DDrare: Database of Drug Development for Rare Diseases

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No.	DrugBank	Drug (Description in trials)	KEGG DRUG	KEGG GENES	KEGG PATHWAY On map, Yellow: Drug target genes	Disease ID
1	Acteoside	[2] Acteoside; Reh-acteoside;	-	-	-	[1] 66 💬
2	Aliskiren	[1] Aliskiren;	[1] D03208 💬	[1] REN 💬	[3] Diabetic cardiomyopathy, Renin secretion, Renin-angiotensin system	[4] 66, 167, 222, 223 💬
3	Allopurinol	[4] Allopurinol; Allopurinol sandoz 100 mg, tabletten; Allopurinol sodium; Azathioprine and allopurinol;	[1] D00224 💬	[1] XDH 💬	[5] Caffeine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Peroxisome, Purine metabolism	[6] 6 , 46, 57, 66, 96, 97 💬
4	Angiotensin II	[2] Angiotensin ii; Symptomatic treatment (converting enzyme inhibitor, angiotensin ii, anti-renin, aldosterone antagonist diuretic, beta blocker, calcium inhibitor, statin);	[2] D00150 D02014 💬	[2] AGTR1, AGTR2 💬	[16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway	[7] 17, 19, 46, 66, 86, 222, 224 💬
5	Artesunate	[1] Artesunate;	[1] D02482 💬	-	-	[7] 46, 53, 66, 96, 97, 215, 271 💬
6	Atacicept	[9] Atacicept; Atacicept 150 mg; Atacicept 25 mg; Atacicept 75 mg; Atacicept 75 milligram (mg); Atacicept150mg; Atacicept25mg; Atacicept75mg; Atacicept: with loading dose;	[1] D09704 💬	[2] TNFSF13, TNFSF13B 💬	[4] Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, NF-kappa B signaling pathway, Rheumatoid arthritis	[4] 13, 46, 49, 66 💬
7	Atrasentan	[1] Atrasentan;	-	-	-	[3] 66, 218, 222 💬
8	Azathioprine	[38] Azathioprine; Azathioprine (aza); Azathioprine (aza) caps; Azathioprine (aza) or 6-mercaptopurine (6-mp); Azathioprine (imuran) 50 mg overencapsulated tablet; Azathioprine - ratiopharm 50 mg; Azathioprine / 6 mercaptopurine; Azathioprine 25 mg; Azathioprine and allopurinol; Azathioprine in case of endoscopic recurrence; Azathioprine individualised dose; Azathioprine or 6-mercaptopurine; Azathioprine or adalimumab and infliximab; Azathioprine or mesalazine; Azathioprine or methotrexate; Azathioprine or mycophenolate mofetil; Azathioprine weight-based dose; Azathioprine+enteral nutrition; Azathioprine/prednisone; Combination of protein a immunoadsorption, rituximab, dexamethasone plus azathioprine; Continuation of azathioprine; Corticosteroid and azathioprine; Cyclophosphamide followed by methotrexate (azathioprine) + glucocorticoids or methotrexate (azathioprine) + glucocorticoids; Cyclophosphamide, azathioprine,prednisone,methylprednisolone; Cyclophosphamide-prednisone-azathioprine; Early immunosuppressants (azathioprine, methotrexate); Immunosuppressive regime (azathioprine, mycophenolate mofetil or methotrexate); Infliximab and azathioprine combination at week 0; Infliximab and azathioprine combination at week 14; Infliximab with azathioprine (iifx + aza); Infliximab+azathioprine; Infliximab, azathioprine; Overencapsulated azathioprine (imuran) 50 mg tablet; Prednisone - azathioprine; Products containing azathioprine or 6-mercaptopurine; Rituximab (rtx) and azathioprine (aza); Steroids plus azathioprine; Symptomatic treatment, steroids, immunosuppressive agents( azathioprine, tacrolimus, mycophenolate mofetil);	[2] D00238 D03033 💬	-	-	[20] 6 , 11, 13, 19, 35, 42, 43, 44, 45, 46, 49, 63, 65, 66, 85, 94, 95, 96, 97, 162 💬
9	Bardoxolone	[9] Bardoxolone; Bardoxolone methyl; Bardoxolone methyl 10 mg; Bardoxolone methyl 15 mg; Bardoxolone methyl 20 mg; Bardoxolone methyl 5 mg; Bardoxolone methyl capsules; Bardoxolone methyl oral capsule; Bardoxolone methyl, cddo-me, cddo-methyl ester, nsc 713200, chemical name: oleana-1,9(11)-dien-28-oic acid, 2-cyano-3,12-dioxo-, methyl ester;	[1] D09584 💬	-	-	[7] 66, 67, 84, 85, 86, 218, 222 💬
10	Bardoxolone methyl	[8] Bardoxolone methyl; Bardoxolone methyl 10 mg; Bardoxolone methyl 15 mg; Bardoxolone methyl 20 mg; Bardoxolone methyl 5 mg; Bardoxolone methyl capsules; Bardoxolone methyl oral capsule; Bardoxolone methyl, cddo-me, cddo-methyl ester, nsc 713200, chemical name: oleana-1,9(11)-dien-28-oic acid, 2-cyano-3,12-dioxo-, methyl ester;	[1] D09585 💬	-	-	[7] 66, 67, 84, 85, 86, 218, 222 💬

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