Target Gene/Pathway(薬物標的遺伝子/パスウェイリスト)
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z other
No. | KEGG PATHWAY * On map, Yellow: Drug target, Red: Disease-related |
KEGG GENES * | KEGG DRUG * | DrugBank | 指定難病告示番号 * |
1 | Adipocytokine signaling pathway |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
2 | African trypanosomiasis |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
3 | AGE-RAGE signaling pathway in diabetic complications |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
4 | Allograft rejection |
2件: CD80, CD86 | D03203 | Abatacept | 24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 | ||
5 | Alzheimer disease |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
6 | Amoebiasis |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
7 | Amyotrophic lateral sclerosis (ALS) |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
8 | Antifolate resistance |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
9 | Antigen processing and presentation |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
10 | Apoptosis |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
11 | Asthma |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
12 | Autoimmune thyroid disease |
2件: CD80, CD86 | D03203 | Abatacept | 24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 |
13 | C-type lectin receptor signaling pathway |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
14 | Cell adhesion molecules (CAMs) |
2件: CD80, CD86 | D03203 | Abatacept | 24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 |
15 | Chagas disease (American trypanosomiasis) |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
16 | Cytokine-cytokine receptor interaction |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
17 | Dilated cardiomyopathy (DCM) |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
18 | Drug metabolism - other enzymes |
2件: IMPDH1, IMPDH2 | D00752 | Mycophenolate mofetil | 32件: 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 |
D05094 | |||||
D05095 | |||||
D05096 | Mycophenolic acid | 34件: 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 | |||
19 | Epstein-Barr virus infection |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
20 | Fc epsilon RI signaling pathway |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
21 | Fluid shear stress and atherosclerosis |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
22 | Graft-versus-host disease |
2件: CD80, CD86 | D03203 | Abatacept | 24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 | ||
23 | Hematopoietic cell lineage |
1件: MS4A1 | D02994 | Rituximab | 42件: 11, 13, 14, 17, 35, 36, 43, 44, 45, 46, 49, 50, 51, 52, 53, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 223, 229, 256, 271, 283, 284, 285, 288, 300, 331 |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 | ||
24 | Hepatitis B |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
25 | Hepatitis C |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
26 | Herpes simplex virus 1 infection |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
27 | Human cytomegalovirus infection |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
28 | Human immunodeficiency virus 1 infection |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
29 | Human papillomavirus infection |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
30 | Human T-cell leukemia virus 1 infection |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
31 | Hypertrophic cardiomyopathy (HCM) |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
32 | IL-17 signaling pathway |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
33 | Inflammatory bowel disease (IBD) |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
34 | Influenza A |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
35 | Insulin resistance |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
36 | Intestinal immune network for IgA production |
2件: CD80, CD86 | D03203 | Abatacept | 24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 |
37 | Kaposi sarcoma-associated herpesvirus infection |
1件: CD86 | D03203 | Abatacept | 24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 |
38 | Legionellosis |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
39 | Leishmaniasis |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
40 | Malaria |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
41 | MAPK signaling pathway |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
42 | Metabolic pathways |
1件: DHODH | D00749 | Leflunomide | 10件: 11, 40, 46, 49, 53, 66, 162, 224, 271, 300 |
2件: IMPDH1, IMPDH2 | D00752 | Mycophenolate mofetil | 32件: 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 | ||
D05094 | |||||
D05095 | |||||
D05096 | Mycophenolic acid | 34件: 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 | |||
43 | mTOR signaling pathway |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
44 | Natural killer cell mediated cytotoxicity |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
45 | Necroptosis |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
46 | Neuroactive ligand-receptor interaction |
1件: NR3C1 | D00472 | Prednisolone | 38件: 11, 13, 25, 26, 35, 38, 39, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 |
D00980 | |||||
D00981 | |||||
D00982 | |||||
D01239 | |||||
D01998 | |||||
D02156 | |||||
D03301 | |||||
D00473 | Prednisone | 44件: 2, 11, 13, 14, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 81, 84, 85, 86, 95, 96, 97, 113, 145, 162, 164, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331 | |||
47 | NF-kappa B signaling pathway |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
48 | NOD-like receptor signaling pathway |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
49 | Non-alcoholic fatty liver disease (NAFLD) |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
50 | Osteoclast differentiation |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
51 | Pathogenic Escherichia coli infection |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
52 | Pertussis |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
53 | Proteoglycans in cancer |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
54 | Purine metabolism |
2件: IMPDH1, IMPDH2 | D00752 | Mycophenolate mofetil | 32件: 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 |
D05094 | |||||
D05095 | |||||
D05096 | Mycophenolic acid | 34件: 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 | |||
55 | Pyrimidine metabolism |
1件: DHODH | D00749 | Leflunomide | 10件: 11, 40, 46, 49, 53, 66, 162, 224, 271, 300 |
56 | Rheumatoid arthritis |
2件: CD80, CD86 | D03203 | Abatacept | 24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 | ||
57 | RIG-I-like receptor signaling pathway |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
58 | Shigellosis |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
59 | Sphingolipid signaling pathway |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
60 | Systemic lupus erythematosus |
2件: CD80, CD86 | D03203 | Abatacept | 24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 | ||
61 | T cell receptor signaling pathway |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
62 | TGF-beta signaling pathway |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
63 | TNF signaling pathway |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
64 | Toll-like receptor signaling pathway |
2件: CD80, CD86 | D03203 | Abatacept | 24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 | ||
65 | Toxoplasmosis |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
66 | Transcriptional misregulation in cancer |
1件: CD86 | D03203 | Abatacept | 24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 |
67 | Tuberculosis |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
68 | Type I diabetes mellitus |
2件: CD80, CD86 | D03203 | Abatacept | 24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 | ||
69 | Type II diabetes mellitus |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
70 | Viral myocarditis |
2件: CD80, CD86 | D03203 | Abatacept | 24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 |
71 | Viral protein interaction with cytokine and cytokine receptor |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |
72 | Yersinia infection |
1件: TNF | D04687 | Lenalidomide | 8件: 16, 26, 28, 34, 49, 96, 284, 300 |