DDrare: Database of Drug Development for Rare Diseases

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Adrenergic signaling in cardiomyocytes 💬	[5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬	D00255 💬	Carvedilol	[5] 6 , 57, 86, 113, 210 💬
2	Adrenergic signaling in cardiomyocytes 💬	[5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬	D03415 💬	Carvedilol	[5] 6 , 57, 86, 113, 210 💬
3	Adrenergic signaling in cardiomyocytes 💬	[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬	D00298 💬	Digoxin	[3] 8 , 46, 210 💬
4	Aldosterone synthesis and secretion 💬	[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬	D00298 💬	Digoxin	[3] 8 , 46, 210 💬
5	Aldosterone-regulated sodium reabsorption 💬	[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬	D00298 💬	Digoxin	[3] 8 , 46, 210 💬
6	Aldosterone-regulated sodium reabsorption 💬	[1] NR3C2 💬	D01115 💬	Eplerenone	[4] 75, 113, 210, 215 💬
7	Aldosterone-regulated sodium reabsorption 💬	[1] NR3C2 💬	D00443 💬	Spironolactone	[7] 58, 67, 86, 113, 210, 218, 225 💬
8	Alzheimer disease 💬	[1] PTGS2 💬	D00109 💬	Acetylsalicylic acid	[14] 13, 22, 34, 46, 49, 51, 86, 96, 97, 113, 158, 210, 231, 251 💬
9	Alzheimer disease 💬	[9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬	D00570 💬	Colchicine	[7] 2 , 42, 46, 56, 93, 210, 266 💬
10	AMPK signaling pathway 💬	[1] ADRA1A 💬	D00255 💬	Carvedilol	[5] 6 , 57, 86, 113, 210 💬

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