DDrare: Database of Drug Development for Rare Diseases

Target Gene/Pathway

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25 / 275 pathways found* Show info (disease name, etc.) on mouse-over.

No.	KEGG PATHWAY * On map, Yellow: Drug target, Red: Disease-related	KEGG GENES * [Number of genes]	KEGG DRUG *	DrugBank	Disease ID * [Number of diseases]
1	Alcoholism 1 gene, 1 drug (DrugBank), 5 diseases shown	[1] DRD2	D01745	Domperidone	[5] 6, 13, 17, 51, 230
			D07868
2	Bile secretion 1 gene, 1 drug (DrugBank), 6 diseases shown	[1] CA2	D00218	Acetazolamide	[6] 13, 90, 115, 155, 225, 230
			D01196
3	Breast cancer 2 genes, 1 drug (DrugBank), 1 disease shown	[2] ESR1, PGR	D02367	Desogestrel	[1] 230
4	cAMP signaling pathway 1 gene, 1 drug (DrugBank), 5 diseases shown	[1] DRD2	D01745	Domperidone	[5] 6, 13, 17, 51, 230
			D07868
5	Cocaine addiction 1 gene, 1 drug (DrugBank), 5 diseases shown	[1] DRD2	D01745	Domperidone	[5] 6, 13, 17, 51, 230
			D07868
6	Collecting duct acid secretion 1 gene, 1 drug (DrugBank), 6 diseases shown	[1] CA2	D00218	Acetazolamide	[6] 13, 90, 115, 155, 225, 230
			D01196
7	Dopaminergic synapse 1 gene, 1 drug (DrugBank), 5 diseases shown	[1] DRD2	D01745	Domperidone	[5] 6, 13, 17, 51, 230
			D07868
8	Endocrine and other factor-regulated calcium reabsorption 1 gene, 1 drug (DrugBank), 1 disease shown	[1] ESR1	D02367	Desogestrel	[1] 230
9	Endocrine resistance 1 gene, 1 drug (DrugBank), 1 disease shown	[1] ESR1	D02367	Desogestrel	[1] 230
10	Estrogen signaling pathway 2 genes, 1 drug (DrugBank), 1 disease shown	[2] ESR1, PGR	D02367	Desogestrel	[1] 230
11	Gap junction 1 gene, 1 drug (DrugBank), 5 diseases shown	[1] DRD2	D01745	Domperidone	[5] 6, 13, 17, 51, 230
			D07868
12	Gastric acid secretion 1 gene, 1 drug (DrugBank), 6 diseases shown	[1] CA2	D00218	Acetazolamide	[6] 13, 90, 115, 155, 225, 230
			D01196
13	Metabolic pathways 13 genes, 1 drug (DrugBank), 6 diseases shown	[13] CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9	D00218	Acetazolamide	[6] 13, 90, 115, 155, 225, 230
			D01196
14	Neuroactive ligand-receptor interaction 1 gene, 1 drug (DrugBank), 5 diseases shown	[1] DRD2	D01745	Domperidone	[5] 6, 13, 17, 51, 230
			D07868
15	Nitrogen metabolism 13 genes, 1 drug (DrugBank), 6 diseases shown	[13] CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9	D00218	Acetazolamide	[6] 13, 90, 115, 155, 225, 230
			D01196
16	Oocyte meiosis 1 gene, 1 drug (DrugBank), 1 disease shown	[1] PGR	D02367	Desogestrel	[1] 230
17	Pancreatic secretion 1 gene, 1 drug (DrugBank), 6 diseases shown	[1] CA2	D00218	Acetazolamide	[6] 13, 90, 115, 155, 225, 230
			D01196
18	Parkinson disease 1 gene, 1 drug (DrugBank), 5 diseases shown	[1] DRD2	D01745	Domperidone	[5] 6, 13, 17, 51, 230
			D07868
19	Pathways in cancer 1 gene, 1 drug (DrugBank), 1 disease shown	[1] ESR1	D02367	Desogestrel	[1] 230
20	Progesterone-mediated oocyte maturation 1 gene, 1 drug (DrugBank), 1 disease shown	[1] PGR	D02367	Desogestrel	[1] 230
21	Prolactin signaling pathway 1 gene, 1 drug (DrugBank), 1 disease shown	[1] ESR1	D02367	Desogestrel	[1] 230
22	Proteoglycans in cancer 1 gene, 1 drug (DrugBank), 1 disease shown	[1] ESR1	D02367	Desogestrel	[1] 230
23	Proximal tubule bicarbonate reclamation 2 genes, 1 drug (DrugBank), 6 diseases shown	[2] CA2, CA4	D00218	Acetazolamide	[6] 13, 90, 115, 155, 225, 230
			D01196
24	Rap1 signaling pathway 1 gene, 1 drug (DrugBank), 5 diseases shown	[1] DRD2	D01745	Domperidone	[5] 6, 13, 17, 51, 230
			D07868
25	Thyroid hormone signaling pathway 1 gene, 1 drug (DrugBank), 1 disease shown	[1] ESR1	D02367	Desogestrel	[1] 230