DDrare: Database of Drug Development for Rare Diseases

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Acute myeloid leukemia 💬	[1] KIT 💬	D10229 💬	Masitinib	[6] 2 , 5 , 6 , 13, 46, 96 💬
2	Acute myeloid leukemia 💬	[2] MAP2K1, MAP2K2 💬	D10175 💬	Trametinib	[4] 2 , 34, 279, 280 💬
3	Acute myeloid leukemia 💬	[1] MPO 💬	D11684 💬	Verdiperstat	[2] 2 , 17 💬
4	Acute myeloid leukemia 💬	[1] MTOR 💬	D00753 💬	Sirolimus	[40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
5	Acute myeloid leukemia 💬	[2] PML, RARA 💬	D00094 💬	Tretinoin	[5] 2 , 63, 75, 94, 231 💬
6	Adherens junction 💬	[1] SRC 💬	D03252 💬	Bosutinib	[2] 2 , 67 💬
7	Adipocytokine signaling pathway 💬	[1] MTOR 💬	D00753 💬	Sirolimus	[40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
8	Adipocytokine signaling pathway 💬	[2] PRKAA1, PRKAA2 💬	D00944 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
9	Adipocytokine signaling pathway 💬	[2] PRKAA1, PRKAA2 💬	D04966 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
10	Adipocytokine signaling pathway 💬	[1] TNF 💬	D00754 💬	Thalidomide	[20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬

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