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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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43 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Acute myeloid leukemia 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 2  Adipocytokine signaling pathway 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 3  AMPK signaling pathway 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 4  Apelin signaling pathway 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 5  Autophagy - animal 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 6  Autophagy - other 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 7  Breast cancer 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 8  Cellular senescence 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 9  Central carbon metabolism in cancer 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 10  Choline metabolism in cancer 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 11  Colorectal cancer 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 12  EGFR tyrosine kinase inhibitor resistance 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 13  Endocrine resistance 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 14  ErbB signaling pathway 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 15  Gastric cancer 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 16  Glioma 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 17  Growth hormone synthesis, secretion and action 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 18  Hepatocellular carcinoma 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 19  Herpes simplex virus 1 infection 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 20  HIF-1 signaling pathway 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 21  Human cytomegalovirus infection 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 22  Human immunodeficiency virus 1 infection 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 23  Human papillomavirus infection 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 24  Insulin resistance 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 25  Insulin signaling pathway 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 26  JAK-STAT signaling pathway 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 27  Kaposi sarcoma-associated herpesvirus infection 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 28  Longevity regulating pathway 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 29  Longevity regulating pathway - multiple species 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 30  MicroRNAs in cancer 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 31  mTOR signaling pathway 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 32  Pancreatic cancer 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 33  Pathways in cancer 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 34  PD-L1 expression and PD-1 checkpoint pathway in cancer 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 35  Phospholipase D signaling pathway 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 36  PI3K-Akt signaling pathway 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 37  Prostate cancer 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 38  Proteoglycans in cancer 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 39  Shigellosis 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 40  Th17 cell differentiation 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 41  Thermogenesis 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 42  Thyroid hormone signaling pathway 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 43  Type II diabetes mellitus 
 1 gene, 2 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 

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