No. |
Drug (Description in trials) |
DrugBank |
KEGG DRUG * |
KEGG GENES * [Number of genes] |
KEGG PATHWAY [Number of pathways] |
Disease ID * [Number of diseases] |
1 |
Ac-203 1% topical ointment |
- |
- |
- |
- |
[1] 162 |
2 |
Acetate |
Acetate |
- |
- |
- |
[40] 1, 2, 6, 10, 13, 35, 40, 46, 49, 51, 60, 64, 70, 71, 73, 75, 76, 78, 81, 83, 85, 86, 88, 90, 96, 97, 113, 145, 156, 162, 171, 206, 222, 224, 225, 235, 265, 288, 298, 299 |
3 |
Arava |
Leflunomide |
D00749 |
[1] DHODH |
[2] Metabolic pathways, Pyrimidine metabolism |
[2] 46, 162 |
4 |
Azathioprine |
Azathioprine |
D00238, D03033 |
- |
- |
[18] 11, 13, 19, 35, 42, 43, 44, 45, 46, 49, 65, 66, 85, 94, 95, 96, 97, 162 |
5 |
Azathioprine or mycophenolate mofetil |
Mycophenolate mofetil |
D00752, D05094, D05095 |
[2] IMPDH1, IMPDH2 |
[3] Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism |
[1] 162 |
6 |
Bertilimumab |
- |
- |
- |
- |
[2] 97, 162 |
7 |
Biv009 |
- |
- |
- |
- |
[2] 61, 162 |
8 |
Blood test |
- |
- |
- |
- |
[5] 36, 86, 113, 162, 299 |
9 |
Carboxymethylcellulose |
Carboxymethylcellulose |
D07622 |
- |
- |
[2] 35, 162 |
10 |
Cellcept® in autoimmune bullous dermatoses |
- |
- |
- |
- |
[2] 35, 162 |
11 |
Cellulose |
Microcrystalline cellulose |
D00093 |
- |
- |
[2] 35, 162 |
12 |
Clobetasol |
Clobetasol |
D07715 |
[1] NR3C1 |
[1] Neuroactive ligand-receptor interaction |
[2] 39, 162 |
13 |
Clobetasol 0.05% topical ointment |
Clobetasol |
D07715 |
[1] NR3C1 |
[1] Neuroactive ligand-receptor interaction |
[1] 162 |
14 |
Clobetasol propionate |
Clobetasol propionate |
D01272, D07715 |
[1] NR3C1 |
[1] Neuroactive ligand-receptor interaction |
[1] 162 |
15 |
Clobetasol propionate + methotrexate |
Clobetasol propionate |
D01272, D07715 |
[1] NR3C1 |
[1] Neuroactive ligand-receptor interaction |
[1] 162 |
16 |
Clobetasol propionate alone |
Clobetasol propionate |
D01272, D07715 |
[1] NR3C1 |
[1] Neuroactive ligand-receptor interaction |
[1] 162 |
17 |
Clobetasol propionate cream treatment |
Clobetasol propionate |
D01272, D07715 |
[1] NR3C1 |
[1] Neuroactive ligand-receptor interaction |
[1] 162 |
18 |
Collagenase |
Collagenase clostridium histolyticum |
D09596 |
- |
- |
[1] 162 |
19 |
Cortancyl |
Prednisone acetate |
D08416 |
[1] NR3C1 |
[1] Neuroactive ligand-receptor interaction |
[3] 35, 41, 162 |
20 |
Cortancyl 20 mg |
Prednisone acetate |
D08416 |
[1] NR3C1 |
[1] Neuroactive ligand-receptor interaction |
[2] 35, 162 |
21 |
Cotton |
Cotton |
- |
- |
- |
[2] 35, 162 |
22 |
Cultivated oral mucosal epithelial sheet transplantation |
- |
- |
- |
- |
[2] 38, 162 |
23 |
Cyclophosphamide |
Cyclophosphamide |
D00287, D07760 |
- |
- |
[43] 13, 14, 16, 19, 20, 26, 28, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 56, 60, 61, 62, 65, 66, 84, 85, 93, 96, 162, 164, 172, 222, 224, 265, 274, 283, 284, 285, 288, 326, 331 |
24 |
Cyclophosphamide 50mg oral tablet |
Cyclophosphamide |
D00287, D07760 |
- |
- |
[1] 162 |
25 |
Cyclosporine |
Ciclosporin |
D00184 |
[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 |
[30] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis (ALS), Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway |
[33] 11, 14, 19, 20, 28, 36, 40, 41, 42, 45, 46, 49, 50, 53, 56, 58, 60, 62, 64, 65, 90, 95, 97, 162, 164, 222, 226, 228, 234, 283, 284, 285, 302 |
26 |
Data report |
- |
- |
- |
- |
[1] 162 |
27 |
Dermoval |
- |
- |
- |
- |
[2] 35, 162 |
28 |
Df2156a |
- |
- |
- |
- |
[1] 162 |
29 |
Doxycycline |
Doxycycline |
D00307, D02129, D03903, D03904, D07876 |
- |
- |
[15] 13, 23, 28, 46, 84, 85, 89, 96, 97, 158, 162, 167, 227, 280, 299 |
30 |
Halometasone |
Halometasone |
D07202 |
[1] NR3C1 |
[1] Neuroactive ligand-receptor interaction |
[1] 162 |
31 |
Imatinib |
Imatinib |
D01441, D08066 |
[3] ABL1, KIT, PDGFRA |
[32] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Shigellosis, Viral myocarditis |
[11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 |
32 |
Infliximab |
Infliximab |
D02598 |
[1] TNF |
[61] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis (ALS), Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease (American trypanosomiasis), Cytokine-cytokine receptor interaction, Dilated cardiomyopathy (DCM), Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy (HCM), IL-17 signaling pathway, Inflammatory bowel disease (IBD), Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease (NAFLD), Osteoclast differentiation, Pathogenic Escherichia coli infection, Pertussis, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway |
[22] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 95, 96, 97, 98, 162, 164, 269, 271 |
33 |
Ixekizumab |
Ixekizumab |
D10071 |
[1] IL17A |
[5] Cytokine-cytokine receptor interaction, IL-17 signaling pathway, Inflammatory bowel disease (IBD), Rheumatoid arthritis, Th17 cell differentiation |
[4] 37, 162, 269, 271 |
34 |
Ladarixin |
- |
- |
- |
- |
[1] 162 |
35 |
Mabthera |
- |
- |
- |
- |
[15] 11, 13, 35, 46, 50, 51, 53, 61, 63, 64, 65, 83, 162, 222, 271 |
36 |
Mabthéra |
- |
- |
- |
- |
[2] 35, 162 |
37 |
Mathéra |
- |
- |
- |
- |
[2] 35, 162 |
38 |
Mepolizumab |
Mepolizumab |
D04923 |
[1] IL5 |
[13] Allograft rejection, Asthma, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Fc epsilon RI signaling pathway, Hematopoietic cell lineage, IL-17 signaling pathway, Inflammatory bowel disease (IBD), Intestinal immune network for IgA production, JAK-STAT signaling pathway, Pathways in cancer, T cell receptor signaling pathway, Th1 and Th2 cell differentiation |
[4] 44, 45, 98, 162 |
39 |
Mepolizumab (a-il-5 antibody) |
Mepolizumab |
D04923 |
[1] IL5 |
[13] Allograft rejection, Asthma, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Fc epsilon RI signaling pathway, Hematopoietic cell lineage, IL-17 signaling pathway, Inflammatory bowel disease (IBD), Intestinal immune network for IgA production, JAK-STAT signaling pathway, Pathways in cancer, T cell receptor signaling pathway, Th1 and Th2 cell differentiation |
[1] 162 |
40 |
Methotrexate |
Methotrexate |
D00142, D02115 |
[2] DHFR, DHFR2 |
[4] Antifolate resistance, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
[33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 |
41 |
Minocycline |
Minocycline |
D00850, D05045 |
- |
- |
[13] 2, 6, 8, 13, 46, 85, 90, 94, 162, 201, 206, 280, 299 |
42 |
Mitomycin |
Mitomycin |
D00208 |
- |
- |
[3] 94, 162, 329 |
43 |
Mycophenolate |
Mycophenolic acid |
D05096 |
[2] IMPDH1, IMPDH2 |
[3] Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism |
[33] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 |
44 |
Mycophenolate mofetil |
Mycophenolate mofetil |
D00752, D05094, D05095 |
[2] IMPDH1, IMPDH2 |
[3] Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism |
[32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 |
45 |
Myfortic 180 mg |
- |
- |
- |
- |
[1] 162 |
46 |
Myfortic 180 mg filmtabletten |
- |
- |
- |
- |
[1] 162 |
47 |
Nicotinamide |
Nicotinamide |
D00036 |
- |
- |
[3] 6, 49, 162 |
48 |
Npb-01 |
- |
- |
- |
- |
[3] 13, 14, 162 |
49 |
Omalizumab |
Omalizumab |
D05251 |
[1] FCER1A |
[4] Asthma, Fc epsilon RI signaling pathway, Phospholipase D signaling pathway, Sphingolipid signaling pathway |
[6] 53, 65, 98, 162, 226, 299 |
50 |
Petrolatum |
Petrolatum |
D05304, D05331 |
- |
- |
[3] 35, 158, 162 |
51 |
Prednisolone |
Prednisolone |
D00472, D00980, D00981, D00982, D01239, D01998, D02156, D03301 |
[1] NR3C1 |
[1] Neuroactive ligand-receptor interaction |
[38] 11, 13, 25, 26, 35, 38, 39, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 |
52 |
Prednisone |
Prednisone |
D00473 |
[1] NR3C1 |
[1] Neuroactive ligand-receptor interaction |
[43] 2, 11, 13, 14, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 81, 84, 85, 86, 95, 96, 97, 113, 162, 164, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331 |
53 |
Qge031 |
- |
- |
- |
- |
[1] 162 |
54 |
Restasis |
Ciclosporin |
D00184 |
[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 |
[30] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis (ALS), Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway |
[2] 53, 162 |
55 |
Riboflavin |
Riboflavin |
D00050, D01622, D01913 |
- |
- |
[8] 13, 38, 46, 96, 97, 162, 168, 265 |
56 |
Rituximab |
Rituximab |
D02994 |
[1] MS4A1 |
[1] Hematopoietic cell lineage |
[42] 11, 13, 14, 17, 35, 36, 43, 44, 45, 46, 49, 50, 51, 52, 53, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 223, 229, 256, 271, 283, 284, 285, 288, 300, 331 |
57 |
Rituximab 1g iv |
Rituximab |
D02994 |
[1] MS4A1 |
[1] Hematopoietic cell lineage |
[1] 162 |
58 |
Rituximab combined with omalizumab |
Omalizumab |
D05251 |
[1] FCER1A |
[4] Asthma, Fc epsilon RI signaling pathway, Phospholipase D signaling pathway, Sphingolipid signaling pathway |
[1] 162 |
59 |
Rva576 |
- |
- |
- |
- |
[3] 62, 109, 162 |
60 |
Silver |
Silver |
- |
- |
- |
[2] 35, 162 |
61 |
Simvastatin |
Simvastatin |
D00434 |
[1] HMGCR |
[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
[19] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 162, 195, 265, 298, 299, 310 |
62 |
Simvastatin-ratiopharm |
Simvastatin |
D00434 |
[1] HMGCR |
[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
[1] 162 |
63 |
Simvastatin-ratiopharm® |
Simvastatin |
D00434 |
[1] HMGCR |
[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis |
[1] 162 |
64 |
Solu-medrone |
- |
- |
- |
- |
[3] 51, 83, 162 |
65 |
Topical infliximab |
Infliximab |
D02598 |
[1] TNF |
[61] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis (ALS), Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease (American trypanosomiasis), Cytokine-cytokine receptor interaction, Dilated cardiomyopathy (DCM), Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy (HCM), IL-17 signaling pathway, Inflammatory bowel disease (IBD), Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease (NAFLD), Osteoclast differentiation, Pathogenic Escherichia coli infection, Pertussis, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway |
[3] 38, 39, 162 |
66 |
Treatment systemic therapy (prednisone) |
Prednisone |
D00473 |
[1] NR3C1 |
[1] Neuroactive ligand-receptor interaction |
[1] 162 |
67 |
Treatment with systemic therapy (doxycycline) |
Doxycycline |
D00307, D02129, D03903, D03904, D07876 |
- |
- |
[1] 162 |
68 |
Treatment with systemic therapy (methotrexate) |
Methotrexate |
D00142, D02115 |
[2] DHFR, DHFR2 |
[4] Antifolate resistance, Folate biosynthesis, Metabolic pathways, One carbon pool by folate |
[1] 162 |
69 |
Treatment with systemic therapy (prednisone) |
Prednisone |
D00473 |
[1] NR3C1 |
[1] Neuroactive ligand-receptor interaction |
[1] 162 |
70 |
Treatment with topical superpotent corticosteroid therapy |
- |
- |
- |
- |
[1] 162 |
71 |
Tripterygium |
Tripterygium wilfordii whole |
- |
- |
- |
[8] 46, 66, 67, 96, 162, 222, 224, 271 |
72 |
Ustekinumab |
Ustekinumab |
D09214 |
[3] IL12A, IL12B, IL23A |
[25] African trypanosomiasis, Allograft rejection, Amoebiasis, C-type lectin receptor signaling pathway, Chagas disease (American trypanosomiasis), Cytokine-cytokine receptor interaction, Herpes simplex virus 1 infection, Inflammatory bowel disease (IBD), Influenza A, JAK-STAT signaling pathway, Legionellosis, Leishmaniasis, Malaria, Measles, Pathways in cancer, Pertussis, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus |
[15] 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 |