Drug    DrugBank | All Description Patterns💬 Info on mouse-over

No.	Drug (Description in trials)	DrugBank	KEGG DRUG	KEGG GENES	KEGG PATHWAY On map, Yellow: Drug target genes	Disease ID
1	Act-064992 (macitentan)	Macitentan	[1] D10135 💬	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 85 💬
2	Era and pde-5i (sildenafil, tadalafil, bosentan, macitentan)	Bosentan	[6] D01227, D02008, D02229, D07538, D08514, D10135 💬	[3] EDNRA, EDNRB, PDE5A 💬	[11] Calcium signaling pathway, Melanogenesis, Metabolic pathways, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 86 💬
3	Fdc macitentan/tadalafil	Macitentan	[2] D02008, D10135 💬	[3] EDNRA, EDNRB, PDE5A 💬	[11] Calcium signaling pathway, Melanogenesis, Metabolic pathways, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 86 💬
4	Macitentan	Macitentan	[1] D10135 💬	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[5] 51, 85, 86, 88, 210 💬
5	Macitentan (act-064992)	Macitentan	[1] D10135 💬	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 86 💬
6	Macitentan 10 mg	Macitentan	[1] D10135 💬	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[3] 51, 86, 88 💬
7	Macitentan 10 mg tablet, once daily.	Macitentan	[1] D10135 💬	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 86 💬
8	Macitentan 10mg	Macitentan	[1] D10135 💬	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 51 💬
9	Macitentan 3 mg	Macitentan	[1] D10135 💬	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 51 💬
10	Macitentan 37.5 mg	Macitentan	[1] D10135 💬	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 86 💬
11	Macitentan 3mg	Macitentan	[1] D10135 💬	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 51 💬
12	Macitentan 75 mg	Macitentan	[1] D10135 💬	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 86 💬
13	Macitentan group	Macitentan	[1] D10135 💬	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 86 💬
14	Macitentan tablets	Macitentan	[1] D10135 💬	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[2] 86, 88 💬
15	Opsumit (macitentan)	Macitentan	[1] D10135 💬	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 86 💬