DDrare: Database of Drug Development for Rare Diseases

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No.	DrugBank	Drug (Description in trials)	KEGG DRUG	KEGG GENES	KEGG PATHWAY On map, Yellow: Drug target genes	Disease ID
1	ACR-16	[5] Acr16; Acr16 10 mg; Acr16 22.5 mg; Acr16 45 mg; Acr16 hydrochloride, asp2314 hydrochloride, fr310826;	-	-	-	[1] 8 💬
2	Alprazolam	[1] Alprazolam;	[1] D00225 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬	[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction	[1] 8 💬
3	Amantadine	[13] 240mg amantadine hcl er tablets; 320mg amantadine hcl er tablets; Ads-5102 (extended release amantadine hcl); Amantadine; Amantadine 300 mg; Amantadine hcl er; Amantadine hcl extended release; Amantadine hcl extended release capsule; Amantadine hydrochloride; Amantadine hydrochloride (hcl); Amantadine sulfate; Determination of drug effects through amantadine cessation; Pk-merz® 200mg/500ml inj(amantadine) , normal saline 500ml inj;	[2] D00777 D07441 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬	[20] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway	[4] 6 , 8 , 13, 127 💬
4	Atomoxetine	[1] Atomoxetine;	[2] D02574 D07473 💬	[1] SLC6A2 💬	[1] Synaptic vesicle cycle	[3] 6 , 8 , 13 💬
5	Bevantolol	[2] Bevantolol; Bevantolol hydrochloride;	-	-	-	[1] 8 💬
6	Biotin	[7] Biotin; Biotina; D-biotin; D-biotina; High doses of thiamine y biotin; Moderate doses of thiamine y biotin; Prebiotics (prebiotin prebiotic fiber stick pac);	[1] D00029 💬	-	-	[5] 2 , 8 , 10, 13, 20 💬
7	Bupropion	[4] Bupropion; Bupropion & citalopram; Bupropion hydrochloride; Wellbutrin (bupropion);	[3] D00817 D07591 D07938 💬	[2] SLC6A2, SLC6A3 💬	[7] Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Synaptic vesicle cycle	[5] 8 , 18, 21, 96, 171 💬
8	Cannabidiol	[11] Avcn583601 (3% cannabidiol cream); Cannabidiol; Cannabidiol (cbd); Cannabidiol , synthetic form; Cannabidiol / dronabinol capsule 5 mg+2,5 mg; Cannabidiol botanical drug substance (cbd bds); Cannabidiol capsule 5 mg; Cannabidiol oral solution; Cannabidiol tablet 10 mg; Cannabidiol vaginal suppository; Delta-9-tetrahydrocannabinol (thc) and cannabidiol (cbd);	[1] D10915 💬	[2] CNR1, CNR2 💬	[4] Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis	[19] 2 , 6 , 8 , 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
9	Citalopram	[8] 20mg daily citalopram; Bupropion & citalopram; Citalopram; Citalopram 20mg; Escitalopram; Escitalopram oxalate; Escitalopram oxalate antidepressant; Oral escitalopram;	[2] D00822 D07704 💬	[1] SLC6A4 💬	[2] Serotonergic synapse, Synaptic vesicle cycle	[6] 6 , 8 , 13, 18, 46, 127 💬
10	Creatine	[4] Creatine; Creatine monohydrate; Creatine-13c; Pyruvate, creatine, niacinamide;	-	-	-	[12] 1 , 2 , 5 , 6 , 8 , 13, 46, 49, 50, 113, 156, 201 💬

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