DDrare: Database of Drug Development for Rare Diseases

Target Gene/Pathway💬 Info on mouse-over

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	GABAergic synapse 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬	D04300 💬	Ganaxolone	[4] 145, 152, 158, 206 💬
2	Morphine addiction 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬	D04300 💬	Ganaxolone	[4] 145, 152, 158, 206 💬
3	Neuroactive ligand-receptor interaction 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬	D04300 💬	Ganaxolone	[4] 145, 152, 158, 206 💬
4	Nicotine addiction 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬	D04300 💬	Ganaxolone	[4] 145, 152, 158, 206 💬
5	Retrograde endocannabinoid signaling 💬	[16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬	D04300 💬	Ganaxolone	[4] 145, 152, 158, 206 💬
6	Serotonergic synapse 💬	[3] GABRB1, GABRB2, GABRB3 💬	D04300 💬	Ganaxolone	[4] 145, 152, 158, 206 💬
7	Taste transduction 💬	[6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬	D04300 💬	Ganaxolone	[4] 145, 152, 158, 206 💬

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