Target Gene/Pathway
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z other
No. | KEGG PATHWAY * On map, Yellow: Drug target, Red: Disease-related |
KEGG GENES * [Number of genes] |
KEGG DRUG * | DrugBank | Disease ID * [Number of diseases] |
1 | Alcoholism |
[1] DDC | D00558 | Carbidopa | [8] 2, 4, 6, 13, 17, 90, 164, 201 |
[2] DRD1, DRD2 | D00059 | Levodopa | [7] 2, 4, 6, 17, 90, 164, 201 | ||
[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D | D07283 | Esketamine | [3] 2, 4, 70 | ||
2 | Alzheimer disease |
[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D | D07283 | Esketamine | [3] 2, 4, 70 |
3 | Amphetamine addiction |
[1] DDC | D00558 | Carbidopa | [8] 2, 4, 6, 13, 17, 90, 164, 201 |
[1] DRD1 | D00059 | Levodopa | [7] 2, 4, 6, 17, 90, 164, 201 | ||
[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D | D07283 | Esketamine | [3] 2, 4, 70 | ||
4 | Amyotrophic lateral sclerosis (ALS) |
[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D | D07283 | Esketamine | [3] 2, 4, 70 |
5 | Calcium signaling pathway |
[2] DRD1, DRD5 | D00059 | Levodopa | [7] 2, 4, 6, 17, 90, 164, 201 |
[4] GRIN1, GRIN2A, GRIN2C, GRIN2D | D07283 | Esketamine | [3] 2, 4, 70 | ||
6 | cAMP signaling pathway |
[3] DRD1, DRD2, DRD5 | D00059 | Levodopa | [7] 2, 4, 6, 17, 90, 164, 201 |
[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D | D07283 | Esketamine | [3] 2, 4, 70 | ||
7 | cGMP-PKG signaling pathway |
[3] ADRA2A, ADRA2B, ADRA2C | D00514 | Dexmedetomidine | [11] 2, 4, 6, 21, 34, 70, 113, 212, 215, 226, 280 |
D01205 | |||||
8 | Circadian entrainment |
[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D | D07283 | Esketamine | [3] 2, 4, 70 |
9 | Cocaine addiction |
[1] DDC | D00558 | Carbidopa | [8] 2, 4, 6, 13, 17, 90, 164, 201 |
[2] DRD1, DRD2 | D00059 | Levodopa | [7] 2, 4, 6, 17, 90, 164, 201 | ||
[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D | D07283 | Esketamine | [3] 2, 4, 70 | ||
10 | Cortisol synthesis and secretion |
[1] KCNA4 | D04127 | Dalfampridine | [3] 3, 4, 13 |
11 | Cushing syndrome |
[1] KCNA4 | D04127 | Dalfampridine | [3] 3, 4, 13 |
12 | Dopaminergic synapse |
[1] DDC | D00558 | Carbidopa | [8] 2, 4, 6, 13, 17, 90, 164, 201 |
[5] DRD1, DRD2, DRD3, DRD4, DRD5 | D00059 | Levodopa | [7] 2, 4, 6, 17, 90, 164, 201 | ||
[2] GRIN2A, GRIN2B | D07283 | Esketamine | [3] 2, 4, 70 | ||
13 | ECM-receptor interaction |
[1] SV2A | D00709 | Levetiracetam | [4] 2, 4, 6, 13 |
14 | Gap junction |
[2] DRD1, DRD2 | D00059 | Levodopa | [7] 2, 4, 6, 17, 90, 164, 201 |
15 | Glutamatergic synapse |
[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D | D07283 | Esketamine | [3] 2, 4, 70 |
16 | Huntington disease |
[2] GRIN1, GRIN2B | D07283 | Esketamine | [3] 2, 4, 70 |
17 | Long-term potentiation |
[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D | D07283 | Esketamine | [3] 2, 4, 70 |
18 | Metabolic pathways |
[1] DDC | D00558 | Carbidopa | [8] 2, 4, 6, 13, 17, 90, 164, 201 |
19 | Morphine addiction |
[1] DRD1 | D00059 | Levodopa | [7] 2, 4, 6, 17, 90, 164, 201 |
20 | Neuroactive ligand-receptor interaction |
[3] ADRA2A, ADRA2B, ADRA2C | D00514 | Dexmedetomidine | [11] 2, 4, 6, 21, 34, 70, 113, 212, 215, 226, 280 |
D01205 | |||||
[5] DRD1, DRD2, DRD3, DRD4, DRD5 | D00059 | Levodopa | [7] 2, 4, 6, 17, 90, 164, 201 | ||
[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D | D07283 | Esketamine | [3] 2, 4, 70 | ||
21 | Nicotine addiction |
[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D | D07283 | Esketamine | [3] 2, 4, 70 |
22 | Parkinson disease |
[2] DRD1, DRD2 | D00059 | Levodopa | [7] 2, 4, 6, 17, 90, 164, 201 |
23 | Phenylalanine metabolism |
[1] DDC | D00558 | Carbidopa | [8] 2, 4, 6, 13, 17, 90, 164, 201 |
24 | Rap1 signaling pathway |
[1] DRD2 | D00059 | Levodopa | [7] 2, 4, 6, 17, 90, 164, 201 |
[3] GRIN1, GRIN2A, GRIN2B | D07283 | Esketamine | [3] 2, 4, 70 | ||
25 | Ras signaling pathway |
[3] GRIN1, GRIN2A, GRIN2B | D07283 | Esketamine | [3] 2, 4, 70 |
26 | Serotonergic synapse |
[1] DDC | D00558 | Carbidopa | [8] 2, 4, 6, 13, 17, 90, 164, 201 |
[1] KCND2 | D04127 | Dalfampridine | [3] 3, 4, 13 | ||
27 | Systemic lupus erythematosus |
[2] GRIN2A, GRIN2B | D07283 | Esketamine | [3] 2, 4, 70 |
28 | Tryptophan metabolism |
[1] DDC | D00558 | Carbidopa | [8] 2, 4, 6, 13, 17, 90, 164, 201 |
29 | Tyrosine metabolism |
[1] DDC | D00558 | Carbidopa | [8] 2, 4, 6, 13, 17, 90, 164, 201 |