DDrare: Database of Drug Development for Rare Diseases

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No.	DrugBank	Drug (Description in trials)	KEGG DRUG	KEGG GENES	KEGG PATHWAY On map, Yellow: Drug target genes	Disease ID
1	Aliskiren	[1] Aliskiren;	[1] D03208 💬	[1] REN 💬	[3] Diabetic cardiomyopathy, Renin secretion, Renin-angiotensin system	[4] 66, 167, 222, 223 💬
2	Atenolol	[3] Atenolol; Atenolol or propranolol; Losartan and atenolol or propranolol;	[1] D00235 💬	[1] ADRB1 💬	[10] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 167 💬
3	Doxycycline	[10] Antimicrobial therapy: co-trimoxazole or doxycycline; Doxycycline; Doxycycline 100 mg capsules; Doxycycline 100-200mg capsules daily for 6 months; Doxycycline hyclate; Doxycycline hyclate ph.eur; Doxycycline tablets; Interferon beta 1a, oral doxycycline; Other: no doxycycline; Treatment with systemic therapy (doxycycline);	[5] D00307 D02129 D03903 D03904 D07876 💬	-	-	[15] 13, 23, 28, 46, 84, 85, 89, 96, 97, 158, 162, 167, 227, 280, 299 💬
4	Irbesartan	[12] Irbesartan; Irbesartan 150-300mg capsules daily for 6 months; Irbesartan approved in the netherlands; Irbesartan tablets; Irbesartan tablets (approved in the usa. reference listed drug avapro) ndc # 43547-0374-03; Irbesartan tablets (ndc# 0955-1041-90 approved in the usa); Irbesartan tablets (ndc# 43547-0374-03 and ndc 43547-374-09, approved in the usa) generic tablets distributed by solco healthcare us, llc; Irbesartan tablets (ndc# 43547-375-50 approved in the usa) generic tablets distributed by solco healthcare us, llc; Over-encapsulated 150 mg irbesartan tablets; Over-encapsulated 75 mg irbesartan tablets; Over-encapsulated irbesartan; Over-encapsulated irbesartan tablets;	[1] D00523 💬	[1] AGTR1 💬	[16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway	[4] 66, 167, 168, 222 💬
5	Losartan	[12] Lisinopril, losartan, and atorvastatin; Losartan; Losartan and atenolol or propranolol; Losartan and nebivolol; Losartan and other angiotensin receptor blockers; Losartan bluefish 50 mg; Losartan hexal; Losartan potasico; Losartan potassium; Losartan tablets & qingremoshen granule; Other: losartan; Sildenafil and losartan;	[2] D00357 D08146 💬	[1] AGTR1 💬	[16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway	[18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
6	Nebivolol	[3] Losartan and nebivolol; Nebivolol; Nebivolol 5 mg;	[1] D05127 💬	[1] ADRB1 💬	[10] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway	[3] 17, 113, 167 💬
7	Perindopril	[3] Coversyl (perindopril); Perindopril; Perindopril 2mg tablets;	[2] D00624 D03753 💬	[1] ACE 💬	[6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system	[3] 113, 167, 222 💬
8	Potassium	[5] Dipotassium salt; Losartan potassium; Potassium; Potassium sparing diuretic; Potassium supplement;	[1] D08403 💬	-	-	[10] 36, 46, 66, 67, 98, 115, 167, 179, 215, 235 💬
9	Propranolol	[5] Atenolol or propranolol; Losartan and atenolol or propranolol; Propranolol; Propranolol hcl cf 40 mg tablet; Propranolol treatment;	[2] D00483 D08443 💬	[3] ADRB1, ADRB2, ADRB3 💬	[11] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Thermogenesis, cAMP signaling pathway, cGMP-PKG signaling pathway	[6] 6 , 158, 167, 227, 278, 296 💬
10	Verapamil	[2] Verapamil; Verapamil sr;	[2] D00619 D02356 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	[36] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[3] 96, 140, 167 💬

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