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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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185 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Acute myeloid leukemia 
 2 genes, 3 drugs (DrugBank), 38 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] RARA   D02815   Alitretinoin   [1] 49 
 D06543   Vitamin A   [4] 13, 49, 53, 90 
 2  Adipocytokine signaling pathway 
 8 genes, 8 drugs (DrugBank), 75 diseases shown 		  [1] JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 [3] RXRA, RXRB, RXRG   D02815   Alitretinoin   [1] 49 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 3  Adrenergic signaling in cardiomyocytes 
 1 gene, 2 drugs (DrugBank), 13 diseases shown 		  [1] ADRB2   D08124   Levosalbutamol   [1] 49 
 D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 4  African trypanosomiasis 
 3 genes, 4 drugs (DrugBank), 40 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 5  AGE-RAGE signaling pathway in diabetic complications 
 2 genes, 5 drugs (DrugBank), 42 diseases shown 		  [1] JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 6  Alcoholism 
 5 genes, 1 drug (DrugBank), 7 diseases shown 		  [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 7  Aldosterone synthesis and secretion 
 1 gene, 1 drug (DrugBank), 12 diseases shown 		  [1] MC2R   D00146   Corticotropin   [12] 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 8  Allograft rejection 
 6 genes, 6 drugs (DrugBank), 48 diseases shown 		  [1] CD40   D11610   Iscalimab   [1] 49 
 [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 9  Alzheimer disease 
 12 genes, 7 drugs (DrugBank), 73 diseases shown 		  [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 [1] LPL   D05255   Omega-3-acid ethyl esters   [1] 49 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 10  Amoebiasis 
 5 genes, 5 drugs (DrugBank), 47 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [2] IL1R1, IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 11  Amphetamine addiction 
 10 genes, 3 drugs (DrugBank), 59 diseases shown 		  [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 12  AMPK signaling pathway 
 5 genes, 7 drugs (DrugBank), 63 diseases shown 		  [1] HMGCR   D00887   Atorvastatin   [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 
 D07474 
 D00893   Pravastatin   [9] 13, 46, 49, 67, 79, 96, 164, 265, 333 
 D08410 
 D01915   Rosuvastatin   [8] 6, 46, 49, 51, 79, 96, 271, 299 
 D08492 
 D00434   Simvastatin   [19] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 162, 195, 265, 298, 299, 310 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 13  Amyotrophic lateral sclerosis (ALS) 
 11 genes, 6 drugs (DrugBank), 73 diseases shown 		  [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 14  Antifolate resistance 
 3 genes, 4 drugs (DrugBank), 51 diseases shown 		  [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 15  Antigen processing and presentation 
 2 genes, 4 drugs (DrugBank), 38 diseases shown 		  [1] CD74   D08944   Milatuzumab   [1] 49 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 16  Apelin signaling pathway 
 3 genes, 2 drugs (DrugBank), 46 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 17  Apoptosis 
 1 gene, 3 drugs (DrugBank), 38 diseases shown 		  [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 18  Arachidonic acid metabolism 
 2 genes, 3 drugs (DrugBank), 17 diseases shown 		  [2] PTGS1, PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 [1] PTGS2   D00969   Meloxicam   [4] 46, 49, 271, 296 
 19  Asthma 
 2 genes, 4 drugs (DrugBank), 38 diseases shown 		  [1] CD40   D11610   Iscalimab   [1] 49 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 20  Autoimmune thyroid disease 
 16 genes, 4 drugs (DrugBank), 24 diseases shown 		  [1] CD40   D11610   Iscalimab   [1] 49 
 [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8   D09662   Rontalizumab   [1] 49 
 D09668   Sifalimumab   [1] 49 
 21  Autophagy - animal 
 3 genes, 2 drugs (DrugBank), 46 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 22  Autophagy - other 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 23  Axon guidance 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 24  B cell receptor signaling pathway 
 7 genes, 4 drugs (DrugBank), 55 diseases shown 		  [1] CD22   D04036   Epratuzumab   [1] 49 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 25  Bile secretion 
 2 genes, 5 drugs (DrugBank), 32 diseases shown 		  [1] HMGCR   D00887   Atorvastatin   [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 
 D07474 
 D00893   Pravastatin   [9] 13, 46, 49, 67, 79, 96, 164, 265, 333 
 D08410 
 D01915   Rosuvastatin   [8] 6, 46, 49, 51, 79, 96, 271, 299 
 D08492 
 D00434   Simvastatin   [19] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 162, 195, 265, 298, 299, 310 
 [1] RXRA   D02815   Alitretinoin   [1] 49 
 26  Breast cancer 
 4 genes, 5 drugs (DrugBank), 41 diseases shown 		  [1] ESR1   D00554   Ethinylestradiol   [4] 13, 46, 49, 299 
 [2] ESR1, ESR2   D00105   Estradiol   [5] 13, 46, 49, 226, 299 
 D01413 
 D01617 
 D01953 
 D04061 
 D04063 
 D04064 
 D04065 
 D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PGR   D00182   Norethisterone   [4] 13, 46, 49, 299 
 D00953 
 27  C-type lectin receptor signaling pathway 
 11 genes, 10 drugs (DrugBank), 77 diseases shown 		  [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00969   Meloxicam   [4] 46, 49, 271, 296 
 [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 28  Calcium signaling pathway 
 11 genes, 6 drugs (DrugBank), 65 diseases shown 		  [1] ADRB2   D08124   Levosalbutamol   [1] 49 
 D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 [4] GRIN1, GRIN2A, GRIN2C, GRIN2D   D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 [1] HRH1   D00300   Diphenhydramine   [5] 49, 51, 70, 86, 256 
 D00669 
 D02419 
 D03285 
 D03360 
 D03854 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 29  cAMP signaling pathway 
 8 genes, 5 drugs (DrugBank), 29 diseases shown 		  [1] ADRB2   D08124   Levosalbutamol   [1] 49 
 D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 [1] MC2R   D00146   Corticotropin   [12] 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 [1] PDE4A   D00302   Dipyridamole   [5] 46, 49, 51, 66, 224 
 30  Cell adhesion molecules (CAMs) 
 6 genes, 5 drugs (DrugBank), 28 diseases shown 		  [1] CD22   D04036   Epratuzumab   [1] 49 
 [1] CD40   D11610   Iscalimab   [1] 49 
 [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 [1] PDCD1   D10316   Nivolumab   [10] 13, 26, 41, 46, 49, 50, 51, 53, 96, 97 
 31  Cellular senescence 
 6 genes, 3 drugs (DrugBank), 72 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 32  Central carbon metabolism in cancer 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 33  cGMP-PKG signaling pathway 
 7 genes, 5 drugs (DrugBank), 60 diseases shown 		  [1] ADRB2   D08124   Levosalbutamol   [1] 49 
 D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 [1] PDE5A   D00302   Dipyridamole   [5] 46, 49, 51, 66, 224 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 34  Chagas disease (American trypanosomiasis) 
 4 genes, 5 drugs (DrugBank), 45 diseases shown 		  [1] ACE   D00421   Ramipril   [7] 46, 49, 66, 67, 113, 218, 257 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 35  Chemical carcinogenesis 
 1 gene, 3 drugs (DrugBank), 17 diseases shown 		  [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00969   Meloxicam   [4] 46, 49, 271, 296 
 36  Chemokine signaling pathway 
 2 genes, 2 drugs (DrugBank), 13 diseases shown 		  [1] JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 [2] JAK2, JAK3   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 37  Cholesterol metabolism 
 2 genes, 1 drug (DrugBank), 1 disease shown 		  [2] CETP, LPL   D05255   Omega-3-acid ethyl esters   [1] 49 
 38  Choline metabolism in cancer 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 39  Cholinergic synapse 
 1 gene, 2 drugs (DrugBank), 13 diseases shown 		  [1] JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 40  Circadian entrainment 
 7 genes, 2 drugs (DrugBank), 12 diseases shown 		  [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 [2] MTNR1A, MTNR1B   D08170   Melatonin   [8] 6, 13, 46, 49, 90, 97, 144, 202 
 41  Circadian rhythm 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 42  Cocaine addiction 
 5 genes, 1 drug (DrugBank), 7 diseases shown 		  [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 43  Colorectal cancer 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 44  Complement and coagulation cascades 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] F10   D07086   Rivaroxaban   [2] 46, 49 
 45  Cortisol synthesis and secretion 
 1 gene, 1 drug (DrugBank), 12 diseases shown 		  [1] MC2R   D00146   Corticotropin   [12] 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 46  Cushing syndrome 
 1 gene, 1 drug (DrugBank), 12 diseases shown 		  [1] MC2R   D00146   Corticotropin   [12] 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 47  Cytokine-cytokine receptor interaction 
 29 genes, 15 drugs (DrugBank), 60 diseases shown 		  [1] CD40   D11610   Iscalimab   [1] 49 
 [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8   D09662   Rontalizumab   [1] 49 
 D09668   Sifalimumab   [1] 49 
 [2] IFNAR1, IFNAR2   D11082   Anifrolumab   [2] 46, 49 
 [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [2] IL1R1, IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [3] IL2RA, IL2RB, IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [1] TNFRSF8   D09587   Brentuximab vedotin   [2] 49, 51 
 [2] TNFSF13, TNFSF13B   D09704   Atacicept   [4] 13, 46, 49, 66 
 [1] TNFSF13B   D03068   Belimumab   [8] 11, 43, 44, 46, 49, 51, 53, 222 
 D10083   Tabalumab   [2] 46, 49 
 48  Cytosolic DNA-sensing pathway 
 13 genes, 2 drugs (DrugBank), 1 disease shown 		  [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8   D09662   Rontalizumab   [1] 49 
 D09668   Sifalimumab   [1] 49 
 49  Dilated cardiomyopathy (DCM) 
 1 gene, 3 drugs (DrugBank), 38 diseases shown 		  [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 50  DNA replication 
 2 genes, 1 drug (DrugBank), 9 diseases shown 		  [2] POLA1, POLA2   D03546   Clofarabine   [9] 19, 20, 40, 46, 49, 60, 96, 234, 326 
 51  Dopaminergic synapse 
 5 genes, 3 drugs (DrugBank), 59 diseases shown 		  [2] GRIN2A, GRIN2B   D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 [3] PPP3CA, PPP3CB, PPP3CC   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 52  Drug metabolism - other enzymes 
 3 genes, 5 drugs (DrugBank), 39 diseases shown 		  [2] IMPDH1, IMPDH2   D01392   Mizoribine   [8] 46, 49, 51, 53, 66, 94, 222, 224 
 D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 [1] RRM1   D03546   Clofarabine   [9] 19, 20, 40, 46, 49, 60, 96, 234, 326 
 D01907   Fludarabine   [17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 
 D07966 
 53  EGFR tyrosine kinase inhibitor resistance 
 3 genes, 4 drugs (DrugBank), 45 diseases shown 		  [1] JAK1   D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 54  Endocrine and other factor-regulated calcium reabsorption 
 2 genes, 6 drugs (DrugBank), 26 diseases shown 		  [1] ESR1   D00105   Estradiol   [5] 13, 46, 49, 226, 299 
 D01413 
 D01617 
 D01953 
 D04061 
 D04063 
 D04064 
 D04065 
 D00554   Ethinylestradiol   [4] 13, 46, 49, 299 
 D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 [1] VDR   D01518   Alfacalcidol   [6] 41, 46, 49, 50, 96, 235 
 D00129   Calcitriol   [8] 37, 46, 49, 66, 96, 158, 235, 326 
 D00188   Cholecalciferol   [15] 6, 13, 19, 20, 34, 46, 49, 53, 60, 65, 96, 97, 228, 298, 299 
 55  Endocrine resistance 
 3 genes, 4 drugs (DrugBank), 41 diseases shown 		  [1] ESR1   D00554   Ethinylestradiol   [4] 13, 46, 49, 299 
 [2] ESR1, ESR2   D00105   Estradiol   [5] 13, 46, 49, 226, 299 
 D01413 
 D01617 
 D01953 
 D04061 
 D04063 
 D04064 
 D04065 
 D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 56  Endocytosis 
 3 genes, 1 drug (DrugBank), 4 diseases shown 		  [3] IL2RA, IL2RB, IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 57  Epstein-Barr virus infection 
 22 genes, 12 drugs (DrugBank), 46 diseases shown 		  [1] CD40   D11610   Iscalimab   [1] 49 
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8   D09662   Rontalizumab   [1] 49 
 D09668   Sifalimumab   [1] 49 
 [2] IFNAR1, IFNAR2   D11082   Anifrolumab   [2] 46, 49 
 [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 [1] JAK1   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [3] JAK1, JAK3, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 58  ErbB signaling pathway 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 59  Estrogen signaling pathway 
 4 genes, 6 drugs (DrugBank), 11 diseases shown 		  [1] ESR1   D00554   Ethinylestradiol   [4] 13, 46, 49, 299 
 [2] ESR1, ESR2   D00105   Estradiol   [5] 13, 46, 49, 226, 299 
 D01413 
 D01617 
 D01953 
 D04061 
 D04063 
 D04064 
 D04065 
 D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 [1] PGR   D00182   Norethisterone   [4] 13, 46, 49, 299 
 D00953 
 [1] RARA   D02815   Alitretinoin   [1] 49 
 D06543   Vitamin A   [4] 13, 49, 53, 90 
 60  Fat digestion and absorption 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] NPC1L1   D01966   Ezetimibe   [4] 49, 79, 93, 260 
 61  Fc epsilon RI signaling pathway 
 2 genes, 4 drugs (DrugBank), 40 diseases shown 		  [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 62  Fc gamma R-mediated phagocytosis 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 63  Fluid shear stress and atherosclerosis 
 7 genes, 7 drugs (DrugBank), 61 diseases shown 		  [2] IL1R1, IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] KEAP1   D03846   Dimethyl fumarate   [5] 13, 46, 49, 51, 86 
 [1] NQO1   D00564   Warfarin   [10] 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 
 D01280 
 D08682 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 64  Folate biosynthesis 
 2 genes, 1 drug (DrugBank), 33 diseases shown 		  [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 65  FoxO signaling pathway 
 3 genes, 2 drugs (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 [1] S1PR1   D11283   Cenerimod   [1] 49 
 66  Gap junction 
 9 genes, 1 drug (DrugBank), 2 diseases shown 		  [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8   D09587   Brentuximab vedotin   [2] 49, 51 
 67  Gastric cancer 
 5 genes, 3 drugs (DrugBank), 38 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] RARB   D06543   Vitamin A   [4] 13, 49, 53, 90 
 [4] RARB, RXRA, RXRB, RXRG   D02815   Alitretinoin   [1] 49 
 68  Glioma 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 69  Glucagon signaling pathway 
 7 genes, 3 drugs (DrugBank), 64 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 70  Glutamatergic synapse 
 10 genes, 3 drugs (DrugBank), 59 diseases shown 		  [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 71  Glutathione metabolism 
 1 gene, 2 drugs (DrugBank), 21 diseases shown 		  [1] RRM1   D03546   Clofarabine   [9] 19, 20, 40, 46, 49, 60, 96, 234, 326 
 D01907   Fludarabine   [17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 
 D07966 
 72  Glycerolipid metabolism 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] LPL   D05255   Omega-3-acid ethyl esters   [1] 49 
 73  GnRH secretion 
 1 gene, 2 drugs (DrugBank), 10 diseases shown 		  [1] ESR2   D00105   Estradiol   [5] 13, 46, 49, 226, 299 
 D01413 
 D01617 
 D01953 
 D04061 
 D04063 
 D04064 
 D04065 
 D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 74  GnRH signaling pathway 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] GNRHR   D06247   Triptorelin   [2] 49, 76 
 75  Graft-versus-host disease 
 3 genes, 4 drugs (DrugBank), 48 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 76  Growth hormone synthesis, secretion and action 
 2 genes, 3 drugs (DrugBank), 45 diseases shown 		  [1] JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 77  Hematopoietic cell lineage 
 7 genes, 9 drugs (DrugBank), 71 diseases shown 		  [1] CD22   D04036   Epratuzumab   [1] 49 
 [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [2] IL1R1, IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] IL2RA   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [1] MS4A1   D05218   Ocrelizumab   [3] 13, 46, 49 
 D02994   Rituximab   [42] 11, 13, 14, 17, 35, 36, 43, 44, 45, 46, 49, 50, 51, 52, 53, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 223, 229, 256, 271, 283, 284, 285, 288, 300, 331 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 78  Hepatitis B 
 19 genes, 9 drugs (DrugBank), 42 diseases shown 		  [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8   D09662   Rontalizumab   [1] 49 
 D09668   Sifalimumab   [1] 49 
 [1] IFNAR1   D11082   Anifrolumab   [2] 46, 49 
 [1] JAK1   D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 [4] JAK1, JAK2, JAK3, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 79  Hepatitis C 
 19 genes, 10 drugs (DrugBank), 42 diseases shown 		  [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8   D09662   Rontalizumab   [1] 49 
 D09668   Sifalimumab   [1] 49 
 [2] IFNAR1, IFNAR2   D11082   Anifrolumab   [2] 46, 49 
 [1] JAK1   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] RXRA   D02815   Alitretinoin   [1] 49 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 80  Hepatocellular carcinoma 
 3 genes, 3 drugs (DrugBank), 40 diseases shown 		  [1] KEAP1   D03846   Dimethyl fumarate   [5] 13, 46, 49, 51, 86 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] NQO1   D00564   Warfarin   [10] 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 
 D01280 
 D08682 
 81  Herpes simplex virus 1 infection 
 24 genes, 13 drugs (DrugBank), 66 diseases shown 		  [1] CD74   D08944   Milatuzumab   [1] 49 
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8   D09662   Rontalizumab   [1] 49 
 D09668   Sifalimumab   [1] 49 
 [2] IFNAR1, IFNAR2   D11082   Anifrolumab   [2] 46, 49 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] JAK1   D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 [3] JAK1, JAK2, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 82  HIF-1 signaling pathway 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 83  Human cytomegalovirus infection 
 23 genes, 15 drugs (DrugBank), 93 diseases shown 		  [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8   D09662   Rontalizumab   [1] 49 
 D09668   Sifalimumab   [1] 49 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] JAK1   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00969   Meloxicam   [4] 46, 49, 271, 296 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 84  Human immunodeficiency virus 1 infection 
 20 genes, 8 drugs (DrugBank), 81 diseases shown 		  [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8   D09662   Rontalizumab   [1] 49 
 D09668   Sifalimumab   [1] 49 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 85  Human papillomavirus infection 
 20 genes, 13 drugs (DrugBank), 73 diseases shown 		  [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8   D09662   Rontalizumab   [1] 49 
 D09668   Sifalimumab   [1] 49 
 [2] IFNAR1, IFNAR2   D11082   Anifrolumab   [2] 46, 49 
 [1] JAK1   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00969   Meloxicam   [4] 46, 49, 271, 296 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 86  Human T-cell leukemia virus 1 infection 
 16 genes, 13 drugs (DrugBank), 76 diseases shown 		  [1] CD40   D11610   Iscalimab   [1] 49 
 [1] FDPS   D08056   Ibandronate   [2] 46, 49 
 [2] IL1R1, IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [3] IL2RA, IL2RB, IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 [1] JAK1   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK3   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 87  Huntington disease 
 3 genes, 2 drugs (DrugBank), 20 diseases shown 		  [2] GRIN1, GRIN2B   D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 88  Hypertrophic cardiomyopathy (HCM) 
 4 genes, 5 drugs (DrugBank), 56 diseases shown 		  [1] ACE   D00421   Ramipril   [7] 46, 49, 66, 67, 113, 218, 257 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 89  IL-17 signaling pathway 
 2 genes, 6 drugs (DrugBank), 49 diseases shown 		  [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00969   Meloxicam   [4] 46, 49, 271, 296 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 90  Inflammatory bowel disease (IBD) 
 5 genes, 5 drugs (DrugBank), 40 diseases shown 		  [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 91  Inflammatory mediator regulation of TRP channels 
 2 genes, 2 drugs (DrugBank), 20 diseases shown 		  [1] HRH1   D00300   Diphenhydramine   [5] 49, 51, 70, 86, 256 
 D00669 
 D02419 
 D03285 
 D03360 
 D03854 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 92  Influenza A 
 22 genes, 11 drugs (DrugBank), 43 diseases shown 		  [1] FDPS   D08056   Ibandronate   [2] 46, 49 
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8   D09662   Rontalizumab   [1] 49 
 D09668   Sifalimumab   [1] 49 
 [2] IFNAR1, IFNAR2   D11082   Anifrolumab   [2] 46, 49 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] JAK1   D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 [3] JAK1, JAK2, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 93  Insulin resistance 
 4 genes, 5 drugs (DrugBank), 72 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 94  Insulin signaling pathway 
 3 genes, 2 drugs (DrugBank), 46 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 95  Intestinal immune network for IgA production 
 5 genes, 5 drugs (DrugBank), 26 diseases shown 		  [1] CD40   D11610   Iscalimab   [1] 49 
 [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [2] TNFSF13, TNFSF13B   D09704   Atacicept   [4] 13, 46, 49, 66 
 [1] TNFSF13B   D03068   Belimumab   [8] 11, 43, 44, 46, 49, 51, 53, 222 
 D10083   Tabalumab   [2] 46, 49 
 96  JAK-STAT signaling pathway 
 27 genes, 10 drugs (DrugBank), 61 diseases shown 		  [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8   D09662   Rontalizumab   [1] 49 
 D09668   Sifalimumab   [1] 49 
 [2] IFNAR1, IFNAR2   D11082   Anifrolumab   [2] 46, 49 
 [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [3] IL2RA, IL2RB, IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [1] JAK1   D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 [4] JAK1, JAK2, JAK3, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 97  Kaposi sarcoma-associated herpesvirus infection 
 27 genes, 14 drugs (DrugBank), 86 diseases shown 		  [1] CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8   D09662   Rontalizumab   [1] 49 
 D09668   Sifalimumab   [1] 49 
 [2] IFNAR1, IFNAR2   D11082   Anifrolumab   [2] 46, 49 
 [1] JAK1   D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 [3] JAK1, JAK2, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00969   Meloxicam   [4] 46, 49, 271, 296 
 [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 98  Legionellosis 
 3 genes, 4 drugs (DrugBank), 40 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 99  Leishmaniasis 
 6 genes, 10 drugs (DrugBank), 53 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] JAK1   D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00969   Meloxicam   [4] 46, 49, 271, 296 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 100  Leukocyte transendothelial migration 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 101  Long-term potentiation 
 10 genes, 3 drugs (DrugBank), 59 diseases shown 		  [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 102  Longevity regulating pathway 
 4 genes, 3 drugs (DrugBank), 50 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 103  Longevity regulating pathway - multiple species 
 3 genes, 2 drugs (DrugBank), 46 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 104  Malaria 
 4 genes, 6 drugs (DrugBank), 42 diseases shown 		  [1] CD40   D11610   Iscalimab   [1] 49 
 [1] IL12A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 105  MAPK signaling pathway 
 7 genes, 6 drugs (DrugBank), 73 diseases shown 		  [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 106  Measles 
 23 genes, 8 drugs (DrugBank), 21 diseases shown 		  [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8   D09662   Rontalizumab   [1] 49 
 D09668   Sifalimumab   [1] 49 
 [2] IFNAR1, IFNAR2   D11082   Anifrolumab   [2] 46, 49 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [3] IL2RA, IL2RB, IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [1] JAK1   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [3] JAK1, JAK3, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 107  Metabolic pathways 
 14 genes, 17 drugs (DrugBank), 76 diseases shown 		  [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 [1] DHODH   D00749   Leflunomide   [10] 11, 40, 46, 49, 53, 66, 162, 224, 271, 300 
 [1] FDPS   D08056   Ibandronate   [2] 46, 49 
 [1] HMGCR   D00887   Atorvastatin   [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 
 D07474 
 D00893   Pravastatin   [9] 13, 46, 49, 67, 79, 96, 164, 265, 333 
 D08410 
 D01915   Rosuvastatin   [8] 6, 46, 49, 51, 79, 96, 271, 299 
 D08492 
 D00434   Simvastatin   [19] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 162, 195, 265, 298, 299, 310 
 [2] IMPDH1, IMPDH2   D01392   Mizoribine   [8] 46, 49, 51, 53, 66, 94, 222, 224 
 D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 [2] NQO1, VKORC1   D00564   Warfarin   [10] 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 
 D01280 
 D08682 
 [2] PDE4A, PDE5A   D00302   Dipyridamole   [5] 46, 49, 51, 66, 224 
 [2] PTGS1, PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 [1] PTGS2   D00969   Meloxicam   [4] 46, 49, 271, 296 
 [1] RRM1   D03546   Clofarabine   [9] 19, 20, 40, 46, 49, 60, 96, 234, 326 
 D01907   Fludarabine   [17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 
 D07966 
 108  MicroRNAs in cancer 
 2 genes, 4 drugs (DrugBank), 44 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00969   Meloxicam   [4] 46, 49, 271, 296 
 109  Mineral absorption 
 1 gene, 3 drugs (DrugBank), 22 diseases shown 		  [1] VDR   D01518   Alfacalcidol   [6] 41, 46, 49, 50, 96, 235 
 D00129   Calcitriol   [8] 37, 46, 49, 66, 96, 158, 235, 326 
 D00188   Cholecalciferol   [15] 6, 13, 19, 20, 34, 46, 49, 53, 60, 65, 96, 97, 228, 298, 299 
 110  Morphine addiction 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] PDE4A   D00302   Dipyridamole   [5] 46, 49, 51, 66, 224 
 111  mTOR signaling pathway 
 4 genes, 5 drugs (DrugBank), 72 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 112  Natural killer cell mediated cytotoxicity 
 23 genes, 10 drugs (DrugBank), 69 diseases shown 		  [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8   D09662   Rontalizumab   [1] 49 
 D09668   Sifalimumab   [1] 49 
 [2] IFNAR1, IFNAR2   D11082   Anifrolumab   [2] 46, 49 
 [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 113  Necroptosis 
 20 genes, 9 drugs (DrugBank), 42 diseases shown 		  [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8   D09662   Rontalizumab   [1] 49 
 D09668   Sifalimumab   [1] 49 
 [2] IFNAR1, IFNAR2   D11082   Anifrolumab   [2] 46, 49 
 [1] JAK1   D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 [4] JAK1, JAK2, JAK3, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 114  Neuroactive ligand-receptor interaction 
 15 genes, 13 drugs (DrugBank), 71 diseases shown 		  [1] ADRB2   D08124   Levosalbutamol   [1] 49 
 D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 [1] GNRHR   D06247   Triptorelin   [2] 49, 76 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 [1] HRH1   D00300   Diphenhydramine   [5] 49, 51, 70, 86, 256 
 D00669 
 D02419 
 D03285 
 D03360 
 D03854 
 [1] MC2R   D00146   Corticotropin   [12] 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 [2] MTNR1A, MTNR1B   D08170   Melatonin   [8] 6, 13, 46, 49, 90, 97, 144, 202 
 [1] NR3C1   D00407   Methylprednisolone   [36] 2, 13, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 145, 164, 220, 222, 224, 271, 283, 284, 285, 296 
 D00751 
 D00979 
 D05000 
 D05001 
 D05002 
 D00472   Prednisolone   [38] 11, 13, 25, 26, 35, 38, 39, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 
 D00980 
 D00981 
 D00982 
 D01239 
 D01998 
 D02156 
 D03301 
 D00473   Prednisone   [44] 2, 11, 13, 14, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 81, 84, 85, 86, 95, 96, 97, 113, 145, 162, 164, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331 
 D08416   Prednisone acetate   [6] 35, 40, 41, 49, 162, 224 
 [1] S1PR1   D11283   Cenerimod   [1] 49 
 [2] THRA, THRB   D01010   Levothyroxine   [2] 49, 78 
 D08125 
 115  NF-kappa B signaling pathway 
 6 genes, 12 drugs (DrugBank), 60 diseases shown 		  [1] CD40   D11610   Iscalimab   [1] 49 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00969   Meloxicam   [4] 46, 49, 271, 296 
 [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [1] TNFSF13B   D09704   Atacicept   [4] 13, 46, 49, 66 
 D03068   Belimumab   [8] 11, 43, 44, 46, 49, 51, 53, 222 
 D10083   Tabalumab   [2] 46, 49 
 116  Nicotine addiction 
 5 genes, 1 drug (DrugBank), 7 diseases shown 		  [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 117  NOD-like receptor signaling pathway 
 18 genes, 9 drugs (DrugBank), 42 diseases shown 		  [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8   D09662   Rontalizumab   [1] 49 
 D09668   Sifalimumab   [1] 49 
 [2] IFNAR1, IFNAR2   D11082   Anifrolumab   [2] 46, 49 
 [1] JAK1   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 118  Non-alcoholic fatty liver disease (NAFLD) 
 4 genes, 5 drugs (DrugBank), 53 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 [1] RXRA   D02815   Alitretinoin   [1] 49 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 119  Non-small cell lung cancer 
 5 genes, 3 drugs (DrugBank), 12 diseases shown 		  [1] JAK3   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] RARB   D06543   Vitamin A   [4] 13, 49, 53, 90 
 [4] RARB, RXRA, RXRB, RXRG   D02815   Alitretinoin   [1] 49 
 120  One carbon pool by folate 
 2 genes, 1 drug (DrugBank), 33 diseases shown 		  [2] DHFR, DHFR2   D00142   Methotrexate   [33] 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 121  Oocyte meiosis 
 7 genes, 4 drugs (DrugBank), 56 diseases shown 		  [1] AR   D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 [1] PGR   D00182   Norethisterone   [4] 13, 46, 49, 299 
 D00953 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 122  Osteoclast differentiation 
 13 genes, 12 drugs (DrugBank), 81 diseases shown 		  [2] IFNAR1, IFNAR2   D11082   Anifrolumab   [2] 46, 49 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] JAK1   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 123  Ovarian steroidogenesis 
 1 gene, 3 drugs (DrugBank), 17 diseases shown 		  [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00969   Meloxicam   [4] 46, 49, 271, 296 
 124  Oxytocin signaling pathway 
 8 genes, 6 drugs (DrugBank), 73 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00969   Meloxicam   [4] 46, 49, 271, 296 
 125  Pancreatic cancer 
 2 genes, 4 drugs (DrugBank), 45 diseases shown 		  [1] JAK1   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 126  Parathyroid hormone synthesis, secretion and action 
 5 genes, 5 drugs (DrugBank), 24 diseases shown 		  [1] PDE4A   D00302   Dipyridamole   [5] 46, 49, 51, 66, 224 
 [3] RXRA, RXRB, RXRG   D02815   Alitretinoin   [1] 49 
 [1] VDR   D01518   Alfacalcidol   [6] 41, 46, 49, 50, 96, 235 
 D00129   Calcitriol   [8] 37, 46, 49, 66, 96, 158, 235, 326 
 D00188   Cholecalciferol   [15] 6, 13, 19, 20, 34, 46, 49, 53, 60, 65, 96, 97, 228, 298, 299 
 127  Pathogenic Escherichia coli infection 
 11 genes, 5 drugs (DrugBank), 46 diseases shown 		  [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8   D09587   Brentuximab vedotin   [2] 49, 51 
 128  Pathways in cancer 
 38 genes, 21 drugs (DrugBank), 78 diseases shown 		  [3] AR, ESR1, ESR2   D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [1] ESR1   D00554   Ethinylestradiol   [4] 13, 46, 49, 299 
 [2] ESR1, ESR2   D00105   Estradiol   [5] 13, 46, 49, 226, 299 
 D01413 
 D01617 
 D01953 
 D04061 
 D04063 
 D04064 
 D04065 
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8   D09662   Rontalizumab   [1] 49 
 D09668   Sifalimumab   [1] 49 
 [2] IFNAR1, IFNAR2   D11082   Anifrolumab   [2] 46, 49 
 [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [3] IL2RA, IL2RB, IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [1] JAK1   D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 [3] JAK1, JAK2, JAK3   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] KEAP1   D03846   Dimethyl fumarate   [5] 13, 46, 49, 51, 86 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] NQO1   D00564   Warfarin   [10] 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 
 D01280 
 D08682 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00969   Meloxicam   [4] 46, 49, 271, 296 
 [2] RARA, RARB   D06543   Vitamin A   [4] 13, 49, 53, 90 
 [5] RARA, RARB, RXRA, RXRB, RXRG   D02815   Alitretinoin   [1] 49 
 129  PD-L1 expression and PD-1 checkpoint pathway in cancer 
 9 genes, 7 drugs (DrugBank), 78 diseases shown 		  [1] JAK1   D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PDCD1   D10316   Nivolumab   [10] 13, 26, 41, 46, 49, 50, 51, 53, 96, 97 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 130  Pertussis 
 4 genes, 4 drugs (DrugBank), 40 diseases shown 		  [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 131  Phagosome 
 9 genes, 1 drug (DrugBank), 2 diseases shown 		  [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8   D09587   Brentuximab vedotin   [2] 49, 51 
 132  Phospholipase D signaling pathway 
 2 genes, 2 drugs (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 133  PI3K-Akt signaling pathway 
 27 genes, 12 drugs (DrugBank), 63 diseases shown 		  [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8   D09662   Rontalizumab   [1] 49 
 D09668   Sifalimumab   [1] 49 
 [2] IFNAR1, IFNAR2   D11082   Anifrolumab   [2] 46, 49 
 [3] IL2RA, IL2RB, IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [1] JAK1   D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 [3] JAK1, JAK2, JAK3   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 [1] RXRA   D02815   Alitretinoin   [1] 49 
 [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 134  Platelet activation 
 3 genes, 4 drugs (DrugBank), 18 diseases shown 		  [1] P2RY12   D00769   Clopidogrel   [2] 49, 86 
 D07729 
 D10823 
 D10824 
 [1] PTGS1   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 135  PPAR signaling pathway 
 5 genes, 3 drugs (DrugBank), 17 diseases shown 		  [1] LPL   D05255   Omega-3-acid ethyl esters   [1] 49 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 [3] RXRA, RXRB, RXRG   D02815   Alitretinoin   [1] 49 
 136  Primary immunodeficiency 
 3 genes, 3 drugs (DrugBank), 11 diseases shown 		  [1] CD40   D11610   Iscalimab   [1] 49 
 [1] IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [1] JAK3   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 137  Progesterone-mediated oocyte maturation 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] PGR   D00182   Norethisterone   [4] 13, 46, 49, 299 
 D00953 
 138  Prolactin signaling pathway 
 3 genes, 5 drugs (DrugBank), 20 diseases shown 		  [1] ESR1   D00554   Ethinylestradiol   [4] 13, 46, 49, 299 
 [2] ESR1, ESR2   D00105   Estradiol   [5] 13, 46, 49, 226, 299 
 D01413 
 D01617 
 D01953 
 D04061 
 D04063 
 D04064 
 D04065 
 D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 [1] JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 139  Prostate cancer 
 3 genes, 3 drugs (DrugBank), 49 diseases shown 		  [1] AR   D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 [1] IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 140  Proteasome 
 1 gene, 1 drug (DrugBank), 13 diseases shown 		  [1] PSMB5   D03150   Bortezomib   [13] 11, 26, 28, 46, 49, 51, 61, 63, 66, 228, 256, 288, 331 
 141  Proteoglycans in cancer 
 4 genes, 8 drugs (DrugBank), 67 diseases shown 		  [1] ESR1   D00105   Estradiol   [5] 13, 46, 49, 226, 299 
 D01413 
 D01617 
 D01953 
 D04061 
 D04063 
 D04064 
 D04065 
 D00554   Ethinylestradiol   [4] 13, 46, 49, 299 
 D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 [1] IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 142  Purine metabolism 
 5 genes, 6 drugs (DrugBank), 39 diseases shown 		  [2] IMPDH1, IMPDH2   D01392   Mizoribine   [8] 46, 49, 51, 53, 66, 94, 222, 224 
 D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 [2] PDE4A, PDE5A   D00302   Dipyridamole   [5] 46, 49, 51, 66, 224 
 [1] RRM1   D03546   Clofarabine   [9] 19, 20, 40, 46, 49, 60, 96, 234, 326 
 D01907   Fludarabine   [17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 
 D07966 
 143  Pyrimidine metabolism 
 2 genes, 3 drugs (DrugBank), 28 diseases shown 		  [1] DHODH   D00749   Leflunomide   [10] 11, 40, 46, 49, 53, 66, 162, 224, 271, 300 
 [1] RRM1   D03546   Clofarabine   [9] 19, 20, 40, 46, 49, 60, 96, 234, 326 
 D01907   Fludarabine   [17] 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 326 
 D07966 
 144  Rap1 signaling pathway 
 4 genes, 2 drugs (DrugBank), 14 diseases shown 		  [3] GRIN1, GRIN2A, GRIN2B   D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 145  Ras signaling pathway 
 3 genes, 1 drug (DrugBank), 7 diseases shown 		  [3] GRIN1, GRIN2A, GRIN2B   D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 146  Regulation of actin cytoskeleton 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 147  Regulation of lipolysis in adipocytes 
 3 genes, 5 drugs (DrugBank), 23 diseases shown 		  [1] ADRB2   D08124   Levosalbutamol   [1] 49 
 D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 [2] PTGS1, PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 [1] PTGS2   D00969   Meloxicam   [4] 46, 49, 271, 296 
 148  Renin secretion 
 7 genes, 5 drugs (DrugBank), 63 diseases shown 		  [1] ACE   D00421   Ramipril   [7] 46, 49, 66, 67, 113, 218, 257 
 [1] ADRB2   D08124   Levosalbutamol   [1] 49 
 D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 149  Renin-angiotensin system 
 1 gene, 1 drug (DrugBank), 7 diseases shown 		  [1] ACE   D00421   Ramipril   [7] 46, 49, 66, 67, 113, 218, 257 
 150  Retrograde endocannabinoid signaling 
 1 gene, 3 drugs (DrugBank), 17 diseases shown 		  [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00969   Meloxicam   [4] 46, 49, 271, 296 
 151  Rheumatoid arthritis 
 7 genes, 9 drugs (DrugBank), 50 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [2] TNFSF13, TNFSF13B   D09704   Atacicept   [4] 13, 46, 49, 66 
 [1] TNFSF13B   D03068   Belimumab   [8] 11, 43, 44, 46, 49, 51, 53, 222 
 D10083   Tabalumab   [2] 46, 49 
 152  RIG-I-like receptor signaling pathway 
 16 genes, 6 drugs (DrugBank), 40 diseases shown 		  [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8   D09662   Rontalizumab   [1] 49 
 D09668   Sifalimumab   [1] 49 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 153  Salivary secretion 
 1 gene, 2 drugs (DrugBank), 13 diseases shown 		  [1] ADRB2   D08124   Levosalbutamol   [1] 49 
 D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 154  Serotonergic synapse 
 3 genes, 5 drugs (DrugBank), 17 diseases shown 		  [2] PTGS1, PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 [1] PTGS2   D00969   Meloxicam   [4] 46, 49, 271, 296 
 [1] SLC6A4   D01179   Duloxetine   [3] 6, 13, 49 
 D07880 
 D08222   Milnacipran   [2] 46, 49 
 155  Shigellosis 
 3 genes, 5 drugs (DrugBank), 67 diseases shown 		  [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 156  Signaling pathways regulating pluripotency of stem cells 
 3 genes, 3 drugs (DrugBank), 13 diseases shown 		  [1] JAK1   D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 [3] JAK1, JAK2, JAK3   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 157  Small cell lung cancer 
 5 genes, 5 drugs (DrugBank), 19 diseases shown 		  [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00969   Meloxicam   [4] 46, 49, 271, 296 
 [1] RARB   D06543   Vitamin A   [4] 13, 49, 53, 90 
 [4] RARB, RXRA, RXRB, RXRG   D02815   Alitretinoin   [1] 49 
 158  Sphingolipid signaling pathway 
 2 genes, 4 drugs (DrugBank), 38 diseases shown 		  [1] S1PR1   D11283   Cenerimod   [1] 49 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 159  Staphylococcus aureus infection 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 160  Synaptic vesicle cycle 
 2 genes, 2 drugs (DrugBank), 4 diseases shown 		  [2] SLC6A2, SLC6A4   D01179   Duloxetine   [3] 6, 13, 49 
 D07880 
 D08222   Milnacipran   [2] 46, 49 
 161  Systemic lupus erythematosus 
 6 genes, 6 drugs (DrugBank), 52 diseases shown 		  [1] CD40   D11610   Iscalimab   [1] 49 
 [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [2] GRIN2A, GRIN2B   D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 162  T cell receptor signaling pathway 
 7 genes, 6 drugs (DrugBank), 69 diseases shown 		  [1] PDCD1   D10316   Nivolumab   [10] 13, 26, 41, 46, 49, 50, 51, 53, 96, 97 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 163  Terpenoid backbone biosynthesis 
 2 genes, 5 drugs (DrugBank), 32 diseases shown 		  [1] FDPS   D08056   Ibandronate   [2] 46, 49 
 [1] HMGCR   D00887   Atorvastatin   [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 
 D07474 
 D00893   Pravastatin   [9] 13, 46, 49, 67, 79, 96, 164, 265, 333 
 D08410 
 D01915   Rosuvastatin   [8] 6, 46, 49, 51, 79, 96, 271, 299 
 D08492 
 D00434   Simvastatin   [19] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 162, 195, 265, 298, 299, 310 
 164  TGF-beta signaling pathway 
 1 gene, 3 drugs (DrugBank), 38 diseases shown 		  [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 165  Th1 and Th2 cell differentiation 
 14 genes, 7 drugs (DrugBank), 62 diseases shown 		  [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [3] IL2RA, IL2RB, IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [1] JAK1   D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 [4] JAK1, JAK2, JAK3, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 166  Th17 cell differentiation 
 19 genes, 11 drugs (DrugBank), 81 diseases shown 		  [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [3] IL2RA, IL2RB, IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [1] JAK1   D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 [4] JAK1, JAK2, JAK3, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] RARA   D06543   Vitamin A   [4] 13, 49, 53, 90 
 [4] RARA, RXRA, RXRB, RXRG   D02815   Alitretinoin   [1] 49 
 167  Thermogenesis 
 4 genes, 3 drugs (DrugBank), 50 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 168  Thyroid cancer 
 4 genes, 2 drugs (DrugBank), 17 diseases shown 		  [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 [3] RXRA, RXRB, RXRG   D02815   Alitretinoin   [1] 49 
 169  Thyroid hormone signaling pathway 
 7 genes, 6 drugs (DrugBank), 42 diseases shown 		  [1] ESR1   D00105   Estradiol   [5] 13, 46, 49, 226, 299 
 D01413 
 D01617 
 D01953 
 D04061 
 D04063 
 D04064 
 D04065 
 D00554   Ethinylestradiol   [4] 13, 46, 49, 299 
 D08409   Prasterone   [6] 49, 53, 83, 86, 96, 113 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [3] RXRA, RXRB, RXRG   D02815   Alitretinoin   [1] 49 
 [2] THRA, THRB   D01010   Levothyroxine   [2] 49, 78 
 D08125 
 170  Tight junction 
 2 genes, 1 drug (DrugBank), 17 diseases shown 		  [2] PRKAA1, PRKAA2   D00944   Metformin   [17] 6, 13, 46, 49, 67, 75, 77, 81, 86, 113, 158, 206, 225, 233, 265, 285, 299 
 D04966 
 171  TNF signaling pathway 
 2 genes, 6 drugs (DrugBank), 49 diseases shown 		  [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00969   Meloxicam   [4] 46, 49, 271, 296 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 172  Toll-like receptor signaling pathway 
 21 genes, 9 drugs (DrugBank), 48 diseases shown 		  [1] CD40   D11610   Iscalimab   [1] 49 
 [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8   D09662   Rontalizumab   [1] 49 
 D09668   Sifalimumab   [1] 49 
 [2] IFNAR1, IFNAR2   D11082   Anifrolumab   [2] 46, 49 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 173  Toxoplasmosis 
 7 genes, 8 drugs (DrugBank), 43 diseases shown 		  [1] CD40   D11610   Iscalimab   [1] 49 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] JAK1   D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 [3] JAK1, JAK2, TYK2   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 174  Transcriptional misregulation in cancer 
 9 genes, 7 drugs (DrugBank), 41 diseases shown 		  [1] CD40   D11610   Iscalimab   [1] 49 
 [1] CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] IL2RB   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 [1] RARA   D06543   Vitamin A   [4] 13, 49, 53, 90 
 [4] RARA, RXRA, RXRB, RXRG   D02815   Alitretinoin   [1] 49 
 175  Tuberculosis 
 27 genes, 16 drugs (DrugBank), 75 diseases shown 		  [1] CD74   D08944   Milatuzumab   [1] 49 
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8   D09662   Rontalizumab   [1] 49 
 D09668   Sifalimumab   [1] 49 
 [3] IL12A, IL12B, IL23A   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] JAK1   D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK2   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [1] VDR   D01518   Alfacalcidol   [6] 41, 46, 49, 50, 96, 235 
 D00129   Calcitriol   [8] 37, 46, 49, 66, 96, 158, 235, 326 
 D00188   Cholecalciferol   [15] 6, 13, 19, 20, 34, 46, 49, 53, 60, 65, 96, 97, 228, 298, 299 
 176  Type I diabetes mellitus 
 5 genes, 5 drugs (DrugBank), 48 diseases shown 		  [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [2] IL12A, IL12B   D09214   Ustekinumab   [16] 13, 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 177  Type II diabetes mellitus 
 2 genes, 4 drugs (DrugBank), 62 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 178  Ubiquinone and other terpenoid-quinone biosynthesis 
 2 genes, 1 drug (DrugBank), 10 diseases shown 		  [2] NQO1, VKORC1   D00564   Warfarin   [10] 6, 8, 13, 19, 46, 49, 66, 85, 88, 96 
 D01280 
 D08682 
 179  Ubiquitin mediated proteolysis 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] KEAP1   D03846   Dimethyl fumarate   [5] 13, 46, 49, 51, 86 
 180  VEGF signaling pathway 
 6 genes, 5 drugs (DrugBank), 65 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGS2   D00217   Acetaminophen   [13] 3, 6, 13, 34, 35, 46, 49, 51, 70, 86, 231, 256, 271 
 D00109   Acetylsalicylic acid   [10] 13, 22, 34, 46, 49, 51, 86, 113, 158, 231 
 D00969   Meloxicam   [4] 46, 49, 271, 296 
 181  Viral carcinogenesis 
 3 genes, 4 drugs (DrugBank), 15 diseases shown 		  [1] JAK1   D10308   Baricitinib   [8] 41, 46, 49, 50, 93, 107, 265, 325 
 D10994   Upadacitinib   [6] 41, 46, 49, 96, 97, 271 
 [2] JAK1, JAK3   D09970   Tofacitinib   [9] 46, 49, 50, 51, 84, 96, 97, 107, 271 
 [1] SYK   D09347   Fostamatinib   [4] 46, 49, 61, 66 
 182  Viral myocarditis 
 4 genes, 3 drugs (DrugBank), 27 diseases shown 		  [1] CD40   D11610   Iscalimab   [1] 49 
 [2] CD80, CD86   D03203   Abatacept   [24] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 [1] ITGAL   D03959   Efalizumab   [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 
 183  Viral protein interaction with cytokine and cytokine receptor 
 4 genes, 4 drugs (DrugBank), 38 diseases shown 		  [3] IL2RA, IL2RB, IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 184  Wnt signaling pathway 
 5 genes, 2 drugs (DrugBank), 55 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 185  Yersinia infection 
 1 gene, 3 drugs (DrugBank), 38 diseases shown 		  [1] TNF   D02598   Infliximab   [23] 35, 37, 38, 39, 40, 41, 43, 45, 46, 49, 50, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 
 D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 

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