No. |
KEGG PATHWAY * On map, Yellow: Drug target, Red: Disease-related |
KEGG GENES * |
KEGG DRUG * |
DrugBank |
指定難病告示番号 * |
1 | Adrenergic signaling in cardiomyocytes 7 genes, 6 drugs (DrugBank) and 25 diseases shown |
1件: ADRB1 |
D00235 |
Atenolol |
1件: 167 |
D05127 |
Nebivolol |
3件: 17, 113, 167 |
2件: ADRB1, ADRB2 |
D00483 |
Propranolol |
5件: 6, 158, 167, 227, 278 |
D08443 |
1件: AGTR1 |
D00523 |
Irbesartan |
4件: 66, 167, 168, 222 |
D00357 |
Losartan |
18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 |
D08146 |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00619 |
Verapamil |
4件: 96, 130, 140, 167 |
D02356 |
2 | AGE-RAGE signaling pathway in diabetic complications 1 gene, 2 drugs (DrugBank) and 19 diseases shown |
1件: AGTR1 |
D00523 |
Irbesartan |
4件: 66, 167, 168, 222 |
D00357 |
Losartan |
18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 |
D08146 |
3 | Aldosterone synthesis and secretion 5 genes, 3 drugs (DrugBank) and 21 diseases shown |
1件: AGTR1 |
D00523 |
Irbesartan |
4件: 66, 167, 168, 222 |
D00357 |
Losartan |
18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 |
D08146 |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00619 |
Verapamil |
4件: 96, 130, 140, 167 |
D02356 |
4 | Alzheimer disease 4 genes, 1 drug (DrugBank) and 4 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00619 |
Verapamil |
4件: 96, 130, 140, 167 |
D02356 |
5 | Amphetamine addiction 2 genes, 1 drug (DrugBank) and 4 diseases shown |
2件: CACNA1C, CACNA1D |
D00619 |
Verapamil |
4件: 96, 130, 140, 167 |
D02356 |
6 | Apelin signaling pathway 1 gene, 2 drugs (DrugBank) and 19 diseases shown |
1件: AGTR1 |
D00523 |
Irbesartan |
4件: 66, 167, 168, 222 |
D00357 |
Losartan |
18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 |
D08146 |
7 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) 4 genes, 1 drug (DrugBank) and 4 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00619 |
Verapamil |
4件: 96, 130, 140, 167 |
D02356 |
8 | Calcium signaling pathway 8 genes, 6 drugs (DrugBank) and 25 diseases shown |
1件: ADRB1 |
D00235 |
Atenolol |
1件: 167 |
D05127 |
Nebivolol |
3件: 17, 113, 167 |
3件: ADRB1, ADRB2, ADRB3 |
D00483 |
Propranolol |
5件: 6, 158, 167, 227, 278 |
D08443 |
1件: AGTR1 |
D00523 |
Irbesartan |
4件: 66, 167, 168, 222 |
D00357 |
Losartan |
18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 |
D08146 |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00619 |
Verapamil |
4件: 96, 130, 140, 167 |
D02356 |
9 | cAMP signaling pathway 6 genes, 4 drugs (DrugBank) and 10 diseases shown |
1件: ADRB1 |
D00235 |
Atenolol |
1件: 167 |
D05127 |
Nebivolol |
3件: 17, 113, 167 |
2件: ADRB1, ADRB2 |
D00483 |
Propranolol |
5件: 6, 158, 167, 227, 278 |
D08443 |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00619 |
Verapamil |
4件: 96, 130, 140, 167 |
D02356 |
10 | Carbohydrate digestion and absorption 1 gene, 1 drug (DrugBank) and 4 diseases shown |
1件: CACNA1D |
D00619 |
Verapamil |
4件: 96, 130, 140, 167 |
D02356 |
11 | Cardiac muscle contraction 4 genes, 1 drug (DrugBank) and 4 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00619 |
Verapamil |
4件: 96, 130, 140, 167 |
D02356 |
12 | Cellular senescence 1 gene, 1 drug (DrugBank) and 4 diseases shown |
1件: CACNA1D |
D00619 |
Verapamil |
4件: 96, 130, 140, 167 |
D02356 |
13 | cGMP-PKG signaling pathway 8 genes, 6 drugs (DrugBank) and 25 diseases shown |
1件: ADRB1 |
D00235 |
Atenolol |
1件: 167 |
D05127 |
Nebivolol |
3件: 17, 113, 167 |
3件: ADRB1, ADRB2, ADRB3 |
D00483 |
Propranolol |
5件: 6, 158, 167, 227, 278 |
D08443 |
1件: AGTR1 |
D00523 |
Irbesartan |
4件: 66, 167, 168, 222 |
D00357 |
Losartan |
18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 |
D08146 |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00619 |
Verapamil |
4件: 96, 130, 140, 167 |
D02356 |
14 | Chagas disease (American trypanosomiasis) 1 gene, 1 drug (DrugBank) and 2 diseases shown |
1件: ACE |
D00624 |
Perindopril |
2件: 167, 222 |
D03753 |
15 | Cholinergic synapse 4 genes, 1 drug (DrugBank) and 4 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00619 |
Verapamil |
4件: 96, 130, 140, 167 |
D02356 |
16 | Circadian entrainment 2 genes, 1 drug (DrugBank) and 4 diseases shown |
2件: CACNA1C, CACNA1D |
D00619 |
Verapamil |
4件: 96, 130, 140, 167 |
D02356 |
17 | Cortisol synthesis and secretion 5 genes, 3 drugs (DrugBank) and 21 diseases shown |
1件: AGTR1 |
D00523 |
Irbesartan |
4件: 66, 167, 168, 222 |
D00357 |
Losartan |
18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 |
D08146 |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00619 |
Verapamil |
4件: 96, 130, 140, 167 |
D02356 |
18 | Cushing syndrome 5 genes, 3 drugs (DrugBank) and 21 diseases shown |
1件: AGTR1 |
D00523 |
Irbesartan |
4件: 66, 167, 168, 222 |
D00357 |
Losartan |
18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 |
D08146 |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00619 |
Verapamil |
4件: 96, 130, 140, 167 |
D02356 |
19 | Dilated cardiomyopathy (DCM) 5 genes, 4 drugs (DrugBank) and 10 diseases shown |
1件: ADRB1 |
D00235 |
Atenolol |
1件: 167 |
D05127 |
Nebivolol |
3件: 17, 113, 167 |
D00483 |
Propranolol |
5件: 6, 158, 167, 227, 278 |
D08443 |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00619 |
Verapamil |
4件: 96, 130, 140, 167 |
D02356 |
20 | Dopaminergic synapse 2 genes, 1 drug (DrugBank) and 4 diseases shown |
2件: CACNA1C, CACNA1D |
D00619 |
Verapamil |
4件: 96, 130, 140, 167 |
D02356 |
21 | GABAergic synapse 4 genes, 1 drug (DrugBank) and 4 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00619 |
Verapamil |
4件: 96, 130, 140, 167 |
D02356 |
22 | Gap junction 1 gene, 3 drugs (DrugBank) and 7 diseases shown |
1件: ADRB1 |
D00235 |
Atenolol |
1件: 167 |
D05127 |
Nebivolol |
3件: 17, 113, 167 |
D00483 |
Propranolol |
5件: 6, 158, 167, 227, 278 |
D08443 |
23 | Glutamatergic synapse 2 genes, 1 drug (DrugBank) and 4 diseases shown |
2件: CACNA1C, CACNA1D |
D00619 |
Verapamil |
4件: 96, 130, 140, 167 |
D02356 |
24 | GnRH secretion 4 genes, 1 drug (DrugBank) and 4 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00619 |
Verapamil |
4件: 96, 130, 140, 167 |
D02356 |
25 | GnRH signaling pathway 4 genes, 1 drug (DrugBank) and 4 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00619 |
Verapamil |
4件: 96, 130, 140, 167 |
D02356 |
26 | Growth hormone synthesis, secretion and action 4 genes, 1 drug (DrugBank) and 4 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00619 |
Verapamil |
4件: 96, 130, 140, 167 |
D02356 |
27 | Hypertrophic cardiomyopathy (HCM) 5 genes, 2 drugs (DrugBank) and 5 diseases shown |
1件: ACE |
D00624 |
Perindopril |
2件: 167, 222 |
D03753 |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00619 |
Verapamil |
4件: 96, 130, 140, 167 |
D02356 |
28 | Insulin secretion 4 genes, 1 drug (DrugBank) and 4 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00619 |
Verapamil |
4件: 96, 130, 140, 167 |
D02356 |
29 | Long-term potentiation 1 gene, 1 drug (DrugBank) and 4 diseases shown |
1件: CACNA1C |
D00619 |
Verapamil |
4件: 96, 130, 140, 167 |
D02356 |
30 | MAPK signaling pathway 4 genes, 1 drug (DrugBank) and 4 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00619 |
Verapamil |
4件: 96, 130, 140, 167 |
D02356 |
31 | Neuroactive ligand-receptor interaction 4 genes, 5 drugs (DrugBank) and 23 diseases shown |
1件: ADRB1 |
D00235 |
Atenolol |
1件: 167 |
D05127 |
Nebivolol |
3件: 17, 113, 167 |
3件: ADRB1, ADRB2, ADRB3 |
D00483 |
Propranolol |
5件: 6, 158, 167, 227, 278 |
D08443 |
1件: AGTR1 |
D00523 |
Irbesartan |
4件: 66, 167, 168, 222 |
D00357 |
Losartan |
18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 |
D08146 |
32 | Oxytocin signaling pathway 4 genes, 1 drug (DrugBank) and 4 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00619 |
Verapamil |
4件: 96, 130, 140, 167 |
D02356 |
33 | Pathways in cancer 1 gene, 2 drugs (DrugBank) and 19 diseases shown |
1件: AGTR1 |
D00523 |
Irbesartan |
4件: 66, 167, 168, 222 |
D00357 |
Losartan |
18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 |
D08146 |
34 | Phospholipase D signaling pathway 1 gene, 2 drugs (DrugBank) and 19 diseases shown |
1件: AGTR1 |
D00523 |
Irbesartan |
4件: 66, 167, 168, 222 |
D00357 |
Losartan |
18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 |
D08146 |
35 | Regulation of lipolysis in adipocytes 3 genes, 3 drugs (DrugBank) and 7 diseases shown |
1件: ADRB1 |
D00235 |
Atenolol |
1件: 167 |
D05127 |
Nebivolol |
3件: 17, 113, 167 |
3件: ADRB1, ADRB2, ADRB3 |
D00483 |
Propranolol |
5件: 6, 158, 167, 227, 278 |
D08443 |
36 | Renin secretion 10 genes, 8 drugs (DrugBank) and 25 diseases shown |
1件: ACE |
D00624 |
Perindopril |
2件: 167, 222 |
D03753 |
1件: ADRB1 |
D00235 |
Atenolol |
1件: 167 |
D05127 |
Nebivolol |
3件: 17, 113, 167 |
3件: ADRB1, ADRB2, ADRB3 |
D00483 |
Propranolol |
5件: 6, 158, 167, 227, 278 |
D08443 |
1件: AGTR1 |
D00523 |
Irbesartan |
4件: 66, 167, 168, 222 |
D00357 |
Losartan |
18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 |
D08146 |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00619 |
Verapamil |
4件: 96, 130, 140, 167 |
D02356 |
1件: REN |
D03208 |
Aliskiren |
3件: 66, 167, 222 |
37 | Renin-angiotensin system 3 genes, 4 drugs (DrugBank) and 19 diseases shown |
1件: ACE |
D00624 |
Perindopril |
2件: 167, 222 |
D03753 |
1件: AGTR1 |
D00523 |
Irbesartan |
4件: 66, 167, 168, 222 |
D00357 |
Losartan |
18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 |
D08146 |
1件: REN |
D03208 |
Aliskiren |
3件: 66, 167, 222 |
38 | Retrograde endocannabinoid signaling 4 genes, 1 drug (DrugBank) and 4 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00619 |
Verapamil |
4件: 96, 130, 140, 167 |
D02356 |
39 | Salivary secretion 3 genes, 3 drugs (DrugBank) and 7 diseases shown |
1件: ADRB1 |
D00235 |
Atenolol |
1件: 167 |
D05127 |
Nebivolol |
3件: 17, 113, 167 |
3件: ADRB1, ADRB2, ADRB3 |
D00483 |
Propranolol |
5件: 6, 158, 167, 227, 278 |
D08443 |
40 | Serotonergic synapse 4 genes, 1 drug (DrugBank) and 4 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00619 |
Verapamil |
4件: 96, 130, 140, 167 |
D02356 |
41 | Taste transduction 1 gene, 1 drug (DrugBank) and 4 diseases shown |
1件: CACNA1C |
D00619 |
Verapamil |
4件: 96, 130, 140, 167 |
D02356 |
42 | Thermogenesis 1 gene, 1 drug (DrugBank) and 5 diseases shown |
1件: ADRB3 |
D00483 |
Propranolol |
5件: 6, 158, 167, 227, 278 |
D08443 |
43 | Tight junction 1 gene, 1 drug (DrugBank) and 4 diseases shown |
1件: CACNA1D |
D00619 |
Verapamil |
4件: 96, 130, 140, 167 |
D02356 |
44 | Type II diabetes mellitus 2 genes, 1 drug (DrugBank) and 4 diseases shown |
2件: CACNA1C, CACNA1D |
D00619 |
Verapamil |
4件: 96, 130, 140, 167 |
D02356 |
45 | Vascular smooth muscle contraction 5 genes, 3 drugs (DrugBank) and 21 diseases shown |
1件: AGTR1 |
D00523 |
Irbesartan |
4件: 66, 167, 168, 222 |
D00357 |
Losartan |
18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 |
D08146 |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00619 |
Verapamil |
4件: 96, 130, 140, 167 |
D02356 |