DDrare: Database of Drug Development for Rare Diseases

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Alzheimer disease 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00184 💬	Cyclosporine	[43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
2	Amphetamine addiction 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00184 💬	Cyclosporine	[43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
3	Amyotrophic lateral sclerosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00184 💬	Cyclosporine	[43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
4	Axon guidance 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00184 💬	Cyclosporine	[43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
5	B cell receptor signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00184 💬	Cyclosporine	[43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
6	Bile secretion 💬	[1] NR1H4 💬	D00163 💬	Chenodeoxycholic acid	[4] 20, 96, 234, 263 💬
7	Bile secretion 💬	[1] NR1H4 💬	D10699 💬	Cholic Acid	[4] 20, 234, 265, 310 💬
8	Bile secretion 💬	[1] NR1H4 💬	D00734 💬	Ursodeoxycholic acid	[13] 6 , 8 , 20, 67, 84, 93, 94, 95, 96, 97, 234, 296, 299 💬
9	C-type lectin receptor signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00184 💬	Cyclosporine	[43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
10	Calcium signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00184 💬	Cyclosporine	[43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬

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