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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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126 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Acute myeloid leukemia 
 2 genes, 4 drugs (DrugBank), 40 diseases shown 		  [1] KIT   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 2  Adherens junction 
 3 genes, 3 drugs (DrugBank), 8 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] FGFR1   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] SRC   D09664   Saracatinib   [2] 6, 89 
 3  Adipocytokine signaling pathway 
 1 gene, 3 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 4  Adrenergic signaling in cardiomyocytes 
 1 gene, 1 drug (DrugBank), 13 diseases shown 		  [1] ADRB2   D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 5  AGE-RAGE signaling pathway in diabetic complications 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 6  Alanine, aspartate and glutamate metabolism 
 4 genes, 1 drug (DrugBank), 14 diseases shown 		  [4] ABAT, ALDH5A1, GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 7  Aldosterone synthesis and secretion 
 3 genes, 1 drug (DrugBank), 14 diseases shown 		  [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 8  AMPK signaling pathway 
 2 genes, 4 drugs (DrugBank), 46 diseases shown 		  [1] HMGCR   D00434   Simvastatin   [19] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 162, 195, 265, 298, 299, 310 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 9  Apelin signaling pathway 
 1 gene, 3 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 10  Arachidonic acid metabolism 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 11  Autophagy - animal 
 1 gene, 3 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 12  Autophagy - other 
 1 gene, 3 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 13  Axon guidance 
 2 genes, 2 drugs (DrugBank), 12 diseases shown 		  [1] ABL1   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [2] ABL1, SRC   D09664   Saracatinib   [2] 6, 89 
 14  Bacterial invasion of epithelial cells 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SRC   D09664   Saracatinib   [2] 6, 89 
 15  beta-Alanine metabolism 
 3 genes, 1 drug (DrugBank), 14 diseases shown 		  [3] ABAT, GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 16  Bile secretion 
 1 gene, 1 drug (DrugBank), 19 diseases shown 		  [1] HMGCR   D00434   Simvastatin   [19] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 162, 195, 265, 298, 299, 310 
 17  Bladder cancer 
 4 genes, 4 drugs (DrugBank), 12 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] FGFR3   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] SRC   D09664   Saracatinib   [2] 6, 89 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 18  Breast cancer 
 5 genes, 6 drugs (DrugBank), 40 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [2] FGFR1, FLT4   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] KIT   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 19  Butanoate metabolism 
 4 genes, 1 drug (DrugBank), 14 diseases shown 		  [4] ABAT, ALDH5A1, GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 20  C-type lectin receptor signaling pathway 
 2 genes, 2 drugs (DrugBank), 10 diseases shown 		  [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 [1] SRC   D09664   Saracatinib   [2] 6, 89 
 21  Calcium signaling pathway 
 7 genes, 5 drugs (DrugBank), 30 diseases shown 		  [1] ADRB2   D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [2] PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 22  cAMP signaling pathway 
 2 genes, 2 drugs (DrugBank), 19 diseases shown 		  [1] ADRB2   D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 [1] SSTR2   D00442   Octreotide   [8] 67, 75, 84, 85, 89, 96, 193, 227 
 D06495 
 23  Cell cycle 
 1 gene, 2 drugs (DrugBank), 12 diseases shown 		  [1] ABL1   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 D09664   Saracatinib   [2] 6, 89 
 24  Cellular senescence 
 1 gene, 3 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 25  Central carbon metabolism in cancer 
 8 genes, 6 drugs (DrugBank), 40 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [5] FGFR1, FGFR2, FGFR3, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [2] KIT, PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 26  cGMP-PKG signaling pathway 
 1 gene, 1 drug (DrugBank), 13 diseases shown 		  [1] ADRB2   D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 27  Chemical carcinogenesis 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 28  Chemokine signaling pathway 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SRC   D09664   Saracatinib   [2] 6, 89 
 29  Choline metabolism in cancer 
 4 genes, 6 drugs (DrugBank), 40 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [2] PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 30  Chronic myeloid leukemia 
 1 gene, 2 drugs (DrugBank), 12 diseases shown 		  [1] ABL1   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 D09664   Saracatinib   [2] 6, 89 
 31  Circadian entrainment 
 3 genes, 1 drug (DrugBank), 14 diseases shown 		  [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 32  Colorectal cancer 
 2 genes, 4 drugs (DrugBank), 37 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 33  Cortisol synthesis and secretion 
 3 genes, 1 drug (DrugBank), 14 diseases shown 		  [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 34  Cushing syndrome 
 4 genes, 2 drugs (DrugBank), 16 diseases shown 		  [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 35  EGFR tyrosine kinase inhibitor resistance 
 9 genes, 8 drugs (DrugBank), 42 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [5] FGFR2, FGFR3, KDR, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] SRC   D09664   Saracatinib   [2] 6, 89 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 36  Endocrine resistance 
 3 genes, 5 drugs (DrugBank), 38 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] SRC   D09664   Saracatinib   [2] 6, 89 
 37  Endocytosis 
 5 genes, 4 drugs (DrugBank), 14 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [3] FGFR2, FGFR3, PDGFRA   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] SRC   D09664   Saracatinib   [2] 6, 89 
 38  Endometrial cancer 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 39  Epithelial cell signaling in Helicobacter pylori infection 
 2 genes, 2 drugs (DrugBank), 6 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] SRC   D09664   Saracatinib   [2] 6, 89 
 40  ErbB signaling pathway 
 4 genes, 6 drugs (DrugBank), 41 diseases shown 		  [1] ABL1   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [2] ABL1, SRC   D09664   Saracatinib   [2] 6, 89 
 [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 41  Estrogen signaling pathway 
 2 genes, 2 drugs (DrugBank), 6 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] SRC   D09664   Saracatinib   [2] 6, 89 
 42  Fluid shear stress and atherosclerosis 
 3 genes, 3 drugs (DrugBank), 12 diseases shown 		  [1] KDR   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] SRC   D09664   Saracatinib   [2] 6, 89 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 43  Focal adhesion 
 8 genes, 5 drugs (DrugBank), 16 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [5] FLT1, FLT4, KDR, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] SRC   D09664   Saracatinib   [2] 6, 89 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 44  FoxO signaling pathway 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 45  GABAergic synapse 
 4 genes, 2 drugs (DrugBank), 15 diseases shown 		  [3] ABAT, GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [1] SRC   D09664   Saracatinib   [2] 6, 89 
 46  Gap junction 
 4 genes, 4 drugs (DrugBank), 14 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [2] PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] SRC   D09664   Saracatinib   [2] 6, 89 
 47  Gastric acid secretion 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] SSTR2   D00442   Octreotide   [8] 67, 75, 84, 85, 89, 96, 193, 227 
 D06495 
 48  Gastric cancer 
 3 genes, 5 drugs (DrugBank), 37 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] FGFR2   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 49  Glioma 
 4 genes, 6 drugs (DrugBank), 40 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [2] PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 50  GnRH secretion 
 3 genes, 1 drug (DrugBank), 14 diseases shown 		  [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 51  GnRH signaling pathway 
 2 genes, 2 drugs (DrugBank), 6 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] SRC   D09664   Saracatinib   [2] 6, 89 
 52  Growth hormone synthesis, secretion and action 
 2 genes, 4 drugs (DrugBank), 41 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] SSTR2   D00442   Octreotide   [8] 67, 75, 84, 85, 89, 96, 193, 227 
 D06495 
 53  Hematopoietic cell lineage 
 1 gene, 1 drug (DrugBank), 11 diseases shown 		  [1] KIT   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 54  Hepatitis B 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SRC   D09664   Saracatinib   [2] 6, 89 
 55  Hepatitis C 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 56  Hepatocellular carcinoma 
 2 genes, 4 drugs (DrugBank), 37 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 57  Herpes simplex virus 1 infection 
 2 genes, 4 drugs (DrugBank), 38 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] SRC   D09664   Saracatinib   [2] 6, 89 
 58  HIF-1 signaling pathway 
 4 genes, 6 drugs (DrugBank), 39 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] FLT1   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 59  Human cytomegalovirus infection 
 6 genes, 9 drugs (DrugBank), 46 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 [1] SRC   D09664   Saracatinib   [2] 6, 89 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 60  Human immunodeficiency virus 1 infection 
 1 gene, 3 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 61  Human papillomavirus infection 
 5 genes, 7 drugs (DrugBank), 43 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 62  IL-17 signaling pathway 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 63  Inflammatory mediator regulation of TRP channels 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SRC   D09664   Saracatinib   [2] 6, 89 
 64  Insulin resistance 
 1 gene, 3 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 65  Insulin signaling pathway 
 1 gene, 3 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 66  JAK-STAT signaling pathway 
 4 genes, 6 drugs (DrugBank), 40 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [2] PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 67  Kaposi sarcoma-associated herpesvirus infection 
 4 genes, 6 drugs (DrugBank), 44 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 [1] SRC   D09664   Saracatinib   [2] 6, 89 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 68  Leishmaniasis 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 69  Longevity regulating pathway 
 1 gene, 3 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 70  Longevity regulating pathway - multiple species 
 1 gene, 3 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 71  MAPK signaling pathway 
 14 genes, 5 drugs (DrugBank), 26 diseases shown 		  [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [8] FGFR1, FGFR2, FGFR3, FLT1, FLT4, KDR, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [2] KIT, PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 72  Melanogenesis 
 1 gene, 1 drug (DrugBank), 11 diseases shown 		  [1] KIT   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 73  Melanoma 
 4 genes, 3 drugs (DrugBank), 13 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [3] FGFR1, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 74  Metabolic pathways 
 7 genes, 4 drugs (DrugBank), 36 diseases shown 		  [4] ABAT, ALDH5A1, GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [1] CYP19A1   D00964   Letrozole   [2] 81, 89 
 [1] HMGCR   D00434   Simvastatin   [19] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 162, 195, 265, 298, 299, 310 
 [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 75  MicroRNAs in cancer 
 8 genes, 9 drugs (DrugBank), 46 diseases shown 		  [1] ABL1   D09664   Saracatinib   [2] 6, 89 
 [2] ABL1, PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [3] FGFR3, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 76  Mitophagy - animal 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SRC   D09664   Saracatinib   [2] 6, 89 
 77  mTOR signaling pathway 
 1 gene, 3 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 78  Neuroactive ligand-receptor interaction 
 2 genes, 2 drugs (DrugBank), 19 diseases shown 		  [1] ADRB2   D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 [1] SSTR2   D00442   Octreotide   [8] 67, 75, 84, 85, 89, 96, 193, 227 
 D06495 
 79  Neurotrophin signaling pathway 
 1 gene, 2 drugs (DrugBank), 12 diseases shown 		  [1] ABL1   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 D09664   Saracatinib   [2] 6, 89 
 80  NF-kappa B signaling pathway 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 81  Non-small cell lung cancer 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 82  Ovarian steroidogenesis 
 2 genes, 2 drugs (DrugBank), 10 diseases shown 		  [1] CYP19A1   D00964   Letrozole   [2] 81, 89 
 [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 83  Oxytocin signaling pathway 
 3 genes, 3 drugs (DrugBank), 13 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 [1] SRC   D09664   Saracatinib   [2] 6, 89 
 84  Pancreatic cancer 
 3 genes, 5 drugs (DrugBank), 39 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 85  Parathyroid hormone synthesis, secretion and action 
 2 genes, 2 drugs (DrugBank), 7 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] FGFR1   D10481   Nintedanib   [4] 51, 85, 89, 228 
 86  Pathogenic Escherichia coli infection 
 1 gene, 2 drugs (DrugBank), 12 diseases shown 		  [1] ABL1   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 D09664   Saracatinib   [2] 6, 89 
 87  Pathways in cancer 
 12 genes, 9 drugs (DrugBank), 46 diseases shown 		  [1] ABL1   D09664   Saracatinib   [2] 6, 89 
 [3] ABL1, KIT, PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [6] FGFR1, FGFR2, FGFR3, FLT4, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 88  PD-L1 expression and PD-1 checkpoint pathway in cancer 
 2 genes, 4 drugs (DrugBank), 37 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 89  Phospholipase D signaling pathway 
 5 genes, 6 drugs (DrugBank), 40 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [2] KIT, PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [2] PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 90  PI3K-Akt signaling pathway 
 12 genes, 7 drugs (DrugBank), 41 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [8] FGFR1, FGFR2, FGFR3, FLT1, FLT4, KDR, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [2] KIT, PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 91  Platelet activation 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SRC   D09664   Saracatinib   [2] 6, 89 
 92  Prolactin signaling pathway 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SRC   D09664   Saracatinib   [2] 6, 89 
 93  Propanoate metabolism 
 1 gene, 1 drug (DrugBank), 14 diseases shown 		  [1] ABAT   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 94  Prostate cancer 
 6 genes, 6 drugs (DrugBank), 40 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [4] FGFR1, FGFR2, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 95  Proteoglycans in cancer 
 6 genes, 7 drugs (DrugBank), 40 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [2] FGFR1, KDR   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] SRC   D09664   Saracatinib   [2] 6, 89 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 96  Rap1 signaling pathway 
 12 genes, 5 drugs (DrugBank), 16 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [8] FGFR1, FGFR2, FGFR3, FLT1, FLT4, KDR, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [2] KIT, PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] SRC   D09664   Saracatinib   [2] 6, 89 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 97  Ras signaling pathway 
 12 genes, 5 drugs (DrugBank), 16 diseases shown 		  [1] ABL1   D09664   Saracatinib   [2] 6, 89 
 [3] ABL1, KIT, PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [8] FGFR1, FGFR2, FGFR3, FLT1, FLT4, KDR, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 98  Regulation of actin cytoskeleton 
 7 genes, 4 drugs (DrugBank), 14 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [5] FGFR1, FGFR2, FGFR3, PDGFRA, PDGFRB   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] PDGFRA   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [1] SRC   D09664   Saracatinib   [2] 6, 89 
 99  Regulation of lipolysis in adipocytes 
 2 genes, 2 drugs (DrugBank), 20 diseases shown 		  [1] ADRB2   D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 100  Relaxin signaling pathway 
 3 genes, 3 drugs (DrugBank), 11 diseases shown 		  [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] SRC   D09664   Saracatinib   [2] 6, 89 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 101  Renal cell carcinoma 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 102  Renin secretion 
 1 gene, 1 drug (DrugBank), 13 diseases shown 		  [1] ADRB2   D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 103  Retrograde endocannabinoid signaling 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 104  Rheumatoid arthritis 
 2 genes, 2 drugs (DrugBank), 11 diseases shown 		  [1] FLT1   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 105  Salivary secretion 
 1 gene, 1 drug (DrugBank), 13 diseases shown 		  [1] ADRB2   D02147   Salbutamol   [13] 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 106  Serotonergic synapse 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 107  Shigellosis 
 4 genes, 6 drugs (DrugBank), 41 diseases shown 		  [1] ABL1   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 [2] ABL1, SRC   D09664   Saracatinib   [2] 6, 89 
 [1] EGFR   D03455   Cetuximab   [5] 34, 51, 86, 89, 331 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 108  Signaling pathways regulating pluripotency of stem cells 
 3 genes, 1 drug (DrugBank), 4 diseases shown 		  [3] FGFR1, FGFR2, FGFR3   D10481   Nintedanib   [4] 51, 85, 89, 228 
 109  Small cell lung cancer 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 110  Steroid hormone biosynthesis 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] CYP19A1   D00964   Letrozole   [2] 81, 89 
 111  Taurine and hypotaurine metabolism 
 2 genes, 1 drug (DrugBank), 14 diseases shown 		  [2] GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 112  Terpenoid backbone biosynthesis 
 1 gene, 1 drug (DrugBank), 19 diseases shown 		  [1] HMGCR   D00434   Simvastatin   [19] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 162, 195, 265, 298, 299, 310 
 113  Th17 cell differentiation 
 1 gene, 3 drugs (DrugBank), 37 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 114  Thermogenesis 
 2 genes, 4 drugs (DrugBank), 37 diseases shown 		  [1] FGFR1   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 115  Thyroid hormone signaling pathway 
 2 genes, 4 drugs (DrugBank), 38 diseases shown 		  [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 [1] SRC   D09664   Saracatinib   [2] 6, 89 
 116  Tight junction 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SRC   D09664   Saracatinib   [2] 6, 89 
 117  TNF signaling pathway 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 118  Transcriptional misregulation in cancer 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] FLT1   D10481   Nintedanib   [4] 51, 85, 89, 228 
 119  Tuberculosis 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SRC   D09664   Saracatinib   [2] 6, 89 
 120  Type I diabetes mellitus 
 2 genes, 1 drug (DrugBank), 14 diseases shown 		  [2] GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 121  Type II diabetes mellitus 
 2 genes, 4 drugs (DrugBank), 44 diseases shown 		  [1] CACNA1G   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [1] MTOR   D02714   Everolimus   [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 
 D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 D06068   Temsirolimus   [4] 13, 34, 89, 331 
 122  Valine, leucine and isoleucine degradation 
 1 gene, 1 drug (DrugBank), 14 diseases shown 		  [1] ABAT   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 123  VEGF signaling pathway 
 4 genes, 4 drugs (DrugBank), 19 diseases shown 		  [1] KDR   D10481   Nintedanib   [4] 51, 85, 89, 228 
 [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 [1] SRC   D09664   Saracatinib   [2] 6, 89 
 [1] VEGFA   D06409   Bevacizumab   [9] 13, 34, 85, 86, 87, 89, 227, 280, 331 
 124  Viral carcinogenesis 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SRC   D09664   Saracatinib   [2] 6, 89 
 125  Viral myocarditis 
 1 gene, 2 drugs (DrugBank), 12 diseases shown 		  [1] ABL1   D01441   Imatinib   [11] 13, 28, 34, 35, 46, 51, 85, 86, 87, 89, 162 
 D08066 
 D09664   Saracatinib   [2] 6, 89 
 126  Yersinia infection 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SRC   D09664   Saracatinib   [2] 6, 89 

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