No. |
KEGG PATHWAY * On map, Yellow: Drug target, Red: Disease-related |
KEGG GENES * |
KEGG DRUG * |
DrugBank |
指定難病告示番号 * |
1 | Adherens junction 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: IGF1R |
D03297 |
Mecasermin |
6件: 65, 78, 96, 168, 265, 299 |
D04870 |
2 | Adrenergic signaling in cardiomyocytes 7 genes, 5 drugs (DrugBank) and 17 diseases shown |
5件: ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 |
D00095 |
Epinephrine |
9件: 6, 13, 46, 86, 96, 168, 226, 231, 256 |
D00996 |
D02149 |
1件: ADRB1 |
D07660 |
Celiprolol |
1件: 168 |
1件: AGTR1 |
D00523 |
Irbesartan |
4件: 66, 167, 168, 222 |
1件: SCN5A |
D01450 |
Bupivacaine |
7件: 46, 53, 70, 96, 168, 226, 298 |
D07552 |
D00358 |
Lidocaine |
10件: 6, 13, 46, 84, 86, 97, 168, 226, 231, 256 |
D02086 |
D08127 |
3 | AGE-RAGE signaling pathway in diabetic complications 1 gene, 1 drug (DrugBank) and 4 diseases shown |
1件: AGTR1 |
D00523 |
Irbesartan |
4件: 66, 167, 168, 222 |
4 | Aldosterone synthesis and secretion 1 gene, 1 drug (DrugBank) and 4 diseases shown |
1件: AGTR1 |
D00523 |
Irbesartan |
4件: 66, 167, 168, 222 |
5 | AMPK signaling pathway 2 genes, 2 drugs (DrugBank) and 13 diseases shown |
1件: ADRA1A |
D00095 |
Epinephrine |
9件: 6, 13, 46, 86, 96, 168, 226, 231, 256 |
D00996 |
D02149 |
1件: IGF1R |
D03297 |
Mecasermin |
6件: 65, 78, 96, 168, 265, 299 |
D04870 |
6 | Apelin signaling pathway 1 gene, 1 drug (DrugBank) and 4 diseases shown |
1件: AGTR1 |
D00523 |
Irbesartan |
4件: 66, 167, 168, 222 |
7 | Autophagy - animal 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: IGF1R |
D03297 |
Mecasermin |
6件: 65, 78, 96, 168, 265, 299 |
D04870 |
8 | Breast cancer 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: IGF1R |
D03297 |
Mecasermin |
6件: 65, 78, 96, 168, 265, 299 |
D04870 |
9 | Calcium signaling pathway 7 genes, 3 drugs (DrugBank) and 12 diseases shown |
6件: ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3 |
D00095 |
Epinephrine |
9件: 6, 13, 46, 86, 96, 168, 226, 231, 256 |
D00996 |
D02149 |
1件: ADRB1 |
D07660 |
Celiprolol |
1件: 168 |
1件: AGTR1 |
D00523 |
Irbesartan |
4件: 66, 167, 168, 222 |
10 | cAMP signaling pathway 2 genes, 2 drugs (DrugBank) and 9 diseases shown |
1件: ADRB1 |
D07660 |
Celiprolol |
1件: 168 |
2件: ADRB1, ADRB2 |
D00095 |
Epinephrine |
9件: 6, 13, 46, 86, 96, 168, 226, 231, 256 |
D00996 |
D02149 |
11 | cGMP-PKG signaling pathway 10 genes, 3 drugs (DrugBank) and 12 diseases shown |
9件: ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 |
D00095 |
Epinephrine |
9件: 6, 13, 46, 86, 96, 168, 226, 231, 256 |
D00996 |
D02149 |
1件: ADRB1 |
D07660 |
Celiprolol |
1件: 168 |
1件: AGTR1 |
D00523 |
Irbesartan |
4件: 66, 167, 168, 222 |
12 | Cortisol synthesis and secretion 1 gene, 1 drug (DrugBank) and 4 diseases shown |
1件: AGTR1 |
D00523 |
Irbesartan |
4件: 66, 167, 168, 222 |
13 | Cushing syndrome 1 gene, 1 drug (DrugBank) and 4 diseases shown |
1件: AGTR1 |
D00523 |
Irbesartan |
4件: 66, 167, 168, 222 |
14 | Cytokine-cytokine receptor interaction 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: GHR |
D03297 |
Mecasermin |
6件: 65, 78, 96, 168, 265, 299 |
D04870 |
15 | Dilated cardiomyopathy (DCM) 1 gene, 2 drugs (DrugBank) and 9 diseases shown |
1件: ADRB1 |
D07660 |
Celiprolol |
1件: 168 |
D00095 |
Epinephrine |
9件: 6, 13, 46, 86, 96, 168, 226, 231, 256 |
D00996 |
D02149 |
16 | Dopaminergic synapse 1 gene, 2 drugs (DrugBank) and 14 diseases shown |
1件: SCN1A |
D01450 |
Bupivacaine |
7件: 46, 53, 70, 96, 168, 226, 298 |
D07552 |
D00358 |
Lidocaine |
10件: 6, 13, 46, 84, 86, 97, 168, 226, 231, 256 |
D02086 |
D08127 |
17 | EGFR tyrosine kinase inhibitor resistance 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: IGF1R |
D03297 |
Mecasermin |
6件: 65, 78, 96, 168, 265, 299 |
D04870 |
18 | Endocrine resistance 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: IGF1R |
D03297 |
Mecasermin |
6件: 65, 78, 96, 168, 265, 299 |
D04870 |
19 | Endocytosis 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: IGF1R |
D03297 |
Mecasermin |
6件: 65, 78, 96, 168, 265, 299 |
D04870 |
20 | Focal adhesion 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: IGF1R |
D03297 |
Mecasermin |
6件: 65, 78, 96, 168, 265, 299 |
D04870 |
21 | FoxO signaling pathway 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: IGF1R |
D03297 |
Mecasermin |
6件: 65, 78, 96, 168, 265, 299 |
D04870 |
22 | Gap junction 1 gene, 2 drugs (DrugBank) and 9 diseases shown |
1件: ADRB1 |
D07660 |
Celiprolol |
1件: 168 |
D00095 |
Epinephrine |
9件: 6, 13, 46, 86, 96, 168, 226, 231, 256 |
D00996 |
D02149 |
23 | Glioma 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: IGF1R |
D03297 |
Mecasermin |
6件: 65, 78, 96, 168, 265, 299 |
D04870 |
24 | Growth hormone synthesis, secretion and action 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: GHR |
D03297 |
Mecasermin |
6件: 65, 78, 96, 168, 265, 299 |
D04870 |
25 | Hepatocellular carcinoma 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: IGF1R |
D03297 |
Mecasermin |
6件: 65, 78, 96, 168, 265, 299 |
D04870 |
26 | HIF-1 signaling pathway 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: IGF1R |
D03297 |
Mecasermin |
6件: 65, 78, 96, 168, 265, 299 |
D04870 |
27 | JAK-STAT signaling pathway 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: GHR |
D03297 |
Mecasermin |
6件: 65, 78, 96, 168, 265, 299 |
D04870 |
28 | Long-term depression 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: IGF1R |
D03297 |
Mecasermin |
6件: 65, 78, 96, 168, 265, 299 |
D04870 |
29 | Longevity regulating pathway 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: IGF1R |
D03297 |
Mecasermin |
6件: 65, 78, 96, 168, 265, 299 |
D04870 |
30 | Longevity regulating pathway - multiple species 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: IGF1R |
D03297 |
Mecasermin |
6件: 65, 78, 96, 168, 265, 299 |
D04870 |
31 | MAPK signaling pathway 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: IGF1R |
D03297 |
Mecasermin |
6件: 65, 78, 96, 168, 265, 299 |
D04870 |
32 | Melanoma 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: IGF1R |
D03297 |
Mecasermin |
6件: 65, 78, 96, 168, 265, 299 |
D04870 |
33 | mTOR signaling pathway 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: IGF1R |
D03297 |
Mecasermin |
6件: 65, 78, 96, 168, 265, 299 |
D04870 |
34 | Neuroactive ligand-receptor interaction 11 genes, 4 drugs (DrugBank) and 16 diseases shown |
9件: ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 |
D00095 |
Epinephrine |
9件: 6, 13, 46, 86, 96, 168, 226, 231, 256 |
D00996 |
D02149 |
1件: ADRB1 |
D07660 |
Celiprolol |
1件: 168 |
1件: AGTR1 |
D00523 |
Irbesartan |
4件: 66, 167, 168, 222 |
1件: GHR |
D03297 |
Mecasermin |
6件: 65, 78, 96, 168, 265, 299 |
D04870 |
35 | Oocyte meiosis 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: IGF1R |
D03297 |
Mecasermin |
6件: 65, 78, 96, 168, 265, 299 |
D04870 |
36 | Ovarian steroidogenesis 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: IGF1R |
D03297 |
Mecasermin |
6件: 65, 78, 96, 168, 265, 299 |
D04870 |
37 | Pathways in cancer 2 genes, 2 drugs (DrugBank) and 9 diseases shown |
1件: AGTR1 |
D00523 |
Irbesartan |
4件: 66, 167, 168, 222 |
1件: IGF1R |
D03297 |
Mecasermin |
6件: 65, 78, 96, 168, 265, 299 |
D04870 |
38 | Phospholipase D signaling pathway 1 gene, 1 drug (DrugBank) and 4 diseases shown |
1件: AGTR1 |
D00523 |
Irbesartan |
4件: 66, 167, 168, 222 |
39 | PI3K-Akt signaling pathway 2 genes, 1 drug (DrugBank) and 6 diseases shown |
2件: GHR, IGF1R |
D03297 |
Mecasermin |
6件: 65, 78, 96, 168, 265, 299 |
D04870 |
40 | Progesterone-mediated oocyte maturation 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: IGF1R |
D03297 |
Mecasermin |
6件: 65, 78, 96, 168, 265, 299 |
D04870 |
41 | Prostate cancer 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: IGF1R |
D03297 |
Mecasermin |
6件: 65, 78, 96, 168, 265, 299 |
D04870 |
42 | Proteoglycans in cancer 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: IGF1R |
D03297 |
Mecasermin |
6件: 65, 78, 96, 168, 265, 299 |
D04870 |
43 | Rap1 signaling pathway 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: IGF1R |
D03297 |
Mecasermin |
6件: 65, 78, 96, 168, 265, 299 |
D04870 |
44 | Ras signaling pathway 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: IGF1R |
D03297 |
Mecasermin |
6件: 65, 78, 96, 168, 265, 299 |
D04870 |
45 | Regulation of lipolysis in adipocytes 3 genes, 2 drugs (DrugBank) and 9 diseases shown |
1件: ADRB1 |
D07660 |
Celiprolol |
1件: 168 |
3件: ADRB1, ADRB2, ADRB3 |
D00095 |
Epinephrine |
9件: 6, 13, 46, 86, 96, 168, 226, 231, 256 |
D00996 |
D02149 |
46 | Renin secretion 4 genes, 3 drugs (DrugBank) and 12 diseases shown |
1件: ADRB1 |
D07660 |
Celiprolol |
1件: 168 |
3件: ADRB1, ADRB2, ADRB3 |
D00095 |
Epinephrine |
9件: 6, 13, 46, 86, 96, 168, 226, 231, 256 |
D00996 |
D02149 |
1件: AGTR1 |
D00523 |
Irbesartan |
4件: 66, 167, 168, 222 |
47 | Renin-angiotensin system 1 gene, 1 drug (DrugBank) and 4 diseases shown |
1件: AGTR1 |
D00523 |
Irbesartan |
4件: 66, 167, 168, 222 |
48 | Salivary secretion 6 genes, 2 drugs (DrugBank) and 9 diseases shown |
6件: ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3 |
D00095 |
Epinephrine |
9件: 6, 13, 46, 86, 96, 168, 226, 231, 256 |
D00996 |
D02149 |
1件: ADRB1 |
D07660 |
Celiprolol |
1件: 168 |
49 | Signaling pathways regulating pluripotency of stem cells 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: IGF1R |
D03297 |
Mecasermin |
6件: 65, 78, 96, 168, 265, 299 |
D04870 |
50 | Taste transduction 3 genes, 2 drugs (DrugBank) and 14 diseases shown |
3件: SCN2A, SCN3A, SCN9A |
D01450 |
Bupivacaine |
7件: 46, 53, 70, 96, 168, 226, 298 |
D07552 |
D00358 |
Lidocaine |
10件: 6, 13, 46, 84, 86, 97, 168, 226, 231, 256 |
D02086 |
D08127 |
51 | Thermogenesis 1 gene, 1 drug (DrugBank) and 9 diseases shown |
1件: ADRB3 |
D00095 |
Epinephrine |
9件: 6, 13, 46, 86, 96, 168, 226, 231, 256 |
D00996 |
D02149 |
52 | Transcriptional misregulation in cancer 1 gene, 1 drug (DrugBank) and 6 diseases shown |
1件: IGF1R |
D03297 |
Mecasermin |
6件: 65, 78, 96, 168, 265, 299 |
D04870 |
53 | Vascular smooth muscle contraction 4 genes, 2 drugs (DrugBank) and 12 diseases shown |
3件: ADRA1A, ADRA1B, ADRA1D |
D00095 |
Epinephrine |
9件: 6, 13, 46, 86, 96, 168, 226, 231, 256 |
D00996 |
D02149 |
1件: AGTR1 |
D00523 |
Irbesartan |
4件: 66, 167, 168, 222 |