DDrare: Database of Drug Development for Rare Diseases

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No.	Drug (Description in trials)	DrugBank	KEGG DRUG	KEGG GENES	KEGG PATHWAY On map, Yellow: Drug target genes	Disease ID
1	Carmustine, etoposide, cytarabine, and melphalan (beam)	Carmustine	[7] D00125, D00168, D00254, D00369, D03046, D03637, D04107 💬	[2] TOP2A, TOP2B 💬	[1] Platinum drug resistance	[1] 13 💬
2	Fludarabine, melphalan, thiotepa	Fludarabine	[4] D00369, D00583, D01907, D07966 💬	[1] RRM1 💬	[5] Drug metabolism - other enzymes, Glutathione metabolism, Metabolic pathways, Purine metabolism, Pyrimidine metabolism	[1] 65 💬
3	Fludarabine/ melphalan	Fludarabine	[3] D00369, D01907, D07966 💬	[1] RRM1 💬	[5] Drug metabolism - other enzymes, Glutathione metabolism, Metabolic pathways, Purine metabolism, Pyrimidine metabolism	[1] 60 💬
4	Melphalan	Melphalan	[1] D00369 💬	-	-	[15] 11, 13, 14, 19, 20, 28, 60, 62, 65, 96, 164, 234, 284, 285, 299 💬
5	Melphalan fulfenamide hydrochloride	Melphalan	[1] D00369 💬	-	-	[1] 28 💬
6	Melphalan hydrochloride	Melphalan	[1] D00369 💬	-	-	[1] 60 💬
7	Melphalan, thalidomide and dexamethasone	Dexamethasone	[11] D00292, D00369, D00754, D00975, D01510, D01615, D01632, D01948, D02174, D02591, D02592 💬	[2] NR3C1, TNF 💬	[66] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway	[1] 28 💬
8	Melphalan-flufenamide (melflufen)	Melphalan	[1] D00369 💬	-	-	[1] 28 💬
9	Propylene glycol-free melphalan hydrochloride	Melphalan	[2] D00078, D00369 💬	-	-	[1] 28 💬
10	Transplant preparative regimen of alemtuzumab, fludarabine, thiotepa, and melphalan	Alemtuzumab	[5] D00369, D00583, D01907, D02802, D07966 💬	[1] RRM1 💬	[5] Drug metabolism - other enzymes, Glutathione metabolism, Metabolic pathways, Purine metabolism, Pyrimidine metabolism	[2] 65, 164 💬

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