DDrare: Database of Drug Development for Rare Diseases

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Adipocytokine signaling pathway 💬	[2] PRKAA1, PRKAA2 💬	D00944 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
2	Adipocytokine signaling pathway 💬	[2] PRKAA1, PRKAA2 💬	D04966 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
3	Aldosterone-regulated sodium reabsorption 💬	[1] NR3C2 💬	D00443 💬	Spironolactone	[7] 58, 67, 86, 113, 210, 218, 225 💬
4	Aldosterone-regulated sodium reabsorption 💬	[3] SCNN1A, SCNN1B, SCNN1G 💬	D00649 💬	Amiloride	[3] 13, 225, 299 💬
5	Aldosterone-regulated sodium reabsorption 💬	[3] SCNN1A, SCNN1B, SCNN1G 💬	D07447 💬	Amiloride	[3] 13, 225, 299 💬
6	Alzheimer disease 💬	[1] PTGS2 💬	D00141 💬	Indomethacin	[3] 225, 271, 298 💬
7	Alzheimer disease 💬	[1] PTGS2 💬	D01565 💬	Indomethacin	[3] 225, 271, 298 💬
8	Alzheimer disease 💬	[1] PTGS2 💬	D02110 💬	Indomethacin	[3] 225, 271, 298 💬
9	AMPK signaling pathway 💬	[1] HMGCR 💬	D00887 💬	Atorvastatin	[17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 💬
10	AMPK signaling pathway 💬	[1] HMGCR 💬	D07474 💬	Atorvastatin	[17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 💬

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