Target Gene/Pathway（薬物標的遺伝子／パスウェイリスト）💬 Info on mouse-over
| No. | KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related |
KEGG GENES | KEGG DRUG | DrugBank | 指定難病告示番号 |
| 1 | Alcoholism 💬 28 genes, 69 drugs (DrugBank) and 52 diseases |
GRIN1 5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
D04905 D04905 💬 |
Memantine | 002 7件: 2 , 6 , 8 , 13, 49, 127, 205 💬 |
| 2 | Alcoholism 💬 28 genes, 69 drugs (DrugBank) and 52 diseases |
GRIN1 5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
D08174 D08174 💬 |
Memantine | 002 7件: 2 , 6 , 8 , 13, 49, 127, 205 💬 |
| 3 | Alzheimer disease 💬 54 genes, 110 drugs (DrugBank) and 116 diseases |
GRIN1 5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
D04905 D04905 💬 |
Memantine | 002 7件: 2 , 6 , 8 , 13, 49, 127, 205 💬 |
| 4 | Alzheimer disease 💬 54 genes, 110 drugs (DrugBank) and 116 diseases |
GRIN1 5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
D08174 D08174 💬 |
Memantine | 002 7件: 2 , 6 , 8 , 13, 49, 127, 205 💬 |
| 5 | Amphetamine addiction 💬 24 genes, 48 drugs (DrugBank) and 87 diseases |
GRIN1 5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
D04905 D04905 💬 |
Memantine | 002 7件: 2 , 6 , 8 , 13, 49, 127, 205 💬 |
| 6 | Amphetamine addiction 💬 24 genes, 48 drugs (DrugBank) and 87 diseases |
GRIN1 5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
D08174 D08174 💬 |
Memantine | 002 7件: 2 , 6 , 8 , 13, 49, 127, 205 💬 |
| 7 | Amyotrophic lateral sclerosis 💬 33 genes, 44 drugs (DrugBank) and 102 diseases |
GRIN1 5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
D04905 D04905 💬 |
Memantine | 002 7件: 2 , 6 , 8 , 13, 49, 127, 205 💬 |
| 8 | Amyotrophic lateral sclerosis 💬 33 genes, 44 drugs (DrugBank) and 102 diseases |
GRIN1 5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
D08174 D08174 💬 |
Memantine | 002 7件: 2 , 6 , 8 , 13, 49, 127, 205 💬 |
| 9 | Calcium signaling pathway 💬 74 genes, 175 drugs (DrugBank) and 126 diseases |
GRIN1 4件: GRIN1, GRIN2A, GRIN2C, GRIN2D 💬 |
D04905 D04905 💬 |
Memantine | 002 7件: 2 , 6 , 8 , 13, 49, 127, 205 💬 |
| 10 | Calcium signaling pathway 💬 74 genes, 175 drugs (DrugBank) and 126 diseases |
GRIN1 4件: GRIN1, GRIN2A, GRIN2C, GRIN2D 💬 |
D08174 D08174 💬 |
Memantine | 002 7件: 2 , 6 , 8 , 13, 49, 127, 205 💬 |
| 11 | cAMP signaling pathway 💬 63 genes, 157 drugs (DrugBank) and 108 diseases |
GRIN1 5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
D04905 D04905 💬 |
Memantine | 002 7件: 2 , 6 , 8 , 13, 49, 127, 205 💬 |
| 12 | cAMP signaling pathway 💬 63 genes, 157 drugs (DrugBank) and 108 diseases |
GRIN1 5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
D08174 D08174 💬 |
Memantine | 002 7件: 2 , 6 , 8 , 13, 49, 127, 205 💬 |
| 13 | Circadian entrainment 💬 21 genes, 30 drugs (DrugBank) and 54 diseases |
GRIN1 5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
D04905 D04905 💬 |
Memantine | 002 7件: 2 , 6 , 8 , 13, 49, 127, 205 💬 |
| 14 | Circadian entrainment 💬 21 genes, 30 drugs (DrugBank) and 54 diseases |
GRIN1 5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
D08174 D08174 💬 |
Memantine | 002 7件: 2 , 6 , 8 , 13, 49, 127, 205 💬 |
| 15 | Cocaine addiction 💬 14 genes, 58 drugs (DrugBank) and 47 diseases |
GRIN1 5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
D04905 D04905 💬 |
Memantine | 002 7件: 2 , 6 , 8 , 13, 49, 127, 205 💬 |
| 16 | Cocaine addiction 💬 14 genes, 58 drugs (DrugBank) and 47 diseases |
GRIN1 5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
D08174 D08174 💬 |
Memantine | 002 7件: 2 , 6 , 8 , 13, 49, 127, 205 💬 |
| 17 | Dopaminergic synapse 💬 30 genes, 93 drugs (DrugBank) and 97 diseases |
GRIN2A 2件: GRIN2A, GRIN2B 💬 |
D04905 D04905 💬 |
Memantine | 002 7件: 2 , 6 , 8 , 13, 49, 127, 205 💬 |
| 18 | Dopaminergic synapse 💬 30 genes, 93 drugs (DrugBank) and 97 diseases |
GRIN2A 2件: GRIN2A, GRIN2B 💬 |
D08174 D08174 💬 |
Memantine | 002 7件: 2 , 6 , 8 , 13, 49, 127, 205 💬 |
| 19 | GABAergic synapse 💬 28 genes, 37 drugs (DrugBank) and 54 diseases |
GABRA1 16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 |
D11149 D11149 💬 |
Brexanolone | 205 1件: 205 💬 |
| 20 | Glutamatergic synapse 💬 22 genes, 26 drugs (DrugBank) and 79 diseases |
GRIN1 5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
D04905 D04905 💬 |
Memantine | 002 7件: 2 , 6 , 8 , 13, 49, 127, 205 💬 |
| 21 | Glutamatergic synapse 💬 22 genes, 26 drugs (DrugBank) and 79 diseases |
GRIN1 5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
D08174 D08174 💬 |
Memantine | 002 7件: 2 , 6 , 8 , 13, 49, 127, 205 💬 |
| 22 | Huntington disease 💬 23 genes, 29 drugs (DrugBank) and 77 diseases |
GRIN1 2件: GRIN1, GRIN2B 💬 |
D04905 D04905 💬 |
Memantine | 002 7件: 2 , 6 , 8 , 13, 49, 127, 205 💬 |
| 23 | Huntington disease 💬 23 genes, 29 drugs (DrugBank) and 77 diseases |
GRIN1 2件: GRIN1, GRIN2B 💬 |
D08174 D08174 💬 |
Memantine | 002 7件: 2 , 6 , 8 , 13, 49, 127, 205 💬 |
| 24 | Long-term potentiation 💬 17 genes, 30 drugs (DrugBank) and 82 diseases |
GRIN1 5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
D04905 D04905 💬 |
Memantine | 002 7件: 2 , 6 , 8 , 13, 49, 127, 205 💬 |
| 25 | Long-term potentiation 💬 17 genes, 30 drugs (DrugBank) and 82 diseases |
GRIN1 5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
D08174 D08174 💬 |
Memantine | 002 7件: 2 , 6 , 8 , 13, 49, 127, 205 💬 |
| 26 | Morphine addiction 💬 40 genes, 59 drugs (DrugBank) and 71 diseases |
GABRA1 16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 |
D11149 D11149 💬 |
Brexanolone | 205 1件: 205 💬 |
| 27 | Neuroactive ligand-receptor interaction 💬 146 genes, 309 drugs (DrugBank) and 144 diseases |
GABRA1 16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 |
D11149 D11149 💬 |
Brexanolone | 205 1件: 205 💬 |
| 28 | Neuroactive ligand-receptor interaction 💬 146 genes, 309 drugs (DrugBank) and 144 diseases |
GRIN1 5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
D04905 D04905 💬 |
Memantine | 002 7件: 2 , 6 , 8 , 13, 49, 127, 205 💬 |
| 29 | Neuroactive ligand-receptor interaction 💬 146 genes, 309 drugs (DrugBank) and 144 diseases |
GRIN1 5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
D08174 D08174 💬 |
Memantine | 002 7件: 2 , 6 , 8 , 13, 49, 127, 205 💬 |
| 30 | Nicotine addiction 💬 30 genes, 32 drugs (DrugBank) and 40 diseases |
GABRA1 16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 |
D11149 D11149 💬 |
Brexanolone | 205 1件: 205 💬 |
| 31 | Nicotine addiction 💬 30 genes, 32 drugs (DrugBank) and 40 diseases |
GRIN1 5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
D04905 D04905 💬 |
Memantine | 002 7件: 2 , 6 , 8 , 13, 49, 127, 205 💬 |
| 32 | Nicotine addiction 💬 30 genes, 32 drugs (DrugBank) and 40 diseases |
GRIN1 5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
D08174 D08174 💬 |
Memantine | 002 7件: 2 , 6 , 8 , 13, 49, 127, 205 💬 |
| 33 | Pathways of neurodegeneration - multiple diseases 💬 56 genes, 111 drugs (DrugBank) and 117 diseases |
GRIN1 5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
D04905 D04905 💬 |
Memantine | 002 7件: 2 , 6 , 8 , 13, 49, 127, 205 💬 |
| 34 | Pathways of neurodegeneration - multiple diseases 💬 56 genes, 111 drugs (DrugBank) and 117 diseases |
GRIN1 5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
D08174 D08174 💬 |
Memantine | 002 7件: 2 , 6 , 8 , 13, 49, 127, 205 💬 |
| 35 | Prion disease 💬 40 genes, 59 drugs (DrugBank) and 103 diseases |
GRIN1 5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
D04905 D04905 💬 |
Memantine | 002 7件: 2 , 6 , 8 , 13, 49, 127, 205 💬 |
| 36 | Prion disease 💬 40 genes, 59 drugs (DrugBank) and 103 diseases |
GRIN1 5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
D08174 D08174 💬 |
Memantine | 002 7件: 2 , 6 , 8 , 13, 49, 127, 205 💬 |
| 37 | Rap1 signaling pathway 💬 40 genes, 91 drugs (DrugBank) and 82 diseases |
GRIN1 3件: GRIN1, GRIN2A, GRIN2B 💬 |
D04905 D04905 💬 |
Memantine | 002 7件: 2 , 6 , 8 , 13, 49, 127, 205 💬 |
| 38 | Rap1 signaling pathway 💬 40 genes, 91 drugs (DrugBank) and 82 diseases |
GRIN1 3件: GRIN1, GRIN2A, GRIN2B 💬 |
D08174 D08174 💬 |
Memantine | 002 7件: 2 , 6 , 8 , 13, 49, 127, 205 💬 |
| 39 | Ras signaling pathway 💬 32 genes, 45 drugs (DrugBank) and 58 diseases |
GRIN1 3件: GRIN1, GRIN2A, GRIN2B 💬 |
D04905 D04905 💬 |
Memantine | 002 7件: 2 , 6 , 8 , 13, 49, 127, 205 💬 |
| 40 | Ras signaling pathway 💬 32 genes, 45 drugs (DrugBank) and 58 diseases |
GRIN1 3件: GRIN1, GRIN2A, GRIN2B 💬 |
D08174 D08174 💬 |
Memantine | 002 7件: 2 , 6 , 8 , 13, 49, 127, 205 💬 |
| 41 | Retrograde endocannabinoid signaling 💬 33 genes, 61 drugs (DrugBank) and 62 diseases |
GABRA1 16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 |
D11149 D11149 💬 |
Brexanolone | 205 1件: 205 💬 |
| 42 | Serotonergic synapse 💬 37 genes, 105 drugs (DrugBank) and 73 diseases |
GABRB1 3件: GABRB1, GABRB2, GABRB3 💬 |
D11149 D11149 💬 |
Brexanolone | 205 1件: 205 💬 |
| 43 | Spinocerebellar ataxia 💬 16 genes, 23 drugs (DrugBank) and 66 diseases |
GRIN1 5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
D04905 D04905 💬 |
Memantine | 002 7件: 2 , 6 , 8 , 13, 49, 127, 205 💬 |
| 44 | Spinocerebellar ataxia 💬 16 genes, 23 drugs (DrugBank) and 66 diseases |
GRIN1 5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
D08174 D08174 💬 |
Memantine | 002 7件: 2 , 6 , 8 , 13, 49, 127, 205 💬 |
| 45 | Systemic lupus erythematosus 💬 27 genes, 34 drugs (DrugBank) and 77 diseases |
GRIN2A 2件: GRIN2A, GRIN2B 💬 |
D04905 D04905 💬 |
Memantine | 002 7件: 2 , 6 , 8 , 13, 49, 127, 205 💬 |
| 46 | Systemic lupus erythematosus 💬 27 genes, 34 drugs (DrugBank) and 77 diseases |
GRIN2A 2件: GRIN2A, GRIN2B 💬 |
D08174 D08174 💬 |
Memantine | 002 7件: 2 , 6 , 8 , 13, 49, 127, 205 💬 |
| 47 | Taste transduction 💬 30 genes, 78 drugs (DrugBank) and 65 diseases |
GABRA1 6件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬 |
D11149 D11149 💬 |
Brexanolone | 205 1件: 205 💬 |