No. |
KEGG PATHWAY * On map, Yellow: Drug target, Red: Disease-related |
KEGG GENES * [Number of genes] |
KEGG DRUG * |
DrugBank |
Disease ID * [Number of diseases] |
1 | Adrenergic signaling in cardiomyocytes 2 genes, 1 drug (DrugBank), 7 diseases shown |
[2] AGTR1, AGTR2 |
D00150 |
Angiotensin II |
[7] 17, 19, 46, 66, 86, 222, 224 |
D02014 |
2 | AGE-RAGE signaling pathway in diabetic complications 1 gene, 1 drug (DrugBank), 7 diseases shown |
[1] AGTR1 |
D00150 |
Angiotensin II |
[7] 17, 19, 46, 66, 86, 222, 224 |
D02014 |
3 | Aldosterone synthesis and secretion 1 gene, 1 drug (DrugBank), 7 diseases shown |
[1] AGTR1 |
D00150 |
Angiotensin II |
[7] 17, 19, 46, 66, 86, 222, 224 |
D02014 |
4 | Alzheimer disease 5 genes, 1 drug (DrugBank), 30 diseases shown |
[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 |
D00107 |
Tacrolimus |
[30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 |
D08556 |
5 | Amphetamine addiction 5 genes, 1 drug (DrugBank), 30 diseases shown |
[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 |
D00107 |
Tacrolimus |
[30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 |
D08556 |
6 | Amyotrophic lateral sclerosis (ALS) 5 genes, 1 drug (DrugBank), 30 diseases shown |
[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 |
D00107 |
Tacrolimus |
[30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 |
D08556 |
7 | Apelin signaling pathway 1 gene, 1 drug (DrugBank), 7 diseases shown |
[1] AGTR1 |
D00150 |
Angiotensin II |
[7] 17, 19, 46, 66, 86, 222, 224 |
D02014 |
8 | Axon guidance 5 genes, 1 drug (DrugBank), 30 diseases shown |
[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 |
D00107 |
Tacrolimus |
[30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 |
D08556 |
9 | B cell receptor signaling pathway 5 genes, 1 drug (DrugBank), 30 diseases shown |
[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 |
D00107 |
Tacrolimus |
[30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 |
D08556 |
10 | C-type lectin receptor signaling pathway 5 genes, 1 drug (DrugBank), 30 diseases shown |
[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 |
D00107 |
Tacrolimus |
[30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 |
D08556 |
11 | Calcium signaling pathway 6 genes, 2 drugs (DrugBank), 32 diseases shown |
[1] AGTR1 |
D00150 |
Angiotensin II |
[7] 17, 19, 46, 66, 86, 222, 224 |
D02014 |
[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 |
D00107 |
Tacrolimus |
[30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 |
D08556 |
12 | cAMP signaling pathway 1 gene, 1 drug (DrugBank), 5 diseases shown |
[1] PDE4A |
D00302 |
Dipyridamole |
[5] 46, 49, 51, 66, 224 |
13 | Cellular senescence 5 genes, 1 drug (DrugBank), 30 diseases shown |
[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 |
D00107 |
Tacrolimus |
[30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 |
D08556 |
14 | cGMP-PKG signaling pathway 7 genes, 3 drugs (DrugBank), 32 diseases shown |
[1] AGTR1 |
D00150 |
Angiotensin II |
[7] 17, 19, 46, 66, 86, 222, 224 |
D02014 |
[1] PDE5A |
D00302 |
Dipyridamole |
[5] 46, 49, 51, 66, 224 |
[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 |
D00107 |
Tacrolimus |
[30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 |
D08556 |
15 | Chagas disease (American trypanosomiasis) 1 gene, 1 drug (DrugBank), 3 diseases shown |
[1] ACE |
D00620 |
Benazepril |
[3] 57, 218, 224 |
D07499 |
16 | Complement and coagulation cascades 1 gene, 1 drug (DrugBank), 11 diseases shown |
[1] SERPINC1 |
D07510 |
Heparin |
[11] 60, 70, 79, 84, 107, 224, 226, 280, 299, 316, 317 |
17 | Cortisol synthesis and secretion 1 gene, 1 drug (DrugBank), 7 diseases shown |
[1] AGTR1 |
D00150 |
Angiotensin II |
[7] 17, 19, 46, 66, 86, 222, 224 |
D02014 |
18 | Cushing syndrome 1 gene, 1 drug (DrugBank), 7 diseases shown |
[1] AGTR1 |
D00150 |
Angiotensin II |
[7] 17, 19, 46, 66, 86, 222, 224 |
D02014 |
19 | Dopaminergic synapse 3 genes, 1 drug (DrugBank), 30 diseases shown |
[3] PPP3CA, PPP3CB, PPP3CC |
D00107 |
Tacrolimus |
[30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 |
D08556 |
20 | Drug metabolism - other enzymes 2 genes, 3 drugs (DrugBank), 36 diseases shown |
[2] IMPDH1, IMPDH2 |
D01392 |
Mizoribine |
[8] 46, 49, 51, 53, 66, 94, 222, 224 |
D00752 |
Mycophenolate mofetil |
[32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 |
D05094 |
D05095 |
D05096 |
Mycophenolic acid |
[34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 |
21 | Glucagon signaling pathway 5 genes, 1 drug (DrugBank), 30 diseases shown |
[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 |
D00107 |
Tacrolimus |
[30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 |
D08556 |
22 | Glutamatergic synapse 5 genes, 1 drug (DrugBank), 30 diseases shown |
[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 |
D00107 |
Tacrolimus |
[30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 |
D08556 |
23 | Human cytomegalovirus infection 5 genes, 1 drug (DrugBank), 30 diseases shown |
[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 |
D00107 |
Tacrolimus |
[30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 |
D08556 |
24 | Human immunodeficiency virus 1 infection 5 genes, 1 drug (DrugBank), 30 diseases shown |
[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 |
D00107 |
Tacrolimus |
[30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 |
D08556 |
25 | Human T-cell leukemia virus 1 infection 5 genes, 1 drug (DrugBank), 30 diseases shown |
[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 |
D00107 |
Tacrolimus |
[30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 |
D08556 |
26 | Hypertrophic cardiomyopathy (HCM) 1 gene, 1 drug (DrugBank), 3 diseases shown |
[1] ACE |
D00620 |
Benazepril |
[3] 57, 218, 224 |
D07499 |
27 | Kaposi sarcoma-associated herpesvirus infection 5 genes, 1 drug (DrugBank), 30 diseases shown |
[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 |
D00107 |
Tacrolimus |
[30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 |
D08556 |
28 | Long-term potentiation 5 genes, 1 drug (DrugBank), 30 diseases shown |
[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 |
D00107 |
Tacrolimus |
[30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 |
D08556 |
29 | MAPK signaling pathway 5 genes, 1 drug (DrugBank), 30 diseases shown |
[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 |
D00107 |
Tacrolimus |
[30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 |
D08556 |
30 | Metabolic pathways 5 genes, 5 drugs (DrugBank), 38 diseases shown |
[1] DHODH |
D00749 |
Leflunomide |
[10] 11, 40, 46, 49, 53, 66, 162, 224, 271, 300 |
[2] IMPDH1, IMPDH2 |
D01392 |
Mizoribine |
[8] 46, 49, 51, 53, 66, 94, 222, 224 |
D00752 |
Mycophenolate mofetil |
[32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 |
D05094 |
D05095 |
D05096 |
Mycophenolic acid |
[34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 |
[2] PDE4A, PDE5A |
D00302 |
Dipyridamole |
[5] 46, 49, 51, 66, 224 |
31 | Morphine addiction 1 gene, 1 drug (DrugBank), 5 diseases shown |
[1] PDE4A |
D00302 |
Dipyridamole |
[5] 46, 49, 51, 66, 224 |
32 | Natural killer cell mediated cytotoxicity 5 genes, 1 drug (DrugBank), 30 diseases shown |
[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 |
D00107 |
Tacrolimus |
[30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 |
D08556 |
33 | Neuroactive ligand-receptor interaction 3 genes, 4 drugs (DrugBank), 54 diseases shown |
[2] AGTR1, AGTR2 |
D00150 |
Angiotensin II |
[7] 17, 19, 46, 66, 86, 222, 224 |
D02014 |
[1] NR3C1 |
D00407 |
Methylprednisolone |
[36] 2, 13, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 145, 164, 220, 222, 224, 271, 283, 284, 285, 296 |
D00751 |
D00979 |
D05000 |
D05001 |
D05002 |
D00473 |
Prednisone |
[44] 2, 11, 13, 14, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 81, 84, 85, 86, 95, 96, 97, 113, 145, 162, 164, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331 |
D08416 |
Prednisone acetate |
[6] 35, 40, 41, 49, 162, 224 |
34 | Oocyte meiosis 5 genes, 1 drug (DrugBank), 30 diseases shown |
[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 |
D00107 |
Tacrolimus |
[30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 |
D08556 |
35 | Osteoclast differentiation 5 genes, 1 drug (DrugBank), 30 diseases shown |
[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 |
D00107 |
Tacrolimus |
[30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 |
D08556 |
36 | Oxytocin signaling pathway 5 genes, 1 drug (DrugBank), 30 diseases shown |
[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 |
D00107 |
Tacrolimus |
[30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 |
D08556 |
37 | Parathyroid hormone synthesis, secretion and action 1 gene, 1 drug (DrugBank), 5 diseases shown |
[1] PDE4A |
D00302 |
Dipyridamole |
[5] 46, 49, 51, 66, 224 |
38 | Pathways in cancer 1 gene, 1 drug (DrugBank), 7 diseases shown |
[1] AGTR1 |
D00150 |
Angiotensin II |
[7] 17, 19, 46, 66, 86, 222, 224 |
D02014 |
39 | PD-L1 expression and PD-1 checkpoint pathway in cancer 5 genes, 1 drug (DrugBank), 30 diseases shown |
[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 |
D00107 |
Tacrolimus |
[30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 |
D08556 |
40 | Phospholipase D signaling pathway 1 gene, 1 drug (DrugBank), 7 diseases shown |
[1] AGTR1 |
D00150 |
Angiotensin II |
[7] 17, 19, 46, 66, 86, 222, 224 |
D02014 |
41 | Purine metabolism 4 genes, 4 drugs (DrugBank), 36 diseases shown |
[2] IMPDH1, IMPDH2 |
D01392 |
Mizoribine |
[8] 46, 49, 51, 53, 66, 94, 222, 224 |
D00752 |
Mycophenolate mofetil |
[32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 |
D05094 |
D05095 |
D05096 |
Mycophenolic acid |
[34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 |
[2] PDE4A, PDE5A |
D00302 |
Dipyridamole |
[5] 46, 49, 51, 66, 224 |
42 | Pyrimidine metabolism 1 gene, 1 drug (DrugBank), 10 diseases shown |
[1] DHODH |
D00749 |
Leflunomide |
[10] 11, 40, 46, 49, 53, 66, 162, 224, 271, 300 |
43 | Renin secretion 7 genes, 3 drugs (DrugBank), 34 diseases shown |
[1] ACE |
D00620 |
Benazepril |
[3] 57, 218, 224 |
D07499 |
[1] AGTR1 |
D00150 |
Angiotensin II |
[7] 17, 19, 46, 66, 86, 222, 224 |
D02014 |
[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 |
D00107 |
Tacrolimus |
[30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 |
D08556 |
44 | Renin-angiotensin system 3 genes, 2 drugs (DrugBank), 9 diseases shown |
[1] ACE |
D00620 |
Benazepril |
[3] 57, 218, 224 |
D07499 |
[2] AGTR1, AGTR2 |
D00150 |
Angiotensin II |
[7] 17, 19, 46, 66, 86, 222, 224 |
D02014 |
45 | T cell receptor signaling pathway 5 genes, 1 drug (DrugBank), 30 diseases shown |
[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 |
D00107 |
Tacrolimus |
[30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 |
D08556 |
46 | Th1 and Th2 cell differentiation 5 genes, 1 drug (DrugBank), 30 diseases shown |
[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 |
D00107 |
Tacrolimus |
[30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 |
D08556 |
47 | Th17 cell differentiation 5 genes, 1 drug (DrugBank), 30 diseases shown |
[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 |
D00107 |
Tacrolimus |
[30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 |
D08556 |
48 | Tuberculosis 5 genes, 1 drug (DrugBank), 30 diseases shown |
[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 |
D00107 |
Tacrolimus |
[30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 |
D08556 |
49 | Vascular smooth muscle contraction 1 gene, 1 drug (DrugBank), 7 diseases shown |
[1] AGTR1 |
D00150 |
Angiotensin II |
[7] 17, 19, 46, 66, 86, 222, 224 |
D02014 |
50 | VEGF signaling pathway 5 genes, 1 drug (DrugBank), 30 diseases shown |
[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 |
D00107 |
Tacrolimus |
[30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 |
D08556 |
51 | Wnt signaling pathway 5 genes, 1 drug (DrugBank), 30 diseases shown |
[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 |
D00107 |
Tacrolimus |
[30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 |
D08556 |