DDrare: Database of Drug Development for Rare Diseases

Searched query = "Toxic epidermal necrolysis", "Toxic epidermal necrosis", "TEN"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

Drug = Clobetasol; Clobetasol 0.05% ointment; Cyclosporine; Cyclosporine 5 mg/kg bid days 0-14; Etanercept; Etanercept 50 mg sc day 0 and day 3; Harmonized supportive care; Infliximab; Intravenous immunoglobulin; Isotretinoin; Methylprednisolone; NaCl 0.9%; Palifermin; Prednisolone; Recombinant granulocyte - colony stimulating factor; Remicaide (infliximab); Site specific standard of care comparison; Topical infliximab

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	JPRN-jRCTs061180044	01/06/2017	12/03/2019	Multicenter Open-trial of Steroid pulse therapy for SJS/TEN	Multicenter Open-trial of Steroid pulse therapy for SJS/TEN - MOSST Study	Stevens-Johnson syndrome and Toxic epidermal necrolysis	1. infusion of methylprednisolone at 500~1000 mg/d (0.9% N/S in 3 hour) for 3 consecutive days. 2. Oral predonisolone (0.5 mg/kg/d) was initiated on the day following the last dose of methylprednisolone, and prednisolone was subsequently tapered within 2 weeks. If the ocular involvement score is more than 2, dose of oral predonisolone (1 mg/kg/d) is recommended.	Morita Eishin	NULL	Not Recruiting	>= 20age old	<= 90age old	Both	20	Phase 2	Taiwan;Germany;Japan

No.

TrialID

Date_
enrollment

Date_
registration

Public_title

Scientific_title

Condition

Intervention

Primary_
sponsor

Secondary_
sponsor

Recruitment_
Status

Inclusion_
agemin

Inclusion_
agemax

Inclusion_
gender

Target_
size

Phase

Countries

JPRN-jRCTs061180044

01/06/2017

12/03/2019

Multicenter Open-trial of Steroid pulse therapy for SJS/TEN

Multicenter Open-trial of Steroid pulse therapy for SJS/TEN - MOSST Study

Stevens-Johnson syndrome and Toxic epidermal necrolysis

1. infusion of methylprednisolone at 500~1000 mg/d
(0.9% N/S in 3 hour) for 3 consecutive days.
2. Oral predonisolone (0.5 mg/kg/d) was initiated on the
day following the last dose of methylprednisolone, and
prednisolone was subsequently tapered within 2 weeks.
If the ocular involvement score is more than 2, dose of
oral predonisolone (1 mg/kg/d) is recommended.

Morita Eishin

NULL

Not Recruiting

>= 20age old

<= 90age old

Both

Phase 2

Taiwan;Germany;Japan