No. |
Drug (Description in trials) |
DrugBank |
KEGG DRUG * |
KEGG GENES * [Number of genes] |
KEGG PATHWAY [Number of pathways] |
Disease ID * [Number of diseases] |
1 |
5-[4-[2-(5-(1-hydroxyethyl)-2-pyridinyl)ethoxy]benzyl]-2,4-thiazolidinedione hydrochloride |
- |
- |
- |
- |
[1] 20 |
2 |
Acetylcysteine |
Acetylcysteine |
D00221 |
- |
- |
[14] 6, 13, 19, 20, 49, 51, 58, 85, 94, 111, 164, 233, 298, 299 |
3 |
Alemtuzumab |
Alemtuzumab |
D02802 |
- |
- |
[13] 13, 15, 19, 20, 46, 51, 60, 63, 65, 85, 96, 164, 284 |
4 |
Autologous cd34+ cells transduced with lenti-d vector encoding abcd1 cdna |
- |
- |
- |
- |
[1] 20 |
5 |
Autologous haematopoietic stem cells transduced with lentiviral vector lenti-d encoding the human abcd1 cdna |
- |
- |
- |
- |
[1] 20 |
6 |
Bezafibrate |
Bezafibrate |
D01366 |
[1] PPARA |
[7] Adipocytokine signaling pathway, Glucagon signaling pathway, Hepatitis C, Insulin resistance, Non-alcoholic fatty liver disease (NAFLD), PPAR signaling pathway, cAMP signaling pathway |
[5] 20, 93, 94, 160, 316 |
7 |
Biotin |
Biotin |
D00029 |
- |
- |
[3] 2, 13, 20 |
8 |
Busulfan |
Busulfan |
D00248 |
- |
- |
[13] 19, 20, 28, 36, 49, 51, 60, 65, 164, 274, 284, 285, 326 |
9 |
Busulfan, cyclophosphamide, antithymocyte globulin |
Cyclophosphamide |
D00287, D07760 |
- |
- |
[2] 19, 20 |
10 |
Cald hr-d (high-risk, regimen c) |
- |
- |
- |
- |
[4] 19, 20, 234, 326 |
11 |
Cald hr-d (high-risk, regimen d) |
- |
- |
- |
- |
[4] 19, 20, 234, 326 |
12 |
Cald sr-a (standard-risk, regimen a) |
- |
- |
- |
- |
[4] 19, 20, 234, 326 |
13 |
Cald sr-b (standard-risk, regimen b) |
- |
- |
- |
- |
[4] 19, 20, 234, 326 |
14 |
Campath-1h |
Alemtuzumab |
D02802 |
- |
- |
[6] 19, 20, 60, 234, 285, 326 |
15 |
Chenodeoxycholic acid |
Chenodeoxycholic acid |
D00163 |
[1] NR1H4 |
[1] Bile secretion |
[4] 20, 96, 234, 263 |
16 |
Cholic acid |
Cholic acid |
D10699 |
[1] NR1H4 |
[1] Bile secretion |
[4] 20, 234, 265, 310 |
17 |
Cholic acids |
- |
- |
- |
- |
[2] 20, 234 |
18 |
Clofarabine |
Clofarabine |
D03546 |
[3] POLA1, POLA2, RRM1 |
[6] DNA replication, Drug metabolism - other enzymes, Glutathione metabolism, Metabolic pathways, Purine metabolism, Pyrimidine metabolism |
[9] 19, 20, 40, 46, 49, 60, 96, 234, 326 |
19 |
Cyclophosphamide |
Cyclophosphamide |
D00287, D07760 |
- |
- |
[43] 13, 14, 16, 19, 20, 26, 28, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 56, 60, 61, 62, 65, 66, 84, 85, 93, 96, 162, 164, 172, 222, 224, 265, 274, 283, 284, 285, 288, 326, 331 |
20 |
Cyclosporine |
Ciclosporin |
D00184 |
[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 |
[30] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis (ALS), Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway |
[33] 11, 14, 19, 20, 28, 36, 40, 41, 42, 45, 46, 49, 50, 53, 56, 58, 60, 62, 64, 65, 90, 95, 97, 162, 164, 222, 226, 228, 234, 283, 284, 285, 302 |
21 |
Cyclosporine a |
Ciclosporin |
D00184 |
[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 |
[30] Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis (ALS), Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway |
[8] 19, 20, 36, 49, 53, 58, 60, 234 |
22 |
D-biotin |
Biotin |
D00029 |
- |
- |
[2] 13, 20 |
23 |
Duoc-01 |
- |
- |
- |
- |
[2] 19, 20 |
24 |
Genetic |
- |
- |
- |
- |
[1] 20 |
25 |
Glyceryl trierucate |
Glyceryl trierucate |
- |
- |
- |
[1] 20 |
26 |
Glyceryl trioleate |
Glyceryl trioleate |
- |
- |
- |
[1] 20 |
27 |
Hematopoietic stem cell infusion |
- |
- |
- |
- |
[2] 19, 20 |
28 |
Hematopoietic stem cell transplantation |
- |
- |
- |
- |
[12] 11, 13, 14, 19, 20, 35, 46, 49, 51, 96, 234, 285 |
29 |
Human placental derived stem cell |
- |
- |
- |
- |
[4] 19, 20, 60, 284 |
30 |
Hydroxyurea |
Hydroxyurea |
D00341 |
[1] RRM2 |
[6] Drug metabolism - other enzymes, Glutathione metabolism, Metabolic pathways, Purine metabolism, Pyrimidine metabolism, p53 signaling pathway |
[8] 3, 13, 19, 20, 65, 85, 86, 284 |
31 |
Imd preparative regimen |
- |
- |
- |
- |
[4] 19, 20, 234, 326 |
32 |
Interferon beta |
Human interferon beta |
- |
- |
- |
[6] 13, 14, 20, 26, 96, 97 |
33 |
Lenti-d drug product |
- |
- |
- |
- |
[1] 20 |
34 |
Lipoic acid |
Lipoic acid |
D00048, D00086 |
- |
- |
[5] 2, 5, 13, 14, 20 |
35 |
Lorenzo's oil |
- |
- |
- |
- |
[1] 20 |
36 |
Md1003 |
- |
- |
- |
- |
[5] 2, 10, 13, 14, 20 |
37 |
Md1003 100 mg capsule |
- |
- |
- |
- |
[1] 20 |
38 |
Melphalan |
Melphalan |
D00369 |
- |
- |
[14] 11, 13, 14, 19, 20, 28, 60, 62, 65, 96, 164, 234, 284, 285 |
39 |
Mesenchymal stem cells |
- |
- |
- |
- |
[11] 2, 6, 13, 20, 49, 51, 60, 96, 222, 274, 299 |
40 |
Min-102 |
- |
- |
- |
- |
[1] 20 |
41 |
Modified cobratoxin |
- |
- |
- |
- |
[1] 20 |
42 |
Mycophenolate |
Mycophenolic acid |
D05096 |
[2] IMPDH1, IMPDH2 |
[3] Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism |
[33] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 |
43 |
Mycophenolate mofetil |
Mycophenolate mofetil |
D00752, D05094, D05095 |
[2] IMPDH1, IMPDH2 |
[3] Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism |
[32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 |
44 |
Mycophenylate mofetil |
- |
- |
- |
- |
[2] 19, 20 |
45 |
N-acetylcysteine |
Acetylcysteine |
D00221 |
- |
- |
[10] 6, 13, 19, 20, 49, 58, 85, 111, 164, 299 |
46 |
Osteopetrosis haploidentical only preparative regimen |
- |
- |
- |
- |
[4] 19, 20, 234, 326 |
47 |
Osteopetrosis only preparative regimen |
- |
- |
- |
- |
[4] 19, 20, 234, 326 |
48 |
Pioglitazone |
Pioglitazone |
D00945, D08378 |
[1] PPARG |
[9] AMPK signaling pathway, Huntington disease, Longevity regulating pathway, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer |
[17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 |
49 |
Rpi78m |
Rpi78m |
- |
- |
- |
[1] 20 |
50 |
Rpi78m for injection |
Rpi78m |
- |
- |
- |
[1] 20 |
51 |
Sobetirome |
Sobetirome |
D09381 |
[1] THRB |
[2] Neuroactive ligand-receptor interaction, Thyroid hormone signaling pathway |
[1] 20 |
52 |
Sobetirome (nv1205) |
Sobetirome |
D09381 |
[1] THRB |
[2] Neuroactive ligand-receptor interaction, Thyroid hormone signaling pathway |
[1] 20 |
53 |
Stem cell transplantation |
- |
- |
- |
- |
[9] 13, 19, 20, 46, 65, 90, 164, 234, 326 |
54 |
Thalidomide |
Thalidomide |
D00754 |
[1] TNF |
[61] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis (ALS), Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease (American trypanosomiasis), Cytokine-cytokine receptor interaction, Dilated cardiomyopathy (DCM), Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy (HCM), IL-17 signaling pathway, Inflammatory bowel disease (IBD), Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease (NAFLD), Osteoclast differentiation, Pathogenic Escherichia coli infection, Pertussis, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway |
[18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 |
55 |
Thiotepa |
Thiotepa |
D00583 |
- |
- |
[11] 13, 19, 20, 28, 51, 60, 65, 85, 96, 164, 284 |
56 |
Thiotepa--escalated dose |
Thiotepa |
D00583 |
- |
- |
[4] 19, 20, 65, 284 |
57 |
Thiotepa--single daily dose |
Thiotepa |
D00583 |
- |
- |
[4] 19, 20, 65, 284 |
58 |
Ursodiol |
Ursodeoxycholic acid |
D00734 |
[1] NR1H4 |
[1] Bile secretion |
[6] 8, 20, 93, 97, 234, 299 |
59 |
Vitamin d3 |
Cholecalciferol |
D00188 |
[1] VDR |
[4] Endocrine and other factor-regulated calcium reabsorption, Mineral absorption, Parathyroid hormone synthesis, secretion and action, Tuberculosis |
[11] 6, 13, 20, 46, 49, 53, 60, 65, 96, 97, 299 |
60 |
Vitamin e |
Vitamin e |
D02331 |
- |
- |
[11] 2, 6, 13, 20, 46, 90, 96, 97, 206, 299, 317 |