DDrare: Database of Drug Development for Rare Diseases

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No.	Drug (Description in trials)	DrugBank	KEGG DRUG	KEGG GENES	KEGG PATHWAY On map, Yellow: Drug target genes	Disease ID
1	Azd4017 and prednisolone	Prednisolone	[8] D00472, D00980, D00981, D00982, D01239, D01998, D02156, D03301 💬	[1] NR3C1 💬	[1] Neuroactive ligand-receptor interaction	[1] 75 💬
2	Combination therapy with vigabatrin and prednisolone	Prednisolone	[9] D00472, D00535, D00980, D00981, D00982, D01239, D01998, D02156, D03301 💬	[2] ABAT, NR3C1 💬	[8] Alanine, aspartate and glutamate metabolism, Butanoate metabolism, GABAergic synapse, Metabolic pathways, Neuroactive ligand-receptor interaction, Propanoate metabolism, Valine, leucine and isoleucine degradation, beta-Alanine metabolism	[1] 145 💬
3	Conventional glucocorticoids (immediate release hydrocortisone, cortisone acetate, prednisone, prednisolone, dexamethasone)	Acetate	[21] D00088, D00292, D00472, D00473, D00973, D00975, D00980, D00981, D00982, D01239, D01510, D01615, D01632, D01948, D01998, D02156, D02174, D02591, D02592, D03301, D07749 💬	[1] NR3C1 💬	[1] Neuroactive ligand-receptor interaction	[1] 81 💬
4	Corticosteroid (prednisolone)	Prednisolone	[8] D00472, D00980, D00981, D00982, D01239, D01998, D02156, D03301 💬	[1] NR3C1 💬	[1] Neuroactive ligand-receptor interaction	[1] 85 💬
5	Corticosteroid treatment (methylprednisolone or prednisolone)	Methylprednisolone	[14] D00407, D00472, D00751, D00979, D00980, D00981, D00982, D01239, D01998, D02156, D03301, D05000, D05001, D05002 💬	[1] NR3C1 💬	[1] Neuroactive ligand-receptor interaction	[1] 64 💬
6	Corticosteroids (prednisone or prednisolone)	Prednisolone	[9] D00472, D00473, D00980, D00981, D00982, D01239, D01998, D02156, D03301 💬	[1] NR3C1 💬	[1] Neuroactive ligand-receptor interaction	[1] 49 💬
7	Etanercept, methotrexate, prednisolone	Etanercept	[11] D00142, D00472, D00742, D00980, D00981, D00982, D01239, D01998, D02115, D02156, D03301 💬	[5] DHFR, DHFR2, LTA, NR3C1, TNF 💬	[70] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Biosynthesis of cofactors, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Folate biosynthesis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, Metabolic pathways, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Neuroactive ligand-receptor interaction, Non-alcoholic fatty liver disease, One carbon pool by folate, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway	[1] 56 💬
8	Glucocorticoid (prednisone or prednisolone)	Prednisolone	[9] D00472, D00473, D00980, D00981, D00982, D01239, D01998, D02156, D03301 💬	[1] NR3C1 💬	[1] Neuroactive ligand-receptor interaction	[1] 84 💬
9	Intravenous methyl prednisolone	Prednisolone	[8] D00472, D00980, D00981, D00982, D01239, D01998, D02156, D03301 💬	[1] NR3C1 💬	[1] Neuroactive ligand-receptor interaction	[1] 43 💬
10	Lodotra (delayed release prednisolone)	Prednisolone	[8] D00472, D00980, D00981, D00982, D01239, D01998, D02156, D03301 💬	[1] NR3C1 💬	[1] Neuroactive ligand-receptor interaction	[1] 41 💬

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