DDrare: Database of Drug Development for Rare Diseases

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No.	DrugBank	Drug (Description in trials)	KEGG DRUG	KEGG GENES	KEGG PATHWAY On map, Yellow: Drug target genes	Disease ID
1	Abatacept	[36] Abatacept; Abatacept (aba); Abatacept (aba) + methotrexate (mtx), double-blind (db); Abatacept (bms-188667); Abatacept (ctla4-ig); Abatacept (iv); Abatacept (sc); Abatacept + csdmard; Abatacept + methotrexate; Abatacept + vaccines; Abatacept active treatment; Abatacept delayed-onset treatment; Abatacept injection; Abatacept placebo; Abatacept prefilled syringe; Abatacept sc; Abatacept subcutaneous; Abatacept, rituximab or tocilizumab; Adalimuab, etanercept, tocilizumab, or abatacept; Bdmard withdrawal (etanercept, adalimumab, infliximab, certolizumab, golimumab, tozilizumab, abatacept); Bms 188667 (abatacept); Decrease tocilizumab, abatacept; Device: abatacept combination product (acp); Double-blind abatacept; Drug: abatacept; Etanercepet, rituximab, abatacept, tocilizumab, sarilumab; Intravenous (iv) abatacept; Iv abatacept; Open-label abatacept; Orencia (abatacept); Orencia abatacept; Orencia® (abatacept); Subcutaneous (sc) abatacept; Subcutaneous abatacept; Subcutaneous(sc) abatacept; Tocilizumab, abatacept;	[1] D03203 💬	[2] CD80, CD86 💬	[12] Allograft rejection, Autoimmune thyroid disease, Cell adhesion molecules, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis	[26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬
2	Acetate	[98] 11c-acetate; 2-(2-(2-amino-9h-purin-9-yl)ethyl)-1,3-propanediol diacetate ester; 20mg/0.5ml glatiramer acetate; 40 mg glatiramer acetate; 90 mg hydrocortisone acetate suppository with sephure suppository applicator; Abiraterone acetate; Acetate; Bazedoxifene acetate; Betamethasone sodium phosphate/betamethasone acetate (celestone® soluspan®), 30 mg im once a day for four days; Caspofungin acetate; Combination product: twice daily 90 mg hydrocortisone acetate suppository administered with sephure applicator; Conventional glucocorticoids (immediate release hydrocortisone, cortisone acetate, prednisone, prednisolone, dexamethasone); Cortisone acetate; Cosyntropin acetate; Cyclophosphamide/glatiramer acetate; Delmitide acetate; Depot leuprolide acetate 3.75 mg; Desmopressin acetate; Desmopressin acetate trihydrate; Device: cellulose acetate with petrolatum; Dichloroacetate; Dichloroacetate sodium; Dirucotide acetate; Edratide acetate; Etiprednol dicloacetate; Experimental glatiramer acetate; Flecainide acetate; Glatiramer acetate; Glatiramer acetate (copaxone®); Glatiramer acetate (db); Glatiramer acetate (ga); Glatiramer acetate (ga) 40 mg; Glatiramer acetate (gtr); Glatiramer acetate (ol); Glatiramer acetate 150mg enteric coated tablets; Glatiramer acetate 150mg enteric-coated (gastro-resistant) tablets; Glatiramer acetate 20 mg; Glatiramer acetate 20 mg, with mitoxantrone; Glatiramer acetate 20 mg/0.5 ml; Glatiramer acetate 40 mg; Glatiramer acetate [ga]; Glatiramer acetate injection with oral cetirizine hydrochloride; Glatiramer acetate with minocycline; Glatiramer acetate, (copaxone®); Glatiramer acetate, ifn-beta 1a (im), ifn-beta 1a (subcutaneous), and ifn-beta 1b; Glatiramer acetate, n-acetylcysteine; Gonadorelin acetate and triptorelin acetate; Human interferon beta-1a and glatiramer acetate; Hydrocortisone acetate; Hydrocortisone sodium acetate; L-lysyl-d-prolyl-l-threonine acetate; L-lysyl-d-prolyl-lthreonine acetate, lyophilisate; Lanreotide acetate; Lapaquistat acetate and current lipid-lowering treatment; Leuprolide acetate (la); Leuprolide acetate 11.25 mg; Leuprolide acetate 3 month depot; Leuprolide acetate 30 mg; Leuprolide acetate 45 mg; Leuprolide acetate depot; Leuprorelin acetate; Leuprorelin acetate 3.75mg injection; Loestrin (norethindrone acetate and ethinyl estradiol); Loestrin 1.5/30 (1.5 mg norethindrone acetate/30 µg ethinyl estradiol); Luphere depot 3.75mg(leuprolide acetate 3.75mg); Lupron (leuprolide acetate); Macimorelin acetate; Megestrol acetate; Megestrol acetate tablet; Methylprednisolone acetate; Nomegestrol acetate; Octreotide acetate; Oxaloacetate (oaa); Phosphate and betamethasone acetate, 2 ml.; Plovamer acetate; Plovamer acetate 0.5 milligram (mg); Plovamer acetate 10 mg; Plovamer acetate 20 mg; Plovamer acetate 3 mg; Prednisolone acetate; Prednisone acetate; Prednisone acetate tablets; Procedure: warm compress prior to injection of glatiramer acetate; Sodium acetate; Sodium-[o-[(2,6-dichlorophenyl)-amino]- phenyl]-acetate; Sodium-[o-[(2,6-dichlorophenyl)-amino]-phenyl]-acetate; Sotrastaurin (inn) acetate; Tetracosactide acetate; Tetracosactide hexaacetate; Tocopherol acetate; Tocopheryl acetate; Triptorelin acetate and gonadorelin acetate; Ulipristal acetate; Zinc acetate; Zinc acetate (20mg/d); Zinc acetate dihydrate; Zuretinol acetate; [n-trans-3-hexenoyl] human growth hormone releasing factor (1-44) acetate;	-	-	-	[43] 1 , 2 , 6 , 10, 13, 35, 40, 46, 49, 51, 60, 64, 67, 70, 71, 73, 75, 76, 78, 79, 81, 83, 85, 86, 88, 90, 96, 97, 113, 145, 156, 162, 171, 206, 222, 224, 225, 227, 235, 265, 288, 298, 299 💬
3	Acyclovir	[1] Acyclovir;	[1] D00222 💬	-	-	[5] 13, 28, 46, 53, 60 💬
4	Alefacept	[1] Alefacept;	[1] D02800 💬	[1] CD58 💬	[2] Cell adhesion molecules, Epstein-Barr virus infection	[6] 37, 60, 65, 164, 284, 285 💬
5	Alemtuzumab	[20] Alemtuzumab; Alemtuzumab (already received by alemtuzumab cohort between 1991 and 1994; Alemtuzumab (already received by alemtuzumab cohort between 1991 and 1994); Alemtuzumab (campath ); Alemtuzumab (campath); Alemtuzumab (gz402673); Alemtuzumab 0.2 mg; Alemtuzumab 0.3 mg; Alemtuzumab 12 mg; Alemtuzumab 24 mg; Alemtuzumab and rituximab; Alemtuzumab gz402673; Alemtuzumab immunotherapy; Alemtuzumab injection; Alemtuzumab injection [lemtrada]; Alemtuzumab, rituximab; Campath-1h (alemtuzumab); Filgrastim, alemtuzumab; Transplant conditioning with mobilization and alemtuzumab; Transplant preparative regimen of alemtuzumab, fludarabine, thiotepa, and melphalan;	[1] D02802 💬	-	-	[21] 13, 15, 19, 20, 43, 44, 46, 49, 51, 60, 62, 63, 65, 85, 96, 164, 234, 283, 284, 285, 326 💬
6	Amikacin	[18] Amikacin; Amikacin nebulization; Amikacin sulfate; Amikacina; Amikacina liposomal (arikace?); Amikacine; Amikacine nebulization; Iv amikacin; Liposomal amikacin; Liposomal amikacin (arikace tm); Liposomal amikacin (arikace™); Liposomal amikacin for inhalation; Liposomal amikacin for inhalation (arikayce™) using the pari investigational eflow® nebulizer.; Nebulization of amikacin during niv (rr: 15 cycles/minute); Nebulization of amikacin during niv (rr: 25 cycles/minute); Slit amikacin; Slit(tm) amikacin; Sulfato de amikacina;	[2] D00865 D02543 💬	-	-	[2] 60, 299 💬
7	Antilymphocyte immunoglobulin (horse)	-	[1] D08808 💬	-	-	[1] 60 💬
8	Antithymocyte immunoglobulin (rabbit)	-	-	-	-	[9] 13, 36, 49, 51, 60, 65, 96, 285, 326 💬
9	Busulfan	[15] Busulfan; Busulfan iv; Busulfan test dose; Busulfan, cyclophosphamide, antithymocyte globulin; Busulfan, cyclophosphamide, atg; Busulfan, cyclophosphamide, atg, gcsf; Busulfan, cyclophosphamide, thymoglobulin, fludarabine (conditioning regimen); Busulfan, fludarabine and atg; Busulfan, fludarabine, & cyclophosphamide with immunosuppression with atg and cyclosporine.; Busulfan, fludarabine, atg, tli; Busulfan/fludarabine phosphate/tacrolimus/methotrexate/g-csf; Busulfano; Campath, busulfan, clofarabine; Fludarabine, busulfan, thymoglobulin; Fludarabine/busulfan;	[1] D00248 💬	-	-	[13] 19, 20, 28, 36, 49, 51, 60, 65, 164, 274, 284, 285, 326 💬
10	Carboplatin	[1] Carboplatin;	[1] D01363 💬	-	-	[4] 28, 34, 60, 85 💬

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