No. |
KEGG PATHWAY * On map, Yellow: Drug target, Red: Disease-related |
KEGG GENES * |
KEGG DRUG * |
DrugBank |
指定難病告示番号 * |
1 | ABC transporters 1 gene, 1 drug (DrugBank) and 1 disease shown |
1件: ABCC8 |
D00294 |
Diazoxide |
1件: 193 |
2 | Adrenergic signaling in cardiomyocytes 6 genes, 2 drugs (DrugBank) and 11 diseases shown |
1件: ADRB1 |
D00601 |
Metoprolol |
7件: 17, 57, 58, 66, 113, 193, 226 |
D02358 |
D05011 |
5件: CACNA1C, CACNA1D, CACNA1F, CACNA1S, SCN5A |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
3 | Aldosterone synthesis and secretion 5 genes, 2 drugs (DrugBank) and 16 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
1件: MC2R |
D00146 |
Corticotropin |
12件: 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 |
4 | Alzheimer disease 4 genes, 1 drug (DrugBank) and 5 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
5 | Amphetamine addiction 6 genes, 1 drug (DrugBank) and 5 diseases shown |
6件: CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
6 | Amyotrophic lateral sclerosis (ALS) 2 genes, 1 drug (DrugBank) and 5 diseases shown |
2件: GRIA1, GRIA2 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
7 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) 4 genes, 1 drug (DrugBank) and 5 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
8 | Bile secretion 1 gene, 1 drug (DrugBank) and 5 diseases shown |
1件: CA2 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
9 | Calcium signaling pathway 6 genes, 4 drugs (DrugBank) and 13 diseases shown |
1件: ADRB1 |
D00601 |
Metoprolol |
7件: 17, 57, 58, 66, 113, 193, 226 |
D02358 |
D05011 |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
1件: OXTR |
D07229 |
Carbetocin |
1件: 193 |
D00089 |
Oxytocin |
4件: 127, 193, 206, 226 |
10 | cAMP signaling pathway 13 genes, 8 drugs (DrugBank) and 29 diseases shown |
1件: ADRB1 |
D00601 |
Metoprolol |
7件: 17, 57, 58, 66, 113, 193, 226 |
D02358 |
D05011 |
8件: CACNA1C, CACNA1D, CACNA1F, CACNA1S, GRIA1, GRIA2, GRIA3, GRIA4 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
1件: GLP1R |
D04121 |
Exenatide |
3件: 6, 193, 233 |
D06404 |
Liraglutide |
3件: 6, 75, 193 |
1件: MC2R |
D00146 |
Corticotropin |
12件: 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 |
1件: OXTR |
D07229 |
Carbetocin |
1件: 193 |
D00089 |
Oxytocin |
4件: 127, 193, 206, 226 |
1件: SSTR2 |
D00442 |
Octreotide |
8件: 67, 75, 84, 85, 89, 96, 193, 227 |
D06495 |
11 | Carbohydrate digestion and absorption 1 gene, 1 drug (DrugBank) and 5 diseases shown |
1件: CACNA1D |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
12 | Cardiac muscle contraction 4 genes, 1 drug (DrugBank) and 5 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
13 | Cellular senescence 1 gene, 1 drug (DrugBank) and 5 diseases shown |
1件: CACNA1D |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
14 | cGMP-PKG signaling pathway 6 genes, 3 drugs (DrugBank) and 11 diseases shown |
1件: ADRA2A |
D00606 |
Guanfacine |
1件: 193 |
D08031 |
1件: ADRB1 |
D00601 |
Metoprolol |
7件: 17, 57, 58, 66, 113, 193, 226 |
D02358 |
D05011 |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
15 | Cholinergic synapse 4 genes, 1 drug (DrugBank) and 5 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
16 | Circadian entrainment 6 genes, 1 drug (DrugBank) and 5 diseases shown |
6件: CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
17 | Cocaine addiction 1 gene, 1 drug (DrugBank) and 5 diseases shown |
1件: GRIA2 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
18 | Collecting duct acid secretion 1 gene, 1 drug (DrugBank) and 5 diseases shown |
1件: CA2 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
19 | Cortisol synthesis and secretion 6 genes, 3 drugs (DrugBank) and 16 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
1件: CYP11B1 |
D00410 |
Metyrapone |
2件: 75, 193 |
D05019 |
1件: MC2R |
D00146 |
Corticotropin |
12件: 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 |
20 | Cushing syndrome 6 genes, 3 drugs (DrugBank) and 16 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
1件: CYP11B1 |
D00410 |
Metyrapone |
2件: 75, 193 |
D05019 |
1件: MC2R |
D00146 |
Corticotropin |
12件: 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 |
21 | Cytokine-cytokine receptor interaction 1 gene, 1 drug (DrugBank) and 18 diseases shown |
1件: GHR |
D02691 |
Somatotropin |
18件: 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 |
22 | Dilated cardiomyopathy (DCM) 5 genes, 2 drugs (DrugBank) and 11 diseases shown |
1件: ADRB1 |
D00601 |
Metoprolol |
7件: 17, 57, 58, 66, 113, 193, 226 |
D02358 |
D05011 |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
23 | Dopaminergic synapse 7 genes, 1 drug (DrugBank) and 5 diseases shown |
7件: CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, SCN1A |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
24 | GABAergic synapse 20 genes, 1 drug (DrugBank) and 5 diseases shown |
20件: CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
25 | Gap junction 1 gene, 1 drug (DrugBank) and 7 diseases shown |
1件: ADRB1 |
D00601 |
Metoprolol |
7件: 17, 57, 58, 66, 113, 193, 226 |
D02358 |
D05011 |
26 | Gastric acid secretion 2 genes, 2 drugs (DrugBank) and 12 diseases shown |
1件: CA2 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
1件: SSTR2 |
D00442 |
Octreotide |
8件: 67, 75, 84, 85, 89, 96, 193, 227 |
D06495 |
27 | Glutamatergic synapse 11 genes, 1 drug (DrugBank) and 5 diseases shown |
11件: CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
28 | GnRH secretion 5 genes, 2 drugs (DrugBank) and 5 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
1件: KCNJ11 |
D00294 |
Diazoxide |
1件: 193 |
29 | GnRH signaling pathway 4 genes, 1 drug (DrugBank) and 5 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
30 | Growth hormone synthesis, secretion and action 6 genes, 3 drugs (DrugBank) and 27 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
1件: GHR |
D02691 |
Somatotropin |
18件: 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 |
1件: SSTR2 |
D00442 |
Octreotide |
8件: 67, 75, 84, 85, 89, 96, 193, 227 |
D06495 |
31 | Hypertrophic cardiomyopathy (HCM) 4 genes, 1 drug (DrugBank) and 5 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
32 | Insulin secretion 7 genes, 4 drugs (DrugBank) and 7 diseases shown |
2件: ABCC8, KCNJ11 |
D00294 |
Diazoxide |
1件: 193 |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
1件: GLP1R |
D04121 |
Exenatide |
3件: 6, 193, 233 |
D06404 |
Liraglutide |
3件: 6, 75, 193 |
33 | JAK-STAT signaling pathway 1 gene, 1 drug (DrugBank) and 18 diseases shown |
1件: GHR |
D02691 |
Somatotropin |
18件: 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 |
34 | Long-term depression 3 genes, 1 drug (DrugBank) and 5 diseases shown |
3件: GRIA1, GRIA2, GRIA3 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
35 | Long-term potentiation 3 genes, 1 drug (DrugBank) and 5 diseases shown |
3件: CACNA1C, GRIA1, GRIA2 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
36 | MAPK signaling pathway 4 genes, 1 drug (DrugBank) and 5 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
37 | Metabolic pathways 4 genes, 3 drugs (DrugBank) and 8 diseases shown |
2件: CA2, CA4 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
1件: CYP11B1 |
D00410 |
Metyrapone |
2件: 75, 193 |
D05019 |
1件: CYP19A1 |
D00960 |
Anastrozole |
3件: 78, 86, 193 |
38 | Morphine addiction 16 genes, 1 drug (DrugBank) and 5 diseases shown |
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
39 | Neuroactive ligand-receptor interaction 34 genes, 12 drugs (DrugBank) and 44 diseases shown |
1件: ADRA2A |
D00606 |
Guanfacine |
1件: 193 |
D08031 |
1件: ADRB1 |
D00601 |
Metoprolol |
7件: 17, 57, 58, 66, 113, 193, 226 |
D02358 |
D05011 |
1件: CNR1 |
D05731 |
Rimonabant |
1件: 193 |
2件: CNR1, CNR2 |
D10915 |
Cannabidiol |
14件: 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 |
25件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
1件: GHR |
D02691 |
Somatotropin |
18件: 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 |
1件: GLP1R |
D04121 |
Exenatide |
3件: 6, 193, 233 |
D06404 |
Liraglutide |
3件: 6, 75, 193 |
1件: MC2R |
D00146 |
Corticotropin |
12件: 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 |
1件: OXTR |
D07229 |
Carbetocin |
1件: 193 |
D00089 |
Oxytocin |
4件: 127, 193, 206, 226 |
1件: SSTR2 |
D00442 |
Octreotide |
8件: 67, 75, 84, 85, 89, 96, 193, 227 |
D06495 |
40 | Nicotine addiction 20 genes, 1 drug (DrugBank) and 5 diseases shown |
20件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
41 | Nitrogen metabolism 2 genes, 1 drug (DrugBank) and 5 diseases shown |
2件: CA2, CA4 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
42 | Ovarian steroidogenesis 1 gene, 1 drug (DrugBank) and 3 diseases shown |
1件: CYP19A1 |
D00960 |
Anastrozole |
3件: 78, 86, 193 |
43 | Oxytocin signaling pathway 5 genes, 3 drugs (DrugBank) and 8 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
1件: OXTR |
D07229 |
Carbetocin |
1件: 193 |
D00089 |
Oxytocin |
4件: 127, 193, 206, 226 |
44 | Pancreatic secretion 1 gene, 1 drug (DrugBank) and 5 diseases shown |
1件: CA2 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
45 | PI3K-Akt signaling pathway 1 gene, 1 drug (DrugBank) and 18 diseases shown |
1件: GHR |
D02691 |
Somatotropin |
18件: 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 |
46 | Proximal tubule bicarbonate reclamation 2 genes, 1 drug (DrugBank) and 5 diseases shown |
2件: CA2, CA4 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
47 | Rap1 signaling pathway 1 gene, 2 drugs (DrugBank) and 14 diseases shown |
1件: CNR1 |
D10915 |
Cannabidiol |
14件: 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 |
D05731 |
Rimonabant |
1件: 193 |
48 | Regulation of lipolysis in adipocytes 1 gene, 1 drug (DrugBank) and 7 diseases shown |
1件: ADRB1 |
D00601 |
Metoprolol |
7件: 17, 57, 58, 66, 113, 193, 226 |
D02358 |
D05011 |
49 | Renin secretion 5 genes, 2 drugs (DrugBank) and 11 diseases shown |
1件: ADRB1 |
D00601 |
Metoprolol |
7件: 17, 57, 58, 66, 113, 193, 226 |
D02358 |
D05011 |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
50 | Retrograde endocannabinoid signaling 25 genes, 3 drugs (DrugBank) and 15 diseases shown |
24件: CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
1件: CNR1 |
D10915 |
Cannabidiol |
14件: 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 |
D05731 |
Rimonabant |
1件: 193 |
51 | Salivary secretion 1 gene, 1 drug (DrugBank) and 7 diseases shown |
1件: ADRB1 |
D00601 |
Metoprolol |
7件: 17, 57, 58, 66, 113, 193, 226 |
D02358 |
D05011 |
52 | Serotonergic synapse 7 genes, 1 drug (DrugBank) and 5 diseases shown |
7件: CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRB1, GABRB2, GABRB3 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
53 | Steroid hormone biosynthesis 2 genes, 2 drugs (DrugBank) and 4 diseases shown |
1件: CYP11B1 |
D00410 |
Metyrapone |
2件: 75, 193 |
D05019 |
1件: CYP19A1 |
D00960 |
Anastrozole |
3件: 78, 86, 193 |
54 | Taste transduction 10 genes, 1 drug (DrugBank) and 5 diseases shown |
10件: CACNA1C, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, SCN2A, SCN3A, SCN9A |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
55 | Thermogenesis 1 gene, 2 drugs (DrugBank) and 14 diseases shown |
1件: CNR1 |
D10915 |
Cannabidiol |
14件: 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 |
D05731 |
Rimonabant |
1件: 193 |
56 | Tight junction 1 gene, 1 drug (DrugBank) and 5 diseases shown |
1件: CACNA1D |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
57 | Transcriptional misregulation in cancer 1 gene, 1 drug (DrugBank) and 5 diseases shown |
1件: GRIA3 |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
58 | Type II diabetes mellitus 4 genes, 2 drugs (DrugBank) and 5 diseases shown |
2件: ABCC8, KCNJ11 |
D00294 |
Diazoxide |
1件: 193 |
2件: CACNA1C, CACNA1D |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |
59 | Vascular smooth muscle contraction 4 genes, 1 drug (DrugBank) and 5 diseases shown |
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S |
D00537 |
Topiramate |
5件: 6, 140, 144, 156, 193 |