DDrare: Database of Drug Development for Rare Diseases

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Acute myeloid leukemia 💬	[1] MTOR 💬	D00753 💬	Sirolimus	[40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
2	Adipocytokine signaling pathway 💬	[1] MTOR 💬	D00753 💬	Sirolimus	[40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
3	Adipocytokine signaling pathway 💬	[1] TNF 💬	D02597 💬	Adalimumab	[16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
4	Adrenergic signaling in cardiomyocytes 💬	[1] AGTR1 💬	D00357 💬	Losartan	[18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
5	Adrenergic signaling in cardiomyocytes 💬	[1] AGTR1 💬	D08146 💬	Losartan	[18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
6	Adrenergic signaling in cardiomyocytes 💬	[2] AGTR1, AGTR2 💬	D00150 💬	Angiotensin II	[7] 17, 19, 46, 66, 86, 222, 224 💬
7	Adrenergic signaling in cardiomyocytes 💬	[2] AGTR1, AGTR2 💬	D02014 💬	Angiotensin II	[7] 17, 19, 46, 66, 86, 222, 224 💬
8	Adrenergic signaling in cardiomyocytes 💬	[4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4 💬	D00332 💬	Gabapentin	[5] 6 , 13, 19, 70, 298 💬
9	African trypanosomiasis 💬	[1] TNF 💬	D02597 💬	Adalimumab	[16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
10	AGE-RAGE signaling pathway in diabetic complications 💬	[1] AGTR1 💬	D00150 💬	Angiotensin II	[7] 17, 19, 46, 66, 86, 222, 224 💬

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