DDrare: Database of Drug Development for Rare Diseases

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No.	DrugBank	Drug (Description in trials)	KEGG DRUG	KEGG GENES	KEGG PATHWAY On map, Yellow: Drug target genes	Disease ID
1	Abiraterone	[2] Abiraterone; Abiraterone acetate;	[1] D09701 💬	-	-	[2] 75, 81 💬
2	Acetate	[98] 11c-acetate; 2-(2-(2-amino-9h-purin-9-yl)ethyl)-1,3-propanediol diacetate ester; 20mg/0.5ml glatiramer acetate; 40 mg glatiramer acetate; 90 mg hydrocortisone acetate suppository with sephure suppository applicator; Abiraterone acetate; Acetate; Bazedoxifene acetate; Betamethasone sodium phosphate/betamethasone acetate (celestone® soluspan®), 30 mg im once a day for four days; Caspofungin acetate; Combination product: twice daily 90 mg hydrocortisone acetate suppository administered with sephure applicator; Conventional glucocorticoids (immediate release hydrocortisone, cortisone acetate, prednisone, prednisolone, dexamethasone); Cortisone acetate; Cosyntropin acetate; Cyclophosphamide/glatiramer acetate; Delmitide acetate; Depot leuprolide acetate 3.75 mg; Desmopressin acetate; Desmopressin acetate trihydrate; Device: cellulose acetate with petrolatum; Dichloroacetate; Dichloroacetate sodium; Dirucotide acetate; Edratide acetate; Etiprednol dicloacetate; Experimental glatiramer acetate; Flecainide acetate; Glatiramer acetate; Glatiramer acetate (copaxone®); Glatiramer acetate (db); Glatiramer acetate (ga); Glatiramer acetate (ga) 40 mg; Glatiramer acetate (gtr); Glatiramer acetate (ol); Glatiramer acetate 150mg enteric coated tablets; Glatiramer acetate 150mg enteric-coated (gastro-resistant) tablets; Glatiramer acetate 20 mg; Glatiramer acetate 20 mg, with mitoxantrone; Glatiramer acetate 20 mg/0.5 ml; Glatiramer acetate 40 mg; Glatiramer acetate [ga]; Glatiramer acetate injection with oral cetirizine hydrochloride; Glatiramer acetate with minocycline; Glatiramer acetate, (copaxone®); Glatiramer acetate, ifn-beta 1a (im), ifn-beta 1a (subcutaneous), and ifn-beta 1b; Glatiramer acetate, n-acetylcysteine; Gonadorelin acetate and triptorelin acetate; Human interferon beta-1a and glatiramer acetate; Hydrocortisone acetate; Hydrocortisone sodium acetate; L-lysyl-d-prolyl-l-threonine acetate; L-lysyl-d-prolyl-lthreonine acetate, lyophilisate; Lanreotide acetate; Lapaquistat acetate and current lipid-lowering treatment; Leuprolide acetate (la); Leuprolide acetate 11.25 mg; Leuprolide acetate 3 month depot; Leuprolide acetate 30 mg; Leuprolide acetate 45 mg; Leuprolide acetate depot; Leuprorelin acetate; Leuprorelin acetate 3.75mg injection; Loestrin (norethindrone acetate and ethinyl estradiol); Loestrin 1.5/30 (1.5 mg norethindrone acetate/30 µg ethinyl estradiol); Luphere depot 3.75mg(leuprolide acetate 3.75mg); Lupron (leuprolide acetate); Macimorelin acetate; Megestrol acetate; Megestrol acetate tablet; Methylprednisolone acetate; Nomegestrol acetate; Octreotide acetate; Oxaloacetate (oaa); Phosphate and betamethasone acetate, 2 ml.; Plovamer acetate; Plovamer acetate 0.5 milligram (mg); Plovamer acetate 10 mg; Plovamer acetate 20 mg; Plovamer acetate 3 mg; Prednisolone acetate; Prednisone acetate; Prednisone acetate tablets; Procedure: warm compress prior to injection of glatiramer acetate; Sodium acetate; Sodium-[o-[(2,6-dichlorophenyl)-amino]- phenyl]-acetate; Sodium-[o-[(2,6-dichlorophenyl)-amino]-phenyl]-acetate; Sotrastaurin (inn) acetate; Tetracosactide acetate; Tetracosactide hexaacetate; Tocopherol acetate; Tocopheryl acetate; Triptorelin acetate and gonadorelin acetate; Ulipristal acetate; Zinc acetate; Zinc acetate (20mg/d); Zinc acetate dihydrate; Zuretinol acetate; [n-trans-3-hexenoyl] human growth hormone releasing factor (1-44) acetate;	-	-	-	[43] 1 , 2 , 6 , 10, 13, 35, 40, 46, 49, 51, 60, 64, 67, 70, 71, 73, 75, 76, 78, 79, 81, 83, 85, 86, 88, 90, 96, 97, 113, 145, 156, 162, 171, 206, 222, 224, 225, 227, 235, 265, 288, 298, 299 💬
3	Cortisone	[17] Conventional glucocorticoids (immediate release hydrocortisone, cortisone acetate, prednisone, prednisolone, dexamethasone); Cortisone; Cortisone acetate; Dual release hydrocortisone (plenadren); Fludrocortisone; Hydrocortisone; Hydrocortisone (solucortef); Hydrocortisone 10mg tablet; Hydrocortisone 10mg tablets; Hydrocortisone 20mg tablets; Hydrocortisone modified release capsules; Hydrocortisone sodium acetate; Hydrocortisone sodium phosphate; Hydrocortisone sodium succinate; Hydrocortisone tablet 2.5 mg; Procedure: hydrocortisone withdrawal; Subcutaneous hydrocortisone;	[1] D07749 💬	[1] NR3C1 💬	[1] Neuroactive ligand-receptor interaction	[1] 81 💬
4	Cortisone acetate	[2] Conventional glucocorticoids (immediate release hydrocortisone, cortisone acetate, prednisone, prednisolone, dexamethasone); Cortisone acetate;	[1] D00973 💬	[1] NR3C1 💬	[1] Neuroactive ligand-receptor interaction	[1] 81 💬
5	Dexamethasone	[48] Bortezomib/dexamethasone; Bortezomib/dexamethasone (bd), followed by autologous stc & maintenance bortezomib/dexamethasone; Bupivacaine/epinephrine/dexamethasone; Combination of protein a immunoadsorption, rituximab, dexamethasone plus azathioprine; Control intervention (no dexamethasone); Conventional glucocorticoids (immediate release hydrocortisone, cortisone acetate, prednisone, prednisolone, dexamethasone); Cyclophosphamide, bortezomib, and dexamethasone (cybord); Cyclophosphamide, bortezomib, dexamethasone; Cyclophosphamide, bortezomib, dexamethasone plus daratumumab; Device: dexamethasone injection; Dexamethasone; Dexamethasone (1 cycle); Dexamethasone (4 cycles); Dexamethasone (50mg 1dd6, 3 consecutive days/month); Dexamethasone 0,1 mg tablets; Dexamethasone 0,5mg; Dexamethasone 0.5mg tablet; Dexamethasone 0.5mg/5ml solution; Dexamethasone 0.5mg/5ml solution in mucolox™; Dexamethasone 1,5 mg tablets; Dexamethasone 21-dihydrogen phosphate; Dexamethasone 21-phosphate; Dexamethasone 2mg tablets; Dexamethasone 4 mg jenapharm; Dexamethasone abcur; Dexamethasone and rituximab; Dexamethasone oral tablet 8mg (dexamethasone krka tablets(8mg), warsaw, poland).; Dexamethasone parotid irrigation; Dexamethasone sodium phosphate; Dexamethasone sodium phosphate 250 mg/ 10 ml; Dexamethasone sodium phosphate 250 mg/10 ml solution; Dexamethasone sodium phosphate ph. eur.; Dexamethasone sodium sulfate; Dexamethasone soduim phosphate; Dexamethasone, 40 mg; Diagnostic test: dexamethasone test; High dose dexamethasone pulses; Intraarticular dexamethasone; Intravenous dexamethasone 1 mg; Lenalidomide and dexamethasone; Lenalidomide+dexamethasone; Lenalidomide, dexamethasone; Lenalidomide, dexamethasone and cyclophosphamide; Melphalan, thalidomide and dexamethasone; Mmf and dexamethasone; Peri-neural dexamethasone 1 mg; Pomalidomide and dexamethasone; Procedure: epidural steroid (dexamethasone) injection;	[9] D00292 D00975 D01510 D01615 D01632 D01948 D02174 D02591 D02592 💬	[1] NR3C1 💬	[1] Neuroactive ligand-receptor interaction	[25] 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 74, 75, 81, 83, 84, 90, 96, 97, 162, 222, 235, 283, 296, 299 💬
6	Fludrocortisone	[1] Fludrocortisone;	[2] D00986 D07967 💬	[1] NR3C2 💬	[1] Aldosterone-regulated sodium reabsorption	[3] 6 , 17, 81 💬
7	Flutamide	[1] Flutamide;	[1] D00586 💬	[1] AR 💬	[3] Oocyte meiosis, Pathways in cancer, Prostate cancer	[1] 81 💬
8	Hydrocortisone	[31] 90 mg hydrocortisone acetate suppository with sephure suppository applicator; Combination oral budesonide and rectal hydrocortisone; Combination product: twice daily 90 mg hydrocortisone acetate suppository administered with sephure applicator; Conventional glucocorticoids (immediate release hydrocortisone, cortisone acetate, prednisone, prednisolone, dexamethasone); Cortef (hydrocortisone); Dual release hydrocortisone (plenadren); Hydrocortisone; Hydrocortisone (solucortef); Hydrocortisone 100mg/ml; Hydrocortisone 10mg; Hydrocortisone 10mg tablet; Hydrocortisone 10mg tablets; Hydrocortisone 20mg tablets; Hydrocortisone acetate; Hydrocortisone cream; Hydrocortisone cream 1%; Hydrocortisone cream 10mg/g fna fagron; Hydrocortisone hydrogen succinate; Hydrocortisone modified release capsules; Hydrocortisone roussel; Hydrocortisone sodium acetate; Hydrocortisone sodium phosphate; Hydrocortisone sodium succinate; Hydrocortisone tablet 2.5 mg; Hydrocortisone takeda, tabletter; Mesalazine with hydrocortisone sodium succinate; Other: hydrocortisone; Procedure: hydrocortisone withdrawal; Solu-cortef (hydrocortisone); Subcutaneous hydrocortisone; Subcutaneous hydrocortisone 10mg;	[1] D00088 💬	[1] NR3C1 💬	[1] Neuroactive ligand-receptor interaction	[9] 6 , 46, 53, 75, 78, 81, 83, 97, 299 💬
9	Hydrocortisone cypionate	-	[1] D00976 💬	[1] NR3C1 💬	[1] Neuroactive ligand-receptor interaction	[3] 6 , 81, 83 💬
10	Hydrocortisone succinate	-	[1] D01442 💬	[1] NR3C1 💬	[1] Neuroactive ligand-receptor interaction	[3] 6 , 81, 83 💬

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