Target Gene/Pathway💬 Info on mouse-over
No. | KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related |
KEGG GENES | KEGG DRUG | DrugBank | Disease ID |
1 | Acute myeloid leukemia 💬 15 genes, 25 drugs (DrugBank) and 59 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
2 | Adipocytokine signaling pathway 💬 15 genes, 30 drugs (DrugBank) and 92 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
3 | Adipocytokine signaling pathway 💬 15 genes, 30 drugs (DrugBank) and 92 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
4 | Adrenergic signaling in cardiomyocytes 💬 26 genes, 77 drugs (DrugBank) and 68 diseases |
AGTR1 [1] AGTR1 💬 |
D00357 D00357 💬 |
Losartan | 017 [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
5 | Adrenergic signaling in cardiomyocytes 💬 26 genes, 77 drugs (DrugBank) and 68 diseases |
AGTR1 [1] AGTR1 💬 |
D08146 D08146 💬 |
Losartan | 017 [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
6 | Adrenergic signaling in cardiomyocytes 💬 26 genes, 77 drugs (DrugBank) and 68 diseases |
AGTR1 [2] AGTR1, AGTR2 💬 |
D00150 D00150 💬 |
Angiotensin II | 017 [7] 17, 19, 46, 66, 86, 222, 224 💬 |
7 | Adrenergic signaling in cardiomyocytes 💬 26 genes, 77 drugs (DrugBank) and 68 diseases |
AGTR1 [2] AGTR1, AGTR2 💬 |
D02014 D02014 💬 |
Angiotensin II | 017 [7] 17, 19, 46, 66, 86, 222, 224 💬 |
8 | Adrenergic signaling in cardiomyocytes 💬 26 genes, 77 drugs (DrugBank) and 68 diseases |
CACNA2D1 [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4 💬 |
D00332 D00332 💬 |
Gabapentin | 006 [5] 6 , 13, 19, 70, 298 💬 |
9 | African trypanosomiasis 💬 7 genes, 19 drugs (DrugBank) and 57 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
10 | AGE-RAGE signaling pathway in diabetic complications 💬 23 genes, 40 drugs (DrugBank) and 84 diseases |
AGTR1 [1] AGTR1 💬 |
D00150 D00150 💬 |
Angiotensin II | 017 [7] 17, 19, 46, 66, 86, 222, 224 💬 |
11 | AGE-RAGE signaling pathway in diabetic complications 💬 23 genes, 40 drugs (DrugBank) and 84 diseases |
AGTR1 [1] AGTR1 💬 |
D02014 D02014 💬 |
Angiotensin II | 017 [7] 17, 19, 46, 66, 86, 222, 224 💬 |
12 | AGE-RAGE signaling pathway in diabetic complications 💬 23 genes, 40 drugs (DrugBank) and 84 diseases |
AGTR1 [1] AGTR1 💬 |
D00357 D00357 💬 |
Losartan | 017 [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
13 | AGE-RAGE signaling pathway in diabetic complications 💬 23 genes, 40 drugs (DrugBank) and 84 diseases |
AGTR1 [1] AGTR1 💬 |
D08146 D08146 💬 |
Losartan | 017 [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
14 | AGE-RAGE signaling pathway in diabetic complications 💬 23 genes, 40 drugs (DrugBank) and 84 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
15 | Alcoholism 💬 28 genes, 69 drugs (DrugBank) and 52 diseases |
HDAC1 [11] HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9 💬 |
D06320 D06320 💬 |
Vorinostat | 019 [3] 19, 75, 96 💬 |
16 | Aldosterone synthesis and secretion 💬 18 genes, 34 drugs (DrugBank) and 64 diseases |
AGTR1 [1] AGTR1 💬 |
D00150 D00150 💬 |
Angiotensin II | 017 [7] 17, 19, 46, 66, 86, 222, 224 💬 |
17 | Aldosterone synthesis and secretion 💬 18 genes, 34 drugs (DrugBank) and 64 diseases |
AGTR1 [1] AGTR1 💬 |
D02014 D02014 💬 |
Angiotensin II | 017 [7] 17, 19, 46, 66, 86, 222, 224 💬 |
18 | Aldosterone synthesis and secretion 💬 18 genes, 34 drugs (DrugBank) and 64 diseases |
AGTR1 [1] AGTR1 💬 |
D00357 D00357 💬 |
Losartan | 017 [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
19 | Aldosterone synthesis and secretion 💬 18 genes, 34 drugs (DrugBank) and 64 diseases |
AGTR1 [1] AGTR1 💬 |
D08146 D08146 💬 |
Losartan | 017 [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
20 | Allograft rejection 💬 30 genes, 22 drugs (DrugBank) and 57 diseases |
CD80 [2] CD80, CD86 💬 |
D03203 D03203 💬 |
Abatacept | 011 [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬 |
21 | Allograft rejection 💬 30 genes, 22 drugs (DrugBank) and 57 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
22 | Alzheimer disease 💬 54 genes, 110 drugs (DrugBank) and 116 diseases |
CASP9 [1] CASP9 💬 |
D11195 D11195 💬 |
Rimiducid | 019 [6] 19, 60, 65, 284, 285, 326 💬 |
23 | Alzheimer disease 💬 54 genes, 110 drugs (DrugBank) and 116 diseases |
CHRM1 [3] CHRM1, CHRM3, CHRM5 💬 |
D00397 D00397 💬 |
Tropicamide | 006 [2] 6 , 19 💬 |
24 | Alzheimer disease 💬 54 genes, 110 drugs (DrugBank) and 116 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
25 | Alzheimer disease 💬 54 genes, 110 drugs (DrugBank) and 116 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
D00184 D00184 💬 |
Cyclosporine | 011 [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 |
26 | Alzheimer disease 💬 54 genes, 110 drugs (DrugBank) and 116 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
27 | Amoebiasis 💬 17 genes, 25 drugs (DrugBank) and 62 diseases |
IL1R1 [2] IL1R1, IL1R2 💬 |
D02934 D02934 💬 |
Anakinra | 002 [19] 2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 |
28 | Amoebiasis 💬 17 genes, 25 drugs (DrugBank) and 62 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
29 | Amphetamine addiction 💬 24 genes, 48 drugs (DrugBank) and 87 diseases |
HDAC1 [2] HDAC1, HDAC2 💬 |
D06320 D06320 💬 |
Vorinostat | 019 [3] 19, 75, 96 💬 |
30 | Amphetamine addiction 💬 24 genes, 48 drugs (DrugBank) and 87 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
D00184 D00184 💬 |
Cyclosporine | 011 [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 |
31 | AMPK signaling pathway 💬 16 genes, 47 drugs (DrugBank) and 86 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
32 | Amyotrophic lateral sclerosis 💬 33 genes, 44 drugs (DrugBank) and 102 diseases |
CASP9 [1] CASP9 💬 |
D11195 D11195 💬 |
Rimiducid | 019 [6] 19, 60, 65, 284, 285, 326 💬 |
33 | Amyotrophic lateral sclerosis 💬 33 genes, 44 drugs (DrugBank) and 102 diseases |
HDAC6 [1] HDAC6 💬 |
D06320 D06320 💬 |
Vorinostat | 019 [3] 19, 75, 96 💬 |
34 | Amyotrophic lateral sclerosis 💬 33 genes, 44 drugs (DrugBank) and 102 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
35 | Amyotrophic lateral sclerosis 💬 33 genes, 44 drugs (DrugBank) and 102 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
D00184 D00184 💬 |
Cyclosporine | 011 [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 |
36 | Amyotrophic lateral sclerosis 💬 33 genes, 44 drugs (DrugBank) and 102 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
37 | Antifolate resistance 💬 7 genes, 20 drugs (DrugBank) and 64 diseases |
DHFR [2] DHFR, DHFR2 💬 |
D00142 D00142 💬 |
Methotrexate | 011 [35] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 271, 284, 285, 326, 331 💬 |
38 | Antifolate resistance 💬 7 genes, 20 drugs (DrugBank) and 64 diseases |
DHFR [2] DHFR, DHFR2 💬 |
D02115 D02115 💬 |
Methotrexate | 011 [35] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 271, 284, 285, 326, 331 💬 |
39 | Antifolate resistance 💬 7 genes, 20 drugs (DrugBank) and 64 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
40 | Antigen processing and presentation 💬 23 genes, 15 drugs (DrugBank) and 53 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
41 | Apelin signaling pathway 💬 12 genes, 26 drugs (DrugBank) and 66 diseases |
AGTR1 [1] AGTR1 💬 |
D00150 D00150 💬 |
Angiotensin II | 017 [7] 17, 19, 46, 66, 86, 222, 224 💬 |
42 | Apelin signaling pathway 💬 12 genes, 26 drugs (DrugBank) and 66 diseases |
AGTR1 [1] AGTR1 💬 |
D02014 D02014 💬 |
Angiotensin II | 017 [7] 17, 19, 46, 66, 86, 222, 224 💬 |
43 | Apelin signaling pathway 💬 12 genes, 26 drugs (DrugBank) and 66 diseases |
AGTR1 [1] AGTR1 💬 |
D00357 D00357 💬 |
Losartan | 017 [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
44 | Apelin signaling pathway 💬 12 genes, 26 drugs (DrugBank) and 66 diseases |
AGTR1 [1] AGTR1 💬 |
D08146 D08146 💬 |
Losartan | 017 [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
45 | Apelin signaling pathway 💬 12 genes, 26 drugs (DrugBank) and 66 diseases |
HDAC4 [2] HDAC4, HDAC5 💬 |
D06320 D06320 💬 |
Vorinostat | 019 [3] 19, 75, 96 💬 |
46 | Apelin signaling pathway 💬 12 genes, 26 drugs (DrugBank) and 66 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
47 | Apoptosis 💬 14 genes, 23 drugs (DrugBank) and 54 diseases |
CASP9 [1] CASP9 💬 |
D11195 D11195 💬 |
Rimiducid | 019 [6] 19, 60, 65, 284, 285, 326 💬 |
48 | Apoptosis 💬 14 genes, 23 drugs (DrugBank) and 54 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
49 | Apoptosis - multiple species 💬 3 genes, 3 drugs (DrugBank) and 8 diseases |
CASP9 [1] CASP9 💬 |
D11195 D11195 💬 |
Rimiducid | 019 [6] 19, 60, 65, 284, 285, 326 💬 |
50 | Arrhythmogenic right ventricular cardiomyopathy 💬 11 genes, 24 drugs (DrugBank) and 28 diseases |
CACNA2D1 [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4 💬 |
D00332 D00332 💬 |
Gabapentin | 006 [5] 6 , 13, 19, 70, 298 💬 |
51 | Ascorbate and aldarate metabolism 💬 1 gene, 1 drug (DrugBank) and 1 disease |
GUSB [1] GUSB 💬 |
D11004 D11004 💬 |
Vestronidase alfa | 019 [1] 19 💬 |
52 | Asthma 💬 21 genes, 21 drugs (DrugBank) and 55 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
53 | Autoimmune thyroid disease 💬 41 genes, 14 drugs (DrugBank) and 37 diseases |
CD80 [2] CD80, CD86 💬 |
D03203 D03203 💬 |
Abatacept | 011 [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬 |
54 | Autophagy - animal 💬 13 genes, 15 drugs (DrugBank) and 57 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
55 | Autophagy - other 💬 1 gene, 3 drugs (DrugBank) and 41 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
56 | Axon guidance 💬 21 genes, 19 drugs (DrugBank) and 65 diseases |
CXCR4 [1] CXCR4 💬 |
D08971 D08971 💬 |
Plerixafor | 019 [6] 19, 20, 51, 65, 285, 299 💬 |
57 | Axon guidance 💬 21 genes, 19 drugs (DrugBank) and 65 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
D00184 D00184 💬 |
Cyclosporine | 011 [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 |
58 | B cell receptor signaling pathway 💬 16 genes, 19 drugs (DrugBank) and 63 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
D00184 D00184 💬 |
Cyclosporine | 011 [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 |
59 | Biosynthesis of cofactors 💬 10 genes, 10 drugs (DrugBank) and 45 diseases |
DHFR [2] DHFR, DHFR2 💬 |
D00142 D00142 💬 |
Methotrexate | 011 [35] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 271, 284, 285, 326, 331 💬 |
60 | Biosynthesis of cofactors 💬 10 genes, 10 drugs (DrugBank) and 45 diseases |
DHFR [2] DHFR, DHFR2 💬 |
D02115 D02115 💬 |
Methotrexate | 011 [35] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 271, 284, 285, 326, 331 💬 |
61 | Biosynthesis of cofactors 💬 10 genes, 10 drugs (DrugBank) and 45 diseases |
GUSB [1] GUSB 💬 |
D11004 D11004 💬 |
Vestronidase alfa | 019 [1] 19 💬 |
62 | Biosynthesis of cofactors 💬 10 genes, 10 drugs (DrugBank) and 45 diseases |
NQO1 [2] NQO1, VKORC1 💬 |
D00564 D00564 💬 |
Warfarin | 006 [11] 6 , 8 , 13, 19, 46, 49, 66, 85, 88, 96, 97 💬 |
63 | Biosynthesis of cofactors 💬 10 genes, 10 drugs (DrugBank) and 45 diseases |
NQO1 [2] NQO1, VKORC1 💬 |
D01280 D01280 💬 |
Warfarin | 006 [11] 6 , 8 , 13, 19, 46, 49, 66, 85, 88, 96, 97 💬 |
64 | Biosynthesis of cofactors 💬 10 genes, 10 drugs (DrugBank) and 45 diseases |
NQO1 [2] NQO1, VKORC1 💬 |
D08682 D08682 💬 |
Warfarin | 006 [11] 6 , 8 , 13, 19, 46, 49, 66, 85, 88, 96, 97 💬 |
65 | Breast cancer 💬 18 genes, 51 drugs (DrugBank) and 69 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
66 | C-type lectin receptor signaling pathway 💬 25 genes, 60 drugs (DrugBank) and 93 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
D00184 D00184 💬 |
Cyclosporine | 011 [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 |
67 | C-type lectin receptor signaling pathway 💬 25 genes, 60 drugs (DrugBank) and 93 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
68 | Calcium signaling pathway 💬 74 genes, 175 drugs (DrugBank) and 126 diseases |
AGTR1 [1] AGTR1 💬 |
D00150 D00150 💬 |
Angiotensin II | 017 [7] 17, 19, 46, 66, 86, 222, 224 💬 |
69 | Calcium signaling pathway 💬 74 genes, 175 drugs (DrugBank) and 126 diseases |
AGTR1 [1] AGTR1 💬 |
D02014 D02014 💬 |
Angiotensin II | 017 [7] 17, 19, 46, 66, 86, 222, 224 💬 |
70 | Calcium signaling pathway 💬 74 genes, 175 drugs (DrugBank) and 126 diseases |
AGTR1 [1] AGTR1 💬 |
D00357 D00357 💬 |
Losartan | 017 [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
71 | Calcium signaling pathway 💬 74 genes, 175 drugs (DrugBank) and 126 diseases |
AGTR1 [1] AGTR1 💬 |
D08146 D08146 💬 |
Losartan | 017 [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
72 | Calcium signaling pathway 💬 74 genes, 175 drugs (DrugBank) and 126 diseases |
CHRM1 [4] CHRM1, CHRM2, CHRM3, CHRM5 💬 |
D00397 D00397 💬 |
Tropicamide | 006 [2] 6 , 19 💬 |
73 | Calcium signaling pathway 💬 74 genes, 175 drugs (DrugBank) and 126 diseases |
CXCR4 [1] CXCR4 💬 |
D08971 D08971 💬 |
Plerixafor | 019 [6] 19, 20, 51, 65, 285, 299 💬 |
74 | Calcium signaling pathway 💬 74 genes, 175 drugs (DrugBank) and 126 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
D00184 D00184 💬 |
Cyclosporine | 011 [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 |
75 | cAMP signaling pathway 💬 63 genes, 157 drugs (DrugBank) and 108 diseases |
CHRM1 [2] CHRM1, CHRM2 💬 |
D00397 D00397 💬 |
Tropicamide | 006 [2] 6 , 19 💬 |
76 | Cardiac muscle contraction 💬 12 genes, 16 drugs (DrugBank) and 25 diseases |
CACNA2D1 [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4 💬 |
D00332 D00332 💬 |
Gabapentin | 006 [5] 6 , 13, 19, 70, 298 💬 |
77 | Cell adhesion molecules 💬 32 genes, 19 drugs (DrugBank) and 37 diseases |
CD80 [2] CD80, CD86 💬 |
D03203 D03203 💬 |
Abatacept | 011 [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬 |
78 | Cell cycle 💬 7 genes, 8 drugs (DrugBank) and 23 diseases |
HDAC1 [2] HDAC1, HDAC2 💬 |
D06320 D06320 💬 |
Vorinostat | 019 [3] 19, 75, 96 💬 |
79 | Cellular senescence 💬 29 genes, 35 drugs (DrugBank) and 90 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
80 | Cellular senescence 💬 29 genes, 35 drugs (DrugBank) and 90 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
D00184 D00184 💬 |
Cyclosporine | 011 [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 |
81 | Central carbon metabolism in cancer 💬 18 genes, 24 drugs (DrugBank) and 55 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
82 | cGMP-PKG signaling pathway 💬 45 genes, 108 drugs (DrugBank) and 112 diseases |
AGTR1 [1] AGTR1 💬 |
D00150 D00150 💬 |
Angiotensin II | 017 [7] 17, 19, 46, 66, 86, 222, 224 💬 |
83 | cGMP-PKG signaling pathway 💬 45 genes, 108 drugs (DrugBank) and 112 diseases |
AGTR1 [1] AGTR1 💬 |
D02014 D02014 💬 |
Angiotensin II | 017 [7] 17, 19, 46, 66, 86, 222, 224 💬 |
84 | cGMP-PKG signaling pathway 💬 45 genes, 108 drugs (DrugBank) and 112 diseases |
AGTR1 [1] AGTR1 💬 |
D00357 D00357 💬 |
Losartan | 017 [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
85 | cGMP-PKG signaling pathway 💬 45 genes, 108 drugs (DrugBank) and 112 diseases |
AGTR1 [1] AGTR1 💬 |
D08146 D08146 💬 |
Losartan | 017 [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
86 | cGMP-PKG signaling pathway 💬 45 genes, 108 drugs (DrugBank) and 112 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
D00184 D00184 💬 |
Cyclosporine | 011 [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 |
87 | Chagas disease 💬 25 genes, 39 drugs (DrugBank) and 76 diseases |
ACE [1] ACE 💬 |
D00621 D00621 💬 |
Enalapril | 019 [7] 19, 46, 66, 113, 210, 222, 223 💬 |
88 | Chagas disease 💬 25 genes, 39 drugs (DrugBank) and 76 diseases |
ACE [1] ACE 💬 |
D07892 D07892 💬 |
Enalapril | 019 [7] 19, 46, 66, 113, 210, 222, 223 💬 |
89 | Chagas disease 💬 25 genes, 39 drugs (DrugBank) and 76 diseases |
ACE [1] ACE 💬 |
D00362 D00362 💬 |
Lisinopril | 019 [7] 19, 46, 49, 66, 67, 113, 222 💬 |
90 | Chagas disease 💬 25 genes, 39 drugs (DrugBank) and 76 diseases |
ACE [1] ACE 💬 |
D08131 D08131 💬 |
Lisinopril | 019 [7] 19, 46, 49, 66, 67, 113, 222 💬 |
91 | Chagas disease 💬 25 genes, 39 drugs (DrugBank) and 76 diseases |
ACE [1] ACE 💬 |
D00459 D00459 💬 |
Quinapril | 019 [1] 19 💬 |
92 | Chagas disease 💬 25 genes, 39 drugs (DrugBank) and 76 diseases |
ACE [1] ACE 💬 |
D03752 D03752 💬 |
Quinapril | 019 [1] 19 💬 |
93 | Chagas disease 💬 25 genes, 39 drugs (DrugBank) and 76 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
94 | Chemokine signaling pathway 💬 20 genes, 23 drugs (DrugBank) and 41 diseases |
CXCR4 [1] CXCR4 💬 |
D08971 D08971 💬 |
Plerixafor | 019 [6] 19, 20, 51, 65, 285, 299 💬 |
95 | Cholesterol metabolism 💬 5 genes, 7 drugs (DrugBank) and 4 diseases |
LIPA [1] LIPA 💬 |
D10377 D10377 💬 |
Sebelipase alfa | 019 [1] 19 💬 |
96 | Choline metabolism in cancer 💬 10 genes, 20 drugs (DrugBank) and 51 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
97 | Cholinergic synapse 💬 31 genes, 48 drugs (DrugBank) and 58 diseases |
CHRM1 [5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 |
D00397 D00397 💬 |
Tropicamide | 006 [2] 6 , 19 💬 |
98 | Chronic myeloid leukemia 💬 14 genes, 15 drugs (DrugBank) and 28 diseases |
HDAC1 [2] HDAC1, HDAC2 💬 |
D06320 D06320 💬 |
Vorinostat | 019 [3] 19, 75, 96 💬 |
99 | Colorectal cancer 💬 14 genes, 19 drugs (DrugBank) and 49 diseases |
CASP9 [1] CASP9 💬 |
D11195 D11195 💬 |
Rimiducid | 019 [6] 19, 60, 65, 284, 285, 326 💬 |
100 | Colorectal cancer 💬 14 genes, 19 drugs (DrugBank) and 49 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
101 | Coronavirus disease - COVID-19 💬 47 genes, 82 drugs (DrugBank) and 93 diseases |
ACE [1] ACE 💬 |
D00621 D00621 💬 |
Enalapril | 019 [7] 19, 46, 66, 113, 210, 222, 223 💬 |
102 | Coronavirus disease - COVID-19 💬 47 genes, 82 drugs (DrugBank) and 93 diseases |
ACE [1] ACE 💬 |
D07892 D07892 💬 |
Enalapril | 019 [7] 19, 46, 66, 113, 210, 222, 223 💬 |
103 | Coronavirus disease - COVID-19 💬 47 genes, 82 drugs (DrugBank) and 93 diseases |
ACE [1] ACE 💬 |
D00362 D00362 💬 |
Lisinopril | 019 [7] 19, 46, 49, 66, 67, 113, 222 💬 |
104 | Coronavirus disease - COVID-19 💬 47 genes, 82 drugs (DrugBank) and 93 diseases |
ACE [1] ACE 💬 |
D08131 D08131 💬 |
Lisinopril | 019 [7] 19, 46, 49, 66, 67, 113, 222 💬 |
105 | Coronavirus disease - COVID-19 💬 47 genes, 82 drugs (DrugBank) and 93 diseases |
ACE [1] ACE 💬 |
D00459 D00459 💬 |
Quinapril | 019 [1] 19 💬 |
106 | Coronavirus disease - COVID-19 💬 47 genes, 82 drugs (DrugBank) and 93 diseases |
ACE [1] ACE 💬 |
D03752 D03752 💬 |
Quinapril | 019 [1] 19 💬 |
107 | Coronavirus disease - COVID-19 💬 47 genes, 82 drugs (DrugBank) and 93 diseases |
AGTR1 [1] AGTR1 💬 |
D00150 D00150 💬 |
Angiotensin II | 017 [7] 17, 19, 46, 66, 86, 222, 224 💬 |
108 | Coronavirus disease - COVID-19 💬 47 genes, 82 drugs (DrugBank) and 93 diseases |
AGTR1 [1] AGTR1 💬 |
D02014 D02014 💬 |
Angiotensin II | 017 [7] 17, 19, 46, 66, 86, 222, 224 💬 |
109 | Coronavirus disease - COVID-19 💬 47 genes, 82 drugs (DrugBank) and 93 diseases |
AGTR1 [1] AGTR1 💬 |
D00357 D00357 💬 |
Losartan | 017 [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
110 | Coronavirus disease - COVID-19 💬 47 genes, 82 drugs (DrugBank) and 93 diseases |
AGTR1 [1] AGTR1 💬 |
D08146 D08146 💬 |
Losartan | 017 [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
111 | Coronavirus disease - COVID-19 💬 47 genes, 82 drugs (DrugBank) and 93 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
112 | Cortisol synthesis and secretion 💬 14 genes, 30 drugs (DrugBank) and 62 diseases |
AGTR1 [1] AGTR1 💬 |
D00150 D00150 💬 |
Angiotensin II | 017 [7] 17, 19, 46, 66, 86, 222, 224 💬 |
113 | Cortisol synthesis and secretion 💬 14 genes, 30 drugs (DrugBank) and 62 diseases |
AGTR1 [1] AGTR1 💬 |
D02014 D02014 💬 |
Angiotensin II | 017 [7] 17, 19, 46, 66, 86, 222, 224 💬 |
114 | Cortisol synthesis and secretion 💬 14 genes, 30 drugs (DrugBank) and 62 diseases |
AGTR1 [1] AGTR1 💬 |
D00357 D00357 💬 |
Losartan | 017 [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
115 | Cortisol synthesis and secretion 💬 14 genes, 30 drugs (DrugBank) and 62 diseases |
AGTR1 [1] AGTR1 💬 |
D08146 D08146 💬 |
Losartan | 017 [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
116 | Cushing syndrome 💬 21 genes, 43 drugs (DrugBank) and 66 diseases |
AGTR1 [1] AGTR1 💬 |
D00150 D00150 💬 |
Angiotensin II | 017 [7] 17, 19, 46, 66, 86, 222, 224 💬 |
117 | Cushing syndrome 💬 21 genes, 43 drugs (DrugBank) and 66 diseases |
AGTR1 [1] AGTR1 💬 |
D02014 D02014 💬 |
Angiotensin II | 017 [7] 17, 19, 46, 66, 86, 222, 224 💬 |
118 | Cushing syndrome 💬 21 genes, 43 drugs (DrugBank) and 66 diseases |
AGTR1 [1] AGTR1 💬 |
D00357 D00357 💬 |
Losartan | 017 [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
119 | Cushing syndrome 💬 21 genes, 43 drugs (DrugBank) and 66 diseases |
AGTR1 [1] AGTR1 💬 |
D08146 D08146 💬 |
Losartan | 017 [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
120 | Cytokine-cytokine receptor interaction 💬 74 genes, 100 drugs (DrugBank) and 97 diseases |
CSF3R [1] CSF3R 💬 |
D03247 D03247 💬 |
Lenograstim | 002 [7] 2 , 13, 16, 18, 19, 57, 65 💬 |
121 | Cytokine-cytokine receptor interaction 💬 74 genes, 100 drugs (DrugBank) and 97 diseases |
CXCR4 [1] CXCR4 💬 |
D08971 D08971 💬 |
Plerixafor | 019 [6] 19, 20, 51, 65, 285, 299 💬 |
122 | Cytokine-cytokine receptor interaction 💬 74 genes, 100 drugs (DrugBank) and 97 diseases |
GHR [1] GHR 💬 |
D02691 D02691 💬 |
Somatotropin | 002 [20] 2 , 3 , 13, 19, 46, 74, 75, 76, 78, 96, 113, 187, 191, 193, 195, 236, 265, 274, 276, 299 💬 |
123 | Cytokine-cytokine receptor interaction 💬 74 genes, 100 drugs (DrugBank) and 97 diseases |
IL1R1 [2] IL1R1, IL1R2 💬 |
D02934 D02934 💬 |
Anakinra | 002 [19] 2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 |
124 | Cytokine-cytokine receptor interaction 💬 74 genes, 100 drugs (DrugBank) and 97 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
125 | Diabetic cardiomyopathy 💬 21 genes, 38 drugs (DrugBank) and 72 diseases |
ACE [1] ACE 💬 |
D00621 D00621 💬 |
Enalapril | 019 [7] 19, 46, 66, 113, 210, 222, 223 💬 |
126 | Diabetic cardiomyopathy 💬 21 genes, 38 drugs (DrugBank) and 72 diseases |
ACE [1] ACE 💬 |
D07892 D07892 💬 |
Enalapril | 019 [7] 19, 46, 66, 113, 210, 222, 223 💬 |
127 | Diabetic cardiomyopathy 💬 21 genes, 38 drugs (DrugBank) and 72 diseases |
ACE [1] ACE 💬 |
D00362 D00362 💬 |
Lisinopril | 019 [7] 19, 46, 49, 66, 67, 113, 222 💬 |
128 | Diabetic cardiomyopathy 💬 21 genes, 38 drugs (DrugBank) and 72 diseases |
ACE [1] ACE 💬 |
D08131 D08131 💬 |
Lisinopril | 019 [7] 19, 46, 49, 66, 67, 113, 222 💬 |
129 | Diabetic cardiomyopathy 💬 21 genes, 38 drugs (DrugBank) and 72 diseases |
ACE [1] ACE 💬 |
D00459 D00459 💬 |
Quinapril | 019 [1] 19 💬 |
130 | Diabetic cardiomyopathy 💬 21 genes, 38 drugs (DrugBank) and 72 diseases |
ACE [1] ACE 💬 |
D03752 D03752 💬 |
Quinapril | 019 [1] 19 💬 |
131 | Diabetic cardiomyopathy 💬 21 genes, 38 drugs (DrugBank) and 72 diseases |
AGTR1 [1] AGTR1 💬 |
D00150 D00150 💬 |
Angiotensin II | 017 [7] 17, 19, 46, 66, 86, 222, 224 💬 |
132 | Diabetic cardiomyopathy 💬 21 genes, 38 drugs (DrugBank) and 72 diseases |
AGTR1 [1] AGTR1 💬 |
D02014 D02014 💬 |
Angiotensin II | 017 [7] 17, 19, 46, 66, 86, 222, 224 💬 |
133 | Diabetic cardiomyopathy 💬 21 genes, 38 drugs (DrugBank) and 72 diseases |
AGTR1 [1] AGTR1 💬 |
D00357 D00357 💬 |
Losartan | 017 [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
134 | Diabetic cardiomyopathy 💬 21 genes, 38 drugs (DrugBank) and 72 diseases |
AGTR1 [1] AGTR1 💬 |
D08146 D08146 💬 |
Losartan | 017 [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
135 | Diabetic cardiomyopathy 💬 21 genes, 38 drugs (DrugBank) and 72 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
136 | Dilated cardiomyopathy 💬 16 genes, 52 drugs (DrugBank) and 81 diseases |
CACNA2D1 [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4 💬 |
D00332 D00332 💬 |
Gabapentin | 006 [5] 6 , 13, 19, 70, 298 💬 |
137 | Dilated cardiomyopathy 💬 16 genes, 52 drugs (DrugBank) and 81 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
138 | DNA replication 💬 2 genes, 1 drug (DrugBank) and 9 diseases |
POLA1 [2] POLA1, POLA2 💬 |
D03546 D03546 💬 |
Clofarabine | 019 [9] 19, 20, 40, 46, 49, 60, 96, 234, 326 💬 |
139 | Dopaminergic synapse 💬 30 genes, 93 drugs (DrugBank) and 97 diseases |
PPP3CA [3] PPP3CA, PPP3CB, PPP3CC 💬 |
D00184 D00184 💬 |
Cyclosporine | 011 [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 |
140 | Drug metabolism - other enzymes 💬 8 genes, 13 drugs (DrugBank) and 46 diseases |
GUSB [1] GUSB 💬 |
D11004 D11004 💬 |
Vestronidase alfa | 019 [1] 19 💬 |
141 | Drug metabolism - other enzymes 💬 8 genes, 13 drugs (DrugBank) and 46 diseases |
IMPDH1 [2] IMPDH1, IMPDH2 💬 |
D00752 D00752 💬 |
Mycophenolate mofetil | 002 [32] 2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬 |
142 | Drug metabolism - other enzymes 💬 8 genes, 13 drugs (DrugBank) and 46 diseases |
IMPDH1 [2] IMPDH1, IMPDH2 💬 |
D05094 D05094 💬 |
Mycophenolate mofetil | 002 [32] 2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬 |
143 | Drug metabolism - other enzymes 💬 8 genes, 13 drugs (DrugBank) and 46 diseases |
IMPDH1 [2] IMPDH1, IMPDH2 💬 |
D05095 D05095 💬 |
Mycophenolate mofetil | 002 [32] 2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬 |
144 | Drug metabolism - other enzymes 💬 8 genes, 13 drugs (DrugBank) and 46 diseases |
IMPDH1 [2] IMPDH1, IMPDH2 💬 |
D05096 D05096 💬 |
Mycophenolic acid | 002 [34] 2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 💬 |
145 | Drug metabolism - other enzymes 💬 8 genes, 13 drugs (DrugBank) and 46 diseases |
RRM1 [1] RRM1 💬 |
D03546 D03546 💬 |
Clofarabine | 019 [9] 19, 20, 40, 46, 49, 60, 96, 234, 326 💬 |
146 | Drug metabolism - other enzymes 💬 8 genes, 13 drugs (DrugBank) and 46 diseases |
RRM1 [1] RRM1 💬 |
D01907 D01907 💬 |
Fludarabine | 013 [18] 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 💬 |
147 | Drug metabolism - other enzymes 💬 8 genes, 13 drugs (DrugBank) and 46 diseases |
RRM1 [1] RRM1 💬 |
D07966 D07966 💬 |
Fludarabine | 013 [18] 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 💬 |
148 | Drug metabolism - other enzymes 💬 8 genes, 13 drugs (DrugBank) and 46 diseases |
RRM2 [1] RRM2 💬 |
D00341 D00341 💬 |
Hydroxyurea | 003 [8] 3 , 13, 19, 20, 65, 85, 86, 284 💬 |
149 | EGFR tyrosine kinase inhibitor resistance 💬 25 genes, 49 drugs (DrugBank) and 81 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
150 | Endocrine and other factor-regulated calcium reabsorption 💬 7 genes, 25 drugs (DrugBank) and 49 diseases |
VDR [1] VDR 💬 |
D00188 D00188 💬 |
Cholecalciferol | 006 [23] 6 , 13, 19, 20, 28, 34, 46, 49, 51, 53, 56, 60, 65, 84, 85, 96, 97, 162, 202, 228, 271, 298, 299 💬 |
151 | Endocrine and other factor-regulated calcium reabsorption 💬 7 genes, 25 drugs (DrugBank) and 49 diseases |
VDR [1] VDR 💬 |
D00930 D00930 💬 |
Paricalcitol | 019 [3] 19, 66, 218 💬 |
152 | Endocrine resistance 💬 19 genes, 37 drugs (DrugBank) and 59 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
153 | Endocytosis 💬 20 genes, 27 drugs (DrugBank) and 50 diseases |
CXCR4 [1] CXCR4 💬 |
D08971 D08971 💬 |
Plerixafor | 019 [6] 19, 20, 51, 65, 285, 299 💬 |
154 | Endometrial cancer 💬 10 genes, 14 drugs (DrugBank) and 21 diseases |
CASP9 [1] CASP9 💬 |
D11195 D11195 💬 |
Rimiducid | 019 [6] 19, 60, 65, 284, 285, 326 💬 |
155 | Epstein-Barr virus infection 💬 61 genes, 52 drugs (DrugBank) and 65 diseases |
CASP9 [1] CASP9 💬 |
D11195 D11195 💬 |
Rimiducid | 019 [6] 19, 60, 65, 284, 285, 326 💬 |
156 | Epstein-Barr virus infection 💬 61 genes, 52 drugs (DrugBank) and 65 diseases |
HDAC1 [2] HDAC1, HDAC2 💬 |
D06320 D06320 💬 |
Vorinostat | 019 [3] 19, 75, 96 💬 |
157 | Epstein-Barr virus infection 💬 61 genes, 52 drugs (DrugBank) and 65 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
158 | ErbB signaling pathway 💬 12 genes, 21 drugs (DrugBank) and 51 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
159 | Fc epsilon RI signaling pathway 💬 19 genes, 35 drugs (DrugBank) and 59 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
160 | Fluid shear stress and atherosclerosis 💬 29 genes, 46 drugs (DrugBank) and 83 diseases |
IL1R1 [2] IL1R1, IL1R2 💬 |
D02934 D02934 💬 |
Anakinra | 002 [19] 2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 |
161 | Fluid shear stress and atherosclerosis 💬 29 genes, 46 drugs (DrugBank) and 83 diseases |
NQO1 [1] NQO1 💬 |
D00564 D00564 💬 |
Warfarin | 006 [11] 6 , 8 , 13, 19, 46, 49, 66, 85, 88, 96, 97 💬 |
162 | Fluid shear stress and atherosclerosis 💬 29 genes, 46 drugs (DrugBank) and 83 diseases |
NQO1 [1] NQO1 💬 |
D01280 D01280 💬 |
Warfarin | 006 [11] 6 , 8 , 13, 19, 46, 49, 66, 85, 88, 96, 97 💬 |
163 | Fluid shear stress and atherosclerosis 💬 29 genes, 46 drugs (DrugBank) and 83 diseases |
NQO1 [1] NQO1 💬 |
D08682 D08682 💬 |
Warfarin | 006 [11] 6 , 8 , 13, 19, 46, 49, 66, 85, 88, 96, 97 💬 |
164 | Fluid shear stress and atherosclerosis 💬 29 genes, 46 drugs (DrugBank) and 83 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
165 | Folate biosynthesis 💬 6 genes, 4 drugs (DrugBank) and 36 diseases |
DHFR [2] DHFR, DHFR2 💬 |
D00142 D00142 💬 |
Methotrexate | 011 [35] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 271, 284, 285, 326, 331 💬 |
166 | Folate biosynthesis 💬 6 genes, 4 drugs (DrugBank) and 36 diseases |
DHFR [2] DHFR, DHFR2 💬 |
D02115 D02115 💬 |
Methotrexate | 011 [35] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 271, 284, 285, 326, 331 💬 |
167 | GABAergic synapse 💬 28 genes, 37 drugs (DrugBank) and 54 diseases |
SLC6A1 [1] SLC6A1 💬 |
D00332 D00332 💬 |
Gabapentin | 006 [5] 6 , 13, 19, 70, 298 💬 |
168 | Galactose metabolism 💬 2 genes, 5 drugs (DrugBank) and 2 diseases |
GLA [1] GLA 💬 |
D02784 D02784 💬 |
Agalsidase alfa | 019 [1] 19 💬 |
169 | Galactose metabolism 💬 2 genes, 5 drugs (DrugBank) and 2 diseases |
GLA [1] GLA 💬 |
D03228 D03228 💬 |
Agalsidase beta | 019 [1] 19 💬 |
170 | Gastric acid secretion 💬 12 genes, 45 drugs (DrugBank) and 49 diseases |
CHRM3 [1] CHRM3 💬 |
D00397 D00397 💬 |
Tropicamide | 006 [2] 6 , 19 💬 |
171 | Gastric cancer 💬 20 genes, 29 drugs (DrugBank) and 57 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
172 | Glioma 💬 12 genes, 24 drugs (DrugBank) and 56 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
173 | Glucagon signaling pathway 💬 13 genes, 18 drugs (DrugBank) and 78 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
D00184 D00184 💬 |
Cyclosporine | 011 [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 |
174 | Glutamatergic synapse 💬 22 genes, 26 drugs (DrugBank) and 79 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
D00184 D00184 💬 |
Cyclosporine | 011 [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 |
175 | Glutathione metabolism 💬 4 genes, 6 drugs (DrugBank) and 24 diseases |
RRM1 [1] RRM1 💬 |
D03546 D03546 💬 |
Clofarabine | 019 [9] 19, 20, 40, 46, 49, 60, 96, 234, 326 💬 |
176 | Glutathione metabolism 💬 4 genes, 6 drugs (DrugBank) and 24 diseases |
RRM1 [1] RRM1 💬 |
D01907 D01907 💬 |
Fludarabine | 013 [18] 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 💬 |
177 | Glutathione metabolism 💬 4 genes, 6 drugs (DrugBank) and 24 diseases |
RRM1 [1] RRM1 💬 |
D07966 D07966 💬 |
Fludarabine | 013 [18] 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 💬 |
178 | Glutathione metabolism 💬 4 genes, 6 drugs (DrugBank) and 24 diseases |
RRM2 [1] RRM2 💬 |
D00341 D00341 💬 |
Hydroxyurea | 003 [8] 3 , 13, 19, 20, 65, 85, 86, 284 💬 |
179 | Glycerolipid metabolism 💬 1 gene, 2 drugs (DrugBank) and 1 disease |
GLA [1] GLA 💬 |
D02784 D02784 💬 |
Agalsidase alfa | 019 [1] 19 💬 |
180 | Glycerolipid metabolism 💬 1 gene, 2 drugs (DrugBank) and 1 disease |
GLA [1] GLA 💬 |
D03228 D03228 💬 |
Agalsidase beta | 019 [1] 19 💬 |
181 | Glycosaminoglycan degradation 💬 5 genes, 6 drugs (DrugBank) and 2 diseases |
ARSB [1] ARSB 💬 |
D06565 D06565 💬 |
Galsulfase | 019 [1] 19 💬 |
182 | Glycosaminoglycan degradation 💬 5 genes, 6 drugs (DrugBank) and 2 diseases |
GALNS [1] GALNS 💬 |
D10333 D10333 💬 |
Elosulfase alfa | 019 [1] 19 💬 |
183 | Glycosaminoglycan degradation 💬 5 genes, 6 drugs (DrugBank) and 2 diseases |
GUSB [1] GUSB 💬 |
D11004 D11004 💬 |
Vestronidase alfa | 019 [1] 19 💬 |
184 | Glycosaminoglycan degradation 💬 5 genes, 6 drugs (DrugBank) and 2 diseases |
IDS [1] IDS 💬 |
D04499 D04499 💬 |
Idursulfase | 019 [1] 19 💬 |
185 | Glycosaminoglycan degradation 💬 5 genes, 6 drugs (DrugBank) and 2 diseases |
IDS [1] IDS 💬 |
D11025 D11025 💬 |
Idursulfase beta | 019 [1] 19 💬 |
186 | Glycosaminoglycan degradation 💬 5 genes, 6 drugs (DrugBank) and 2 diseases |
IDUA [1] IDUA 💬 |
D04670 D04670 💬 |
Laronidase | 019 [2] 19, 256 💬 |
187 | Glycosphingolipid biosynthesis - globo and isoglobo series 💬 1 gene, 2 drugs (DrugBank) and 1 disease |
GLA [1] GLA 💬 |
D02784 D02784 💬 |
Agalsidase alfa | 019 [1] 19 💬 |
188 | Glycosphingolipid biosynthesis - globo and isoglobo series 💬 1 gene, 2 drugs (DrugBank) and 1 disease |
GLA [1] GLA 💬 |
D03228 D03228 💬 |
Agalsidase beta | 019 [1] 19 💬 |
189 | Graft-versus-host disease 💬 27 genes, 22 drugs (DrugBank) and 61 diseases |
CD80 [2] CD80, CD86 💬 |
D03203 D03203 💬 |
Abatacept | 011 [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬 |
190 | Graft-versus-host disease 💬 27 genes, 22 drugs (DrugBank) and 61 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
191 | Growth hormone synthesis, secretion and action 💬 23 genes, 38 drugs (DrugBank) and 81 diseases |
GHR [1] GHR 💬 |
D02691 D02691 💬 |
Somatotropin | 002 [20] 2 , 3 , 13, 19, 46, 74, 75, 76, 78, 96, 113, 187, 191, 193, 195, 236, 265, 274, 276, 299 💬 |
192 | Growth hormone synthesis, secretion and action 💬 23 genes, 38 drugs (DrugBank) and 81 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
193 | Hematopoietic cell lineage 💬 43 genes, 65 drugs (DrugBank) and 92 diseases |
CSF3R [1] CSF3R 💬 |
D03247 D03247 💬 |
Lenograstim | 002 [7] 2 , 13, 16, 18, 19, 57, 65 💬 |
194 | Hematopoietic cell lineage 💬 43 genes, 65 drugs (DrugBank) and 92 diseases |
IL1R1 [2] IL1R1, IL1R2 💬 |
D02934 D02934 💬 |
Anakinra | 002 [19] 2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 |
195 | Hematopoietic cell lineage 💬 43 genes, 65 drugs (DrugBank) and 92 diseases |
MS4A1 [1] MS4A1 💬 |
D02994 D02994 💬 |
Rituximab | 011 [47] 11, 13, 14, 17, 19, 35, 36, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331 💬 |
196 | Hematopoietic cell lineage 💬 43 genes, 65 drugs (DrugBank) and 92 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
197 | Hepatitis B 💬 39 genes, 46 drugs (DrugBank) and 71 diseases |
CASP9 [1] CASP9 💬 |
D11195 D11195 💬 |
Rimiducid | 019 [6] 19, 60, 65, 284, 285, 326 💬 |
198 | Hepatitis B 💬 39 genes, 46 drugs (DrugBank) and 71 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
199 | Hepatitis C 💬 31 genes, 51 drugs (DrugBank) and 70 diseases |
CASP9 [1] CASP9 💬 |
D11195 D11195 💬 |
Rimiducid | 019 [6] 19, 60, 65, 284, 285, 326 💬 |
200 | Hepatitis C 💬 31 genes, 51 drugs (DrugBank) and 70 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
201 | Hepatocellular carcinoma 💬 18 genes, 25 drugs (DrugBank) and 57 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
202 | Hepatocellular carcinoma 💬 18 genes, 25 drugs (DrugBank) and 57 diseases |
NQO1 [1] NQO1 💬 |
D00564 D00564 💬 |
Warfarin | 006 [11] 6 , 8 , 13, 19, 46, 49, 66, 85, 88, 96, 97 💬 |
203 | Hepatocellular carcinoma 💬 18 genes, 25 drugs (DrugBank) and 57 diseases |
NQO1 [1] NQO1 💬 |
D01280 D01280 💬 |
Warfarin | 006 [11] 6 , 8 , 13, 19, 46, 49, 66, 85, 88, 96, 97 💬 |
204 | Hepatocellular carcinoma 💬 18 genes, 25 drugs (DrugBank) and 57 diseases |
NQO1 [1] NQO1 💬 |
D08682 D08682 💬 |
Warfarin | 006 [11] 6 , 8 , 13, 19, 46, 49, 66, 85, 88, 96, 97 💬 |
205 | Herpes simplex virus 1 infection 💬 60 genes, 56 drugs (DrugBank) and 95 diseases |
CASP9 [1] CASP9 💬 |
D11195 D11195 💬 |
Rimiducid | 019 [6] 19, 60, 65, 284, 285, 326 💬 |
206 | Herpes simplex virus 1 infection 💬 60 genes, 56 drugs (DrugBank) and 95 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
207 | Herpes simplex virus 1 infection 💬 60 genes, 56 drugs (DrugBank) and 95 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
208 | HIF-1 signaling pathway 💬 20 genes, 40 drugs (DrugBank) and 73 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
209 | Human cytomegalovirus infection 💬 58 genes, 94 drugs (DrugBank) and 113 diseases |
CASP9 [1] CASP9 💬 |
D11195 D11195 💬 |
Rimiducid | 019 [6] 19, 60, 65, 284, 285, 326 💬 |
210 | Human cytomegalovirus infection 💬 58 genes, 94 drugs (DrugBank) and 113 diseases |
CXCR4 [1] CXCR4 💬 |
D08971 D08971 💬 |
Plerixafor | 019 [6] 19, 20, 51, 65, 285, 299 💬 |
211 | Human cytomegalovirus infection 💬 58 genes, 94 drugs (DrugBank) and 113 diseases |
IL1R1 [1] IL1R1 💬 |
D02934 D02934 💬 |
Anakinra | 002 [19] 2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 |
212 | Human cytomegalovirus infection 💬 58 genes, 94 drugs (DrugBank) and 113 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
213 | Human cytomegalovirus infection 💬 58 genes, 94 drugs (DrugBank) and 113 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
D00184 D00184 💬 |
Cyclosporine | 011 [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 |
214 | Human cytomegalovirus infection 💬 58 genes, 94 drugs (DrugBank) and 113 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
215 | Human immunodeficiency virus 1 infection 💬 44 genes, 38 drugs (DrugBank) and 85 diseases |
CASP9 [1] CASP9 💬 |
D11195 D11195 💬 |
Rimiducid | 019 [6] 19, 60, 65, 284, 285, 326 💬 |
216 | Human immunodeficiency virus 1 infection 💬 44 genes, 38 drugs (DrugBank) and 85 diseases |
CXCR4 [1] CXCR4 💬 |
D08971 D08971 💬 |
Plerixafor | 019 [6] 19, 20, 51, 65, 285, 299 💬 |
217 | Human immunodeficiency virus 1 infection 💬 44 genes, 38 drugs (DrugBank) and 85 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
218 | Human immunodeficiency virus 1 infection 💬 44 genes, 38 drugs (DrugBank) and 85 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
D00184 D00184 💬 |
Cyclosporine | 011 [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 |
219 | Human immunodeficiency virus 1 infection 💬 44 genes, 38 drugs (DrugBank) and 85 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
220 | Human papillomavirus infection 💬 43 genes, 83 drugs (DrugBank) and 102 diseases |
HDAC1 [2] HDAC1, HDAC2 💬 |
D06320 D06320 💬 |
Vorinostat | 019 [3] 19, 75, 96 💬 |
221 | Human papillomavirus infection 💬 43 genes, 83 drugs (DrugBank) and 102 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
222 | Human papillomavirus infection 💬 43 genes, 83 drugs (DrugBank) and 102 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
223 | Human T-cell leukemia virus 1 infection 💬 52 genes, 50 drugs (DrugBank) and 80 diseases |
FDPS [1] FDPS 💬 |
D00939 D00939 💬 |
Alendronic acid | 019 [7] 19, 41, 46, 50, 271, 274, 299 💬 |
224 | Human T-cell leukemia virus 1 infection 💬 52 genes, 50 drugs (DrugBank) and 80 diseases |
FDPS [1] FDPS 💬 |
D07119 D07119 💬 |
Alendronic acid | 019 [7] 19, 41, 46, 50, 271, 274, 299 💬 |
225 | Human T-cell leukemia virus 1 infection 💬 52 genes, 50 drugs (DrugBank) and 80 diseases |
IL1R1 [2] IL1R1, IL1R2 💬 |
D02934 D02934 💬 |
Anakinra | 002 [19] 2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 |
226 | Human T-cell leukemia virus 1 infection 💬 52 genes, 50 drugs (DrugBank) and 80 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
D00184 D00184 💬 |
Cyclosporine | 011 [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 |
227 | Human T-cell leukemia virus 1 infection 💬 52 genes, 50 drugs (DrugBank) and 80 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
228 | Huntington disease 💬 23 genes, 29 drugs (DrugBank) and 77 diseases |
CASP9 [1] CASP9 💬 |
D11195 D11195 💬 |
Rimiducid | 019 [6] 19, 60, 65, 284, 285, 326 💬 |
229 | Huntington disease 💬 23 genes, 29 drugs (DrugBank) and 77 diseases |
HDAC1 [2] HDAC1, HDAC2 💬 |
D06320 D06320 💬 |
Vorinostat | 019 [3] 19, 75, 96 💬 |
230 | Huntington disease 💬 23 genes, 29 drugs (DrugBank) and 77 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
231 | Hypertrophic cardiomyopathy 💬 19 genes, 49 drugs (DrugBank) and 88 diseases |
ACE [1] ACE 💬 |
D00621 D00621 💬 |
Enalapril | 019 [7] 19, 46, 66, 113, 210, 222, 223 💬 |
232 | Hypertrophic cardiomyopathy 💬 19 genes, 49 drugs (DrugBank) and 88 diseases |
ACE [1] ACE 💬 |
D07892 D07892 💬 |
Enalapril | 019 [7] 19, 46, 66, 113, 210, 222, 223 💬 |
233 | Hypertrophic cardiomyopathy 💬 19 genes, 49 drugs (DrugBank) and 88 diseases |
ACE [1] ACE 💬 |
D00362 D00362 💬 |
Lisinopril | 019 [7] 19, 46, 49, 66, 67, 113, 222 💬 |
234 | Hypertrophic cardiomyopathy 💬 19 genes, 49 drugs (DrugBank) and 88 diseases |
ACE [1] ACE 💬 |
D08131 D08131 💬 |
Lisinopril | 019 [7] 19, 46, 49, 66, 67, 113, 222 💬 |
235 | Hypertrophic cardiomyopathy 💬 19 genes, 49 drugs (DrugBank) and 88 diseases |
ACE [1] ACE 💬 |
D00459 D00459 💬 |
Quinapril | 019 [1] 19 💬 |
236 | Hypertrophic cardiomyopathy 💬 19 genes, 49 drugs (DrugBank) and 88 diseases |
ACE [1] ACE 💬 |
D03752 D03752 💬 |
Quinapril | 019 [1] 19 💬 |
237 | Hypertrophic cardiomyopathy 💬 19 genes, 49 drugs (DrugBank) and 88 diseases |
CACNA2D1 [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4 💬 |
D00332 D00332 💬 |
Gabapentin | 006 [5] 6 , 13, 19, 70, 298 💬 |
238 | Hypertrophic cardiomyopathy 💬 19 genes, 49 drugs (DrugBank) and 88 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
239 | IL-17 signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 79 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
240 | Inflammatory bowel disease 💬 35 genes, 40 drugs (DrugBank) and 66 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
241 | Inflammatory mediator regulation of TRP channels 💬 22 genes, 38 drugs (DrugBank) and 55 diseases |
IL1R1 [1] IL1R1 💬 |
D02934 D02934 💬 |
Anakinra | 002 [19] 2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 |
242 | Inflammatory mediator regulation of TRP channels 💬 22 genes, 38 drugs (DrugBank) and 55 diseases |
TRPV1 [1] TRPV1 💬 |
D00250 D00250 💬 |
Capsaicin | 002 [5] 2 , 6 , 19, 86, 226 💬 |
243 | Influenza A 💬 54 genes, 55 drugs (DrugBank) and 81 diseases |
CASP9 [1] CASP9 💬 |
D11195 D11195 💬 |
Rimiducid | 019 [6] 19, 60, 65, 284, 285, 326 💬 |
244 | Influenza A 💬 54 genes, 55 drugs (DrugBank) and 81 diseases |
FDPS [1] FDPS 💬 |
D00939 D00939 💬 |
Alendronic acid | 019 [7] 19, 41, 46, 50, 271, 274, 299 💬 |
245 | Influenza A 💬 54 genes, 55 drugs (DrugBank) and 81 diseases |
FDPS [1] FDPS 💬 |
D07119 D07119 💬 |
Alendronic acid | 019 [7] 19, 41, 46, 50, 271, 274, 299 💬 |
246 | Influenza A 💬 54 genes, 55 drugs (DrugBank) and 81 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
247 | Insulin resistance 💬 16 genes, 29 drugs (DrugBank) and 89 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
248 | Insulin resistance 💬 16 genes, 29 drugs (DrugBank) and 89 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
249 | Insulin secretion 💬 13 genes, 40 drugs (DrugBank) and 43 diseases |
CHRM3 [1] CHRM3 💬 |
D00397 D00397 💬 |
Tropicamide | 006 [2] 6 , 19 💬 |
250 | Insulin signaling pathway 💬 12 genes, 21 drugs (DrugBank) and 59 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
251 | Intestinal immune network for IgA production 💬 27 genes, 23 drugs (DrugBank) and 47 diseases |
CD80 [2] CD80, CD86 💬 |
D03203 D03203 💬 |
Abatacept | 011 [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬 |
252 | Intestinal immune network for IgA production 💬 27 genes, 23 drugs (DrugBank) and 47 diseases |
CXCR4 [1] CXCR4 💬 |
D08971 D08971 💬 |
Plerixafor | 019 [6] 19, 20, 51, 65, 285, 299 💬 |
253 | JAK-STAT signaling pathway 💬 54 genes, 83 drugs (DrugBank) and 104 diseases |
CSF3R [1] CSF3R 💬 |
D03247 D03247 💬 |
Lenograstim | 002 [7] 2 , 13, 16, 18, 19, 57, 65 💬 |
254 | JAK-STAT signaling pathway 💬 54 genes, 83 drugs (DrugBank) and 104 diseases |
GHR [1] GHR 💬 |
D02691 D02691 💬 |
Somatotropin | 002 [20] 2 , 3 , 13, 19, 46, 74, 75, 76, 78, 96, 113, 187, 191, 193, 195, 236, 265, 274, 276, 299 💬 |
255 | JAK-STAT signaling pathway 💬 54 genes, 83 drugs (DrugBank) and 104 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
256 | Kaposi sarcoma-associated herpesvirus infection 💬 52 genes, 75 drugs (DrugBank) and 105 diseases |
CASP9 [1] CASP9 💬 |
D11195 D11195 💬 |
Rimiducid | 019 [6] 19, 60, 65, 284, 285, 326 💬 |
257 | Kaposi sarcoma-associated herpesvirus infection 💬 52 genes, 75 drugs (DrugBank) and 105 diseases |
CD86 [1] CD86 💬 |
D03203 D03203 💬 |
Abatacept | 011 [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬 |
258 | Kaposi sarcoma-associated herpesvirus infection 💬 52 genes, 75 drugs (DrugBank) and 105 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
259 | Kaposi sarcoma-associated herpesvirus infection 💬 52 genes, 75 drugs (DrugBank) and 105 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
D00184 D00184 💬 |
Cyclosporine | 011 [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 |
260 | Legionellosis 💬 7 genes, 19 drugs (DrugBank) and 58 diseases |
CASP9 [1] CASP9 💬 |
D11195 D11195 💬 |
Rimiducid | 019 [6] 19, 60, 65, 284, 285, 326 💬 |
261 | Legionellosis 💬 7 genes, 19 drugs (DrugBank) and 58 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
262 | Leishmaniasis 💬 35 genes, 58 drugs (DrugBank) and 88 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
263 | Leukocyte transendothelial migration 💬 12 genes, 11 drugs (DrugBank) and 25 diseases |
CXCR4 [1] CXCR4 💬 |
D08971 D08971 💬 |
Plerixafor | 019 [6] 19, 20, 51, 65, 285, 299 💬 |
264 | Long-term potentiation 💬 17 genes, 30 drugs (DrugBank) and 82 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
D00184 D00184 💬 |
Cyclosporine | 011 [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 |
265 | Longevity regulating pathway 💬 10 genes, 16 drugs (DrugBank) and 61 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
266 | Longevity regulating pathway - multiple species 💬 10 genes, 13 drugs (DrugBank) and 56 diseases |
HDAC1 [2] HDAC1, HDAC2 💬 |
D06320 D06320 💬 |
Vorinostat | 019 [3] 19, 75, 96 💬 |
267 | Longevity regulating pathway - multiple species 💬 10 genes, 13 drugs (DrugBank) and 56 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
268 | Lysosome 💬 12 genes, 19 drugs (DrugBank) and 2 diseases |
ARSB [1] ARSB 💬 |
D06565 D06565 💬 |
Galsulfase | 019 [1] 19 💬 |
269 | Lysosome 💬 12 genes, 19 drugs (DrugBank) and 2 diseases |
GALNS [1] GALNS 💬 |
D10333 D10333 💬 |
Elosulfase alfa | 019 [1] 19 💬 |
270 | Lysosome 💬 12 genes, 19 drugs (DrugBank) and 2 diseases |
GBA [1] GBA 💬 |
D02810 D02810 💬 |
Alglucerase | 019 [1] 19 💬 |
271 | Lysosome 💬 12 genes, 19 drugs (DrugBank) and 2 diseases |
GBA [1] GBA 💬 |
D03020 D03020 💬 |
Imiglucerase | 019 [1] 19 💬 |
272 | Lysosome 💬 12 genes, 19 drugs (DrugBank) and 2 diseases |
GBA [1] GBA 💬 |
D09675 D09675 💬 |
Taliglucerase alfa | 019 [1] 19 💬 |
273 | Lysosome 💬 12 genes, 19 drugs (DrugBank) and 2 diseases |
GBA [1] GBA 💬 |
D09029 D09029 💬 |
Velaglucerase alfa | 019 [1] 19 💬 |
274 | Lysosome 💬 12 genes, 19 drugs (DrugBank) and 2 diseases |
GLA [1] GLA 💬 |
D02784 D02784 💬 |
Agalsidase alfa | 019 [1] 19 💬 |
275 | Lysosome 💬 12 genes, 19 drugs (DrugBank) and 2 diseases |
GLA [1] GLA 💬 |
D03228 D03228 💬 |
Agalsidase beta | 019 [1] 19 💬 |
276 | Lysosome 💬 12 genes, 19 drugs (DrugBank) and 2 diseases |
GUSB [1] GUSB 💬 |
D11004 D11004 💬 |
Vestronidase alfa | 019 [1] 19 💬 |
277 | Lysosome 💬 12 genes, 19 drugs (DrugBank) and 2 diseases |
IDS [1] IDS 💬 |
D04499 D04499 💬 |
Idursulfase | 019 [1] 19 💬 |
278 | Lysosome 💬 12 genes, 19 drugs (DrugBank) and 2 diseases |
IDS [1] IDS 💬 |
D11025 D11025 💬 |
Idursulfase beta | 019 [1] 19 💬 |
279 | Lysosome 💬 12 genes, 19 drugs (DrugBank) and 2 diseases |
IDUA [1] IDUA 💬 |
D04670 D04670 💬 |
Laronidase | 019 [2] 19, 256 💬 |
280 | Lysosome 💬 12 genes, 19 drugs (DrugBank) and 2 diseases |
LIPA [1] LIPA 💬 |
D10377 D10377 💬 |
Sebelipase alfa | 019 [1] 19 💬 |
281 | Lysosome 💬 12 genes, 19 drugs (DrugBank) and 2 diseases |
MAN2B1 [1] MAN2B1 💬 |
D11024 D11024 💬 |
Velmanase alfa | 019 [1] 19 💬 |
282 | Lysosome 💬 12 genes, 19 drugs (DrugBank) and 2 diseases |
SMPD1 [1] SMPD1 💬 |
D10820 D10820 💬 |
Olipudase alfa | 019 [1] 19 💬 |
283 | Lysosome 💬 12 genes, 19 drugs (DrugBank) and 2 diseases |
TPP1 [1] TPP1 💬 |
D10813 D10813 💬 |
Cerliponase alfa | 019 [1] 19 💬 |
284 | Malaria 💬 14 genes, 25 drugs (DrugBank) and 62 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
285 | MAPK signaling pathway 💬 57 genes, 76 drugs (DrugBank) and 106 diseases |
CACNA2D1 [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4 💬 |
D00332 D00332 💬 |
Gabapentin | 006 [5] 6 , 13, 19, 70, 298 💬 |
286 | MAPK signaling pathway 💬 57 genes, 76 drugs (DrugBank) and 106 diseases |
IL1R1 [1] IL1R1 💬 |
D02934 D02934 💬 |
Anakinra | 002 [19] 2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 |
287 | MAPK signaling pathway 💬 57 genes, 76 drugs (DrugBank) and 106 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
D00184 D00184 💬 |
Cyclosporine | 011 [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 |
288 | MAPK signaling pathway 💬 57 genes, 76 drugs (DrugBank) and 106 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
289 | Measles 💬 36 genes, 37 drugs (DrugBank) and 49 diseases |
CASP9 [1] CASP9 💬 |
D11195 D11195 💬 |
Rimiducid | 019 [6] 19, 60, 65, 284, 285, 326 💬 |
290 | Metabolic pathways 💬 104 genes, 142 drugs (DrugBank) and 128 diseases |
ARSB [1] ARSB 💬 |
D06565 D06565 💬 |
Galsulfase | 019 [1] 19 💬 |
291 | Metabolic pathways 💬 104 genes, 142 drugs (DrugBank) and 128 diseases |
DHFR [2] DHFR, DHFR2 💬 |
D00142 D00142 💬 |
Methotrexate | 011 [35] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 271, 284, 285, 326, 331 💬 |
292 | Metabolic pathways 💬 104 genes, 142 drugs (DrugBank) and 128 diseases |
DHFR [2] DHFR, DHFR2 💬 |
D02115 D02115 💬 |
Methotrexate | 011 [35] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 271, 284, 285, 326, 331 💬 |
293 | Metabolic pathways 💬 104 genes, 142 drugs (DrugBank) and 128 diseases |
FDPS [1] FDPS 💬 |
D00939 D00939 💬 |
Alendronic acid | 019 [7] 19, 41, 46, 50, 271, 274, 299 💬 |
294 | Metabolic pathways 💬 104 genes, 142 drugs (DrugBank) and 128 diseases |
FDPS [1] FDPS 💬 |
D07119 D07119 💬 |
Alendronic acid | 019 [7] 19, 41, 46, 50, 271, 274, 299 💬 |
295 | Metabolic pathways 💬 104 genes, 142 drugs (DrugBank) and 128 diseases |
GALNS [1] GALNS 💬 |
D10333 D10333 💬 |
Elosulfase alfa | 019 [1] 19 💬 |
296 | Metabolic pathways 💬 104 genes, 142 drugs (DrugBank) and 128 diseases |
GBA [1] GBA 💬 |
D02810 D02810 💬 |
Alglucerase | 019 [1] 19 💬 |
297 | Metabolic pathways 💬 104 genes, 142 drugs (DrugBank) and 128 diseases |
GBA [1] GBA 💬 |
D03020 D03020 💬 |
Imiglucerase | 019 [1] 19 💬 |
298 | Metabolic pathways 💬 104 genes, 142 drugs (DrugBank) and 128 diseases |
GBA [1] GBA 💬 |
D09675 D09675 💬 |
Taliglucerase alfa | 019 [1] 19 💬 |
299 | Metabolic pathways 💬 104 genes, 142 drugs (DrugBank) and 128 diseases |
GBA [1] GBA 💬 |
D09029 D09029 💬 |
Velaglucerase alfa | 019 [1] 19 💬 |
300 | Metabolic pathways 💬 104 genes, 142 drugs (DrugBank) and 128 diseases |
GLA [1] GLA 💬 |
D02784 D02784 💬 |
Agalsidase alfa | 019 [1] 19 💬 |
301 | Metabolic pathways 💬 104 genes, 142 drugs (DrugBank) and 128 diseases |
GLA [1] GLA 💬 |
D03228 D03228 💬 |
Agalsidase beta | 019 [1] 19 💬 |
302 | Metabolic pathways 💬 104 genes, 142 drugs (DrugBank) and 128 diseases |
GUSB [1] GUSB 💬 |
D11004 D11004 💬 |
Vestronidase alfa | 019 [1] 19 💬 |
303 | Metabolic pathways 💬 104 genes, 142 drugs (DrugBank) and 128 diseases |
IDS [1] IDS 💬 |
D04499 D04499 💬 |
Idursulfase | 019 [1] 19 💬 |
304 | Metabolic pathways 💬 104 genes, 142 drugs (DrugBank) and 128 diseases |
IDS [1] IDS 💬 |
D11025 D11025 💬 |
Idursulfase beta | 019 [1] 19 💬 |
305 | Metabolic pathways 💬 104 genes, 142 drugs (DrugBank) and 128 diseases |
IDUA [1] IDUA 💬 |
D04670 D04670 💬 |
Laronidase | 019 [2] 19, 256 💬 |
306 | Metabolic pathways 💬 104 genes, 142 drugs (DrugBank) and 128 diseases |
IMPDH1 [2] IMPDH1, IMPDH2 💬 |
D00752 D00752 💬 |
Mycophenolate mofetil | 002 [32] 2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬 |
307 | Metabolic pathways 💬 104 genes, 142 drugs (DrugBank) and 128 diseases |
IMPDH1 [2] IMPDH1, IMPDH2 💬 |
D05094 D05094 💬 |
Mycophenolate mofetil | 002 [32] 2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬 |
308 | Metabolic pathways 💬 104 genes, 142 drugs (DrugBank) and 128 diseases |
IMPDH1 [2] IMPDH1, IMPDH2 💬 |
D05095 D05095 💬 |
Mycophenolate mofetil | 002 [32] 2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬 |
309 | Metabolic pathways 💬 104 genes, 142 drugs (DrugBank) and 128 diseases |
IMPDH1 [2] IMPDH1, IMPDH2 💬 |
D05096 D05096 💬 |
Mycophenolic acid | 002 [34] 2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 💬 |
310 | Metabolic pathways 💬 104 genes, 142 drugs (DrugBank) and 128 diseases |
NQO1 [2] NQO1, VKORC1 💬 |
D00564 D00564 💬 |
Warfarin | 006 [11] 6 , 8 , 13, 19, 46, 49, 66, 85, 88, 96, 97 💬 |
311 | Metabolic pathways 💬 104 genes, 142 drugs (DrugBank) and 128 diseases |
NQO1 [2] NQO1, VKORC1 💬 |
D01280 D01280 💬 |
Warfarin | 006 [11] 6 , 8 , 13, 19, 46, 49, 66, 85, 88, 96, 97 💬 |
312 | Metabolic pathways 💬 104 genes, 142 drugs (DrugBank) and 128 diseases |
NQO1 [2] NQO1, VKORC1 💬 |
D08682 D08682 💬 |
Warfarin | 006 [11] 6 , 8 , 13, 19, 46, 49, 66, 85, 88, 96, 97 💬 |
313 | Metabolic pathways 💬 104 genes, 142 drugs (DrugBank) and 128 diseases |
RRM1 [1] RRM1 💬 |
D03546 D03546 💬 |
Clofarabine | 019 [9] 19, 20, 40, 46, 49, 60, 96, 234, 326 💬 |
314 | Metabolic pathways 💬 104 genes, 142 drugs (DrugBank) and 128 diseases |
RRM1 [1] RRM1 💬 |
D01907 D01907 💬 |
Fludarabine | 013 [18] 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 💬 |
315 | Metabolic pathways 💬 104 genes, 142 drugs (DrugBank) and 128 diseases |
RRM1 [1] RRM1 💬 |
D07966 D07966 💬 |
Fludarabine | 013 [18] 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 💬 |
316 | Metabolic pathways 💬 104 genes, 142 drugs (DrugBank) and 128 diseases |
RRM2 [1] RRM2 💬 |
D00341 D00341 💬 |
Hydroxyurea | 003 [8] 3 , 13, 19, 20, 65, 85, 86, 284 💬 |
317 | Metabolic pathways 💬 104 genes, 142 drugs (DrugBank) and 128 diseases |
SMPD1 [1] SMPD1 💬 |
D10820 D10820 💬 |
Olipudase alfa | 019 [1] 19 💬 |
318 | Metabolic pathways 💬 104 genes, 142 drugs (DrugBank) and 128 diseases |
UGCG [1] UGCG 💬 |
D09893 D09893 💬 |
Eliglustat | 019 [1] 19 💬 |
319 | Metabolic pathways 💬 104 genes, 142 drugs (DrugBank) and 128 diseases |
UGCG [1] UGCG 💬 |
D11439 D11439 💬 |
Lucerastat | 019 [1] 19 💬 |
320 | Metabolic pathways 💬 104 genes, 142 drugs (DrugBank) and 128 diseases |
UGCG [1] UGCG 💬 |
D05032 D05032 💬 |
Miglustat | 019 [3] 19, 256, 299 💬 |
321 | Metabolic pathways 💬 104 genes, 142 drugs (DrugBank) and 128 diseases |
UGCG [1] UGCG 💬 |
D11633 D11633 💬 |
Venglustat | 006 [3] 6 , 19, 67 💬 |
322 | MicroRNAs in cancer 💬 30 genes, 59 drugs (DrugBank) and 77 diseases |
HDAC1 [4] HDAC1, HDAC2, HDAC4, HDAC5 💬 |
D06320 D06320 💬 |
Vorinostat | 019 [3] 19, 75, 96 💬 |
323 | MicroRNAs in cancer 💬 30 genes, 59 drugs (DrugBank) and 77 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
324 | Mineral absorption 💬 8 genes, 13 drugs (DrugBank) and 37 diseases |
VDR [1] VDR 💬 |
D00188 D00188 💬 |
Cholecalciferol | 006 [23] 6 , 13, 19, 20, 28, 34, 46, 49, 51, 53, 56, 60, 65, 84, 85, 96, 97, 162, 202, 228, 271, 298, 299 💬 |
325 | Mineral absorption 💬 8 genes, 13 drugs (DrugBank) and 37 diseases |
VDR [1] VDR 💬 |
D00930 D00930 💬 |
Paricalcitol | 019 [3] 19, 66, 218 💬 |
326 | mTOR signaling pathway 💬 13 genes, 28 drugs (DrugBank) and 86 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
327 | mTOR signaling pathway 💬 13 genes, 28 drugs (DrugBank) and 86 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
328 | Natural killer cell mediated cytotoxicity 💬 41 genes, 39 drugs (DrugBank) and 77 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
D00184 D00184 💬 |
Cyclosporine | 011 [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 |
329 | Natural killer cell mediated cytotoxicity 💬 41 genes, 39 drugs (DrugBank) and 77 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
330 | Necroptosis 💬 28 genes, 37 drugs (DrugBank) and 68 diseases |
SMPD1 [1] SMPD1 💬 |
D10820 D10820 💬 |
Olipudase alfa | 019 [1] 19 💬 |
331 | Necroptosis 💬 28 genes, 37 drugs (DrugBank) and 68 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
332 | Neuroactive ligand-receptor interaction 💬 146 genes, 309 drugs (DrugBank) and 144 diseases |
AGTR1 [1] AGTR1 💬 |
D00357 D00357 💬 |
Losartan | 017 [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
333 | Neuroactive ligand-receptor interaction 💬 146 genes, 309 drugs (DrugBank) and 144 diseases |
AGTR1 [1] AGTR1 💬 |
D08146 D08146 💬 |
Losartan | 017 [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
334 | Neuroactive ligand-receptor interaction 💬 146 genes, 309 drugs (DrugBank) and 144 diseases |
AGTR1 [2] AGTR1, AGTR2 💬 |
D00150 D00150 💬 |
Angiotensin II | 017 [7] 17, 19, 46, 66, 86, 222, 224 💬 |
335 | Neuroactive ligand-receptor interaction 💬 146 genes, 309 drugs (DrugBank) and 144 diseases |
AGTR1 [2] AGTR1, AGTR2 💬 |
D02014 D02014 💬 |
Angiotensin II | 017 [7] 17, 19, 46, 66, 86, 222, 224 💬 |
336 | Neuroactive ligand-receptor interaction 💬 146 genes, 309 drugs (DrugBank) and 144 diseases |
CHRM1 [5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 |
D00397 D00397 💬 |
Tropicamide | 006 [2] 6 , 19 💬 |
337 | Neuroactive ligand-receptor interaction 💬 146 genes, 309 drugs (DrugBank) and 144 diseases |
GHR [1] GHR 💬 |
D02691 D02691 💬 |
Somatotropin | 002 [20] 2 , 3 , 13, 19, 46, 74, 75, 76, 78, 96, 113, 187, 191, 193, 195, 236, 265, 274, 276, 299 💬 |
338 | Neuroactive ligand-receptor interaction 💬 146 genes, 309 drugs (DrugBank) and 144 diseases |
NR3C1 [1] NR3C1 💬 |
D00407 D00407 💬 |
Methylprednisolone | 002 [44] 2 , 6 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296 💬 |
339 | Neuroactive ligand-receptor interaction 💬 146 genes, 309 drugs (DrugBank) and 144 diseases |
NR3C1 [1] NR3C1 💬 |
D00751 D00751 💬 |
Methylprednisolone | 002 [44] 2 , 6 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296 💬 |
340 | Neuroactive ligand-receptor interaction 💬 146 genes, 309 drugs (DrugBank) and 144 diseases |
NR3C1 [1] NR3C1 💬 |
D00979 D00979 💬 |
Methylprednisolone | 002 [44] 2 , 6 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296 💬 |
341 | Neuroactive ligand-receptor interaction 💬 146 genes, 309 drugs (DrugBank) and 144 diseases |
NR3C1 [1] NR3C1 💬 |
D05000 D05000 💬 |
Methylprednisolone | 002 [44] 2 , 6 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296 💬 |
342 | Neuroactive ligand-receptor interaction 💬 146 genes, 309 drugs (DrugBank) and 144 diseases |
NR3C1 [1] NR3C1 💬 |
D05001 D05001 💬 |
Methylprednisolone | 002 [44] 2 , 6 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296 💬 |
343 | Neuroactive ligand-receptor interaction 💬 146 genes, 309 drugs (DrugBank) and 144 diseases |
NR3C1 [1] NR3C1 💬 |
D05002 D05002 💬 |
Methylprednisolone | 002 [44] 2 , 6 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296 💬 |
344 | Neuroactive ligand-receptor interaction 💬 146 genes, 309 drugs (DrugBank) and 144 diseases |
NR3C1 [1] NR3C1 💬 |
D00473 D00473 💬 |
Prednisone | 002 [47] 2 , 6 , 11, 13, 14, 19, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 81, 84, 85, 86, 93, 95, 96, 97, 113, 127, 162, 164, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331 💬 |
345 | Neuroactive ligand-receptor interaction 💬 146 genes, 309 drugs (DrugBank) and 144 diseases |
THRA [2] THRA, THRB 💬 |
D01010 D01010 💬 |
Levothyroxine | 019 [4] 19, 49, 78, 222 💬 |
346 | Neuroactive ligand-receptor interaction 💬 146 genes, 309 drugs (DrugBank) and 144 diseases |
THRA [2] THRA, THRB 💬 |
D08125 D08125 💬 |
Levothyroxine | 019 [4] 19, 49, 78, 222 💬 |
347 | Neuroactive ligand-receptor interaction 💬 146 genes, 309 drugs (DrugBank) and 144 diseases |
TRPV1 [1] TRPV1 💬 |
D00250 D00250 💬 |
Capsaicin | 002 [5] 2 , 6 , 19, 86, 226 💬 |
348 | Neutrophil extracellular trap formation 💬 32 genes, 27 drugs (DrugBank) and 56 diseases |
HDAC1 [11] HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9 💬 |
D06320 D06320 💬 |
Vorinostat | 019 [3] 19, 75, 96 💬 |
349 | Neutrophil extracellular trap formation 💬 32 genes, 27 drugs (DrugBank) and 56 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
350 | NF-kappa B signaling pathway 💬 17 genes, 59 drugs (DrugBank) and 82 diseases |
IL1R1 [1] IL1R1 💬 |
D02934 D02934 💬 |
Anakinra | 002 [19] 2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 |
351 | NF-kappa B signaling pathway 💬 17 genes, 59 drugs (DrugBank) and 82 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
352 | NOD-like receptor signaling pathway 💬 29 genes, 38 drugs (DrugBank) and 64 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
353 | Non-alcoholic fatty liver disease 💬 17 genes, 37 drugs (DrugBank) and 80 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
354 | Non-small cell lung cancer 💬 18 genes, 27 drugs (DrugBank) and 42 diseases |
CASP9 [1] CASP9 💬 |
D11195 D11195 💬 |
Rimiducid | 019 [6] 19, 60, 65, 284, 285, 326 💬 |
355 | Notch signaling pathway 💬 7 genes, 3 drugs (DrugBank) and 5 diseases |
HDAC1 [2] HDAC1, HDAC2 💬 |
D06320 D06320 💬 |
Vorinostat | 019 [3] 19, 75, 96 💬 |
356 | One carbon pool by folate 💬 3 genes, 3 drugs (DrugBank) and 36 diseases |
DHFR [2] DHFR, DHFR2 💬 |
D00142 D00142 💬 |
Methotrexate | 011 [35] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 271, 284, 285, 326, 331 💬 |
357 | One carbon pool by folate 💬 3 genes, 3 drugs (DrugBank) and 36 diseases |
DHFR [2] DHFR, DHFR2 💬 |
D02115 D02115 💬 |
Methotrexate | 011 [35] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 271, 284, 285, 326, 331 💬 |
358 | Oocyte meiosis 💬 14 genes, 38 drugs (DrugBank) and 75 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
D00184 D00184 💬 |
Cyclosporine | 011 [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 |
359 | Osteoclast differentiation 💬 34 genes, 58 drugs (DrugBank) and 89 diseases |
IL1R1 [1] IL1R1 💬 |
D02934 D02934 💬 |
Anakinra | 002 [19] 2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 |
360 | Osteoclast differentiation 💬 34 genes, 58 drugs (DrugBank) and 89 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
D00184 D00184 💬 |
Cyclosporine | 011 [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 |
361 | Osteoclast differentiation 💬 34 genes, 58 drugs (DrugBank) and 89 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
362 | Other glycan degradation 💬 2 genes, 5 drugs (DrugBank) and 1 disease |
GBA [1] GBA 💬 |
D02810 D02810 💬 |
Alglucerase | 019 [1] 19 💬 |
363 | Other glycan degradation 💬 2 genes, 5 drugs (DrugBank) and 1 disease |
GBA [1] GBA 💬 |
D03020 D03020 💬 |
Imiglucerase | 019 [1] 19 💬 |
364 | Other glycan degradation 💬 2 genes, 5 drugs (DrugBank) and 1 disease |
GBA [1] GBA 💬 |
D09675 D09675 💬 |
Taliglucerase alfa | 019 [1] 19 💬 |
365 | Other glycan degradation 💬 2 genes, 5 drugs (DrugBank) and 1 disease |
GBA [1] GBA 💬 |
D09029 D09029 💬 |
Velaglucerase alfa | 019 [1] 19 💬 |
366 | Other glycan degradation 💬 2 genes, 5 drugs (DrugBank) and 1 disease |
MAN2B1 [1] MAN2B1 💬 |
D11024 D11024 💬 |
Velmanase alfa | 019 [1] 19 💬 |
367 | Oxytocin signaling pathway 💬 33 genes, 65 drugs (DrugBank) and 99 diseases |
CACNA2D1 [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4 💬 |
D00332 D00332 💬 |
Gabapentin | 006 [5] 6 , 13, 19, 70, 298 💬 |
368 | Oxytocin signaling pathway 💬 33 genes, 65 drugs (DrugBank) and 99 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
D00184 D00184 💬 |
Cyclosporine | 011 [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 |
369 | p53 signaling pathway 💬 3 genes, 3 drugs (DrugBank) and 12 diseases |
CASP9 [1] CASP9 💬 |
D11195 D11195 💬 |
Rimiducid | 019 [6] 19, 60, 65, 284, 285, 326 💬 |
370 | p53 signaling pathway 💬 3 genes, 3 drugs (DrugBank) and 12 diseases |
RRM2 [1] RRM2 💬 |
D00341 D00341 💬 |
Hydroxyurea | 003 [8] 3 , 13, 19, 20, 65, 85, 86, 284 💬 |
371 | Pancreatic cancer 💬 16 genes, 29 drugs (DrugBank) and 64 diseases |
CASP9 [1] CASP9 💬 |
D11195 D11195 💬 |
Rimiducid | 019 [6] 19, 60, 65, 284, 285, 326 💬 |
372 | Pancreatic cancer 💬 16 genes, 29 drugs (DrugBank) and 64 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
373 | Pancreatic secretion 💬 10 genes, 34 drugs (DrugBank) and 33 diseases |
CHRM3 [1] CHRM3 💬 |
D00397 D00397 💬 |
Tropicamide | 006 [2] 6 , 19 💬 |
374 | Parathyroid hormone synthesis, secretion and action 💬 19 genes, 40 drugs (DrugBank) and 58 diseases |
VDR [1] VDR 💬 |
D00188 D00188 💬 |
Cholecalciferol | 006 [23] 6 , 13, 19, 20, 28, 34, 46, 49, 51, 53, 56, 60, 65, 84, 85, 96, 97, 162, 202, 228, 271, 298, 299 💬 |
375 | Parathyroid hormone synthesis, secretion and action 💬 19 genes, 40 drugs (DrugBank) and 58 diseases |
VDR [1] VDR 💬 |
D00930 D00930 💬 |
Paricalcitol | 019 [3] 19, 66, 218 💬 |
376 | Parkinson disease 💬 21 genes, 64 drugs (DrugBank) and 63 diseases |
CASP9 [1] CASP9 💬 |
D11195 D11195 💬 |
Rimiducid | 019 [6] 19, 60, 65, 284, 285, 326 💬 |
377 | Pathogenic Escherichia coli infection 💬 25 genes, 35 drugs (DrugBank) and 71 diseases |
CASP9 [1] CASP9 💬 |
D11195 D11195 💬 |
Rimiducid | 019 [6] 19, 60, 65, 284, 285, 326 💬 |
378 | Pathogenic Escherichia coli infection 💬 25 genes, 35 drugs (DrugBank) and 71 diseases |
IL1R1 [1] IL1R1 💬 |
D02934 D02934 💬 |
Anakinra | 002 [19] 2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 |
379 | Pathogenic Escherichia coli infection 💬 25 genes, 35 drugs (DrugBank) and 71 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
380 | Pathways in cancer 💬 97 genes, 177 drugs (DrugBank) and 130 diseases |
AGTR1 [1] AGTR1 💬 |
D00150 D00150 💬 |
Angiotensin II | 017 [7] 17, 19, 46, 66, 86, 222, 224 💬 |
381 | Pathways in cancer 💬 97 genes, 177 drugs (DrugBank) and 130 diseases |
AGTR1 [1] AGTR1 💬 |
D02014 D02014 💬 |
Angiotensin II | 017 [7] 17, 19, 46, 66, 86, 222, 224 💬 |
382 | Pathways in cancer 💬 97 genes, 177 drugs (DrugBank) and 130 diseases |
AGTR1 [1] AGTR1 💬 |
D00357 D00357 💬 |
Losartan | 017 [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
383 | Pathways in cancer 💬 97 genes, 177 drugs (DrugBank) and 130 diseases |
AGTR1 [1] AGTR1 💬 |
D08146 D08146 💬 |
Losartan | 017 [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
384 | Pathways in cancer 💬 97 genes, 177 drugs (DrugBank) and 130 diseases |
CASP9 [1] CASP9 💬 |
D11195 D11195 💬 |
Rimiducid | 019 [6] 19, 60, 65, 284, 285, 326 💬 |
385 | Pathways in cancer 💬 97 genes, 177 drugs (DrugBank) and 130 diseases |
CSF3R [1] CSF3R 💬 |
D03247 D03247 💬 |
Lenograstim | 002 [7] 2 , 13, 16, 18, 19, 57, 65 💬 |
386 | Pathways in cancer 💬 97 genes, 177 drugs (DrugBank) and 130 diseases |
CXCR4 [1] CXCR4 💬 |
D08971 D08971 💬 |
Plerixafor | 019 [6] 19, 20, 51, 65, 285, 299 💬 |
387 | Pathways in cancer 💬 97 genes, 177 drugs (DrugBank) and 130 diseases |
HDAC1 [2] HDAC1, HDAC2 💬 |
D06320 D06320 💬 |
Vorinostat | 019 [3] 19, 75, 96 💬 |
388 | Pathways in cancer 💬 97 genes, 177 drugs (DrugBank) and 130 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
389 | Pathways in cancer 💬 97 genes, 177 drugs (DrugBank) and 130 diseases |
NQO1 [1] NQO1 💬 |
D00564 D00564 💬 |
Warfarin | 006 [11] 6 , 8 , 13, 19, 46, 49, 66, 85, 88, 96, 97 💬 |
390 | Pathways in cancer 💬 97 genes, 177 drugs (DrugBank) and 130 diseases |
NQO1 [1] NQO1 💬 |
D01280 D01280 💬 |
Warfarin | 006 [11] 6 , 8 , 13, 19, 46, 49, 66, 85, 88, 96, 97 💬 |
391 | Pathways in cancer 💬 97 genes, 177 drugs (DrugBank) and 130 diseases |
NQO1 [1] NQO1 💬 |
D08682 D08682 💬 |
Warfarin | 006 [11] 6 , 8 , 13, 19, 46, 49, 66, 85, 88, 96, 97 💬 |
392 | Pathways of neurodegeneration - multiple diseases 💬 56 genes, 111 drugs (DrugBank) and 117 diseases |
CASP9 [1] CASP9 💬 |
D11195 D11195 💬 |
Rimiducid | 019 [6] 19, 60, 65, 284, 285, 326 💬 |
393 | Pathways of neurodegeneration - multiple diseases 💬 56 genes, 111 drugs (DrugBank) and 117 diseases |
CHRM1 [3] CHRM1, CHRM3, CHRM5 💬 |
D00397 D00397 💬 |
Tropicamide | 006 [2] 6 , 19 💬 |
394 | Pathways of neurodegeneration - multiple diseases 💬 56 genes, 111 drugs (DrugBank) and 117 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
395 | Pathways of neurodegeneration - multiple diseases 💬 56 genes, 111 drugs (DrugBank) and 117 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
D00184 D00184 💬 |
Cyclosporine | 011 [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 |
396 | Pathways of neurodegeneration - multiple diseases 💬 56 genes, 111 drugs (DrugBank) and 117 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
397 | PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 31 genes, 42 drugs (DrugBank) and 89 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
398 | PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 31 genes, 42 drugs (DrugBank) and 89 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
D00184 D00184 💬 |
Cyclosporine | 011 [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 |
399 | Pentose and glucuronate interconversions 💬 1 gene, 1 drug (DrugBank) and 1 disease |
GUSB [1] GUSB 💬 |
D11004 D11004 💬 |
Vestronidase alfa | 019 [1] 19 💬 |
400 | Pertussis 💬 16 genes, 32 drugs (DrugBank) and 65 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
401 | Phospholipase D signaling pathway 💬 23 genes, 45 drugs (DrugBank) and 75 diseases |
AGTR1 [1] AGTR1 💬 |
D00150 D00150 💬 |
Angiotensin II | 017 [7] 17, 19, 46, 66, 86, 222, 224 💬 |
402 | Phospholipase D signaling pathway 💬 23 genes, 45 drugs (DrugBank) and 75 diseases |
AGTR1 [1] AGTR1 💬 |
D02014 D02014 💬 |
Angiotensin II | 017 [7] 17, 19, 46, 66, 86, 222, 224 💬 |
403 | Phospholipase D signaling pathway 💬 23 genes, 45 drugs (DrugBank) and 75 diseases |
AGTR1 [1] AGTR1 💬 |
D00357 D00357 💬 |
Losartan | 017 [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
404 | Phospholipase D signaling pathway 💬 23 genes, 45 drugs (DrugBank) and 75 diseases |
AGTR1 [1] AGTR1 💬 |
D08146 D08146 💬 |
Losartan | 017 [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
405 | Phospholipase D signaling pathway 💬 23 genes, 45 drugs (DrugBank) and 75 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
406 | PI3K-Akt signaling pathway 💬 70 genes, 106 drugs (DrugBank) and 116 diseases |
CASP9 [1] CASP9 💬 |
D11195 D11195 💬 |
Rimiducid | 019 [6] 19, 60, 65, 284, 285, 326 💬 |
407 | PI3K-Akt signaling pathway 💬 70 genes, 106 drugs (DrugBank) and 116 diseases |
CHRM1 [2] CHRM1, CHRM2 💬 |
D00397 D00397 💬 |
Tropicamide | 006 [2] 6 , 19 💬 |
408 | PI3K-Akt signaling pathway 💬 70 genes, 106 drugs (DrugBank) and 116 diseases |
CSF3R [1] CSF3R 💬 |
D03247 D03247 💬 |
Lenograstim | 002 [7] 2 , 13, 16, 18, 19, 57, 65 💬 |
409 | PI3K-Akt signaling pathway 💬 70 genes, 106 drugs (DrugBank) and 116 diseases |
GHR [1] GHR 💬 |
D02691 D02691 💬 |
Somatotropin | 002 [20] 2 , 3 , 13, 19, 46, 74, 75, 76, 78, 96, 113, 187, 191, 193, 195, 236, 265, 274, 276, 299 💬 |
410 | PI3K-Akt signaling pathway 💬 70 genes, 106 drugs (DrugBank) and 116 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
411 | Platinum drug resistance 💬 9 genes, 12 drugs (DrugBank) and 22 diseases |
CASP9 [1] CASP9 💬 |
D11195 D11195 💬 |
Rimiducid | 019 [6] 19, 60, 65, 284, 285, 326 💬 |
412 | Porphyrin and chlorophyll metabolism 💬 5 genes, 4 drugs (DrugBank) and 2 diseases |
GUSB [1] GUSB 💬 |
D11004 D11004 💬 |
Vestronidase alfa | 019 [1] 19 💬 |
413 | Prion disease 💬 40 genes, 59 drugs (DrugBank) and 103 diseases |
CASP9 [1] CASP9 💬 |
D11195 D11195 💬 |
Rimiducid | 019 [6] 19, 60, 65, 284, 285, 326 💬 |
414 | Prion disease 💬 40 genes, 59 drugs (DrugBank) and 103 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
D00184 D00184 💬 |
Cyclosporine | 011 [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 |
415 | Prion disease 💬 40 genes, 59 drugs (DrugBank) and 103 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
416 | Prostate cancer 💬 21 genes, 46 drugs (DrugBank) and 78 diseases |
CASP9 [1] CASP9 💬 |
D11195 D11195 💬 |
Rimiducid | 019 [6] 19, 60, 65, 284, 285, 326 💬 |
417 | Prostate cancer 💬 21 genes, 46 drugs (DrugBank) and 78 diseases |
IL1R2 [1] IL1R2 💬 |
D02934 D02934 💬 |
Anakinra | 002 [19] 2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 |
418 | Prostate cancer 💬 21 genes, 46 drugs (DrugBank) and 78 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
419 | Proteoglycans in cancer 💬 28 genes, 60 drugs (DrugBank) and 92 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
420 | Proteoglycans in cancer 💬 28 genes, 60 drugs (DrugBank) and 92 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
421 | Purine metabolism 💬 30 genes, 31 drugs (DrugBank) and 68 diseases |
IMPDH1 [2] IMPDH1, IMPDH2 💬 |
D00752 D00752 💬 |
Mycophenolate mofetil | 002 [32] 2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬 |
422 | Purine metabolism 💬 30 genes, 31 drugs (DrugBank) and 68 diseases |
IMPDH1 [2] IMPDH1, IMPDH2 💬 |
D05094 D05094 💬 |
Mycophenolate mofetil | 002 [32] 2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬 |
423 | Purine metabolism 💬 30 genes, 31 drugs (DrugBank) and 68 diseases |
IMPDH1 [2] IMPDH1, IMPDH2 💬 |
D05095 D05095 💬 |
Mycophenolate mofetil | 002 [32] 2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬 |
424 | Purine metabolism 💬 30 genes, 31 drugs (DrugBank) and 68 diseases |
IMPDH1 [2] IMPDH1, IMPDH2 💬 |
D05096 D05096 💬 |
Mycophenolic acid | 002 [34] 2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 💬 |
425 | Purine metabolism 💬 30 genes, 31 drugs (DrugBank) and 68 diseases |
RRM1 [1] RRM1 💬 |
D03546 D03546 💬 |
Clofarabine | 019 [9] 19, 20, 40, 46, 49, 60, 96, 234, 326 💬 |
426 | Purine metabolism 💬 30 genes, 31 drugs (DrugBank) and 68 diseases |
RRM1 [1] RRM1 💬 |
D01907 D01907 💬 |
Fludarabine | 013 [18] 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 💬 |
427 | Purine metabolism 💬 30 genes, 31 drugs (DrugBank) and 68 diseases |
RRM1 [1] RRM1 💬 |
D07966 D07966 💬 |
Fludarabine | 013 [18] 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 💬 |
428 | Purine metabolism 💬 30 genes, 31 drugs (DrugBank) and 68 diseases |
RRM2 [1] RRM2 💬 |
D00341 D00341 💬 |
Hydroxyurea | 003 [8] 3 , 13, 19, 20, 65, 85, 86, 284 💬 |
429 | Pyrimidine metabolism 💬 4 genes, 8 drugs (DrugBank) and 32 diseases |
RRM1 [1] RRM1 💬 |
D03546 D03546 💬 |
Clofarabine | 019 [9] 19, 20, 40, 46, 49, 60, 96, 234, 326 💬 |
430 | Pyrimidine metabolism 💬 4 genes, 8 drugs (DrugBank) and 32 diseases |
RRM1 [1] RRM1 💬 |
D01907 D01907 💬 |
Fludarabine | 013 [18] 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 💬 |
431 | Pyrimidine metabolism 💬 4 genes, 8 drugs (DrugBank) and 32 diseases |
RRM1 [1] RRM1 💬 |
D07966 D07966 💬 |
Fludarabine | 013 [18] 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 💬 |
432 | Pyrimidine metabolism 💬 4 genes, 8 drugs (DrugBank) and 32 diseases |
RRM2 [1] RRM2 💬 |
D00341 D00341 💬 |
Hydroxyurea | 003 [8] 3 , 13, 19, 20, 65, 85, 86, 284 💬 |
433 | Regulation of actin cytoskeleton 💬 26 genes, 50 drugs (DrugBank) and 53 diseases |
CHRM1 [5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 |
D00397 D00397 💬 |
Tropicamide | 006 [2] 6 , 19 💬 |
434 | Regulation of actin cytoskeleton 💬 26 genes, 50 drugs (DrugBank) and 53 diseases |
CXCR4 [1] CXCR4 💬 |
D08971 D08971 💬 |
Plerixafor | 019 [6] 19, 20, 51, 65, 285, 299 💬 |
435 | Renin secretion 💬 28 genes, 77 drugs (DrugBank) and 105 diseases |
ACE [1] ACE 💬 |
D00621 D00621 💬 |
Enalapril | 019 [7] 19, 46, 66, 113, 210, 222, 223 💬 |
436 | Renin secretion 💬 28 genes, 77 drugs (DrugBank) and 105 diseases |
ACE [1] ACE 💬 |
D07892 D07892 💬 |
Enalapril | 019 [7] 19, 46, 66, 113, 210, 222, 223 💬 |
437 | Renin secretion 💬 28 genes, 77 drugs (DrugBank) and 105 diseases |
ACE [1] ACE 💬 |
D00362 D00362 💬 |
Lisinopril | 019 [7] 19, 46, 49, 66, 67, 113, 222 💬 |
438 | Renin secretion 💬 28 genes, 77 drugs (DrugBank) and 105 diseases |
ACE [1] ACE 💬 |
D08131 D08131 💬 |
Lisinopril | 019 [7] 19, 46, 49, 66, 67, 113, 222 💬 |
439 | Renin secretion 💬 28 genes, 77 drugs (DrugBank) and 105 diseases |
ACE [1] ACE 💬 |
D00459 D00459 💬 |
Quinapril | 019 [1] 19 💬 |
440 | Renin secretion 💬 28 genes, 77 drugs (DrugBank) and 105 diseases |
ACE [1] ACE 💬 |
D03752 D03752 💬 |
Quinapril | 019 [1] 19 💬 |
441 | Renin secretion 💬 28 genes, 77 drugs (DrugBank) and 105 diseases |
AGTR1 [1] AGTR1 💬 |
D00150 D00150 💬 |
Angiotensin II | 017 [7] 17, 19, 46, 66, 86, 222, 224 💬 |
442 | Renin secretion 💬 28 genes, 77 drugs (DrugBank) and 105 diseases |
AGTR1 [1] AGTR1 💬 |
D02014 D02014 💬 |
Angiotensin II | 017 [7] 17, 19, 46, 66, 86, 222, 224 💬 |
443 | Renin secretion 💬 28 genes, 77 drugs (DrugBank) and 105 diseases |
AGTR1 [1] AGTR1 💬 |
D00357 D00357 💬 |
Losartan | 017 [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
444 | Renin secretion 💬 28 genes, 77 drugs (DrugBank) and 105 diseases |
AGTR1 [1] AGTR1 💬 |
D08146 D08146 💬 |
Losartan | 017 [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
445 | Renin secretion 💬 28 genes, 77 drugs (DrugBank) and 105 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
D00184 D00184 💬 |
Cyclosporine | 011 [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 |
446 | Renin-angiotensin system 💬 6 genes, 21 drugs (DrugBank) and 32 diseases |
ACE [1] ACE 💬 |
D00621 D00621 💬 |
Enalapril | 019 [7] 19, 46, 66, 113, 210, 222, 223 💬 |
447 | Renin-angiotensin system 💬 6 genes, 21 drugs (DrugBank) and 32 diseases |
ACE [1] ACE 💬 |
D07892 D07892 💬 |
Enalapril | 019 [7] 19, 46, 66, 113, 210, 222, 223 💬 |
448 | Renin-angiotensin system 💬 6 genes, 21 drugs (DrugBank) and 32 diseases |
ACE [1] ACE 💬 |
D00362 D00362 💬 |
Lisinopril | 019 [7] 19, 46, 49, 66, 67, 113, 222 💬 |
449 | Renin-angiotensin system 💬 6 genes, 21 drugs (DrugBank) and 32 diseases |
ACE [1] ACE 💬 |
D08131 D08131 💬 |
Lisinopril | 019 [7] 19, 46, 49, 66, 67, 113, 222 💬 |
450 | Renin-angiotensin system 💬 6 genes, 21 drugs (DrugBank) and 32 diseases |
ACE [1] ACE 💬 |
D00459 D00459 💬 |
Quinapril | 019 [1] 19 💬 |
451 | Renin-angiotensin system 💬 6 genes, 21 drugs (DrugBank) and 32 diseases |
ACE [1] ACE 💬 |
D03752 D03752 💬 |
Quinapril | 019 [1] 19 💬 |
452 | Renin-angiotensin system 💬 6 genes, 21 drugs (DrugBank) and 32 diseases |
AGTR1 [1] AGTR1 💬 |
D00357 D00357 💬 |
Losartan | 017 [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
453 | Renin-angiotensin system 💬 6 genes, 21 drugs (DrugBank) and 32 diseases |
AGTR1 [1] AGTR1 💬 |
D08146 D08146 💬 |
Losartan | 017 [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
454 | Renin-angiotensin system 💬 6 genes, 21 drugs (DrugBank) and 32 diseases |
AGTR1 [2] AGTR1, AGTR2 💬 |
D00150 D00150 💬 |
Angiotensin II | 017 [7] 17, 19, 46, 66, 86, 222, 224 💬 |
455 | Renin-angiotensin system 💬 6 genes, 21 drugs (DrugBank) and 32 diseases |
AGTR1 [2] AGTR1, AGTR2 💬 |
D02014 D02014 💬 |
Angiotensin II | 017 [7] 17, 19, 46, 66, 86, 222, 224 💬 |
456 | Rheumatoid arthritis 💬 37 genes, 49 drugs (DrugBank) and 73 diseases |
CD80 [2] CD80, CD86 💬 |
D03203 D03203 💬 |
Abatacept | 011 [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬 |
457 | Rheumatoid arthritis 💬 37 genes, 49 drugs (DrugBank) and 73 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
458 | RIG-I-like receptor signaling pathway 💬 21 genes, 17 drugs (DrugBank) and 53 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
459 | Salivary secretion 💬 16 genes, 58 drugs (DrugBank) and 55 diseases |
CHRM3 [1] CHRM3 💬 |
D00397 D00397 💬 |
Tropicamide | 006 [2] 6 , 19 💬 |
460 | Salmonella infection 💬 25 genes, 32 drugs (DrugBank) and 62 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
461 | Shigellosis 💬 21 genes, 36 drugs (DrugBank) and 83 diseases |
IL1R1 [1] IL1R1 💬 |
D02934 D02934 💬 |
Anakinra | 002 [19] 2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 |
462 | Shigellosis 💬 21 genes, 36 drugs (DrugBank) and 83 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
463 | Shigellosis 💬 21 genes, 36 drugs (DrugBank) and 83 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
464 | Small cell lung cancer 💬 11 genes, 35 drugs (DrugBank) and 51 diseases |
CASP9 [1] CASP9 💬 |
D11195 D11195 💬 |
Rimiducid | 019 [6] 19, 60, 65, 284, 285, 326 💬 |
465 | Sphingolipid metabolism 💬 4 genes, 11 drugs (DrugBank) and 5 diseases |
GBA [1] GBA 💬 |
D02810 D02810 💬 |
Alglucerase | 019 [1] 19 💬 |
466 | Sphingolipid metabolism 💬 4 genes, 11 drugs (DrugBank) and 5 diseases |
GBA [1] GBA 💬 |
D03020 D03020 💬 |
Imiglucerase | 019 [1] 19 💬 |
467 | Sphingolipid metabolism 💬 4 genes, 11 drugs (DrugBank) and 5 diseases |
GBA [1] GBA 💬 |
D09675 D09675 💬 |
Taliglucerase alfa | 019 [1] 19 💬 |
468 | Sphingolipid metabolism 💬 4 genes, 11 drugs (DrugBank) and 5 diseases |
GBA [1] GBA 💬 |
D09029 D09029 💬 |
Velaglucerase alfa | 019 [1] 19 💬 |
469 | Sphingolipid metabolism 💬 4 genes, 11 drugs (DrugBank) and 5 diseases |
GLA [1] GLA 💬 |
D02784 D02784 💬 |
Agalsidase alfa | 019 [1] 19 💬 |
470 | Sphingolipid metabolism 💬 4 genes, 11 drugs (DrugBank) and 5 diseases |
GLA [1] GLA 💬 |
D03228 D03228 💬 |
Agalsidase beta | 019 [1] 19 💬 |
471 | Sphingolipid metabolism 💬 4 genes, 11 drugs (DrugBank) and 5 diseases |
SMPD1 [1] SMPD1 💬 |
D10820 D10820 💬 |
Olipudase alfa | 019 [1] 19 💬 |
472 | Sphingolipid metabolism 💬 4 genes, 11 drugs (DrugBank) and 5 diseases |
UGCG [1] UGCG 💬 |
D09893 D09893 💬 |
Eliglustat | 019 [1] 19 💬 |
473 | Sphingolipid metabolism 💬 4 genes, 11 drugs (DrugBank) and 5 diseases |
UGCG [1] UGCG 💬 |
D11439 D11439 💬 |
Lucerastat | 019 [1] 19 💬 |
474 | Sphingolipid metabolism 💬 4 genes, 11 drugs (DrugBank) and 5 diseases |
UGCG [1] UGCG 💬 |
D05032 D05032 💬 |
Miglustat | 019 [3] 19, 256, 299 💬 |
475 | Sphingolipid metabolism 💬 4 genes, 11 drugs (DrugBank) and 5 diseases |
UGCG [1] UGCG 💬 |
D11633 D11633 💬 |
Venglustat | 006 [3] 6 , 19, 67 💬 |
476 | Sphingolipid signaling pathway 💬 28 genes, 45 drugs (DrugBank) and 69 diseases |
SMPD1 [1] SMPD1 💬 |
D10820 D10820 💬 |
Olipudase alfa | 019 [1] 19 💬 |
477 | Sphingolipid signaling pathway 💬 28 genes, 45 drugs (DrugBank) and 69 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
478 | Spinocerebellar ataxia 💬 16 genes, 23 drugs (DrugBank) and 66 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
479 | Steroid biosynthesis 💬 1 gene, 1 drug (DrugBank) and 1 disease |
LIPA [1] LIPA 💬 |
D10377 D10377 💬 |
Sebelipase alfa | 019 [1] 19 💬 |
480 | Synaptic vesicle cycle 💬 7 genes, 29 drugs (DrugBank) and 37 diseases |
SLC6A1 [1] SLC6A1 💬 |
D00332 D00332 💬 |
Gabapentin | 006 [5] 6 , 13, 19, 70, 298 💬 |
481 | Systemic lupus erythematosus 💬 27 genes, 34 drugs (DrugBank) and 77 diseases |
CD80 [2] CD80, CD86 💬 |
D03203 D03203 💬 |
Abatacept | 011 [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬 |
482 | Systemic lupus erythematosus 💬 27 genes, 34 drugs (DrugBank) and 77 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
483 | T cell receptor signaling pathway 💬 30 genes, 39 drugs (DrugBank) and 77 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
D00184 D00184 💬 |
Cyclosporine | 011 [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 |
484 | T cell receptor signaling pathway 💬 30 genes, 39 drugs (DrugBank) and 77 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
485 | Taste transduction 💬 30 genes, 78 drugs (DrugBank) and 65 diseases |
CHRM3 [1] CHRM3 💬 |
D00397 D00397 💬 |
Tropicamide | 006 [2] 6 , 19 💬 |
486 | Terpenoid backbone biosynthesis 💬 4 genes, 13 drugs (DrugBank) and 48 diseases |
FDPS [1] FDPS 💬 |
D00939 D00939 💬 |
Alendronic acid | 019 [7] 19, 41, 46, 50, 271, 274, 299 💬 |
487 | Terpenoid backbone biosynthesis 💬 4 genes, 13 drugs (DrugBank) and 48 diseases |
FDPS [1] FDPS 💬 |
D07119 D07119 💬 |
Alendronic acid | 019 [7] 19, 41, 46, 50, 271, 274, 299 💬 |
488 | TGF-beta signaling pathway 💬 11 genes, 20 drugs (DrugBank) and 54 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
489 | Th1 and Th2 cell differentiation 💬 44 genes, 33 drugs (DrugBank) and 69 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
D00184 D00184 💬 |
Cyclosporine | 011 [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 |
490 | Th17 cell differentiation 💬 53 genes, 60 drugs (DrugBank) and 96 diseases |
IL1R1 [1] IL1R1 💬 |
D02934 D02934 💬 |
Anakinra | 002 [19] 2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 |
491 | Th17 cell differentiation 💬 53 genes, 60 drugs (DrugBank) and 96 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
492 | Th17 cell differentiation 💬 53 genes, 60 drugs (DrugBank) and 96 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
D00184 D00184 💬 |
Cyclosporine | 011 [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 |
493 | Thermogenesis 💬 17 genes, 27 drugs (DrugBank) and 74 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
494 | Thyroid hormone signaling pathway 💬 22 genes, 35 drugs (DrugBank) and 61 diseases |
CASP9 [1] CASP9 💬 |
D11195 D11195 💬 |
Rimiducid | 019 [6] 19, 60, 65, 284, 285, 326 💬 |
495 | Thyroid hormone signaling pathway 💬 22 genes, 35 drugs (DrugBank) and 61 diseases |
HDAC1 [3] HDAC1, HDAC2, HDAC3 💬 |
D06320 D06320 💬 |
Vorinostat | 019 [3] 19, 75, 96 💬 |
496 | Thyroid hormone signaling pathway 💬 22 genes, 35 drugs (DrugBank) and 61 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
497 | Thyroid hormone signaling pathway 💬 22 genes, 35 drugs (DrugBank) and 61 diseases |
THRA [2] THRA, THRB 💬 |
D01010 D01010 💬 |
Levothyroxine | 019 [4] 19, 49, 78, 222 💬 |
498 | Thyroid hormone signaling pathway 💬 22 genes, 35 drugs (DrugBank) and 61 diseases |
THRA [2] THRA, THRB 💬 |
D08125 D08125 💬 |
Levothyroxine | 019 [4] 19, 49, 78, 222 💬 |
499 | TNF signaling pathway 💬 18 genes, 51 drugs (DrugBank) and 79 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
500 | Toll-like receptor signaling pathway 💬 34 genes, 39 drugs (DrugBank) and 64 diseases |
CD80 [2] CD80, CD86 💬 |
D03203 D03203 💬 |
Abatacept | 011 [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬 |
501 | Toll-like receptor signaling pathway 💬 34 genes, 39 drugs (DrugBank) and 64 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
502 | Toxoplasmosis 💬 38 genes, 36 drugs (DrugBank) and 66 diseases |
CASP9 [1] CASP9 💬 |
D11195 D11195 💬 |
Rimiducid | 019 [6] 19, 60, 65, 284, 285, 326 💬 |
503 | Toxoplasmosis 💬 38 genes, 36 drugs (DrugBank) and 66 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
504 | Transcriptional misregulation in cancer 💬 24 genes, 43 drugs (DrugBank) and 71 diseases |
CD86 [1] CD86 💬 |
D03203 D03203 💬 |
Abatacept | 011 [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬 |
505 | Transcriptional misregulation in cancer 💬 24 genes, 43 drugs (DrugBank) and 71 diseases |
HDAC1 [2] HDAC1, HDAC2 💬 |
D06320 D06320 💬 |
Vorinostat | 019 [3] 19, 75, 96 💬 |
506 | Transcriptional misregulation in cancer 💬 24 genes, 43 drugs (DrugBank) and 71 diseases |
IL1R2 [1] IL1R2 💬 |
D02934 D02934 💬 |
Anakinra | 002 [19] 2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 |
507 | Tuberculosis 💬 60 genes, 61 drugs (DrugBank) and 89 diseases |
CASP9 [1] CASP9 💬 |
D11195 D11195 💬 |
Rimiducid | 019 [6] 19, 60, 65, 284, 285, 326 💬 |
508 | Tuberculosis 💬 60 genes, 61 drugs (DrugBank) and 89 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
D00184 D00184 💬 |
Cyclosporine | 011 [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 |
509 | Tuberculosis 💬 60 genes, 61 drugs (DrugBank) and 89 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
510 | Tuberculosis 💬 60 genes, 61 drugs (DrugBank) and 89 diseases |
VDR [1] VDR 💬 |
D00188 D00188 💬 |
Cholecalciferol | 006 [23] 6 , 13, 19, 20, 28, 34, 46, 49, 51, 53, 56, 60, 65, 84, 85, 96, 97, 162, 202, 228, 271, 298, 299 💬 |
511 | Tuberculosis 💬 60 genes, 61 drugs (DrugBank) and 89 diseases |
VDR [1] VDR 💬 |
D00930 D00930 💬 |
Paricalcitol | 019 [3] 19, 66, 218 💬 |
512 | Type I diabetes mellitus 💬 31 genes, 23 drugs (DrugBank) and 69 diseases |
CD80 [2] CD80, CD86 💬 |
D03203 D03203 💬 |
Abatacept | 011 [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬 |
513 | Type I diabetes mellitus 💬 31 genes, 23 drugs (DrugBank) and 69 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
514 | Type II diabetes mellitus 💬 14 genes, 38 drugs (DrugBank) and 90 diseases |
MTOR [1] MTOR 💬 |
D00753 D00753 💬 |
Sirolimus | 002 [40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬 |
515 | Type II diabetes mellitus 💬 14 genes, 38 drugs (DrugBank) and 90 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
516 | Ubiquinone and other terpenoid-quinone biosynthesis 💬 3 genes, 3 drugs (DrugBank) and 14 diseases |
NQO1 [2] NQO1, VKORC1 💬 |
D00564 D00564 💬 |
Warfarin | 006 [11] 6 , 8 , 13, 19, 46, 49, 66, 85, 88, 96, 97 💬 |
517 | Ubiquinone and other terpenoid-quinone biosynthesis 💬 3 genes, 3 drugs (DrugBank) and 14 diseases |
NQO1 [2] NQO1, VKORC1 💬 |
D01280 D01280 💬 |
Warfarin | 006 [11] 6 , 8 , 13, 19, 46, 49, 66, 85, 88, 96, 97 💬 |
518 | Ubiquinone and other terpenoid-quinone biosynthesis 💬 3 genes, 3 drugs (DrugBank) and 14 diseases |
NQO1 [2] NQO1, VKORC1 💬 |
D08682 D08682 💬 |
Warfarin | 006 [11] 6 , 8 , 13, 19, 46, 49, 66, 85, 88, 96, 97 💬 |
519 | Vascular smooth muscle contraction 💬 30 genes, 71 drugs (DrugBank) and 65 diseases |
AGTR1 [1] AGTR1 💬 |
D00150 D00150 💬 |
Angiotensin II | 017 [7] 17, 19, 46, 66, 86, 222, 224 💬 |
520 | Vascular smooth muscle contraction 💬 30 genes, 71 drugs (DrugBank) and 65 diseases |
AGTR1 [1] AGTR1 💬 |
D02014 D02014 💬 |
Angiotensin II | 017 [7] 17, 19, 46, 66, 86, 222, 224 💬 |
521 | Vascular smooth muscle contraction 💬 30 genes, 71 drugs (DrugBank) and 65 diseases |
AGTR1 [1] AGTR1 💬 |
D00357 D00357 💬 |
Losartan | 017 [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
522 | Vascular smooth muscle contraction 💬 30 genes, 71 drugs (DrugBank) and 65 diseases |
AGTR1 [1] AGTR1 💬 |
D08146 D08146 💬 |
Losartan | 017 [18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 |
523 | VEGF signaling pathway 💬 20 genes, 48 drugs (DrugBank) and 84 diseases |
CASP9 [1] CASP9 💬 |
D11195 D11195 💬 |
Rimiducid | 019 [6] 19, 60, 65, 284, 285, 326 💬 |
524 | VEGF signaling pathway 💬 20 genes, 48 drugs (DrugBank) and 84 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
D00184 D00184 💬 |
Cyclosporine | 011 [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 |
525 | Viral carcinogenesis 💬 27 genes, 19 drugs (DrugBank) and 36 diseases |
HDAC1 [11] HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9 💬 |
D06320 D06320 💬 |
Vorinostat | 019 [3] 19, 75, 96 💬 |
526 | Viral myocarditis 💬 29 genes, 18 drugs (DrugBank) and 46 diseases |
CASP9 [1] CASP9 💬 |
D11195 D11195 💬 |
Rimiducid | 019 [6] 19, 60, 65, 284, 285, 326 💬 |
527 | Viral myocarditis 💬 29 genes, 18 drugs (DrugBank) and 46 diseases |
CD80 [2] CD80, CD86 💬 |
D03203 D03203 💬 |
Abatacept | 011 [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬 |
528 | Viral protein interaction with cytokine and cytokine receptor 💬 17 genes, 27 drugs (DrugBank) and 58 diseases |
CXCR4 [1] CXCR4 💬 |
D08971 D08971 💬 |
Plerixafor | 019 [6] 19, 20, 51, 65, 285, 299 💬 |
529 | Viral protein interaction with cytokine and cytokine receptor 💬 17 genes, 27 drugs (DrugBank) and 58 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |
530 | Wnt signaling pathway 💬 8 genes, 7 drugs (DrugBank) and 56 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
D00184 D00184 💬 |
Cyclosporine | 011 [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 |
531 | Yersinia infection 💬 20 genes, 32 drugs (DrugBank) and 66 diseases |
TNF [1] TNF 💬 |
D02597 D02597 💬 |
Adalimumab | 019 [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 |