DDrare: Database of Drug Development for Rare Diseases

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Target Gene/Pathway（薬物標的遺伝子／パスウェイリスト）💬 Info on mouse-over

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	指定難病告示番号
1	Allograft rejection 💬	2件: CD80, CD86 💬	D03203 💬	Abatacept	26件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬
2	Allograft rejection 💬	1件: IL5 💬	D04923 💬	Mepolizumab	4件: 44, 45, 98, 162 💬
3	Allograft rejection 💬	1件: IL5 💬	D08985 💬	Reslizumab	2件: 44, 98 💬
4	Antifolate resistance 💬	2件: DHFR, DHFR2 💬	D00142 💬	Methotrexate	35件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 271, 284, 285, 326, 331 💬
5	Antifolate resistance 💬	2件: DHFR, DHFR2 💬	D02115 💬	Methotrexate	35件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 271, 284, 285, 326, 331 💬
6	Asthma 💬	1件: IL5 💬	D04923 💬	Mepolizumab	4件: 44, 45, 98, 162 💬
7	Asthma 💬	1件: IL5 💬	D08985 💬	Reslizumab	2件: 44, 98 💬
8	Autoimmune thyroid disease 💬	2件: CD80, CD86 💬	D03203 💬	Abatacept	26件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬
9	Autoimmune thyroid disease 💬	1件: IL5 💬	D04923 💬	Mepolizumab	4件: 44, 45, 98, 162 💬
10	Autoimmune thyroid disease 💬	1件: IL5 💬	D08985 💬	Reslizumab	2件: 44, 98 💬

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