DDrare: Database of Drug Development for Rare Diseases

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Target Gene/Pathway（薬物標的遺伝子／パスウェイリスト）💬 Info on mouse-over

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	指定難病告示番号
1	Acute myeloid leukemia 💬	1件: RARA 💬	D06543 💬	Vitamin A	3件: 13, 53, 90 💬
2	Adrenergic signaling in cardiomyocytes 💬	4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D01908 💬	Nilvadipine	1件: 90 💬
3	AGE-RAGE signaling pathway in diabetic complications 💬	2件: VEGFA, VEGFB 💬	D09574 💬	Aflibercept	2件: 90, 166 💬
4	Alanine, aspartate and glutamate metabolism 💬	4件: ABAT, ALDH5A1, GAD1, GAD2 💬	D00399 💬	Valproic acid	16件: 2 , 3 , 5 , 6 , 13, 26, 34, 65, 85, 89, 90, 102, 222, 233, 256, 331 💬
5	Alcoholism 💬	1件: DDC 💬	D00558 💬	Carbidopa	9件: 2 , 4 , 6 , 13, 17, 90, 140, 164, 201 💬
6	Alcoholism 💬	2件: DRD1, DRD2 💬	D00059 💬	Levodopa	8件: 2 , 4 , 6 , 17, 90, 140, 164, 201 💬
7	Aldosterone synthesis and secretion 💬	4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D01908 💬	Nilvadipine	1件: 90 💬
8	Aldosterone synthesis and secretion 💬	3件: CACNA1G, CACNA1H, CACNA1I 💬	D00399 💬	Valproic acid	16件: 2 , 3 , 5 , 6 , 13, 26, 34, 65, 85, 89, 90, 102, 222, 233, 256, 331 💬
9	Alzheimer disease 💬	4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	D01908 💬	Nilvadipine	1件: 90 💬
10	Alzheimer disease 💬	5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00184 💬	Cyclosporine	43件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬

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