoxicillin hydrate; Amoxicillin, metronidazole and tetracycline; Clartihromycin, amoxicillin, and omeprazole; Lansoprazole, amoxicillin, clarithromycin; Takecab tablets + amoxicillin + clarithromycin (first-line eradication) takecab tablets + amoxicillin + metronidazole (second-line eradication);	3件: D00229 D02925 D07452 💬	-	-	9件: 6 , 19, 46, 63, 84, 96, 97, 222, 299 💬
4	Atorvastatin	9件: Atorvastatin; Atorvastatin 10mg; Atorvastatin 20mg; Atorvastatin calcium; Atorvastatin tablet 20 mg; Interferon beta treatment to add-on atorvastatin treatment; Interferon beta-1b/atorvastatin group; Lisinopril, losartan, and atorvastatin; Untreated to atorvastatin treatment;	3件: D00258 D00887 D07474 💬	1件: HMGCR 💬	4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis	17件: 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 💬
5	Avatrombopag	5件: Avatrombopag; Avatrombopag (proposed); Avatrombopag maleate; Avatrombopag tablets; Open label (avatrombopag tablets);	1件: D10306 💬	-	-	1件: 63 💬
6	Azathioprine	38件: Azathioprine; Azathioprine (aza); Azathioprine (aza) caps; Azathioprine (aza) or 6-mercaptopurine (6-mp); Azathioprine (imuran) 50 mg overencapsulated tablet; Azathioprine - ratiopharm 50 mg; Azathioprine / 6 mercaptopurine; Azathioprine 25 mg; Azathioprine and allopurinol; Azathioprine in case of endoscopic recurrence; Azathioprine individualised dose; Azathioprine or 6-mercaptopurine; Azathioprine or adalimumab and infliximab; Azathioprine or mesalazine; Azathioprine or methotrexate; Azathioprine or mycophenolate mofetil; Azathioprine weight-based dose; Azathioprine+enteral nutrition; Azathioprine/prednisone; Combination of protein a immunoadsorption, rituximab, dexamethasone plus azathioprine; Continuation of azathioprine; Corticosteroid and azathioprine; Cyclophosphamide followed by methotrexate (azathioprine) + glucocorticoids or methotrexate (azathioprine) + glucocorticoids; Cyclophosphamide, azathioprine,prednisone,methylprednisolone; Cyclophosphamide-prednisone-azathioprine; Early immunosuppressants (azathioprine, methotrexate); Immunosuppressive regime (azathioprine, mycophenolate mofetil or methotrexate); Infliximab and azathioprine combination at week 0; Infliximab and azathioprine combination at week 14; Infliximab with azathioprine (iifx + aza); Infliximab+azathioprine; Infliximab, azathioprine; Overencapsulated azathioprine (imuran) 50 mg tablet; Prednisone - azathioprine; Products containing azathioprine or 6-mercaptopurine; Rituximab (rtx) and azathioprine (aza); Steroids plus azathioprine; Symptomatic treatment, steroids, immunosuppressive agents( azathioprine, tacrolimus, mycophenolate mofetil);	2件: D00238 D03033 💬	-	-	20件: 6 , 11, 13, 19, 35, 42, 43, 44, 45, 46, 49, 63, 65, 66, 85, 94, 95, 96, 97, 162 💬
7	Bevifimod	-	-	-	-	1件: 63 💬
8	Blisibimod	2件: Blisibimod; Blisibimod injection;	1件: D10311 💬	-	-	5件: 43, 44, 49, 63, 66 💬
9	Bortezomib	8件: Bortezomib; Bortezomib (velcade®); Bortezomib/dexamethasone; Bortezomib/dexamethasone (bd), followed by autologous stc & maintenance bortezomib/dexamethasone; Combination of a single dose anti-cd20 antibody and bortezomib; Cyclophosphamide, bortezomib, and dexamethasone (cybord); Cyclophosphamide, bortezomib, dexamethasone; Cyclophosphamide, bortezomib, dexamethasone plus daratumumab;	1件: D03150 💬	1件: PSMB5 💬	8件: Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Prion disease, Proteasome, Spinocerebellar ataxia	15件: 11, 13, 26, 28, 46, 49, 51, 61, 63, 66, 228, 256, 283, 288, 331 💬
10	Clarithromycin	8件: A fixed-dose combination of 95 mg clarithromycin, 45 mg rifabutin, and 10 mg clofazimine; Biaxin ( clarithromycin); Clarithromycin; Clarithromycin (not used as of 4/2020); Lansoprazole, amoxicillin, clarithromycin; Lansoprazole, clarithromycin, amoxycillin; Rifabutin, clarithromycin, and clofazimine; Takecab tablets + amoxicillin + clarithromycin (first-line eradication) takecab tablets + amoxicillin + metronidazole (second-line eradication);	1件: D00276 💬	-	-	8件: 6 , 63, 84, 96, 97, 222, 228, 299 💬

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