DDrare: Database of Drug Development for Rare Diseases

Searched query = "Lennox-Gastaut syndrome"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

Drug = Any other approved Antiepileptic Drug; CANNABIDIOL; CBD; CBD - Oral Solution, is known as Epidiolex, and is the approved name in the USA.; CLOBAZAM; Cannabidiol; Cannabidiol (CBD); Cannabidiol Oral Solution; Carisbamate; Clobazam; Clobazam High Dose; Clobazam Low Dose; Clobazam Medium Dose; Clobazam PhEur; Clobazam Pheur; Clobazam Tablets; Clobazam Tablets 10mg; Clobazam Tablets 20mg; Clobazam Tablets 5mg; E2007; E2080; EZOGABINE (US ONLY); EZOGABINE (US only); Ezogabine; Ezogabine/retigabine; FENFLURAMINE HYDROCHLORIDE; Fenfluramine; Fenfluramine HCl, DL-Fenfluramine, (±)-Fenfluramine; Fenfluramine hydrochloride (colorless); Fycompa; GW582892; GWP42003-P; GWP42003-P 20 mg/kg/day Dose; Inovelon; Investigators Choice of Approved AED; Investigators choice of approved AEDs; Lamictal; Lamotrigine; Melatonin; PERAMPANEL; Perampanel; Placebo; Potiga; Procedure: 12-Lead ECG; RETIGABINE; RETIGABINE/EZOGABINE; RUFINAMIDE; Retigabine; Retigabine/Ezogabine; Retigabine/ezogabine; Rufinamide; Rufinamide (E2080); Rufinamide oral suspension; Sodio valproato; TAK-935; Topimarate; Topimarato; Topiramate; Turmeric; ZX008; ZX008 (Fenfluramine Hydrochloride); ZX008 0.2 and 0.8 mg/kg/day; ZX008 0.2 or 0.8 mg/kg/day

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT00297349 (ClinicalTrials.gov)	November 2003	24/2/2006	A Study of the Safety of Topiramate Given in Combination With Other Medications in Adults and Children With Seizures	An Open-label Observation Study of Topiramate Administration as Adjuvant Therapy for Focal Epilepsy, Lennox-Gastaut Syndrome Epileptic Seizures and Generalized Tonoclonic Seizures in Adults and Children Aged 2 Years and Older	Seizures;Epilepsy	Drug: Topiramate	Janssen Cilag Pharmaceutica S.A.C.I., Greece	NULL	Completed	2 Years	N/A	Both	153	N/A	NULL
2	NCT00004776 (ClinicalTrials.gov)	November 1993	24/2/2000	Phase III Randomized, Double-Blind, Placebo-Controlled Study of Oral Topiramate for Lennox-Gastaut Syndrome		Lennox-Gastaut Syndrome	Drug: topiramate	National Center for Research Resources (NCRR)	University of California, Los Angeles	Completed	4 Years	30 Years	Both	10	Phase 3	NULL
3	NCT00236756 (ClinicalTrials.gov)	August 1993	7/10/2005	A Study of the Efficacy and Safety of Topiramate as an add-on Therapy in the Treatment of Epilepsy Patients With Lennox-Gastaut Syndrome	A Double-Blind Trial of Topiramate in Subjects With Lennox-Gastaut Syndrome.	Epilepsy;Seizures	Drug: topiramate	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	NULL	Completed	12 Months	30 Years	Both	100	Phase 3	NULL

No.

TrialID

Date_
enrollment

Date_
registration

Public_title

Scientific_title

Condition

Intervention

Primary_
sponsor

Secondary_
sponsor

Recruitment_
Status

Inclusion_
agemin

Inclusion_
agemax

Inclusion_
gender

Target_
size

Phase

Countries

NCT00297349
(ClinicalTrials.gov)

November 2003

24/2/2006

A Study of the Safety of Topiramate Given in Combination With Other Medications in Adults and Children With Seizures

An Open-label Observation Study of Topiramate Administration as Adjuvant Therapy for Focal Epilepsy, Lennox-Gastaut Syndrome Epileptic Seizures and Generalized Tonoclonic Seizures in Adults and Children Aged 2 Years and Older

Seizures;Epilepsy

Drug: Topiramate

Janssen Cilag Pharmaceutica S.A.C.I., Greece

NULL

Completed

2 Years

N/A

Both

153

N/A

NULL

NCT00004776
(ClinicalTrials.gov)

November 1993

24/2/2000

Phase III Randomized, Double-Blind, Placebo-Controlled Study of Oral Topiramate for Lennox-Gastaut Syndrome

Lennox-Gastaut Syndrome

Drug: topiramate

National Center for Research Resources (NCRR)

University of California, Los Angeles

Completed

4 Years

30 Years

Both

Phase 3

NULL

NCT00236756
(ClinicalTrials.gov)

August 1993

7/10/2005

A Study of the Efficacy and Safety of Topiramate as an add-on Therapy in the Treatment of Epilepsy Patients With Lennox-Gastaut Syndrome

A Double-Blind Trial of Topiramate in Subjects With Lennox-Gastaut Syndrome.

Epilepsy;Seizures

Drug: topiramate

Johnson & Johnson Pharmaceutical Research & Development, L.L.C.

NULL

Completed

12 Months

30 Years

Both

100

Phase 3

NULL